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Metabolomic evidence of independent biotransformation pathways for terpenes in two specialist mammalian herbivores (genus Neotoma)

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Integrative Zoology 2024年第1期19卷 143-155页

作者： Katharina SCHRAMM Michele SKOPEC denise DEARING Department of Biology University of UtahSalt Lake CityUtahUSA Department of Zoology Weber State UniversityOgdenUtahUSA

Herbivory is common in mammals,yet our understanding of detoxification processes used by mammals to biotrans-form plant secondary compounds(PSCs)is *** herbivores are thought to have evolved detoxifica-tion mechanisms that rely more heavily on energetically cheap Phase I biotransformation reactions to process high levels of PSCs in their *** explored this hypothesis by comparing the urinary metabolite patterns of two spe-cialist herbivores(genus Neotoma).Neotoma stephensi is an obligate specialist on one-seeded juniper(Juniperus monosperma).Neotoma lepida is a generalist forager across its range,yet populations in the Great Basin specialize on Utah juniper(***).While both juniper species have high levels of terpenes,the terpene profiles and quantities differ between the *** from both woodrat species were fed diets of each juniper in a cross-over ***,collected over a 24-h period,was extracted and analyzed in an untargeted metabolomics approach using both GC-MS and HPLC-MS/*** obligate specialist *** excreted a unique pattern of Phase I metabolites when fed its native juniper,while *** excreted a unique pattern of Phase II metabolites when fed its native *** woodrat species utilized the Phase II metabolic pathway of glucuronidation more heavily when consuming the more chemically diverse ***,and *** utilized less glucuronida-tion than *** when consuming *** results are consistent with the hypothesis that obligate specialists may have evolved unique and efficient biotransformation mechanisms for dealing with PSCs in their diet.

关键词： dietary specialization herbivory juniper metabolomics Neotoma

Technology-Assisted Reading Instruction for English Language Learners:A Methodological Review

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ECNU Review of Education 2024年第2期7卷 258-282页

作者：左心阅 denise Ives Department of Teacher Education and Curriculum Studies College of Education813 N Pleasant StAmherstMA01003USA

Purpose:By methodologically reviewing the literature on Technology-Assisted Reading Instruction(TARI)for English Language Learners(ELLs)in K-12 settings,this study aims to advance the knowledge of TARI research and guide future research ***/Approach/Methods:This study examines 32 peer-reviewed journal articles published between 2000 and *** article was analyzed for research objectives,reading skills,learner demographics and contexts,theoretical frameworks,research designs,and ***:A review of the literature reveals a strong focus on evaluating the efficacy of TARI through summative assessments,but limited attention to learners'literacy practices and interactive engagement in digital ***,there is a marked lack of alternative approaches to assessing the effectiveness of technology in promoting ELLs'reading progression and a continued emphasis on developing traditional literacy over multimodal *** can enhance reading motivation,foster collaborative learning,provide scaffolding,improve reading performance,andexpand semiotic ***/Value:As one of the first comprehensive methodological reviews of TARl,this study elucidates ELL reading education in the era of *** have implications for technology-mediated education,which expanded rapidly during the COVID-19 pandemic.

关键词： educational technology English language learners multiliteracy reading technology-assisted reading instruction

Six-Writings multimodal processing with pictophonetic coding to enhance Chinese language models

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 84-105页

作者： Li WEIGANG Mayara Chew MARINHO denise Leyi LI Vitor Vasconcelos DE OLIVEIRA Department of Computer Science University of BrasiliaBrasilia 70910-900Brazil Faculty of Economics AdministrationAccounting and ActuariesUniversity of Sao PauloSao Paulo 05508-010Brazil

While large language models(LLMs)have made significant strides in natural language processing(NLP),they continue to face challenges in adequately addressing the intricacies of the Chinese language in certain *** propose a framework called Six-Writings multimodal processing(SWMP)to enable direct integration of Chinese NLP(CNLP)with morphological and semantic *** first part of SWMP,known as Six-Writings pictophonetic coding(SWPC),is introduced with a suitable level of granularity for radicals and components,enabling effective representation of Chinese characters and *** conduct several experimental scenarios,including the following:(1)We establish an experimental database consisting of images and SWPC for Chinese characters,enabling dual-mode processing and matrix generation for CNLP.(2)We characterize various generative modes of Chinese words,such as thousands of Chinese idioms,used as question-and-answer(Q&A)prompt functions,facilitating analogies by *** experiments achieve 100%accuracy in answering all questions in the Chinese morphological data set(CA8-Mor-10177).(3)A fine-tuning mechanism is proposed to refine word embedding results using SWPC,resulting in an average relative error of≤25%for 39.37%of the questions in the Chinese wOrd Similarity data set(COS960).The results demonstrate that SWMP/SWPC methods effectively capture the distinctive features of Chinese and offer a promising mechanism to enhance CNLP with better efficiency.

关键词： Chinese language model Chinese natural language processing(CNLP) Generative language model Multimodal processing Six-Writings

Effects of positive end-expiratory pressure on intracranial pressure,cerebral perfusion pressure,and brain oxygenation in acute brain injury:Friend or foe?A scoping review

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Journal of Intensive Medicine 2024年第2期4卷 247-260页

作者： Greta Zunino denise Battaglini Daniel Agustin Godoy IRCCS Ospedale Policlinico San Martino GenovaItaly Dipartimento di Scienze Diagnostiche e Chirurgiche Integrate Universitàdegli Studi di GenovaGenovaItaly Neurointensive Care Unit Sanatorio PasteurCatamarcaArgentina

Background Patients with acute brain injury(ABI)are a peculiar population because ABI does not only affect the brain but also other organs such as the lungs,as theorized in brain–lung crosstalk *** patients often require mechanical ventilation(MV)to avoid the complications of impaired respiratory function that can follow ABI;MV should be settled with meticulousness owing to its effects on the intracranial compartment,especially regarding positive end-expiratory pressure(PEEP).This scoping review aimed to(1)describe the physiological basis and mechanisms related to the effects of PEEP in ABI;(2)examine how clinical research is conducted on this topic;(3)identify methods for setting PEEP in ABI;and(4)investigate the impact of the application of PEEP in ABI on the *** The five-stage paradigm devised by Peters et *** expanded by Arksey and O'Malley,Levac et al.,and the Joanna Briggs Institute was used for *** also adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)extension *** criteria:we compiled all scientific data from peer-reviewed journals and studies that discussed the application of PEEP and its impact on intracranial pressure,cerebral perfusion pressure,and brain oxygenation in adult patients with *** criteria:studies that only examined a pediatric patient group(those under the age of 18),experiments conducted solely on animals;studies without intracranial pressure and/or cerebral perfusion pressure determinations,and studies with incomplete *** authors searched and screened for inclusion in papers published up to July 2023 using the PubMed-indexed online *** were presented in narrative and tubular *** The initial search yielded 330 references on the application of PEEP in ABI,of which 36 met our inclusion *** has recognized beneficial effects on gas exchange,but it produces hemodynamic changes that should be predicted to avoi

关键词： Acute brain injury Mechanical ventilation Positive end-expiratory pressure Intracranial pressure Brain-lung crosstalk Multimodal monitoring

Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

Effectiveness of seed dispersal by ants in a Neotropical tree

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Integrative Zoology 2011年第3期6卷 222-226页

作者： Britta denise HARDESTY Smithsonian Tropical Research Institute BalboaAncónPanama and Department of Plant BiologyUniversity of GeorgiaAthensGeorgiaUSA and Commonwealth Scientific and Industrial Research Organization(CSIRO)Ecosystem SciencesAthertonQldAustralia

Seed dispersal and subsequent recruitment is the template on which forest regeneration takes ***,considering the scale over which ecological processes occur is key for understanding the overall impact of various dispersal *** explore leafcutter ant(Atta colombica)dispersal effectiveness in space and time,seed movement and subsequent recruitment of a large-seeded predominately vertebrate-dispersed tree,Simarouba amara(***),was investigated on Barro Colorado Island,*** each of 218 reproductive-sized adults(>20 cm diameter at breast height),presence or absence of a leafcutter ant colony was noted,with extensive checks for Atta activity taking place at or in close proximity to seed and seedling transects,which extended 4 cardinal directions for 30 m from each reproductive female tree(n=74).Only at 2 *** trees were nests observed,and in these areas a dense *** seedling carpet was *** nearby nest and dump sites might increase local *** recruitment in the short term,mortality at these sites is complete or nearly ***,the seed dispersal effectiveness by leafcutter ants appears to be ephemeral and likely contributes inconsequentially to the long-term recruitment and distribution patterns of the *** finding highlights the importance of evaluating disperser effectiveness at ecologically relevant spatiotemporal scales.

关键词： Atta colombica Barro Colorado Island seed dispersal effectiveness Simarouba amara

The role of lysosomes in alpha-synucleinopathies: a focus on glial cells

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Neural Regeneration Research 2022年第7期17卷 1486-1488页

作者： denise Balta Friederike Zunke Department of Molecular Neurology University Hospital ErlangenFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Lysosomes are the major degradative compartments within eukaryotic *** their role in the degradation and recycling of intra-and extracellular molecules,they further mediate important biological processes,such as immun... 详细信息

关键词： homeostasis recycling degradation

Use of the area of main influence to fix a relevant boundary for mining damages in Germany

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International Journal of Mining Science and Technology 2018年第1期28卷 79-83页

作者： denise Müller Axel Preusse Faculty of Georesources and Materials Engineering Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining RWTH Aachen University

In 2010, the fracking discussion in Germany caused a number of changes in German law, which came into force in *** the production of gas had to be *** the legislation amendment, the Subsidence-Area Mining Regulation has been revised, *** changes expand the compensation of mining damages, especially to the extraction with drilling from the surface and underground *** the Subsidence-Area Mining Regulation has been revised, the area of main influence(subsidence of 10 cm)remains to determine a relevant boundary for mining *** determination and prediction of this boundary above caverns are presented in this *** addition, further elements of ground movements and their relevance to mine damages are *** usage of the area of main influence to fix a relevant boundary for mining damages does not correspond to the relevant elements of ground movements.A limit for differences in subsidence(tilt) or horizontal changes in length should be preferred to describe the relevance of mining damages on ***, this paper outlines the meaning of using the area of main influence to fix a relevant boundary for mining damages.

关键词： Ground movements Area of main influence Boundary for mining damages Subsidence-area mining regulation Subsidence detection Modeling above caverns

Microbial Community with Potential for Metal Release Isolated from Palca Mine Tailings Pond in Peru

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Journal of Geoscience and Environment Protection 2024年第7期12卷 109-121页

作者： César Wilber Guzmán Moreno Bruno Karolski Solange Kazue Utimura Roberto Castellanos Cabrera Jhon Albert Centeno Torres Daladier Miguel Castillo Cotrina Elisabete de Santis Braga Dayana Sarai Gamonal Fermandez denise Crocce Romano Espinosa Joel Barbujiani Sigolo Department of Sedimentary and Environmental Geology Institute of Geoscience USP So Paulo Brazil Department of Chemical Engineering LAREX USP So Paulo Brazil CEPEMA Environment Training and Research Center USP So Paulo Brazil Facultad de Ciencias Universidad Nacional Jorge Basadre Grohmann UNJBG Tacna Per Department of Physical Chemical and Geological Oceanography USP So Paulo Brazil Facultad de Ciencias Biolgicas Universidad Nacional Pedro Ruiz Gallo UNPRG Lambayeque Per

The improvement of microbial characterization has increased the comprehension of microbial population and their ability in the microbiological metal dissolution. Bioleaching processes have been expanded to use microorganisms for the recovery of metals from ores and wastes. This study introduces Palca mine tailings pond in Peru which turned into acid mine drainage (AMD). AMD is a source of microbial communities whose microorganisms may support the aqueous extractive metallurgy for metal recovery. Four samples of AMD were collected from different locations and the elemental characterization showed concentrations of metals, such as Cu, Zn, Al, Mn, and Fe. The pH of the samples showed variation between 1.9 - 6.8. Twenty-one microorganisms were isolated and selected according the cell morphology. 16s rRNA gene sequences identified five species of which three belong to the bacterial kingdom and two to the Fungi kingdom. Two of the bacterial species were ferrous ion oxidizing bacteria, identified as Acidithiobacillus ferriphilus and Acidithiobacillus ferridurans;and the other one a ferric ion reducing bacteria identified as Acidiphilium acidophilum. The fungi species identified were Rhodotorula sinensis and Exophiala xenobiotica, a filamentous fungus isolated for the first time from an AMD.

关键词： Acidophilic Microorganisms Acid Mine Drainage—AMD Bioleaching Process Metals Recovery Acidithiobacillus