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Journal of Resources and Ecology 2017年第2期8卷 115-120页

作者：于贵瑞陈智张雷明彭长辉陈镜明朴世龙张扬建牛书丽王秋凤骆亦其 Philippe Ciais dennis d.baldocchi 中国科学院地理科学与资源研究所生态系统网络观测与模拟重点实验室北京100101 中国科学院大学资源与环境学院北京100190 加拿大魁北克大学生物科学系和森林研究中心加拿大蒙特利尔H3C3P8 西北农林科技大学土壤侵蚀与旱地农业国家重点实验室、林学院西安712100 加拿大多伦多大学地理系加拿大多伦多M5S2E8 南京大学国际地球系统科学研究所南京210093 北京大学城市与环境学院生态系、地表过程分析与模拟教育部重点实验室北京100871 中国科学院青藏高原研究所高寒生态与生物多样性实验室北京100101 美国俄克拉荷马大学微生物与植物生物学系美国诺曼73019 法国环境与气候科学实验室法国伊维特河畔吉夫91191 美国加利福尼亚大学伯克利分校环境科学、政策与管理系美国伯克利94720

As the Earth entering into the Anthropocene, global sustainable development requires ecological research to evolve into the large-scale, quantitative, and predictive era. It necessitates a revolution of ecological observation technology and a long-term accumulation of scientific data. The ecosystem flux tower observation technology is the right one to meet this requirement. However, the unique advantages and potential values of global-scale flux tower observation are still not fully appreciated. Reviewing the development history of global meteorological observation and its scientific contributions to the society, we can get an important enlightenment to re-cognize the scientific mission of flux observation.

关键词： flux tower observation ecological research scientific data accumulation global sustainable development ecological prediction

Advancing emergency preparedness in a postpandemic world:global collaboration and innovative approaches for hospitals

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Emergency and Critical Care Medicine 2024年第3期4卷 103-104页

作者： Krzysztof Goniewicz dennis G.Barten department of Security Studies Polish Air Force UniversityDęblinPoland department of Emergency Medicine VieCuri Medical CenterVenlothe Netherlands

As the world transitions into a postpandemic era,hospitals and healthcare systems must adapt their emergency management plans to address the unique challenges that *** upon the previous Hospital Emergency Management Plan^([1])during the coronavirus disease 2019 pandemic,this commentary offers updated and novel suggestions for emergency preparedness,emphasizing the need for international coordination and the implementation of innovative strategies.

关键词： innovative prepare global

A detailed comparison of the composition of(RE)-Ba-Cu-O-Ag bulk superconductors

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Superconductivity 2024年第1期9卷 87-94页

作者： J.V.J.Congreve Y.Shi A.R.dennis H.druiff N.C.Tutt d.A.Cardwell J.H.durrell department of Engineering University of CambridgeCambridgeUK

The homogeneity of the microstructure and composition are critical in determining the properties of rare earthbarium‐cuprate,single grain bulk superconductors[(RE)BCO].The magnitude of the trapped magnetic field achieveable in these technologically important materials,in particular,is influenced heavily by the size and distribution of(RE)_(2)BaCuO_(x)(RE‐211)flux pinning inclusions in the bulk microstructure,whereas the size and distribution of silver agglomerates present within the bulk superconducting matrix correlate directly with improved mechanical *** careful engineering,these materials have significant potential for application in range of devices related to energy storage,medicine,electro‐magnetic machinery and microelectronic *** of(RE)BCO bulk superconductors typically involves heating a powder compact above its peritectic decomposition temperature followed by slow cooling to facilitate the growth of a single ***(RE)BCO composition has a different peritectic temperature and growth rate,which,therefore,necessitates different requirements in the heating *** fabrication temperature and growth rate,for example,may have an effect on the RE‐211 and silver distribution,which may,in turn,affect the superconducting properties of the resulting single *** this work we compare the distributions of silver and RE‐211 in the single grain microstructures of YBCOAg,GdBCO‐Ag,EuBCO‐Ag and SmBCO‐Ag bulk superconductors using optical microscopy,scanning electron microscopy and energy dispersive X‐ray *** observe that the distributions are very similar along both the a/b‐axis and c‐axis of these *** suggests that factors other than the maximum temperature used to achieve peritectic decomposition and the rate of single grain growth are particularly influential in determining the properties of the as‐processed samples in the top seeded melt growth *** observation demonstrates there is freedom to us

关键词： YBCO‐Ag GdBCO‐Ag SmBCO‐Ag EuBCO‐Ag Composition Bulk superconductor

CdC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi durani Amin Sabet Moniquetta Shafer Wouter R.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy Manoj Harsha Sridhar dennis Kinyua Hong Zhong Barbara P.Mello Metamia Ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel Colm Morrsey Sanjoy Mehta Jesse Barnes Michael C.Haffner Nichlas d.Socci Richard P.Koche Elisa de Stanchina Sonia Molina-Pinelo Sohrab Salehi Helena A.Yu Joseph M.Chan Charles M.Rudin department of Medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill Cornell Graduate School of Medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA divisionsof Human Biology and Clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening Core Facility Memorial Sloan Kettering Cancer Center New YorkNYUSA department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell Medical College New York NYUSA Present address:Swiss Institute for Experimental Cancer Research(ISREC) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and Retinoblastoma Transcriptional Corepressor 1(RB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase Cell division Cycle 7(CdC7)occurred in tumors during the initial steps of NE transformation,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the CdC7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the MYC Proto-Oncogen(MYC),implicated in stemness and histological *** overexpression of a degradation-resistant MYC isoform reestablished the NE transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate CdC7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

Numerical computation of hurricane effects on historic coastal hydrology in Southern Florida

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Ecological Processes 2015年第1期4卷 37-56页

作者： Eric d Swain dennis Krohn Catherine A Langtimm U.S.Geological Survey Caribbean-Florida Water Science Center7500 SW 36th StreetDavieFL 33314USA U.S.Geological Survey St.Petersburg Coastal and Marine Science Center600 Fourth Street SouthSt.PetersburgFL 33701USA U.S.Geological Survey Southeast Ecological Science Center7920 NW 71st StreetGainesvilleFL 32653USA

Introduction:Numerical models are critical for assessing the effects of sea level rise(SLR),hurricanes,and storm surge on vegetation change in the Everglades National *** model must be capable of representing short-timescale hydrodynamics,salinity transport,and groundwater ***,there is also a strong need to adapt these numerical models to hindcast past conditions in order to examine long-term effects on the distribution of vegetation that cannot be determined using only the modern ***:Based on parameters developed for a numerical model developed for the recent 1996 to 2004 period,a hindcast model was developed to represent sea level and water management for the period of 1926 to 1932,constrained by the limited hydrology and meteorology data available from the historic *** hurricanewind and storm surge representations,required for the hindcast model,are based on information synthesized from modern storm data.A series of simulation scenarios with various hurricane representations inserted into both hindcast and recent numerical models were used to assess the utility of the storm representation in the model and compare the two ***:The comparison of the hindcast and recent models showed differences in the hydrology patterns that are consistent with known differences in water delivery systems and sea level rise.A 30×lower-resolution spatially variable wind grid for the hindcast produced similar results to the original high-resolution full wind grid representation of the recent *** effects on hydrologic patterns demonstrated with the simulations show hydrologic processes that could have a long-term effect on vegetation ***:The hindcast simulation estimated hydrologic processes for the 1926 to 1932 *** shows promise as a simulator in long-term ecological studies to test hypotheses based on theoretical or empirical-based studies at larger landscape scales.

关键词： Hindcast Numerical models Hurricanes Wind fields Storm surge Sea level rise Coastal hydrology

Advances in the phylogenesis of Agaricales and its higher ranks and strategies for establishing phylogenetic hypotheses

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 779-786页

作者： Rui-lin ZHAO dennis E. dESJARdIN Kasem SOYTONG Kevin d. HYdE Faculty of Biology Conservation Southwest Forestry University Kunming 650224 China department of Biology San Francisco State University San Francisco California 94132 USA Faculty of Agricultural Technology King Mongkut＇s Institute of Technology Ladkrabang （KMITL） Ladkrabang Bangkok 10520 Thailand International Fungal Resource and development Centre the Research Institute of Resources Insects Chinese Academy of Forestry Kunming 650224 China Fungal Research Group School of Science Mae Fah Luang University Tasud Chiang Rai 57100 Thailand

We present an overview of previous research results on the molecular phylogenetic analyses in Agaricales and its higher ranks (Agaricomycetes/Agaricomycotina/Basidiomycota) along with the most recent treatments of taxonomic systems in these taxa. Establishing phylogenetic hypotheses using dNA sequences, from which an understanding of the natural evolutionary relationships amongst clades may be derived, requires a robust dataset. It has been recognized that single-gene phylogenies may not truly represent organismal phylogenies, but the concordant phylogenetic genealogies from multiple-gene datasets can resolve this problem. The genes commonly used in mushroom phylogenetic research are summarized.

关键词： Gene Molecular Mushrooms Phylogeny

落叶阔叶林内的光合作用和气孔传导率特征(英文)

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植物生理学报（0257-4829) 1991年第1期17卷 25-36页

作者：王汉杰 d. d. baldocchi 南京林业大学 NOAA/ATdd P. O. Box 2456 OAK Ridge TN 37831 USA

本文根据Wang和BMdocchi(1989)最近提出的冠层辐射模型,进一步给出了一个模拟冠层光合作用速率和气孔传导率的模式.模式将冠层中每一层的叶面积分为向光叶、半影叶、和全遮荫叶三种,并分别计算其光合作用速率和气孔传导率。计算得到的... 详细信息

本文根据Wang和BMdocchi(1989)最近提出的冠层辐射模型,进一步给出了一个模拟冠层光合作用速率和气孔传导率的模式.模式将冠层中每一层的叶面积分为向光叶、半影叶、和全遮荫叶三种,并分别计算其光合作用速率和气孔传导率。计算得到的光合速率廓线表明,在落叶阔叶林内,冠层下部的叶片常处于光照不足状态;半影效应使得透过林冠达于底部的辐射量增大,这对于林下植物的光合作用是有利的。模式计算值与实测值之间的微弱差别应归因于纯辐射模型无法考虑湍流输送机制造成的CO_2传输和冠层底部耐荫性叶对于低光照的适应能力。

关键词：光合作用气孔传导率落叶阔叶林

Evaluation of steroidogenic capacity after follicle stimulating hormone stimulation in bovine granulosa cells of Revalor 200~ implanted heifers

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Journal of Animal Science and Biotechnology 2014年第3期5卷 280-285页

作者： ANdrea d Stapp Craig A Gifford dennis M Hallford Jennifer A Hernandez Gifford department of Animal Science Oklahoma State University department of Animal and Range Science New Mexico State University department of Animal Science 114B Animal Science BuildingOklahoma State University

Background： Heifers not used as breeding stock are often implanted with steroids to increase growth efficiency thereby altering hormone profiles and potentially changing the environment in which ovarian follicles develop. Because bovine granulosa cell culture is a commonly used technique and often bovine ovaries are collected from abattoirs with no record of implant status, the objective of this study was to determine if the presence of an implant during bovine granulosa cell development impacts follicle stimulating hormone-regulated steroidogenic enzyme expression. Paired ovaries were collected from 16 feedlot heifers subjected to 1 of 3 treatments： non-implanted （n = 5）, Revalor 200 for 28 d （n = 5）, or Revalor 200 for 84 d （n = 6）. Small follicle （1 to 5 mm） granulosa cells were isolated from each pair and incubated with phosphate buffered saline （n = 16） or 100 ng/mL follicle stimulating hormone （n = 16） for 24 h. Results： Granulosa cells of implanted heifers treated with follicle stimulating hormone produced medium concentrations of progesterone similar （P = 0.22） to non-implanted heifers, while medium estradiol concentrations were increased （P 〈 0.10） at 28 and 84 d compared to non-implanted heifers indicating efficacy of treatment. Additionally, real-time PCR analysis in response to follicle stimulating hormone treatment demonstrated a decrease in steroidogenic acute regulatory protein （P = 0.05） mRNA expression in heifers implanted for 84 d and an increase in P450 side chain cleavage mRNA in granulosa cells of heifers implanted for 28 （P 〈 0.10） or 84 d （P 〈 0.05） compared to non-implanted females. However, no difference in expression of 3-beta-hydroxysteroid dehydrogenase （P= 0.57） and aromatase （P = 0.23） were demonstrated in implanted or non-implanted heifers. Conclusions： These results indicate follicles which develop in the presence of high concentrations of androgenic and estrogenic steroids via an implant tend to demonstrate an altered capacity to res

关键词： Bovine Follicle stimulating hormone Granulosa cells Implant Steroidogenesis

Bleeding outcomes after non-emergency percutaneous coronary intervention in the very elderly

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Journal of Geriatric Cardiology 2017年第10期14卷 624-631页

作者： Vimalraj Bogana Shanmugam dennis T Wong Hashrul Rashid James d Cameron Yuvaraj Malaiapan Peter J Psaltis Monash Cardiovascular Research Centre Clayton Campus of Monash University Victoria Australia South Australian Health and Medical Research Institute Adelaide Australia

Background Octogenarians constitute an increasing proportion of patients presenting for non-emergency percutaneous coronary intervention （PCI）. Methods This study evaluated the in-hospital procedural characteristics and outcomes, including the bleeding events of 293 octogenarians presenting between January 2010 and december 2012 for non-emergency PCI to a single large volume tertiary care Aus- tralian center. Comparisons were made with 293 consecutive patients aged less than or equal to 60 years, whose lesions were matched with the octogenarians. Results Non-ST elevation myocardial infarction was the most frequent indication for non-emergency PCI in octoge- narians. Compared to the younger cohort, they had a higher prevalence of co-morbidities and more complex coronary disease, comprising more type C and calcified lesions. Peri-procedural use of low molecular weight heparin （LMWH; 1.0% vs. 5.8%; P 〈 0.001） and glycopro- tein IIb/IIIa inhibitors （2.1% vs. 9.6%; P 〈 0.001） was lower, while femoral arterial access was used more commonly than in younger patients （80.9% vs. 67.6%; P 〈 0.001）. Overall, there was a non-significant trend towards higher incidence of all bleeding events in the elderly （9.2% vs. 5.8%; P = 0.12）. There was no significant difference in access site or non-access site bleeding and major or minor bleeding between the two cohorts. Sub-analysis did not reveal any significant influence on bleeding rates by the use of LMWH, glycoprotein IIb/IIIa inhibitors or femoral arterial access. In addition, there were no significant differences in the rates of in-hospital mortality, stroke or acute stent thrombosis between the two groups. Conclusions In this single center study, we did not observe significant increases in adverse in-hospital outcomes including the incidence of bleeding in octogenarians undergoing non-emergency PCI.

关键词： Bleeding Coronary artery disease Octogenarians Percutaneous coronary intervention

The utility of coronary computed tomography angiography in elderly patients

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Journal of Geriatric Cardiology 2019年第7期16卷 507-513页

作者： Jordan Laggoune Nitesh Nerlekar Kiran Munnur Brian SH Ko James d Cameron Sujith Seneviratne dennis TL Wong Monash Cardiovascular Research Centre Monash University and MonashHeartMonash HealthClaytonVictoriaAustralia South Australian Health Medical Research Institute AdelaideAustralia

Background Coronary computed tomography angiography(CCTA)is often avoided in elderly patients due to a presumption that a high proportion of patients will have heavily calcified plaque limiting an accurate *** sought to assess the image quality,luminal stenosis and utility of CCTA in elderly patients with suspected coronary artery disease(CAd)and stable chest *** Retrospective analysis of elderly patients(>75 years)who underwent 320-detector row CCTA between 2012–2017 at *** CCTA was analysed for degree maximal coronary stenosis by CAd-RAdS classification,image quality by a 5-point Likert score(1-poor,2-adequate,3-good,4-very good,5-excellent)and presence of artefact limiting *** 1011 elderly patients(62%females,78.8±3.3 years)were *** risk factor prevalence included:hypertension(65%),hyperlipidaemia(48%),diabetes(19%)and smoking(21%).The CCTA was evaluable in 68%of patients which included 52%with non-obstructive CAd(d(>50%)*** Likert score was 3.1±0.6 corresponding to good image *** the 323(32%)of patients with a non-interpretable CCTA,80%were due to calcified plaque and 20%due to motion *** gender(P=0.009),age(P=0.02),excess motion(Pd diabetes mellitus(P=0.03)were associated with non-interpretable *** Although CCTA is a feasible non-invasive tool for assessment of elderly patients with stable chest pain,clinicians should still be cautious about referring elderly patients for *** who are male,diabetic and>78 years of age are significantly less likely to have interpretable scans.

关键词： Coronary artery calcium Coronary CT angiography Multi-detector row CT The elderly