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Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

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Bioactive Materials 2019年第1期4卷 43-55页

作者： Abdulrahman A.Balhaddad Anmar A.Kansara denise hidan Michael D.Weir Hockin H.K.Xu Mary Anne S.Melo Ph.D.Program in Biomedical Sciences University of Maryland School of DentistryBaltimoreMD21201USA Division of Biomaterials&Tissue Engineering Department of Advanced Oral Sciences and TherapeuticsUniversity of Maryland School of DentistryBaltimoreMD21201USA Department of Restorative Dental Sciences Imam Abdulrahman Bin Faisal UniversityCollege of DentistryDammamSaudi Arabia Department of Restorative Dentistry Umm Al-Qura UniversityCollege of DentistryMakkahSaudi Arabia Division of Operative Dentistry Dept.of General DentistryUniversity of Maryland School of DentistryBaltimoreMD21201USA

Millions of people worldwide suffer from a toothache due to tooth cavity,and often permanent tooth *** caries,also known as tooth decay,is a biofilm-dependent infectious disease that damages teeth by minerals loss and presents a high incidence of clinical restorative polymeric fillings(tooth colored fillings).Until now,restorative polymeric fillings present no *** complexity of oral biofilms contributes to the difficulty in developing effective novel dental *** has been explored in the development of bioactive dental materials to reduce or modulate the activities of caries-related ***-structured platforms based on calcium phosphate and metallic particles have advanced to impart an anti-caries potential to restorative *** bioactivity of these platforms induces prevention of mineral loss of the hard tooth structure and antibacterial activities against caries-related *** has been suggested that this bioactivity could minimize the incidence of caries around restorations(CARS)and increase the longevity of such filling *** last few years witnessed growing numbers of studies on the preparation evaluations of these novel ***,the caries disease process and the role of pathogenic caries-related biofilm,the increasing incidence of CARS,and the recent efforts employed for incorporation of bioactive nanoparticles in restorative polymer materials as useful strategies for prevention and management of caries-related-bacteria are *** highlight the status of the most advanced and widely explored interaction of nanoparticle-based platforms and calcium phosphate compounds with an eye toward translating the potential of these approaches to the dental clinical reality.

关键词： Dental materials Bioactive Nanoparticles Dental caries

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Effectiveness of seed dispersal by ants in a Neotropical tree

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Integrative Zoology 2011年第3期6卷 222-226页

作者： Britta denise HARDESTY Smithsonian Tropical Research Institute BalboaAncónPanama and Department of Plant BiologyUniversity of GeorgiaAthensGeorgiaUSA and Commonwealth Scientific and Industrial Research Organization(CSIRO)Ecosystem SciencesAthertonQldAustralia

Seed dispersal and subsequent recruitment is the template on which forest regeneration takes ***,considering the scale over which ecological processes occur is key for understanding the overall impact of various dispersal *** explore leafcutter ant(Atta colombica)dispersal effectiveness in space and time,seed movement and subsequent recruitment of a large-seeded predominately vertebrate-dispersed tree,Simarouba amara(***),was investigated on Barro Colorado Island,*** each of 218 reproductive-sized adults(>20 cm diameter at breast height),presence or absence of a leafcutter ant colony was noted,with extensive checks for Atta activity taking place at or in close proximity to seed and seedling transects,which extended 4 cardinal directions for 30 m from each reproductive female tree(n=74).Only at 2 *** trees were nests observed,and in these areas a dense *** seedling carpet was *** nearby nest and dump sites might increase local *** recruitment in the short term,mortality at these sites is complete or nearly ***,the seed dispersal effectiveness by leafcutter ants appears to be ephemeral and likely contributes inconsequentially to the long-term recruitment and distribution patterns of the *** finding highlights the importance of evaluating disperser effectiveness at ecologically relevant spatiotemporal scales.

关键词： Atta colombica Barro Colorado Island seed dispersal effectiveness Simarouba amara

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The role of lysosomes in alpha-synucleinopathies: a focus on glial cells

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Neural Regeneration Research 2022年第7期17卷 1486-1488页

作者： denise Balta Friederike Zunke Department of Molecular Neurology University Hospital ErlangenFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Lysosomes are the major degradative compartments within eukaryotic *** their role in the degradation and recycling of intra-and extracellular molecules,they further mediate important biological processes,such as immun... 详细信息

关键词： homeostasis recycling degradation

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Use of the area of main influence to fix a relevant boundary for mining damages in Germany

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International Journal of Mining Science and Technology 2018年第1期28卷 79-83页

作者： denise Müller Axel Preusse Faculty of Georesources and Materials Engineering Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining RWTH Aachen University

In 2010, the fracking discussion in Germany caused a number of changes in German law, which came into force in *** the production of gas had to be *** the legislation amendment, the Subsidence-Area Mining Regulation has been revised, *** changes expand the compensation of mining damages, especially to the extraction with drilling from the surface and underground *** the Subsidence-Area Mining Regulation has been revised, the area of main influence(subsidence of 10 cm)remains to determine a relevant boundary for mining *** determination and prediction of this boundary above caverns are presented in this *** addition, further elements of ground movements and their relevance to mine damages are *** usage of the area of main influence to fix a relevant boundary for mining damages does not correspond to the relevant elements of ground movements.A limit for differences in subsidence(tilt) or horizontal changes in length should be preferred to describe the relevance of mining damages on ***, this paper outlines the meaning of using the area of main influence to fix a relevant boundary for mining damages.

关键词： Ground movements Area of main influence Boundary for mining damages Subsidence-area mining regulation Subsidence detection Modeling above caverns

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High rate of complicated idiopathic gallstone disease in pediatric patients of a North American tertiary care center

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World Journal of Gastroenterology 2008年第10期14卷 1544-1548页

作者： denise Herzog Guylaine Bouchard Division of Gastro-enterology and Nutrition Sainte Justine Hospital University of Montreal Montreal Quebec Canada

AIM: To assess spectrum and etiology of gallstones and biliary sludge in the pediatric population of a North American tertiary care centre. METHODS: Retrospective review of abdominal ultraso- unds recorded at Saint Justine Hospital over a period of 24 mo (8/2003 to 8/2005) in patients 2 years of age idiopathic gallstone disease was found. These 48 patients represent 2.1% of the population who required ultrasound for abdominal pain. Complicated gallstone disease occurred in 28/48 with idiopathic disease, mainly adolescent girls. Patients with hemolytic disorders, cystic fibrosis, oncologic diseases or kidney transplantation and gallstones were asymptomatic and stones were detected during routine abdominal ultrasound. Twenty two patients < 2 years of age not consulting for abdominal pain had gallstone disease of diverse etiology. Biliary sludge was seen in 84 patients, 78.5% on total parenteral nutrition. In 4 patients, sludge progressed to gallstones. CONCLUSION: Idiopathic gallstone disease and its rate of complication are more frequent in our cohort than expected from previous studies. Adolescent girls with abdominal pain and idiopathic gallstones require special attention for complicated disease course.

关键词： Cholecystectomy Hemolytic disease Cystic fibrosis Pancreatitis Choledocholithiasis

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Does digit ratio （2D：4D） predict penile length？

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Asian Journal of Andrology 2011年第5期13卷 667-668页

作者： denise Brooks McQuade Department of Biology Skidmore College SaratogaSprings NY 12866 USA

Now advertized in at least one locale as the ＇sexy ratio＇ with the caption, ＇Your hands give away your hotness＇（http：//***/ #!5794008; accessed 3 May 2011）, an online summary of a recent study linking facial attractiveness to the ratio of the index and ring fingers1 indicates that digit ratio （2D：4D） research has reached mainstream culture. Digit ratio, most commonly the ratio of the index to ring fingers in humans, is sexually dimorphic （males have lower values than females） with greater differences on their right hand.

关键词： associations well established

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Metabolomic evidence of independent biotransformation pathways for terpenes in two specialist mammalian herbivores (genus Neotoma)

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Integrative Zoology 2024年第1期19卷 143-155页

作者： Katharina SCHRAMM Michele SKOPEC denise DEARING Department of Biology University of UtahSalt Lake CityUtahUSA Department of Zoology Weber State UniversityOgdenUtahUSA

Herbivory is common in mammals,yet our understanding of detoxification processes used by mammals to biotrans-form plant secondary compounds(PSCs)is *** herbivores are thought to have evolved detoxifica-tion mechanisms that rely more heavily on energetically cheap Phase I biotransformation reactions to process high levels of PSCs in their *** explored this hypothesis by comparing the urinary metabolite patterns of two spe-cialist herbivores(genus Neotoma).Neotoma stephensi is an obligate specialist on one-seeded juniper(Juniperus monosperma).Neotoma lepida is a generalist forager across its range,yet populations in the Great Basin specialize on Utah juniper(***).While both juniper species have high levels of terpenes,the terpene profiles and quantities differ between the *** from both woodrat species were fed diets of each juniper in a cross-over ***,collected over a 24-h period,was extracted and analyzed in an untargeted metabolomics approach using both GC-MS and HPLC-MS/*** obligate specialist *** excreted a unique pattern of Phase I metabolites when fed its native juniper,while *** excreted a unique pattern of Phase II metabolites when fed its native *** woodrat species utilized the Phase II metabolic pathway of glucuronidation more heavily when consuming the more chemically diverse ***,and *** utilized less glucuronida-tion than *** when consuming *** results are consistent with the hypothesis that obligate specialists may have evolved unique and efficient biotransformation mechanisms for dealing with PSCs in their diet.

关键词： dietary specialization herbivory juniper metabolomics Neotoma

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Leveraging Learning to Improve Disaster Management Outcomes

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International Journal of Disaster Risk Science 2012年第4期3卷 195-206页

作者： denise D.P.Thompson Department of Public Management John Jay College of Criminal JusticeCity University of New YorkNY 10019U.S.A.

Disaster management agencies should be exemplars of learning given the volatility of their operating environment. However, there are cognitive, social, and organizational barriers that prevent these organizations from learning. The purpose of this article is to use the Caribbean Disaster and Emergency Management Agency(CDEMA) as an example of an organization that achieves double-loop learning in spite of known barriers. This research shows significant learning variations in the CDEMA organization from the regional to the national level. The results demonstrate that the CDEMA Coordinating Unit and a few national member agencies achieve double-loop learning, while the opposite is true for many national disaster offices. Analysis of this variation is one contribution to the disaster management and organizational learning literature. The article also suggests that organizational culture is an important precursor to learning and adds a much needed case example to the management and learning literature. The study ends with a proposal for future research in the area of disaster management, culture and learning, and propositions for national disaster offices to consider in order to enhance double-loop learning.

关键词： disaster culture aging

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The Genetic Deafness in Chinese Population

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Journal of Otology 2006年第1期1卷 1-10页

作者： denise Yan Department of Otolaryngology University of MiamiMiamiFloridaUSA

Deafness is an etiologically heterogeneous trait with many known genetic, environmental causes or a combination thereof. The identification of more than 120 independent genes for deafness has provided profound new insights into the pathophysiology of hearing. However, recent findings indicate that a large proportion of both syndromic and nonsyndromic forms of deafness in Chinese population are caused by a small number of mutations. This review is focused on syndromic and nonsyndromic deafness as well as on the latest information linking inherited mitochondrial pathologies to a variety of etiologies of sensorineural deafness in Chinese population. Better understanding of the genetic causes of deafness in Chinese population is important for accurate genetics counseling and early diagnosis for timely intervention and treatment options.

关键词： gene The Genetic Deafness in Chinese Population GJB

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Fibroblast growth factor 21 in dairy cows:current knowledge and potential relevance

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Journal of Animal Science and Biotechnology 2022年第2期13卷 303-315页

作者： Klaus Eder denise K.Gessner Robert Ringseis Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenHeinrich-Buff-Ring 26-3235392 GiessenGermany

Fibroblast growth factor 21(FGF21)has been identified as an important regulator of carbohydrate and lipid metabolism,which plays an important role for metabolic regulation,particularly under conditions of energy deprivation or stress *** cows are subjected to a negative energy balance and various kinds of stress particularly during the periparturient phase and during early *** has been shown that the plasma concentration of FGF21 in dairy cows is dramatically increased at parturition and remains high during the first weeks of *** finding suggests that FGF21 might exert similar functions in dairy cows than in other species,such as mice or ***,the role of FGF21 in dairy cows has been less investigated so *** a brief summary of the previous findings about the function of FGF21 in humans and mice,the present review aims to present the current state of knowledge about the role of FGF21 in dairy *** first part of the review deals with the tissue localization of FGF21 and with conditions leading to an upregulation of FGF21 expression in the liver of dairy *** the second part,the influence of nutrition on FGF21 expression and the role of FGF21 for metabolic diseases in dairy cows is *** the third part,findings of exogenous FGF21 application on metabolism in dairy cows are ***,the potential relevance of FGF21 in dairy cows is *** is concluded that FGF21 might be of great importance for metabolic adaptation to negative energy balance and stress conditions in dairy ***,further studies are needed for a better understanding of the functions of FGF21 in dairy cows.

关键词： Dairy cow Energy deprivation Fibroblast growth factor 21 Metabolic adaptation Stress

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