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科学·哲学·概率

医学与哲学 1983年第10期 48-49页

作者： d·T·dennis 刘云嵘

概率或者事件发生的可能性,对于科学及我们了解正确的科学研究方法学具有重要的意义。概率的概念虽然在我们目前的思想中是基本的,然而在西方文化的科学哲学历史的发展过程中却是慢慢开展的。统计学作为研究概率之数学表达的一门学科,... 详细信息

概率或者事件发生的可能性,对于科学及我们了解正确的科学研究方法学具有重要的意义。概率的概念虽然在我们目前的思想中是基本的,然而在西方文化的科学哲学历史的发展过程中却是慢慢开展的。统计学作为研究概率之数学表达的一门学科,仅仅从上世纪初就很活跃了。概率的概念可视作起源于三种重要的思想。

关键词：概率概念牛顿思维形式

Stable low pressure polymeric insulating phases of carbon monoxide predicted using first principles methods

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Stable low pressure polymeric insulating phases of carbon mo...

第十八届中国高压科学学术会议

作者：夏康 Jian Sun Chris J.Pickard dennis d.Klug Richard J.Needs National Laboratoryof Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures and School of PhysicsNanjing University departmentof Materials Science&Metallurgy University of Cambridge Steacie Institute for Molecular Sciences National Research Council of Canada

We have used crystal structure prediction methods and first-principles caculations to explore low-energy and pressure structures of carbon monoxide(CO).The most stable structure at low pressures is found to be a crystalline polymeric structure of Pna21 symmetry rather than a molecular *** Pna21 structure is insulating,in contrast to an earlier prediction of a metalic ground state structure for *** Pna21structure is insulating,in contrast to an earlier prediction of a metallic ground state

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麦芽与制麦技术

Polycomb response element-binding sites in the MdR of CLL: Potential tumor suppressor regulation

丛书名：美国现代食品科技系列

2005年

作者：（英）dennis E. Briggs 李崎等译

本书描述了麦芽和制麦技术，给出了制麦涉及的各种技术概况，详细介绍了可以进行制麦的各种谷物原料及其化学与生化组成，强调了制麦技术的原理，阐述了制麦设备和制麦技术的发展历史等。

ISBN: (纸本)7501947651

关键词：啤酒原料加工

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Advances in Bioscience and Biotechnology 2013年第1期4卷 129-135页

作者： Christine E. Cutucache Javeed Iqbal Philip J. Bierman Robert Gregory Bociek dennis d. Weisenburger Shantaram S. Joshi department of Biology University of Nebraska at Omaha Omaha USA department of Genetics Cell Biology and Anatomy University of Nebraska Medical Center Omaha USA department of Internal Medicine Oncology/Hematology University of Nebraska Medical Center Omaha USA department of Pathology and Microbiology University of Nebraska Medical Center Omaha USA

Chronic lymphocytic leukemia [CLL] is the most common adult leukemia and is heterogeneous in clinical presentation. CLL cases present with various chromosomal aberrations, including 11q23, 14q32, 17p, and trisomy 12, with the most common abnormality being deletion of 13q14 [1]. Although monoallelic deletion of 13q14 is common, there is a subset of patients who have complete nullisomy at 13q14, a locus that has been hypothesized to contribute to CLL pa thogenesis [2] due to loss of tumor suppressors [dLEU and miR-15a/16-1]. We hypothesized that deletion of both copies of 13q14 would lead to uncontrollable proliferation of CLL cells and a poor prognosis. We examined our 13q14 nullisomy for survival, treatment-free survival, lymphocyte doubling time, and the presence of lymphadenopathy. Furthermore, we compared the gene expression profiles between patients with 13q14 monosomy, nullisomy, or normal karyotype. Our results suggest that patients with 13q nullisomy have a higher incidence of bulky lymphadenopathy [16.6% compared to 10% of monosomy patients], a higher frequency of lymphocyte doubling time [27.7% compared to 7.4% of monosomy patients], and a higher rate of needing treatment [50% compared to 18.5% of monosomy patients]. We observed deletion of dLEU1 and HTR2A, consistent with a gene dosage effect, and observed PRE-binding sites on dLEU1. Patients with homozygous deletion of 13q14 had a worse prognosis compared to heterozygotes. Lastly, the dLEU1 locus is a possible “second hit” loss for CLL progression.

关键词： Chronic Lymphocytic Leukemia Gene Expression 13q14 Nullisomy dLEU Tolerogenic

Randomized Trial of the Use of dexmedetomidine vs. Propofol after Regional Blockade in Shoulder Surgery Patients in Beach Chair Position

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Open Journal of Anesthesiology 2015年第8期5卷 187-191页

作者： Piyush Gupta Ofer Wellisch Mark Kronenfeld Jack Choueka Kenneth d. Eichenbaum Murali Pagala Peter Homel dennis E. Feierman department of Anesthesiology Maimonides Medical Center Brooklyn NY USA department of Surgery Maimonides Medical Center Brooklyn NY USA department of Biostatistics Maimonides Medical Center Brooklyn NY USA

Background: Propofol is often the drug of choice for ambulatory orthopedic cases. However, propofol can be associated with apnea or other events requiring airway interventions. dexmedetomidine (dex) has the unique pharmacologic profile of providing sedation without respiratory depression. This is particularly relevant in patients with morbid obesity and/or challenging airways. The hypotheses were: 1) Propofol would cause more apnea or require more airway manipulations than dexmedetomidine;2) Propofol would have shorter post anesthesia unit recovery times;and 3) dexmedetomidine would be associated with more bradycardia and hypotension. Methods: After IRB approval, 50 patients were randomized to receive either propofol or dex for Total Intravenous anesthesia (TIVA) after interscalene brachial plexus block was performed preoperatively under ultrasound guidance. The main end points that we measured where: airway interventions, intra-operative bradycardia, hypotension, and PACU length of stay. Results: There were more airway interventions in the propofol group compared to the dex group. Additionally, the dex group had significantly longer PACU stays. Conclusion: We would recommend that dex should be preferentially considered for patients predisposed to airway obstruction;however, the standard use of dex over Propofol needed to reconsider since the use of dex as the agent for TIVA was associated with longer PACU stays.

关键词： dexmedetomidine Propofol Beach Chair Regional Block

Viscoelastic Analysis of Heavy duty Flexible Pavements under Three-dimensional Tire-Pavement Contact Stress

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Viscoelastic Analysis of Heavy Duty Flexible Pavements under...

NanoLuc标记的重组克里米亚-刚果出血热病毒及其初步用于抗病毒药物筛选

ISAP2012重载沥青路面和桥面铺装专题会议

作者： Guangming Wang dennis Morian doug Frith Quality Engineering Solutions Inc.

＜正＞Layered elastic analysis has been widely used in the structural analysis of heavy duty flexible ***,asphalt mixtures are well-known to exhibit time-dependent viscoelastic behavior,and consequently,results based on elastic behavior assumptions may not truly represent responses of an asphalt concrete *** the other hand,tire-pavement contact stress is traditionally assumed to be uniform,circular and vertical for pavement design and analysis approximations,while the actual tire-pavement contact stress is three-dimensional（3-d）,non-uniform,and non-circular,

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中华实验和临床病毒学杂志 2018年第6期32卷 620-624页

作者：夏菡袁志明 dennis Bente 中国科学院武汉病毒研究所武汉430071 美国德州大学医学分部微生物与免疫系加尔雏斯顿77555

目的为了构建可分泌表达NanoLuc荧光素酶的重组克里米亚-刚果出血热病毒(Crimean-Congo hemorrhagic fever virus,CCHFV)并探讨其用于抗病毒药物高通量快速初筛的可行性。方法将NanoLuc基因与CCHFVM节段上的mucin编码框融合,拯救重组病... 详细信息

目的为了构建可分泌表达NanoLuc荧光素酶的重组克里米亚-刚果出血热病毒(Crimean-Congo hemorrhagic fever virus,CCHFV)并探讨其用于抗病毒药物高通量快速初筛的可行性。方法将NanoLuc基因与CCHFVM节段上的mucin编码框融合,拯救重组病毒,并以利巴韦林为阳性对照,评估Furin抑制剂在体外对重组病毒的抑制效果。结果成功获得可分泌表达NanoLuc荧光素酶的重组CCHFV(rCCHFV_mucin_NLuc),且在感染细胞上清中,表示NanoLuc活性的相对光单位(relative light unit,RLU)与病毒半数组织感染剂量(TCId50)呈显著正相关性(cor=0.998,P=0.001)。10μmol/L浓度下,Furin抑制剂处理后1~3d感染细胞上清中NanoLuc荧光素酶活力与利巴韦林处理组无明显差异(P>0.1),但第4天Furin抑制剂处理组上清中RLU值显著高于利巴韦林处理组(P=0.001),且与未处理病毒对照组无明显差异(P>0.1)。结论成功构建1株NanoLuc标记的rCCHFV并可用于抗病毒药物的体外快速初筛。

关键词：荧光素酶克里米亚-刚果出血热病毒抗病毒药物筛选

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人鬼情未了

疯狂英语(新策略) 2009年第1期 16-20页

作者： dennis Siluk Ed.d. 乐在其中

读大学时,同宿舍有一个女生从小到大都没停止过记日记。每晚睡觉之前,总看到她趴在台灯下静静地在日记本上写些什么。直到大学毕业收拾行李的时候,她光在大学时期用的日记本就整理出一大摞。我们都"嘲笑"她:这年头谁还像你整天写日记啊... 详细信息

读大学时,同宿舍有一个女生从小到大都没停止过记日记。每晚睡觉之前,总看到她趴在台灯下静静地在日记本上写些什么。直到大学毕业收拾行李的时候,她光在大学时期用的日记本就整理出一大摞。我们都"嘲笑"她:这年头谁还像你整天写日记啊。她淡淡一笑,说道:"我的记忆力不太好"。我想,我是羡慕她的。很多我们以为会念念不忘的事情,就在我们念念不忘的过程里,被我们悄悄遗忘了。而她却把所有值得记忆的往事用笔记下,留给自己。日后翻来,想必她会对当年的痛苦、绝望、快乐、愤怒不禁莞尔吧。留下了日记,仿佛就留住了过往的岁月。本期主题故事,我们为大家选取了几篇陌生人的日记,从中你可以体验他人的所思所想,又或许你能看到自己生活的影子。

关键词：南达科他州拉线盘笔记本明尼苏达州

Vasoactive intestinal polypeptide (VIP) corrects chronic inflammatory response syndrome (CIRS) acquired following exposure to water-damaged buildings

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Health 2013年第3期5卷 396-401页

作者： Ritchie C. Shoemaker dennis House James C. Ryan Center for Research on Biotoxin Associated Illnesses Pocomoke City USA Proteogenomics LLC Vero Beach USA

Exposure in water-damaged buildings (WdB) to airborne bioaerosols including metabolic products of toxigenic fungi, bacteria and actinomycetes;and inflammagens, can lead to a persistent innate immune inflammatory illness. This illness, termed a chronic inflammatory response syndrome (CIRS-WdB), is systemic with symptoms acquired from multiple organ systems. Treatment of CIRS-WdB has progressed rapidly as a better understanding of the inflammatory pathophysiology has led to targeted, sequential therapies. The fundamental basis of uncontrolled innate immune responses, the humoral deficiency of regulatory neuropeptides melanocyte stimulating hormone (MSH) or vasoactive intestinal polypeptide (VIP), seen in over 98% of pa tients, has not consistently responded to any treatment modality. Use of replacement VIP has been attempted anecdotally;VIP replacement therapies show promise in short term studies but longer therapies have not been attempted. Here we report an open label trial of 20 patients with refractory CIRS-WdB illness who took replacement VIP in a nasal spray for at least 18 months with confirmation of durable efficacy and absence of significant side effects. These 20 patients were similar in symptoms and lab find- ings to three previously published cohorts in- volving 1829 patients and 169 controls. dosage of VIP was titrated downwards from four to zero doses a day to determine minimum effective dose, and retitrated upwards for maximum improvement over time. The trial showed that VIP therapy safely 1) reduced refractory symptoms to equal controls;2) corrected inflammatory parameters C4a, TGF beta-1, VEGF, MMP9;3) corrected estradiol, testosterone and 25-OH Vitamin d;4) returned pulmonary artery systolic pressure (PASP) during exercise to normal;and 5) enhanced quality of life in 100% of trial patients. Subsequent identification of correction of T-regulatory cell levels supports the potential role of VIP in both innate and adaptive immune function.

关键词： Vasoactive Intestinal Polypeptide (VIP) Chronic Inflammatory Response Syndrome (CIRS) TGF Beta-1 C4a MSH T Regulatory Cells Water-damaged Buildings