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Effects of positive end-expiratory pressure on intracranial pressure,cerebral perfusion pressure,and brain oxygenation in acute brain injury:Friend or foe?A scoping review

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Journal of Intensive Medicine 2024年第2期4卷 247-260页

作者： Greta Zunino denise battaglini Daniel Agustin Godoy IRCCS Ospedale Policlinico San Martino GenovaItaly Dipartimento di Scienze Diagnostiche e Chirurgiche Integrate Universitàdegli Studi di GenovaGenovaItaly Neurointensive Care Unit Sanatorio PasteurCatamarcaArgentina

Background Patients with acute brain injury(ABI)are a peculiar population because ABI does not only affect the brain but also other organs such as the lungs,as theorized in brain–lung crosstalk *** patients often require mechanical ventilation(MV)to avoid the complications of impaired respiratory function that can follow ABI;MV should be settled with meticulousness owing to its effects on the intracranial compartment,especially regarding positive end-expiratory pressure(PEEP).This scoping review aimed to(1)describe the physiological basis and mechanisms related to the effects of PEEP in ABI;(2)examine how clinical research is conducted on this topic;(3)identify methods for setting PEEP in ABI;and(4)investigate the impact of the application of PEEP in ABI on the *** The five-stage paradigm devised by Peters et *** expanded by Arksey and O'Malley,Levac et al.,and the Joanna Briggs Institute was used for *** also adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)extension *** criteria:we compiled all scientific data from peer-reviewed journals and studies that discussed the application of PEEP and its impact on intracranial pressure,cerebral perfusion pressure,and brain oxygenation in adult patients with *** criteria:studies that only examined a pediatric patient group(those under the age of 18),experiments conducted solely on animals;studies without intracranial pressure and/or cerebral perfusion pressure determinations,and studies with incomplete *** authors searched and screened for inclusion in papers published up to July 2023 using the PubMed-indexed online *** were presented in narrative and tubular *** The initial search yielded 330 references on the application of PEEP in ABI,of which 36 met our inclusion *** has recognized beneficial effects on gas exchange,but it produces hemodynamic changes that should be predicted to avoi

关键词： Acute brain injury Mechanical ventilation Positive end-expiratory pressure Intracranial pressure Brain-lung crosstalk Multimodal monitoring

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Ten golden rules for individualized mechanical ventilation in acute respiratory distress syndrome

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Journal of Intensive Medicine 2021年第1期1卷 42-51页

作者： denise battaglini Marco Sottano Lorenzo Ball Chiara Robba Patricia R.M.Rocco Paolo Pelosi Anesthesia and Intensive Care San Martino Policlinico HospitalIRCCS for Oncology and NeuroscienceGenoa 16132Italy Department of Medicine University of BarcelonaBarcelona 08007Spain Department of Surgical Sciences and Integrated Diagnostics University of GenoaGenoa 16126Italy Laboratory of Pulmonary Investigation Carlos Chagas Filho Institute of BiophysicsFederal University of Rio de JaneiroRio de Janeiro 21941-901Brazil

Considerable progress has been made over the last decades in the management of acute respiratory distress syndrome(ARDS).Mechanical ventilation(MV)remains the cornerstone of supportive therapy for ***-protective MV minimizes the risk of ventilator-induced lung injury(VILI)and improves *** parame-ters contribute to the risk of VILI and require careful setting including tidal volume(V_(T)),plateau pressure(P_(plat)),driving pressure(ΔP),positive end-expiratory pressure(PEEP),and respiratory *** of energy and mechanical power allows quantification of the relative contributions of various parameters(V_(T),P_(plat),ΔP,PEEP,respiratory rate,and airflow)for the individualization of MV *** use of neuromuscular blocking agents mainly in cases of severe ARDS can improve oxygenation and reduce asynchrony,although they are not known to confer a survival *** respiratory therapies such as prone positioning,inhaled nitric oxide,and extracorporeal support techniques may be adopted in specific ***,respiratory weaning protocols should also be *** on a review of recent clinical trials,we present 10 golden rules for individualized MV in ARDS management.

关键词： Acute respiratory distress syndrome(ARDS) Protective mechanical ventilation Extracorporeal CO_(2)removal(ECCO_(2)R) Extracorporeal membrane oxygenation (ECMO)

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Expert consensus on difficult airway assessment

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 545-566页

作者： Ming Xia Wuhua Ma Mingzhang Zuo Xiaoming Deng Fushan Xue denise battaglini Vivek Aggarwal Giustino Varrassi Vladimir Cerny Ida Di Giacinto Rita Cataldo Daqing Ma Toru Yamamoto Martina Rekatsina Alessandro De Cassai Andrea Carsetti Marvin G.Chang Edwin Seet Daniel P.Davis Michael G.Irwin Yuguang Huang Hong Jiang Department of Anesthesiology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Anesthesiology The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Department of Anaesthesiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical ScienceBeijingChina Department of Anesthesiology Plastic Surgery HospitalCAMS and PUMCBeijingChina Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Anesthesia and Intensive Care San Martino Policlinico HospitalIRCCS for Oncology and NeuroscienceGenoaItaly Department of Conservative Dentistry&Endodontics Jamia Millia IslamiaNew DelhiIndia Paolo Procacci Foundation RomaItaly Department of Anaesthesiology and Intensive Care Medicine University Hospital Hradec KraloveHradec KraloveCzech Republic Unit of Anesthesia and Intensive Care Mazzoni HospitalAscoli PicenoItaly Unit of Anaesthesia Intensive Care and Pain ManagementDepartment of MedicineUniversitàCampus Bio-Medico of RomeRomaItaly Division of Anaesthetics Pain Medicine&Intensive CareDepartment of Surgery&CancerFaculty of MedicineImperial College Londonand Chelsea and Westminster HospitalLondonUK Division of Dental Anesthesiology Graduate School of Medicine and Dental SciencesNiigata UniversityNiigataJapan Department of Anaesthesiology National and Kapodistrian University of AthensAthensGreece Institute of Anesthesia and Intensive Care Unit University Hospital of PaduaPaduaItaly Department of Biomedical Sciences and Public Health UniversitàPolitecnica delle MarcheAnconaItaly Anesthesia and Intensive Care Unit Azienda Ospedaliero Universitaria delle MarcheAnconaItaly Department of Anesthesia Critical Careand Pain MedicineMassachusetts General HospitalBostonMAUSA Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Department of Anaesthesia Yong Loo Lin School of Medic

Background:Identifying a potentially difficult airway is crucial both in anaesthesia in the operating room(OR)and non-operation room *** are no guidelines or expert consensus focused on the assessment of the difficult airway before,so this expert consensus is developed to provide guidance for airway assessment,making this process more standardized and accurate to reduce airway-related complications and improve ***:Seven members from the Airway Management Group of the Chinese Society of Anaesthesiology(CSA)met to discuss the first draft and then this was sent to 15 international experts for review,comment,and *** Grading of Recommendations,Assessment,Development and Evaluation(GRADE)is used to determine the level of evidence and grade the strength of *** recommendations were revised through a three-round Delphi survey from ***:This expert consensus provides a comprehensive approach to airway assessment based on the medical history,physical examination,comprehensive scores,imaging,and new developments including transnasal endoscopy,virtual laryngoscopy,and 3D *** addition,this consensus also reviews some new technologies currently under development such as prediction from facial images and voice information with the aim of proposing new research directions for the assessment of difficult ***:This consensus applies to anesthesiologists,critical care,and emergency physicians refining the preoperative airway assessment and preparing an appropriate intubation strategy for patients with a potentially difficult airway.

关键词： Expert consensus difficult airway airway management

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Tensegrity: A Novel Conceptual Framework for Rehabilitation of Functional Deficits for Breast Cancer Survivors

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Journal of Science in Sport and Exercise 2020年第3期2卷 215-219页

作者： Marjorie A.King Claudio L.battaglini Department of Physical Therapy Plymouth State UniversityMSC#6817 High StreetPlymouthNH 03264USA Department of Exercise and Sport Science University of North CarolinaChapel HillChapel HillNC 27599USA Lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillNC 27599USA

The current approach to breast cancer rehabilitation is currently narrowly focused on addressing resultant problems such as lymphedema or shoulder *** to rehabilitation are reactive responses to these *** a step back and looking at the breast cancer intervention in totality,it becomes apparent that steps could be taken to minimize or actu-ally prevent some of the ensuing functional problems by proactively treating a breast cancer *** than waiting for problems to arise,immediately post-intervention or ideally pre-intervention and throughout intervention referral of an individual to rehabilitation could provide a supportive role in the functional progression of the ***,while most orthopedic rehabilitation focuses on the function of a particular joint,with the extensive impact of the breast cancer treatments on the soft tissue of the body without any specific intervention at a joint,it is imperative that we begin to shift our rehabilitation approach to focusing on the alterations of the soft tissue prior to addressing any functional limitations in the joints,with the most common victim being the shoulder *** novel approach to breast cancer rehabilitation sug-gests initially addressing soft tissue *** these limitations begin to resolve as optimally as possible,secondary consideration is then given to functional limitations of a joint such as the shoulder joint.

关键词： Tensegrity Soft tissue Fascia Breast cancer rehabilitation

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Are dogs good at spotting movement?Velocity thresholds of motion detection in Canis familiaris

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Current Zoology 2020年第6期66卷 699-701页

作者： Miina Looke Orsolya Kanizsar Luca battaglini Cecile Guerineau Paolo Mongillo Lieta Marinelli Laboratory of Applied Ethology Department of Comparative Biomedicine and Food ScienceUniversity of PaduaViale delPUniversita 16Legnaro(PD)30202Italy Department of General Psychology University of PaduaVia Venezia 8Padua35131Italy

The ability to perceive motion is a fundamental property of the visual system,and one of its most basic aspects is the ability to discriminate moving objects from motionless ones,for example,motion *** thresholds represent the minimum rate of displacement over time unit that an animal is able to perceive as movement,any slower motion being not discriminable from a still *** such topic has grabbed the attention of scientists already at the beginning of the 20th century,the interest has waned in time,and velocity thresholds have thus far been assessed in only a handful of species.

关键词： Dogs methods of limits motion velocity threshold vision

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Effectiveness of seed dispersal by ants in a Neotropical tree

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Integrative Zoology 2011年第3期6卷 222-226页

作者： Britta denise HARDESTY Smithsonian Tropical Research Institute BalboaAncónPanama and Department of Plant BiologyUniversity of GeorgiaAthensGeorgiaUSA and Commonwealth Scientific and Industrial Research Organization(CSIRO)Ecosystem SciencesAthertonQldAustralia

Seed dispersal and subsequent recruitment is the template on which forest regeneration takes ***,considering the scale over which ecological processes occur is key for understanding the overall impact of various dispersal *** explore leafcutter ant(Atta colombica)dispersal effectiveness in space and time,seed movement and subsequent recruitment of a large-seeded predominately vertebrate-dispersed tree,Simarouba amara(***),was investigated on Barro Colorado Island,*** each of 218 reproductive-sized adults(>20 cm diameter at breast height),presence or absence of a leafcutter ant colony was noted,with extensive checks for Atta activity taking place at or in close proximity to seed and seedling transects,which extended 4 cardinal directions for 30 m from each reproductive female tree(n=74).Only at 2 *** trees were nests observed,and in these areas a dense *** seedling carpet was *** nearby nest and dump sites might increase local *** recruitment in the short term,mortality at these sites is complete or nearly ***,the seed dispersal effectiveness by leafcutter ants appears to be ephemeral and likely contributes inconsequentially to the long-term recruitment and distribution patterns of the *** finding highlights the importance of evaluating disperser effectiveness at ecologically relevant spatiotemporal scales.

关键词： Atta colombica Barro Colorado Island seed dispersal effectiveness Simarouba amara

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The role of lysosomes in alpha-synucleinopathies: a focus on glial cells

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Neural Regeneration Research 2022年第7期17卷 1486-1488页

作者： denise Balta Friederike Zunke Department of Molecular Neurology University Hospital ErlangenFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Lysosomes are the major degradative compartments within eukaryotic *** their role in the degradation and recycling of intra-and extracellular molecules,they further mediate important biological processes,such as immun... 详细信息

关键词： homeostasis recycling degradation

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Use of the area of main influence to fix a relevant boundary for mining damages in Germany

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International Journal of Mining Science and Technology 2018年第1期28卷 79-83页

作者： denise Müller Axel Preusse Faculty of Georesources and Materials Engineering Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining RWTH Aachen University

In 2010, the fracking discussion in Germany caused a number of changes in German law, which came into force in *** the production of gas had to be *** the legislation amendment, the Subsidence-Area Mining Regulation has been revised, *** changes expand the compensation of mining damages, especially to the extraction with drilling from the surface and underground *** the Subsidence-Area Mining Regulation has been revised, the area of main influence(subsidence of 10 cm)remains to determine a relevant boundary for mining *** determination and prediction of this boundary above caverns are presented in this *** addition, further elements of ground movements and their relevance to mine damages are *** usage of the area of main influence to fix a relevant boundary for mining damages does not correspond to the relevant elements of ground movements.A limit for differences in subsidence(tilt) or horizontal changes in length should be preferred to describe the relevance of mining damages on ***, this paper outlines the meaning of using the area of main influence to fix a relevant boundary for mining damages.

关键词： Ground movements Area of main influence Boundary for mining damages Subsidence-area mining regulation Subsidence detection Modeling above caverns

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Does digit ratio （2D：4D） predict penile length？

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Asian Journal of Andrology 2011年第5期13卷 667-668页

作者： denise Brooks McQuade Department of Biology Skidmore College SaratogaSprings NY 12866 USA

Now advertized in at least one locale as the ＇sexy ratio＇ with the caption, ＇Your hands give away your hotness＇（http：//***/ #!5794008; accessed 3 May 2011）, an online summary of a recent study linking facial attractiveness to the ratio of the index and ring fingers1 indicates that digit ratio （2D：4D） research has reached mainstream culture. Digit ratio, most commonly the ratio of the index to ring fingers in humans, is sexually dimorphic （males have lower values than females） with greater differences on their right hand.

关键词： Acute lymphocytic leukaemia Cancer microenvironment Myeloproliferative disease

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Metabolomic evidence of independent biotransformation pathways for terpenes in two specialist mammalian herbivores (genus Neotoma)

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Integrative Zoology 2024年第1期19卷 143-155页

作者： Katharina SCHRAMM Michele SKOPEC denise DEARING Department of Biology University of UtahSalt Lake CityUtahUSA Department of Zoology Weber State UniversityOgdenUtahUSA

Herbivory is common in mammals,yet our understanding of detoxification processes used by mammals to biotrans-form plant secondary compounds(PSCs)is *** herbivores are thought to have evolved detoxifica-tion mechanisms that rely more heavily on energetically cheap Phase I biotransformation reactions to process high levels of PSCs in their *** explored this hypothesis by comparing the urinary metabolite patterns of two spe-cialist herbivores(genus Neotoma).Neotoma stephensi is an obligate specialist on one-seeded juniper(Juniperus monosperma).Neotoma lepida is a generalist forager across its range,yet populations in the Great Basin specialize on Utah juniper(***).While both juniper species have high levels of terpenes,the terpene profiles and quantities differ between the *** from both woodrat species were fed diets of each juniper in a cross-over ***,collected over a 24-h period,was extracted and analyzed in an untargeted metabolomics approach using both GC-MS and HPLC-MS/*** obligate specialist *** excreted a unique pattern of Phase I metabolites when fed its native juniper,while *** excreted a unique pattern of Phase II metabolites when fed its native *** woodrat species utilized the Phase II metabolic pathway of glucuronidation more heavily when consuming the more chemically diverse ***,and *** utilized less glucuronida-tion than *** when consuming *** results are consistent with the hypothesis that obligate specialists may have evolved unique and efficient biotransformation mechanisms for dealing with PSCs in their diet.

关键词： dietary specialization herbivory juniper metabolomics Neotoma

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