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Etiopathogenesis of reproductive tract infections and the emerging role of bitter taste receptors:A scoping review

Asian pacific Journal of Reproduction 2021年第4期10卷 145-154页

作者： Menizibeya o.Welcome Abraham Jeremiah dennis o.allagoa Senol Dane Vladimir A.Pereverzev Department of Physiology Faculty of Basic Medical SciencesNile University of NigeriaAbujaNigeria Department of Surgery Federal Medical CentreYenagoaNigeria Department of Surgery Belarusian State Medical UniversityMinskBelarus Department of obstetrics and Gynecology Federal Medical CentreYenagoaNigeria Department of Normal Physiology Belarusian State Medical UniversityMinskBelarus

Reproductive tract infections pose an immense public health concern worldwide as over 600 million new cases are recorded annually along with several complications,including infertility,ectopic pregnancy,preterm delivery,and neonatal *** improved understanding of the mechanisms of pathogenic invasion,the etiopathogenesis of reproductive tract infections is yet to be completely *** data has suggested a critical role of bitter taste receptors of the reproductive tract in etiopathogenesis of reproductive tract ***,we review the literature on current etiopathogenesis of reproductive tract infections and the role of bitter taste receptors of the reproductive tract in etiopathogenesis of reproductive tract *** evidence suggests a critical role of microbiota disorder of the reproductive tract in reproductive tract *** bacterial,protozoan parasitic,helminthic parasitic and viral pathogens have been identified as causative agents of reproductive tract *** pathogens subvert host defenses and activate specific architectural units of the uroepithelium such as Toll-like receptors,which recognize conserved motifs on the *** activated Toll-like receptors mediate downstream signaling,stimulating nuclear factor-κB,which in turn activates the production of proinflammatory *** pathway is also associated with recruitment of immunocytes to the site of aggression and release of proteinases,which drive tissue damage in the reproductive *** in detection of pathogenic components by the bitter taste receptors of the reproductive tract may play a critical role in the etiopathogenesis of reproductive tract *** review provides important information for identification of novel frontiers for the treatment of reproductive tract infections.

关键词： Infection Genital inflammation Reproduction Reproductive tract infections Bitter taste receptor Etiopathogenesis Cytokines

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Medication Non-Adherence and Disability among outpatients with Schizophrenia in North-Central Nigeria

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Journal of Biosciences and Medicines 2022年第9期10卷 86-117页

作者： Maigari Yusufu Taru Lubuola Issa Bamidele Akinyemi opeyemi Faith Tungchama Friday Philip Erefagha Leonardo.allagoa osayande Henry Izevbokun Department of Psychiatry University of Jos Jos Nigeria Department of Psychiatry Jos University Teaching Hospital Jos Nigeria Federal Neuropsychiatric Hospital Kaduna Nigeria Federal Medical Centre Abeokuta Nigeria

Background: About fifty percent of patients with Schizophrenia do not take their medication as prescribed. This scenario often results in disease progression and increased relapse rates, resulting in poor outcomes, including functional disability. Aim: This study was design to evaluate the relationship between medication non-adherence and disability in patients with Schizophrenia attending the outpatient clinic at the Jos University Teaching Hospital, north-central Nigeria, from June 2017 to November 2017. Methods: We carried out a cross-sectional study that employed a systematic sampling method to select 301 eligible subjects. We used the Medication Adherence Rating Scale (MARS) 10 and World Health organization Disability Assessment Schedule version 2.0 (WHoDAS 2.00) to assess medication adherence and levels of disability. Results: The results show that 39.9% of the respondents were medication nonadherent. Medication adherence correlated negatively with the total disability score and all the domains of disability. A low level of education and poor social support were significant predictors of non-adherence. Conclusion: Medication non-adherence and its associated factors, if identified early and proper interventions instituted, a disability could be avoided or minimized among people with Schizophrenia. Therefore, we recommend regular screening of patients with mental disorders for early identification and intervention for medication adherence.

关键词： Disability Medication Non-Adherence Schizophrenia The Associative Role

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