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Tango Controls and.d.ta pipeline for petawatt laser experiments

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High Power Laser Science and.Engineering 2023年第4期 6-12页

作者： Nils Wei?e Leonard.d.yle Johannes Gebhard.Felix Balling Florian Schweiger Florian Haberstroh Laura d.Geulig Jinpu Lin Faran Irshad.Jannik Esslinger Sonja Gerlach Max Gilljohann Vignesh Vaid.anathan dennis Siebert And.eas Münzer Gregor Schilling J?rg Schreiber Peter G.Thirolf Stefan Karsch And.eas d.pp Lud.ig-Maximilians-Universit?t München

The Centre for Ad.anced.Laser Applications in Garching, Germany, is home to the ATLAS-3000 multi-petawatt laser,d.d.cated.to research on laser particle acceleration and.its applications. A control system based.on Tango Controls is implemented.for both the laser and.four experimental areas. The d.vice server approach features high mod.larity,which, in ad.ition to the hard.are control, enables a quick extension of the system and.allows for automated.d.ta acquisition of the laser parameters and.experimental d.ta for each laser shot. In this paper we present an overview of our implementation of the control system, as well as our ad.ances in terms of experimental operation, online supervision and.d.ta processing. We also give an outlook on ad.anced.experimental supervision and.online d.ta evaluation ± where the d.ta can be processed.in a pipeline ± which is being d.veloped.on the basis of this infrastructure.

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Tango Controls and.d.ta pipeline for petawatt laser experiments

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High Power Laser Science and.Engineering 2023年第4期11卷 2-8页

作者： Nils Weiße Leonard.d.yle Johannes Gebhard.Felix Balling Florian Schweiger Florian Haberstroh Laura d.Geulig Jinpu Lin Faran Irshad.Jannik Esslinger Sonja Gerlach Max Gilljohann Vignesh Vaid.anathan dennis Siebert And.eas Münzer Gregor Schilling Jörg Schreiber Peter G.Thirolf Stefan Karsch And.eas d.pp Lud.ig-Maximilians-Universität München GarchingGermany

The Centre for Ad.anced.Laser Applications in Garching,Germany,is home to the ATLAS-3000 multi-petawatt laser,d.d.cated.to research on laser particle acceleration and.its applications.A control system based.on Tango Controls is implemented.for both the laser and.four experimental *** d.vice server approach features high mod.larity,which,in ad.ition to the hard.are control,enables a quick extension of the system and.allows for automated.d.ta acquisition of the laser parameters and.experimental d.ta for each laser *** this paper we present an overview of our implementation of the control system,as well as our ad.ances in terms of experimental operation,online supervision and.d.ta *** also give an outlook on ad.anced.experimental supervision and.online d.ta evaluation–where the d.ta can be processed.in a pipeline–which is being d.veloped.on the basis of this infrastructure.

关键词： d.ta processing high-power laser experiments laser-plasma acceleration online d.agnostics

鼎湖山森林演替初期优势种马尾松的树干液流特征

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应用与环境生物学报 2022年第5期28卷 1167-1174页

作者：许天云黄健强曾小平张宜辉孟泽 dennis Otieno 李跃林中国科学院华南植物园广州510650 厦门大学环境与生态学院厦门361005 中国科学院大学北京100049 肯尼亚奥丁加科技大学邦多210-40601

采用Granier热消散探针法(thermal d.ssipation probes,Td.),对鼎湖山南亚热带森林演替初期优势树种马尾松(Pinus massoniana)的树干液流变化进行连续监测,同时监测林分光合有效辐射、空气相对湿度、空气温度等环境因子,以探究演替初期... 详细信息

采用Granier热消散探针法(thermal d.ssipation probes,Td.),对鼎湖山南亚热带森林演替初期优势树种马尾松(Pinus massoniana)的树干液流变化进行连续监测,同时监测林分光合有效辐射、空气相对湿度、空气温度等环境因子,以探究演替初期马尾松树干液流特征、耗水量与其对环境的响应.结果表明:(1)日尺度上针叶林马尾松不同个体树干液流日变化趋势一致,晴天日变化为典型昼高夜低的单峰型曲线,峰值一般出现在中午12:00-14:00;雨天树干液流日变化呈单峰或多峰趋势,液流速率显著低于晴天,峰值出现在降雨后1-2 h内.在干季与湿季,马尾松的液流速率在各方面存在显著差异,干季(10月)马尾松的夜间液流速率显著小于湿季(8月)(P d.蒸腾耗水随着胸径的增大而增大,估算得到马尾松林日均蒸腾耗水为5 415 kg d.(-1)hm^(-2).(3)马尾松树干液流变化受中雨及以上降雨量影响,但低降雨量如小雨对树干液流特征无显著影响(P> 0.05).日尺度上针叶林马尾松晴天树干液流主要受光合有效辐射、水汽压亏缺的影响(P <0.01);雨天主要受水汽压亏缺、相对湿度、温度的影响.在湿季(8月)与干季(10月)日尺度上马尾松的树干液流特征均首要受到水汽压亏缺的调控.本研究的马尾松林处于演替初期,其优势种马尾松蒸腾量高于同地带演替中期的马尾松,但相比其他地区针叶林,该演替初期马尾松蒸腾量处于较低水平,这有利于其适应季节性干旱环境.

关键词：马尾松针叶林演替初期树干液流鼎湖山

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应用磷灰石和交换性HN4—斜发沸石的混合物控制和重新释放土壤中的磷

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土壤学进展 1988年第6期 48-51页

作者： Tung-Ming Lai dennis d.Eberl 万强

应用 NH4饱和斜发沸石促使磷灰石溶解是一种可控制并能重新释放养分的体系。由此可释放为植物吸收的可溶牲 N、P 和交换性 Ca。该体系的原理为交换体可吸收磷灰石所释放的难溶性 Ca21,导致磷灰石的进一步溶解。实验表明,利用这种方法获... 详细信息

应用 NH4饱和斜发沸石促使磷灰石溶解是一种可控制并能重新释放养分的体系。由此可释放为植物吸收的可溶牲 N、P 和交换性 Ca。该体系的原理为交换体可吸收磷灰石所释放的难溶性 Ca21,导致磷灰石的进一步溶解。实验表明,利用这种方法获得的 P 释量比单独施用磷灰石高一个数量级。该体系为磷灰石的酸化提供了另一种技术,并可解决与易溶性肥料有关的问题。

关键词：磷灰石 NH Ca 植物生长磷酸盐矿物 HN4 沸石架状硅酸盐矿物交换性

Are potassium levels in child.en with hemolytic uremic synd.ome pred.ctive of outcome?

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Open Journal of Ped.atrics 2012年第4期2卷 264-267页

作者： Miguel M. Glatstein Vala Snehal Syed.Amir Ahmad.dennis Scolnik d.vision of Clinical Pharmacology and.Toxicology Department of Pediatrics The Hospital for Sick Children University of Toronto Canada d.vision of Neonatal and.Ped.atric Emergency Med.cine Synergy Neonatal and Pediatric Hospital Ahmadabad India d.vision of Ped.atric Emergency Med.cine Department of Pediatrics Dana’s Children Hospital University of Tel Aviv Tel Aviv Is-rael d.vision of Ped.atric Emergency Med.cine Department of Pediatrics The Hospital for Sick Children University of Toronto Toronto Canada

Objective: To ascertain the role of serum potassium levels in pred.cting clinical outcomes in d.arrhea-associated.hemolytic uremic synd.ome (HUS d.). Method.: We reviewed.clinical and.laboratory d.ta from HUS d. patients at our tertiary care institution from 2001 to 2008. Serum potassium concentration at presentation and.d.ring the acute phase of acute renal failure were record.d.and.related.to laboratory parameters and.clinical outcomes. Results: 15 HUS d. cases were id.ntified. E. coli 0157:H7 was found.in 9/15 cases (70%). Potassium levels were not pred.ctive of clinical outcomes. Normal serum potassium levels were found.in the majority of patients. Potassium levels d.nt at presentation in 3/15 patients (23%), and.no patient manifested.hyperkalemia even when creatinine levels were concurrently increase. Conclusions: This stud. suggests the presence of vigorous compensatory mechanisms in the homoestasis of serum potassium levels d.ring HUS d. d.sease since neither the increase stool volumes associated.with d.arrhea nor the presence of renal failure resulted.in clinically significant changes in serum potassium levels.

关键词： d.arrhea Hemolytic Uremic Synd.ome Hypokalemia Potassium Metabolism Acute Renal Failure

d.electric metasurfaces for d.stance measurements and.three-d.mensional imaging

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Ad.anced.Photonics 2019年第3期1卷 20-28页

作者： Chunqi Jin Mina Afsharnia RenéBerlich Stefan Fasold.Chengjun Zou dennis Arslan Isabelle Staud. Thomas Pertsch Frank Setzpfand. Fried.ich Schiller University Jena Institute of Applied PhysicsAbbe Center of PhotonicsJenaGermany Chinese Acad.my of Sciences Changchun Institute of OpticsFine Mechanics and PhysicsChangchunChina University of the Chinese Acad.my of Sciences BeijingChina Fraunhofer Institute for Applied.Optics and.Precision Engineering JenaGermany

Ultrathin metasurfaces have shown the capability to influence all aspects of light *** has mad. them promising options for replacing conventional bulky imaging optics while ad.ing ad.antageous optical properties or *** d.monstrate that such metasurfaces can also be applied.for single-lens three-d.mensional(3-d.imaging based.on a specifically engineered.point-spread.function(PSF).Using Huygens’metasurfaces with high transmission,we d.sign and.realize a phase mask that implements a rotating PSF for 3-d.*** experimentally characterize the properties of the realized.d.uble-helix PSF,find.ng that it can uniquely encod. object d.stances within a wid. ***,we experimentally d.monstrate wid.-field.d.pth retrieval within a 3-d.scene,showing the suitability of metasurfaces to realize optics for 3-d.imaging,using just a single camera and.lens system.

关键词： optics nanophotonics metasurfaces Mie-resonances three-d.mensional imaging point-spread.function engineering

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Molecular Stud.es of Regulators of G-Protein Signaling（RGS）Proteins in Prostate Cancer

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Molecular Studies of Regulators of G-Protein Signaling（RGS...

Survival after inflammatory bowel d.sease-associated.colorectal cancer in the Colon Cancer Family Registry

第九次全国暨2007海内外生物膜学术研讨会

作者： dennis W.Wolff Margaret Scofield.Ming-Fong Lin d.partment of Pharmacology Creighton University School of MedicineOmahaNE 68178（Y.T.Q.J.C.X.Y.X.D.W.W.M.S.） and.d.partment of Biochemistry and.Molecular Biology University of Nebraska Medical CenterOmahaNE 68198（M.F.L.） d.partment of Pharmacology Creighton University School of MedicineOmahaNE 68178（Y.T.Q.J.C.X.Y.X.D.W.W.M.S.） and.d.partment of Biochemistry and.Molecular Biology University of Nebraska Medical CenterOmahaNE 68198（M.F.L.） d.partment of Pharmacology Creighton University School of MedicineOmahaNE 68178（Y.T.Q.J.C.X.Y.X.D.W.W.M.S.） and.d.partment of Biochemistry and.Molecular Biology University of Nebraska Medical CenterOmahaNE 68198（M.F.L.）

＜正＞Prostate cancer is the most commonly d.agnosed.noncutaneous cancer in American men and.the second.lead.ng cause of cancer *** of and.ogen ind.pend.nce and.metastasis by prostate cancer are the key problems d.ring prostate cancer *** precise mechanisms und.rlying progression of prostate cancer to a state of and.ogen-ind.pend.nce remain an active area of research.

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World.Journal of Gastroenterology 2013年第21期19卷 3241-3248页

作者： Scott V Ad.ms dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grad. Loic LeMarchand.Noralane M Lind.r John d.Potter Polly A Newcomb Cancer Prevention Public Health SciencesFred Hutchinson Cancer Research CenterSeattleWA 98109United States d.partment of Med.cine Denver VA Medical Center and University of Colorado School of MedicineDenverCO 80045United States d.partment of Med.cine University of North CarolinaChapel HillNC 27599United States Epid.miology Research Program Department of Intramural ResearchAmerican Cancer SocietyAtlantaGA 30303United States d.vision of General Surgery University of TorontoTorontoON M5G2C4Canada Cancer Research Center of Hawaii University of HawaiiHonoluluHI 96813United States d.partment of Health Science Research Mayo Clinic ArizonaScottsdaleAZ 85259United States

AIM: To investigate the survival of ind.vid.als with colorectal cancer (CRC) with inflammatory bowel d.sease (IBd.associated.CRC) compared.to that of ind.vid.als without IBd.d.agnosed.with CRC. METHOd.: Epid.miologic, clinical, and.follow-up d.ta were obtained.from the Colon Cancer Family Registry (Colon CFR). IBd.associated.cases were id.ntified.from self-report of physician d.agnosis. For a subset of participants, med.cal record. were examined.to confirm self-report of IBd. Cox proportional hazard. regression was applied.to estimate ad.usted.hazard.ratios (aHR) and.95%CI of mortality, comparing IBd.associated.to non-IBd.associated.CRC, ad.usted.for age at CRC d.agnosis, sex, Colon CFR phase, and.number of prior end.scopies. Following imputation to complete CRC stage information, ad.ustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, includ.ng 250 cases of IBd.associated.CRC, were analyzed. Over a twelve year follow-up period.following CRC d.agnosis, 2013 and.74 d.aths occurred.among non-IBd.associated.CRC and.IBd.associated.CRC patients, respectively. The d.fference in survival between IBd.associated.and.non-IBd.CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazard. necessary for valid.inference from Cox regression was not met over the entire follow-up period. and.we therefore limited.analyses to within five years after CRC d.agnosis when the assumption of proportional hazard. was met. Over this period. there was evid.nce of worse prognosis for IBd.associated.CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when ad.usted.for CRC stage, or restricted.to IBd.confirmed.in med.cal record.. CONCLUSION: These results support the hypothesis that IBd.associated.CRC has a worse prognosis than non-IBd.associated.CRC.

关键词： Colorectal cancer Inflammatory bowel d.sease Outcomes research Cancer survival Inflammation

d.tection of KRAS G12d.in colorectal cancer stool by d.oplet d.gital PCR

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World.Journal of Gastroenterology 2017年第39期23卷 7087-7097页

作者： Susana Olmed.llas-López dennis César Lévano-Linares Carmen Laura Aúz Alexand.e Luz Vega-Clemente Ed.rne León Sánchez Alejand.o Villagrasa Jaime Ruíz-Tovar Mariano García-Arranz d.mián García-Olmo Found.tion Health Research Institute-Fund.ción Jiménez d.az University Hospital d.partment of Surgery School of Medicine Universidad Autónoma de Madrid d.partment of Surgery Rey Juan Carlos University Hospital d.partment of Pathology Fundación Jiménez Díaz University Hospital d.partment of Biomed.cine and.Biotechnology Universidad de Alcalá d.partment of Surgery Fundación Jiménez Díaz University Hospital

AIMTo assess KRAS G12d.mutation d.tection by d.oplet d.gital PCR (d.PCR) in stool-d.rived.d.A from colorectal cancer (CRC) *** this stud., tumor tissue and.stool samples were collected.from 70 patients with stage I-IV CRC d.agnosed.by preoperative biopsy. KRAS mutational status was d.termined.by pyrosequencing analysis of d.A obtained.from formalin-fixed.paraffin-embed.ed.(FFPE) tumor tissues. The KRAS G12d.mutation was then analyzed.by d.PCR in FFPE tumors and.stool-d.rived.d.A from patients with this point mutation. Wild.type (WT) tumors, as d.termined.by pyrosequencing, were includ.d.as controls; analysis of FFPE tissue and.stool-d.rived.d.A by d.PCR was performed.for these patients as *** the total 70 patients includ.d. KRAS mutations were d.tected.by pyrosequencing in 32 (45.71%), whereas 38 (54.29%) had.WT tumors. The frequency of KRAS mutations was higher in left-sid.d.tumors (11 located.in the right colon, 15 in the left, and.6 in the rectum). The pred.minant point mutation was KRAS G12d.(14.29%, n = 10), which was more frequent in early-stage tumors (I-IIA, n = 7). In agreement with pyrosequencing results, the KRAS G12d.mutation was d.tected.by d.PCR in FFPE tumor-d.rived.d.A, and.only a resid.al number of mutated.copies was found.in WT controls. The KRAS G12d.mutation was also d.tected.in stool-d.rived.d.A in 80% of all fecal samples from CRC patients with this point *** is a reliable and.sensitive method.to analyze KRAS G12d.mutation in stool-d.rived.d.A from CRC patients, especially at early stages. This non-invasive approach is potentially applicable to other relevant biomarkers for CRC management.

关键词： d.oplet d.gital PCR KRAS Stool Formalin-fixed.paraffin-embed.ed Pyrosequencing Colorectal cancer