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The transcontinental variability of nonalcoholic fatty liver disease

Hepatoma Research 2020年第10期6卷 75-87页

作者： Claudia P.Oliveira Angelo Paredes Mohammed Siddiqui Lawrence Serfaty Abhijit Chowdhury Jose Tadeu Stefano denise siqueira vanni Sherry Boyett Arun J.Sanyal Department of Gastroenterology Faculdade de Medicina da Universidade de São PauloSão PauloSP 01000-000Brazil Laboratório de Gastroenterologia Clínica e Experimental(LIM-07)do Departamento de Gastroenterologia e Hepatologia do Hospital das Clínicas HCFMUSP da Faculdade de Medicina da Universidade de São Paulo São PauloSP 01000-000Brazil Internal Medicine Gastroenterology and Hepatology ServicesBrooke Army Medical CenterSan AntonioTX 78234USA Div.of Gastroenterology Hepatology and NutritionDept.of Internal MedicineVirginia Commonwealth University School of MedicineRichmondVA 23298-0341USA Viral and Metabolic Liver Unit Department of HepatologySaint-Antoine Hospital75012 ParisParis Department of Hepatology School of Digestive and Liver DiseaseInstitute of Post Graduate Medical Education&ResearchKolkata 700020India Disease Biology John C Martin Centre for Liver Research and Innovations SonarpurKolkata 7000150India

Aim:To compare the phenotype of lean versus overweight(OW)and obese(OB)subjects with non-alcoholic fatty liver disease(NAFLD)across multiple ***:A retrospective study of histologically defined subjects from a single center each in France(Fr),Brazil(Br),India(In)and United States(US)was ***:A total of 70 lean[body mass index(BMI)25 kg/m2,BMI29 kg/m2)(n=81:11:22:103).Lean French subjects had the lowest incidence of type 2 diabetes while those from Brazil(P<0.01)had the *** subjects had similar low-density lipoprotein-cholesterol,but higher high-density lipoprotein-cholesterol compared to obese subjects in all *** both lean and obese subjects,there were both insulin-sensitive and insulin-resistant *** French subjects were most insulin-sensitive while those from Brazil were mostly *** each weight category,subjects from India were more insulin-sensitive than those from other *** activity increased from lean to overweight to obese in France but was similar across weight categories in other ***:The phenotype of NAFLD in lean subjects varies by *** obese subjects with NAFLD are *** hypothesize that genetics and region-specific disease modifiers account for these differences.

关键词： Non-alcoholic fatty liver disease phenotype epidemiology demographics

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Disentangling brain PrP^(C)proteoforms and their roles in physiology and disease

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Neural Regeneration Research 2024年第5期19卷 963-965页

作者： Ilaria vanni Nonno Romolo Department of Food Safety Nutrition and Veterinary Public HealthIstituto Superiore di SanitàRomeItaly

The cellular prion protein(PrPC),a cell surface glycoprotein of 209 amino acids,has been considerably studied over the decades mainly due to its critical involvement in transmissible spongiform encephalopathies,or prion ***,it is the misfolding and aggregation of PrPC into pathological assemblies-named PrPSc-that constitute prions,the agents causing these unusual neurodegenerative diseases affecting humans and animals(Prusiner,1982).Furthermore,increasing evidence support its relevance also in other neurodegenerative diseases(NDDs),such as Alzheimer’s and Parkinson’s diseases(Corbett et al.,2020).

关键词： diseases involvement glycoprotein

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On the Properties of the Forced Unsteady-state Ring Reactor Network

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Chinese Journal of Chemical Engineering 2004年第3期12卷 408-414页

作者： Davide FISSORE Antonello A.BARRESI Salvatore VELARDI Marco vanni Dipartimento di Scienza dei Materiali e Ingegneria Chimica Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino ItalyDipartimento di Scienza dei Materiali e Ingegneria Chimica Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino ItalyDipartimento di Scienza dei Materiali e Ingegneria Chimica Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino ItalyDipartimento di Scienza dei Materiali e Ingegneria Chimica Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino Italy

The multi-reactors network, a closed sequence of two or more catalytic fixed bed reactors with periodical change of the feed position, was studied by means of numerical simulations. Two advantages of such a reactor configuration, the possibility of exploiting the thermal storage capacity of the catalyst and the optimal temperature profile for exothermic equilibrium-limited reactions, were analyzed. The former feature acting as a regenerative heat exchanger was simulated in the case of the combustion of lean volatile organic compound (VOC) mixtures, with the possibility of multiple stability windows found when rich mixtures are fed. The latter was demonstrated using the methanol synthesis, with the enhancement of the conversion and product selectivity predicted. The influence of the number of the reactors in the network was pointed out. Some results obtained in the reverse-flow reactors were also presented for comparison.

关键词：化学反应器甲醇反应工程学移动床有机化合物

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Transoesophageal echocardiography during liver transplantation

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World Journal of Hepatology 2015年第23期7卷 2432-2448页

作者： Lesley De Pietri Federico Mocchegiani Chiara Leuzzi Roberto Montalti Marco Vivarelli vanni Agnoletti Division of Anaesthesiology and Intensive Care Unit Azienda Ospedaliero-Universitaria di Modena-Policlinico Transplantation Unit Polytechnic University of Marche Unit of Interventional Cardiology Arcispedale Santa Maria Nuova IRCCS Division of Anaesthesiology and Intensive Care Unit Arcispedale Santa Maria Nuova IRCCS

Liver transplantation(LT) has become the standard of care for patients with end stage liver disease. The allocation of organs, which prioritizes the sickest patients, has made the management of liver trans-plant candidates more complex both as regards their comorbidities and their higher risk of perioperative complications. Patients undergoing LT frequently display considerable physiological changes during the pro-cedures as a result of both the disease process and the surgery. Transoesophageal echocardiography(TEE), which visualizes dynamic cardiac function and overall contractility, has become essential for perioperative LT management and can optimize the anaesthetic management of these highly complex patients. More-over, TEE can provide useful information on volume status and the adequacy of therapeutic interventions and can diagnose early intraoperative complications, such as the embolization of large vessels or development of pulmonary hypertension. In this review, directed at clinicians who manage TEE during LT, we show why the procedure merits a place in challenging anaesthetic environment and how it can provide essential information in the perioperative management of compromised patients undergoing this very complex surgical procedure.

关键词： Liver transplantation Transoesophageal echocardiog

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Palliative oral care in terminal cancer patients:Integrated review

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World Journal of Clinical Cases 2023年第13期11卷 2966-2980页

作者： Ana Rute Preis Silva Augusto vanni Bodanezi Emanuely Silva Chrun Mariah Luz Lisboa Alessandra R de Camargo Etiene Andrade Munhoz Department of Dentistry Federal University of Santa CatarinaFlorianopolis 88040-379Brazil Department of Pathology Federal University of Santa CatarinaFlorianopolis 88040900Brazil Professor Polydoro São Thiago Ernani Hospital Federal University of Santa CatarinaFlorianopolis 88040900Brazil Department of Dentistry Health Science CentreFederal University of Santa CatarinaFlorianopolis 88040-379Brazil

BACKGROUND Palliative care(PC)aims to improve quality of life in patients and its families against life threatening diseases,through suffering’s prevention and *** is the duty of the dental surgeon to possess the knowledge needed to treat a patient with little life span,in order to establish an adequate treatment plan for each *** To synthesize the published evidence on oral conditions,impact,management and challenges in managing oral conditions among palliative *** Articles were selected from PubMed and Scopus electronic platforms,using a research strategy with diverse descriptors related to“palliative care”,“cancer”and“oral health”.The article’s selection was done in two *** first one was performed by the main researcher through the reading of the *** the second phase two researchers selected eligible articles after reading in full those previous *** was tabulated and analyzed,obtaining information about what is found in literature related to this subject and what is necessary to be approached in future researches about *** As results,the total of 15 articles were eligible,being one a qualitative analysis,13(92.8%)clinical trials and one observational *** the 15 articles,8(53.4%)involved questionnaires,while the rest involved:one systematic review about oral care in a hospital environment,2 oral exams and oral sample collection,one investigation of terminal patient’s(TP)oral assessment records,2 collection of oral samples and their respective analysis and one treatment of the observed oral *** It can be concluded that the oral manifestations in oncologic patients in terminal stage are,oral candidiasis,dry mouth,dysphagia,dysgeusia,oral mucositis and orofacial *** a protocol for the care of these and other complications of cancer–or cancer therapy–based on scientific evidence with the latest cutting-edge research results is of fundamental importance for the multidis

关键词： Palliative care Oral lesion Terminal patients,Oral mucositis,Oral candidiasis

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Peripancreatic paraganglioma:Lesson from a round table

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World Journal of Gastroenterology 2022年第21期28卷 2396-2402页

作者： Federica Petrelli Geri Fratini Andrea Sbrozzi-vanni Andrea Giusti Raffele Manta Claudio Vignali Gabriella Nesi Andrea Amorosi Andrea Cavazzana Marco Arganini Maria Raffaella Ambrosio Pathology Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Surgery Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Endoscopic Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Endoscopic Unit Santa Maria Misericordia HospitalPerugia 06122Italy Interventional Radiology Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Department of Health Sciences University of FlorenceFlorence 50139Italy Pathology Unit UniversitàMagna GraeciaCatanzaro 88100Italy

We described the case of a peripancreatic paraganglioma(PGL)misdiagnosed as pancreatic *** exploration revealed an unremarkable pancreas and a large well-defined cystic mass originating at the mesocolon *** enucleation of the mass was performed,preserving the pancreatic ***,a diagnosis of PGL was ***,two previously unreported mutations,one affecting the KDR gene in exon 7 and another on the JAK3 gene in exon 4 were *** mutations are known to be *** and cytologic findings were blindly reviewed by an expert panel of clinicians,radiologists,and pathologists to identify possible causes of the *** major issue was lack of evidence of a cleavage plane from the pancreas at imaging,which prompted radiologists to establish an intraparenchymal *** blinded revision shifted the diagnosis towards an extrapancreatic lesion,as the pancreatic parenchyma showed no structural alterations and no dislocation of the Wirsung *** post,the identified biases were the emergency setting of the radiologic examination and the very thin mesocolon sheet,which hindered clear definition of the lesion *** endoscopic ultrasonography diagnosis was confirmed,emphasizing the intrinsic limit of this technique in detecting large ***,pathologic review favored a diagnosis of PGL due to the morphological features and immonohistochemical *** months after tumor excision,the patient is asymptomatic with no disease relapse evident by either radiology or laboratory *** report strongly highlights the difficulties in rendering an accurate preoperative diagnosis of PGL.

关键词： Peripancreatic paraganglioma Pancreatic neuroendocrine tumor Solid pseudopapillary neoplasm S100 Succinate dehydrogenase subunit B gene and expression Fine needle biopsy

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The Effect of Electromagnetic Fields with the Mg²⁺ Cyclotron Frequency on Mouse Reproductive Performance

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Journal of Electromagnetic Analysis and Applications 2016年第7期8卷 115-123页

作者： Gabriele Gerardi Antonella De Ninno vanni Ferrari Sandro Mazzariol Daniele Bernardini Severino Segato Department of Animal Medicine Production and Health University of Padova Legnaro (PD) Italy ENEA C.R. Frascati Department Fusion and Nuclear Technologies Technologies for Safety and Health Division Frascati (Roma) Italy Department of Comparative Biomedicine and Food Science University of Padova Legnaro (PD) Italy

The present study is aimed to test whether exposure to electromagnetic fields of very weak intensity (≤1 mT) and low frequency (≤100 Hz) may influence reproductive performance and induce teratogenesis in mice. We speculate that a resonant effect occur when the applied frequency matches the cyclotron frequency of Mg2+ (≈60 Hz) involved in the cell duplication. Four groups of mice (four dams and one male each) were exposed to ?50 μT electromagnetic field continuous irradiation of for 100 days. A control group (four dams and one male) was also examined. The exposed dams exhibited a significantly lower number of offspring per birth than the control ones (11.0 vs. 11.6;P = 0.006). A significantly lower average daily gain of body weight per mouse was observed (0.74 vs. 0.77 g/d;P = 0.002), resulting in a reduction of the average body weight per nest at 11 days of age (404 vs. 463 g;P = 0.048). Post mortem examinations revealed a significant increase in mild chronic hepatic inflammatory findings (28 vs. 0%;P = 0.001) in the offspring and myocardial hypertrophy (25 vs. 0%;P = 0.023) in the dams. The exposure of mice to an electromagnetic field with the cyclotron frequency of Mg2+ during pregnancy caused a measurable effect on the reproductive performance in terms of offspring per birth. This finding may be considered as a warning about the environmental effects of the electromagnetic fields on the stability of individual species and ecosystems.

关键词： ELF-EMF Cyclotron Frequency Mouse Birth-Rate Postnatal Growth Histological Findings

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PASCAL^(TM)聚氨酯发泡技术在家电中的应用

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电器 2012年第S1期 200-209页

作者： vanni Parenti Hans Kramer Dow Italia S.r.l. Italy Dow Europe Gmbh

本文主要讲述了采用环保型发泡剂环戊烷的陶氏PASCALTM聚氨酯真空发泡技术在商业化进程中所取得的成果。环戊烷具有零臭氧损耗潜势和低全球变暖潜势等十分卓越的环保属性。与其他替代方案相比,陶氏PASCALTM技术为全球家电行业带来了有... 详细信息

本文主要讲述了采用环保型发泡剂环戊烷的陶氏PASCALTM聚氨酯真空发泡技术在商业化进程中所取得的成果。环戊烷具有零臭氧损耗潜势和低全球变暖潜势等十分卓越的环保属性。与其他替代方案相比,陶氏PASCALTM技术为全球家电行业带来了有助于缓解节能与气候变化挑战的高成本效益解决方案,在符合政府标准的同时,亦能满足消费者的需求,即在不影响时尚设计的前提下,带来品质更为卓越的冰箱产品。

关键词：冰箱真空能效聚氨酯环境

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The Historical Development of the Port of Livorno （Italy） and Its New Port Plan 2010 in Advanced Stage of Elaboration

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Journal of Shipping and Ocean Engineering 2011年第2期1卷 77-100页

作者： P. De Girolamo A. Noli C. vanni A. Del Corona M. Tartaglini Faculty of Engineering DISAT-LIAM University of L ＇Aquila L ＇Aquila 67100 Italy Modimar S.r.l. Roma 00195 Italy Livorno Port Authority Livorno 57123 Italy

The geographical location makes the port of Livorno one of the most important in Italy. The port, in fact, benefits of an extended network of roads and rails connecting it with the rest of Italy, and central and southern Europe as well. The history of Livorno and its port is inextricably linked to that of Pisa and Florence, and to the complexity of events that determined the political set-up of the region along several centuries. Looking at the new port plan of Livorno has made it necessary an extensive overview of the history of both the port, and of its planning. This analysis has allowed： to understand the reason for the different choices made in the past for the development of the port, highlighting, when necessary, the errors made; to identify the strengths and weaknesses of the existing port infrastructure; to identify the works needed to boost the port in the European context. The purpose of this paper is to provide a summary of the analysis performed for the implementation of the new Livorno port plan 2010 and show how the port planning in Italy is often conditioned by hundreds of centuries of history.

关键词： History port of Livomo new port plan.

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Anesthetic management of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy procedures

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World Journal of Obstetrics and Gynecology 2013年第4期2卷 129-136页

作者： Davide Corbella Emanuele Piraccini Paolo Finazzi Pietro Brambillasca Viviana Prussiani Massimo Ruggero Corso Claudio Germandi vanni Agnoletti Department of Anesthesia Azienda Ospedaliera Papa Giovanni XXIII 24100 Bergamo Italy Department of Emergency Anesthesia Unit Morgagni-Pierantoni Hospital 47121 Forlì Italy Department of Anesthesiology Sant’Orsola-Malpighi hospital 40138 Bologna Italy

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy procedure are performed with increasing frequency to treat patients with diffused peritoneal carcinomatosis. These procedures have showed to increase life expectancy in what was previously considered a "terminal condition". Anyway patients face major and life threatening derangements of their hemodynamic, respiratory and metabolic physiologic balance during the surgery and in the immediate postoperative period. Despite the need of an advanced organ monitoring and support all these derangements seem to be mild and short-lived when timely addressed, at least in the majority of patients. Intensive care physicians are involved in providing surveillance and organ support till the patient is effectively weaned after the operation. Moreover, the anesthesiologist as perioperative physician is involved in pain control, metabolic and nutritional support of this cohort of patients. This task can be challenging considering that part of the patients are already on a long list of pain control medication after previous surgery or chemotherapy. A malnourished state is common too and it is secondary to diffi cult feeding, wasting syndrome from the tumor and massive ascites. The last issue the anesthesiologists need to be aware of is the impact over the quality of life(Qo L) of this procedure. The patient's underlying pathology is unlikely to be defi nitively cured so no treatment is an acceptable choice. The possibility to withhold the treatments must be part of the consultation process like the discussion about the Qo L in the immediate, as well as in the long-term, after the operation. Careful monitoring and treatment of every aspect that can impact the Qo L must be taken and the efforts to be poured into an effective preservation of the Qo L must be doubled when compared with a patient scheduled for major abdominal surgery.

关键词： Peritoneal carcinomatosis Anesthesia Hyperthermic intraperitoneal chemotherapy Morbidity Mortality

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