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Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria

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World Journal of Gastroenterology 2007年第2期13卷 236-243页

作者： Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot Bactéries Lactiques and Immunité des Muqueuses Institut Pasteur de Lille France Bactéries Lactiques and Immunité des Muqueuses Institut Pasteur de Lille France Nestlé Research Center Nutrition and Health Department Lausanne Switzerland Danisco France Culture Division France Nestlé Nutrition Vevey Switzerland

AIM： To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS： In vitro immunomodulation was assessed by measuring interleukJn （IL）-12p70, IL-10, tumor necrosis factor alpha （TNFα） and interferon 7 （IFNγ） release by human peripheral blood mononuclear cells （PBMCs） after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS： A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IU12 cytokine ratio could not significantly attenuate colitis symptoms, CONCLUSION：These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria （LAB） based on the cytokine profile we established in vitro. The PBHC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested in murine models for their anti-inflammatory potential.

关键词： Inflammatory bowel disease Probiotics Cytokines Peripheral blood mononuclear cells Trinitrobenzene sulfonate-induced colitis

Soft tissue sarcoma with metastasis to the stomach: A case report

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World Journal of Gastroenterology 2010年第40期16卷 5130-5134页

作者： Lemuel Leon Dent Cesar Yamil Cardona Michael Clause Buchholz Roosevelt Peebles Julie denise Scott Derrick Jerome Beech Billy Ray Ballard Department of Surgery Meharry Medical College Department of Gastroenterology Meharry Medical College Department of Plastic Surgery Meharry Medical College Department of Pathology Meharry Medical College

Soft tissue sarcomas are unusual malignancies comprising 1% of cancer diagnoses in the United States. Undifferentiated pleomorphic sarcoma accounts for approximately 5% of sarcomas occurring in adults. The most common site of metastasis is the lung, with other sites being bone, the brain, and the liver. Metastasis to the gastrointestinal tract has rarely been documented. We present an unusual case of high-grade pleomorphic sarcoma with metastasis to the stomach, complicated by upper gastrointestinal bleeding.

关键词： Gastrointestinal bleeding Metastatic sarcoma Undifferentiated pleomorphic sarcoma

Nucleotide bias of DCL and AGO in plant anti-virus gene silencing

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Protein & Cell 2010年第9期1卷 847-858页

作者： Thien Ho Liang Wang Linfeng Huang Zhigang Li denise W.Pallett Tamas Dalmay Kazusato Ohshima John A.Walsh Hui Wang NERC/Centre for Ecology and Hydrology(CEH)Wallingford Maclean BuildingBenson LaneWallingfordOxfordshire OX108BBUK Department of Biochemistry University of OxfordSouth Parks RoadOxford OX13QUUK Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100029China School of Biological Sciences University of East AngliaNorwich NR47TJUK Laboratory of Plant Virology Faculty of AgricultureSaga University1-banchiHonjo-machiSaga 840-8502Japan Plant-Virus Interactions Group Warwick HRIWarwick UniversityWellesbourneWarwick CV359EFUK Current address:AF Building University of Dundee at SCRIInvergowrieDundee DD25DAUK Current address:Immune Disease Institute 200 Longwood AvenueBoston MA 02115USA

Plant Dicer-like(DCL)and Argonaute(AGO)are the key enzymes involved in anti-virus post-transcriptional gene silencing(AV-PTGS).Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing viral RNA *** comparison with genome sequences of dicot-infecting Turnip mosaic virus(TuMV)and monocot-infecting Cocksfoot streak virus(CSV),viral-derived small interfering RNAs(vsiRNAs)displayed positive correlations between AV-PTGS efficiency and G+C content(GC%).Further investigations on nucleotide contents revealed that the vsiRNA populations had *** finding was further supported by our analyses of previously reported vsiRNA populations in diverse plant-virus associations,and AGO associated Arabidopsis endogenous siRNA populations,indicating that plant AGOs operated with *** further propose a hypothesis that AV-PTGS imposes selection pressure(s)on the evolution of plant *** hypothesis was supported when potyvirus genomes were analysed for evidence of GC elimination,suggesting that plant virus evolution to have low GC%genomes would have a unique function,which is to reduce the host AV-PTGS attack during infections.

关键词： anti-virus post-transcriptional gene silencing siRNA nucleotide bias Dicer-like Argonaute plant virus evolution

Three-dimensional printing in paediatric orthopaedic surgery

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World Journal of Orthopedics 2022年第1期13卷 1-10页

作者： Sven Goetstouwers Dagmar Kempink Bertram The denise Eygendaal Bart van Oirschot Christiaan JA van Bergen Department of Orthopaedic Surgery and Sports Medicine Erasmus Medical Centre/Sophia Children's HospitalRotterdam 3015GDSouth-HollandNetherlands Department of Orthopaedic Surgery Amphia HospitalBreda 4818CKNorth-BrabantNetherlands D Lab Amphia HospitalBreda 4818CKNorth-BrabantNetherlands

Three-dimensional(3D)printing is a rapidly evolving and promising field to improve outcomes of orthopaedic *** use of patient-specific 3D-printed models is specifically interesting in paediatric orthopaedic surgery,as limb deformity corrections often require an individual 3D *** this editorial,various operative applications of 3D printing in paediatric orthopaedic surgery are *** technical aspects and the imaging acquisition with computed tomography and magnetic resonance imaging are ***,there is a focus on the intraoperative applications of 3D printing during paediatric orthopaedic surgical *** overview of various upper and lower limb deformities in paediatrics is given,in which 3D printing is already implemented,including posttraumatic forearm corrections and proximal femoral *** use of patient-specific instrumentation(PSI)or guiding templates during the surgical procedure shows to be promising in reducing operation time,intraoperative haemorrhage and radiation ***,3D-printed models for the use of PSI or patient-specific navigation templates are promising in improving the accuracy of complex limb deformity surgery in ***,the future of 3D printing in paediatric orthopaedics extends beyond the intraoperative applications;various other medical applications include 3D casting and prosthetic limb *** conclusion,3D printing opportunities are numerous,and the fast developments are exciting,but more evidence is required to prove its superiority over conventional paediatric orthopaedic surgery.

关键词： Three-dimensional printing Paediatric Orthopaedic surgery Intraoperative Patient-specific instrumentation Guiding

Comprehensive Analysis of Pan-African Mitochondrial DNA Variation Provides New Insights into Continental Variation and Demography

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Journal of Genetics and Genomics 2016年第3期43卷 133-143页

作者： Maria Cerezo Leonor Gusmao Viktor Cerny Nabeel Uddin denise Syndercombe-Court Alberto Gdmez-Carballa Tanja Gobel Peter M. Schneider Antonio Salas Unidade de Xenetica Departamento de Anatomia Patoloxica e Ciencias Forenses Instituto de Medicina Legal Facultade de Medicina Universidade de Santiago de Compostela Galicia 15782 Spain The Wellcome Trust Sanger Institute Hinxton CBIO 1SA UK DNA Diagnostic Laboratory Institute of Biology State University of Rio de Janeiro Rio de Janeiro 20550-900 Brazil IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto Porto 4200-465 Portugal Archaeogenetics Laboratory Institute of Archaeology of the Academy of Sciences of the Czech Republic Prague 118-01 Czech Republic Faculty of Life Sciences and Medicine King's College London London SE1 9NH UK Barts and The London School of Medicine and Dentistry Blizard Institute London E1 2AT UK Institute of Legal Medicine Medical Faculty University of Cologne Cologne D-50823 Germany

Africa is the cradle of all human beings, and although it has been the focus of a number of genetic studies, there are many questions that remain unresolved. We have performed one of the largest and most comprehensive meta-analyses of mitochondrial DNA （mtDNA） lineages carried out in the African continent to date. We generated high-throughput mtDNA single nucleotide polymorphism （SNP） data （230 SNPs） from 2024 Africans, where more than 500 of them were additionally genotyped for the control region. These data were analyzed together with over 12,700 control region profiles collected from the literature, representing more than 300 population samples from Africa. Insights into the African homeland of humans are discussed. Phylogeographic patterns for the African continent are shown at a high phylogeographic resolution as well as at the population and regional levels. The deepest branch of the mtDNA tree, haplogroup L0, shows the highest sub-haplogroup diversity in Southeast and East Africa, suggesting this region as the homeland for modem humans. Several demographic estimates point to the coast as a facilitator of human migration in Africa, but the data indicate complex patterns, perhaps mirroring the effect of recent continental-scaled demographic events in re-shaping African mtDNA variability.

关键词： mtDNA Haplotype Haplogroup SNP MALDI-TOF

Paper Recycling Process Benefits Environment And Profits

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当代外语研究 2003年第5期 5-7页

作者： denise Mann 江丽云

佛罗里达大学研究人员开发的去除油墨技术,比现有技术更有可能为造纸厂能以更低的成本再生多种纸张打开大门,以达到节约木材,提高效率的目的。

关键词：表面活性剂 Paper Recycling Process Benefits Environment And Profits 再生工艺化学制品佛罗里达大学造纸厂再生纸

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澳门的“袪病”文化:庙宇崇拜与民间信仰

中国文化研究 2018年第4期 106-113页

作者：黄雁鸿 denise 澳门理工学院中西文化研究所

本文整理了澳门各庙宇历史中与"袪病"有关的内容,结合澳门历史上重大的疾病事件,疏理社会出现大型医疗危机时,民众如何透过庙宇和神名崇拜以消灾去病,以研究澳门庙宇和民间信仰中的治病元素和"袪病"文化,探讨民间信仰对社会民生事件的影... 详细信息

本文整理了澳门各庙宇历史中与"袪病"有关的内容,结合澳门历史上重大的疾病事件,疏理社会出现大型医疗危机时,民众如何透过庙宇和神名崇拜以消灾去病,以研究澳门庙宇和民间信仰中的治病元素和"袪病"文化,探讨民间信仰对社会民生事件的影响,以及当中透露的民俗文化和精神信念。

关键词：庙宇崇拜信仰袪病

Smith, Aminda M., Thought Reform and China＇s Dangerous Classes Reeducation, Resistance, and the People

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Frontiers of History in China 2014年第2期9卷 317-321页

作者： denise Y. Ho The Chinese University of Hong Kong

Aminda M. Smith＇s bold and thought-provoking first book examines the reeducation of China＇s ＂dangerous classes＂ in the 1950s, using the process of thought reform to study how the new party-state answered the following question ＂What makes a vast population of heterogeneous individuals into the Chinese People？＂（p. 11）. With an array of primary source materials including government documents from the Beijing Municipal Archive,

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Embedding Knowledge Management in Public Sector Procurement： Redesigning for the Knowledge Economy

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Journal of Modern Accounting and Auditing 2014年第5期10卷 594-606页

作者： denise A. D. Bedford Kent State University Kent USA

There is a perception in the public, political, and trade discourse that private sector procurement performs ＂better＂ than does public sector procurement. This research considers whether this perception is justified. This paper proposes a conceptual framework for assessing issues that influence procurement performance. The framework takes into account the organization＇s business goals, its procurement principles, the design of its procurement capability, the intellectual capital or knowledge that is used to support procurement operations, and the use of knowledge management methods. To represent these factors, the framework adapts the conceptual framework proposed by McElroy （2002）, leverages Andriessen＇s （2005） characterization of intellectual capital, and adopts Bedford＇s （2012） description of the practice of knowledge management. The results, though preliminary and exploratory, suggest that factors which are more often practiced in the private sector than the public sector contribute to higher performance.

关键词： private sector procurement public sector procurement knowledge management intellectual capital management procurement life cycle procurement principles