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水动力学研究与进展（A辑） 2004年第1期19卷 13-18页

作者：章社生卫加宁陈绍平 Yakup Paker dennis Parkinson 武汉理工大学湖北武汉430063 Qeen Mary & West field college University of London

　应用多重网格区域分裂并行计算方法研究具有壁面Weis Fogh机构绕流,将二维物理平面流动区域变换为矩形区域,推导出流函数的多重网格差分计算格式,编制出并行计算程序。全部计算在英国London大学ITL并行计算中心完成。结果表明,多重网... 详细信息

　应用多重网格区域分裂并行计算方法研究具有壁面Weis Fogh机构绕流,将二维物理平面流动区域变换为矩形区域,推导出流函数的多重网格差分计算格式,编制出并行计算程序。全部计算在英国London大学ITL并行计算中心完成。结果表明,多重网格并行计算具有较高的加速比,绕机翼的环量计算值与理论吻合。

关键词： Weis-Fogh机构流体力学并行计算绕流振动翼机构坐标变换差分计算式

Study the Removal of Fluoride from Aqueous Medium by Using Nano-composites

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Journal of Encapsulation and Adsorption Sciences 2015年第1期5卷 38-52页

作者： Tapan K. Rout Reeta Verma Robert V. dennis Sarbajit Banerjee Research & Development Tata Steel Ltd. Jamshedpur India Department of Environment Birla Institute of Technology (BIT) Mesra Ranchi India Department of chemistry Texas A&M University College Station TX USA

Endemic fluorosis disease has become a major geo-environmental health care issue caused by fluoride ion. High-efficiency and low-cost materials to uptake fluoride from water have been a chal-lenge for scientists and engineers. Here, we report a low-cost process by utilising low-cost starting materials to develop nanocomposite adsorbents for fluoride uptake from water. Bermuda grass as a starting source material converted into nanocomposite carbon fibers upon heat treatment at 800°c for one hour in Nitrogen atmosphere in the presence of metal oxides. Iron oxide-based nanocomposite (IBNc) is performing high (≈97%) removal of fluoride ion at a contact time of 60 minutes (pH 4) followed by titania-based nanocomposite (TBNc) (≈92%) and micro carbon fiber (≈88%) respectively. The phenomenon of fluoride ion uptake is realised by Freundlich adsorption model, and both adsorption capacity and adsorption intensity for IBNc are higher than those for TBNc and micro carbon fiber.

关键词： Adsorption Nano-Oxides Grafted carbon Fiber Thermal cVD Fluoride

Mutational landscape of gastric adenocarcinoma in Latin America: A genetic approach for precision medicine

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Genes & Diseases 2022年第4期9卷 928-940页

作者： dennis cerrato-Izaguirre Yolanda I.chirino claudia M.García-cuellar Miguel Santibáñez-Andrade Diddier Prada Angélica Hernández-Guerrero Octavio Alonso Larraga Javier camacho Yesennia Sánchez-Pérez Subdirección de Investigación Básica Instituto Nacional de Cancerología(INCan)TlalpanCiudad de MéxicoCP 14080Mexico Departamento de Farmacología Centro de Investigación y de Estudios Avanzados del I.P.N.(CINVESTAV)Ciudad de MéxicoCP 07360Mexico Unidad de Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoLos Reyes IztacalaTlalnepantla de BazEstado de MéxicoCP 54090Mexico Departamento de Informática Biomédica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacánCiudad de MéxicoCP 04510Mexico Department of Environmental Health Science Mailman School of Public HealthColumbia UniversityNew YorkNY 10027USA Servicio de Endoscopía Instituto Nacional de Cancerología(INCan)TlalpanCiudad de MéxicoCP 14080Mexico

Latin-America (LATAM) is the second region in gastric cancer incidence;gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic variants associated with hereditary GA, b) germline risk variants associated with sporadic GA, and c) somatic variants present in sporadic GA in LATAM, and analyze how this landscape can be applied for precision medicine. We found that Brazil, chile, colombia, Mexico, Peru, and Venezuela are the countries with more published studies from LATAM explicitly related to GA. Our analysis displayed that different germline pathogenic variants for the cDH1 gene have been identified for hereditary GA in Brazilian, chilean, colombian, and Mexican populations. An increased risk of developing somatic GA is associated with the following germline risk variants: IL-4, IL-8, TNF-α, PTGS2, NFKB1, RAF1, KRAS and MAPK1 in Brazilian;IL-10 in chilean;IL-10 in colombian;EGFR and ERRB2 in Mexican, TcF7L2 and chr8q24 in Venezuelan population. The path from mutational landscape to precision medicine requires four development levels: 1) Data compilation, 2) Data analysis and integration, 3) Development and approval of clinical approaches, and 4) Population benefits. Generating local genomic information is the initial padlock to overcome to generate and apply precision medicine.

关键词： Ethnicities Genome Latin America Mutati on Precisi on medicine Stomach neoplasms

Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding

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Microsystems & Nanoengineering 2016年第1期2卷 29-37页

作者： casey c.Glick Mitchell T.Srimongkol Aaron J.Schwartz William S.Zhuang Joseph c.Lin Roseanne H.Warren dennis R.Tekell Panitan A.Satamalee Liwei Lin Department of Physics University of CaliforniaBerkeleyCA 94720USA Department of Mechanical Engineering University of CaliforniaBerkeleyCA 94720USA Department of Mechanical Engineering University of UtahSalt Lake CityUT 84112USA

A critical feature of state-of-the-art microfluidic technologies is the ability to fabricate multilayer structures without relying on the expensive equipment and facilities required by soft lithography-defined ***,three-dimensional(3D)printed polymer molds are used to construct multilayer poly(dimethylsiloxane)(PDMS)devices by employing unique molding,bonding,alignment,and rapid assembly ***,a novel single-layer,two-sided molding method is developed to realize two channel levels,non-planar membranes/valves,vertical interconnects(vias)between channel levels,and integrated inlet/outlet ports for fast linkages to external fluidic *** a demonstration,a single-layer membrane microvalve is constructed and tested by applying various gate pressures under parametric variation of source pressure,illustrating a high degree of flow rate *** addition,multilayer structures are fabricated through an intralayer bonding procedure that uses custom 3D-printed stamps to selectively apply uncured liquid PDMS adhesive only to bonding interfaces without clogging fluidic *** integrated alignment marks to accurately position both stamps and individual layers,this technique is demonstrated by rapidly assembling a six-layer microfluidic *** combining the versatility of 3D printing while retaining the favorable mechanical and biological properties of PDMS,this work can potentially open up a new class of manufacturing techniques for multilayer microfluidic systems.

关键词： 3D printing microfluidics PDMS

8~52周龄比格犬饲喂富含DHA鱼油强化食物对其生理功能的影响

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养殖与饲料 2016年第6期15卷 18-25页

作者：叶得军(译) steven c z dennis e j ryan m y 甘肃省永靖县中小企业局甘肃永靖731600 不详

为了评估健康犬饲喂富含二十二碳六烯酸(DHA)鱼油对其成长的认知、记忆、心理活动、免疫学、视网膜功能,和其他监测值的影响。选择48只比格幼犬,幼犬在断奶后分成3组(样本数n=16/每组),并接受3种饲料(低DHA含量、中DHA含量、高DHA含量)... 详细信息

为了评估健康犬饲喂富含二十二碳六烯酸(DHA)鱼油对其成长的认知、记忆、心理活动、免疫学、视网膜功能,和其他监测值的影响。选择48只比格幼犬,幼犬在断奶后分成3组(样本数n=16/每组),并接受3种饲料(低DHA含量、中DHA含量、高DHA含量)中的一种作为它们的唯一营养,到1岁龄试验结束。在各个时间点对视觉线索辨别学习、记忆任务、心理活动表现任务、心理学进行测试(包括血液和血清生化分析、视网膜电图、双能X线吸收测量)。16周龄注射疫苗后,在1、2、4、8周对其抗狂犬病病毒的抗体滴度进行评价。结果显示,除鱼油的DHA含量浓度有不同外,食物有类似的组分分析结果;高DHA含量食物比其他食物也含有更高的VE、牛磺酸、胆碱、左旋肉碱浓度。高DHA含量的样本组比中和低DHA含量的样本组,其幼犬在反转学习任务、视觉系统对比辨别、障碍迷宫侧侧运动的早期心理活动能力方面有明显增高效果。高DHA含量的食物样本组比其他两个组在疫苗注射后1和2周内,分别有明显较高的抗狂犬病病毒的抗体滴度。在评估的所有时间点上,视网膜电图(ERG)暗视b-波的振幅峰值与血清DHA浓度呈显著正相关性。说明在幼犬断奶后,在日粮中添加富含DHA成分的强化鱼油或其他搭配的营养成分与幼犬神经认知发育有关,能改善生长期的认知、记忆、心理活动、免疫学、视网膜等功能。

关键词：比格犬 DHA 鱼油神经认知

大骨节病死亡受体途径调节因子表达的组织学改变

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南方医科大学学报 2011年第11期31卷 1851-1854页

作者：武世勋郭雄刘江涛张增铁 Bannel S.dennis 张银刚西安交通大学医学院公共卫生系/环境与疾病基因教育部重点实验室环境与地方病研究室/卫生部微量元素与地方病重点实验室陕西西安710061 西安交通大学医学院第一附属医院骨科陕西西安710061

目的观察大骨节病软骨组织中Fas相关死亡结构域蛋白(FADD)和细胞FLIcE抑制蛋白(c-FLIP)表达的变化,明确其在大骨节病软骨损伤中的作用。方法将依据大骨节病和骨关节病诊断标准收集的软骨分为大骨节病组(KBD)、骨关节病组(OA)和正常对照... 详细信息

目的观察大骨节病软骨组织中Fas相关死亡结构域蛋白(FADD)和细胞FLIcE抑制蛋白(c-FLIP)表达的变化,明确其在大骨节病软骨损伤中的作用。方法将依据大骨节病和骨关节病诊断标准收集的软骨分为大骨节病组(KBD)、骨关节病组(OA)和正常对照组。采用免疫组化染色法检测3组关节软骨的死亡受体调节因子FADD和c-FLIP表达变化,并在显微镜下计数和比较3组关节软骨不同层间阳性表达率的显著性差异。结果(1)KBD和OA组软骨[分别为(28.68±2.19)%和(35.40±2.34)%]中层FADD表达显著较正常组增高(F=16.245,P=0.000),而在表、深层3组间均无显著差异(P=0.206,P=0.761);(2)FADD在KBD软骨中表达以中层最高,为(28.68±5.38)%,其次为深层的(17.94±8.38)%;(3)KBD和OA软骨表层FLIP表达均显著低于正常组(F=5.929,P=0.018),而中层和深层与正常组间均无显著差异。结论 KBD软骨中层FADD显著上调,而软骨表层FLIP表达显著下调,表明死亡受体途径及其调节因子在大骨节病软骨损伤中具有重要作用。

关键词：大骨节病死亡受体途径 Fas相关死亡结构域蛋白 FLIcE抑制蛋白免疫组化

Relationship of Pre-Existing Maternal/caregiver Acute Respiratory Infection in the Pattern and Risk of Acute Respiratory Infection among Infants in Rivers State, Nigeria

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International Journal of clinical Medicine 2018年第10期9卷 787-798页

作者： A. S. Ibama I. N. S. Dozie O. c. Abanobi A. N. Amadi G. Iwuoha T. Jaja P. dennis Federal University of Technology Owerri Nigeria University of Port Harcourt Teaching Hospital Port Harcourt Nigeria Rivers State Primary Health care Management Board Port Harcourt Nigeria

History of upper respiratory tract infection in the mother or siblings was associated with higher risk of acute lower respiratory tract infection in cases. Most upper respiratory tract infections were caused by viral pathogens and likely to occur in many members of the family. The study aimed to determine the existence and pattern of relationship between risk of acute respiratory infection (ARI) among infants and exposure to pre-existing maternal/caregiver acute respiratory tract infection. The study was designed as a community-based Nested case-control study of 1100 infants randomly selected from 12 communities out of 6 Local Government Areas of the 3 senatorial districts of Rivers State. A multistage random sampling technique was used in selecting the subjects up to the community level. Descriptive method was used to represent the characteristics of the subjects and the differences in ARI between exposed and unexposed infants were tested in a bivariate logistics regression at 5% level of significance. Odds ratio (OR) was used to interpret the size effect measures of ARI on exposure to pre-existing maternal/caregiver ARI differences. A total of 275 cases of ARI and 825 controls were included in the study. Among exposed infants (N = 104), ARI cases were found to be higher n = 80 (76.9%) than in control n = 24 (23.1%). Whereas, among unexposed infants N = 991, ARI cases were found to be lower n = 195 (19.7%) than in control n = 796 (80.3%). For the exposed infants, the odds for ARI were 13.5 times significantly higher compared to those of their unexposed counterparts (OR-Unadjusted = 13.52, (p cI = 0.047 - 0.121)). The findings will widen the horizon in the etiological consideration of ARI among infants vis-à-vis exposure potential to pre-existing maternal/caregiver ARI via nursing care. Therefore, community-based sensitization programme on barrier nursing care techniques and personal hygiene practices should be on focus.

关键词： Acute-Respiratory-Infection Pattern Risk-Factor Maternal/caregiver Pre-Existing Barrier-Nursing

鼎湖山针阔叶混交林优势种树干液流特征及其与环境因子的关系

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应用生态学报 2012年第5期23卷 1159-1166页

作者：黄德卫张德强周国逸刘世忠 Otieno dennis 李跃林中国科学院华南植物园广州510650 中国科学院研究生院北京100049

运用Granier热扩散式探针法,于2010年干湿季对鼎湖山自然保护区针阔混交林4种优势树种马尾松、锥栗、木荷和广东润楠的树干液流密度进行连续监测,并同步观测气温、相对湿度和光合有效辐射等环境因子的变化,研究其树干液流特征及其对环... 详细信息

运用Granier热扩散式探针法,于2010年干湿季对鼎湖山自然保护区针阔混交林4种优势树种马尾松、锥栗、木荷和广东润楠的树干液流密度进行连续监测,并同步观测气温、相对湿度和光合有效辐射等环境因子的变化,研究其树干液流特征及其对环境因子的响应.结果表明:在干湿季,4种优势树种的树干液流速率日变化均呈"昼高夜低"的典型单峰曲线,阔叶树锥栗、木荷和广东润楠的平均液流速率和峰值以及日液流量均显著大于针叶树马尾松;马尾松、锥栗、木荷和广东润楠的最大树干液流密度分别为29.48、38.54、51.67、58.32gH2O.m-2.s-1.优势树种树干液流速率的变化与环境因子的昼夜变化存在时滞;液流速率变化与光合有效辐射、水汽压亏缺和气温等环境因子的变化呈显著正相关,其中湿季以光合有效辐射为主导因子,干季以气温为主导因子.

关键词：针阔叶混交林树干液流环境因子干湿季鼎湖山

Recognizing the Scientific Mission of Flux Tower Observation Networks——Lay the Solid Scientific Data Foundation for Solving Ecological Issues Related to Global change

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Journal of Resources and Ecology 2017年第2期8卷 115-120页

作者：于贵瑞陈智张雷明彭长辉陈镜明朴世龙张扬建牛书丽王秋凤骆亦其 Philippe ciais dennis D.Baldocchi 中国科学院地理科学与资源研究所生态系统网络观测与模拟重点实验室北京100101 中国科学院大学资源与环境学院北京100190 加拿大魁北克大学生物科学系和森林研究中心加拿大蒙特利尔H3C3P8 西北农林科技大学土壤侵蚀与旱地农业国家重点实验室、林学院西安712100 加拿大多伦多大学地理系加拿大多伦多M5S2E8 南京大学国际地球系统科学研究所南京210093 北京大学城市与环境学院生态系、地表过程分析与模拟教育部重点实验室北京100871 中国科学院青藏高原研究所高寒生态与生物多样性实验室北京100101 美国俄克拉荷马大学微生物与植物生物学系美国诺曼73019 法国环境与气候科学实验室法国伊维特河畔吉夫91191 美国加利福尼亚大学伯克利分校环境科学、政策与管理系美国伯克利94720

As the Earth entering into the Anthropocene, global sustainable development requires ecological research to evolve into the large-scale, quantitative, and predictive era. It necessitates a revolution of ecological observation technology and a long-term accumulation of scientific data. The ecosystem flux tower observation technology is the right one to meet this requirement. However, the unique advantages and potential values of global-scale flux tower observation are still not fully appreciated. Reviewing the development history of global meteorological observation and its scientific contributions to the society, we can get an important enlightenment to re-cognize the scientific mission of flux observation.

关键词： flux tower observation ecological research scientific data accumulation global sustainable development ecological prediction