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Quantitative Trait Loci Analysis Identifies a Prominent Gene Involved in the Production of Fatty Acid-Derived Flavor Volatiles in Tomato

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Molecular Plant 2018年第9期11卷 1147-1165页

作者： Karolina Garbowicz Zhongyuan Liu Saleh Alseekh denise tieman Mark Taylor Anastasiya Kuhalskaya Itai Ofner Dani Zamir Harry J. Klee Alisdair R. Fernie Yariv Brotman Max-Planck-lnstitute of Molecular Plant Physiology Potsdam-Golm Germany Horticultural Sciences Plant Innovation Center University of Florida Gainesville FL USA Center of Plant System Biology and Biotechnology 4000 Plovdiv Bulgaria Department of Life Sciences Ben-Gurion University of the Negev Beersheba Israel Robert H. Smith Institute of Plant Sciences and Genetics Faculty of Agriculture Hebrew University of Jerusalem Rehovot 7610001 Israel These authors contributed equally to this article

To gain insight into the genetic regulation of lipid metabolism in tomato, we conducted metabolic trait loci （mQTL） analysis following the lipidomic profiling of fruit pericarp and leaf tissue of the Solanum pennellii introgression lines （IL）. To enhance mapping resolution for selected fruit-specific mQTL, we profiled the lipids in a subset of independently derived S. pennellii backcross inbred lines, as well as in a nearsogenic sub-iL population. We identified a putative lecithin：cholesterol acyltransferase that controls the levels of several lipids, and two members of the class III lipase family, LIP1 and LIP2, that were associated with decreased levels of diacylglycerols （DAGs） and triacylglycerols （TAGs）. Lipases of this class cleave fatty acids from the glycerol backbone of acylglycerols. The released fatty acids serve as precursors of flavor volatiles. We show that LIP1 expression correlates with fatty acid-derived volatile levels. We further confirm the function of LIP1 in TAG and DAG breakdown and volatile synthesis using transgenic plants. Taken together, our study extensively characterized the genetic architecture of Upophilic compounds in tomato and demonstrated at molecular level that release of free fatty acids from the glycerol backbone can have a major impact on downstream volatile synthesis.

关键词： lipidomics lipids lipase volatile FA-VOC Z-4-decenal

Catabolism of Branched Chain Amino Acids Supports Respiration but Not Volatile Synthesis in Tomato Fruits

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Molecular Plant 2012年第2期5卷 366-375页

作者： Andrej Kochevenko Wagner L. Araujo Gregory S. Maloney denise M. tieman Phuc Thi Do Mark G. Taylor Harry J. Klee Alisdair R. Fernie Max Planck Institute of Molecular Plant Physiology 14476 Potsdam-Golm Germany Departamento de Biologia Vegetal Universidade Federal de Vicosa 36570-000 Vicosa Minas Gerais Brazil Horticultural Sciences Department and the Plant Molecular ＆ Cellular Biology Program University of Florida Gainesville FL 32611 USA

The branched-chain amino acid transaminases （BCATs） have a crucial role in metabolism of the branched-chain amino acids leucine, isoleucine, and valine. These enzymes catalyze the last step of synthesis and the initial step of degradation of these amino acids. Although the biosynthetic pathways of branched chain amino acids in plants have been extensively investigated and a number of genes have been characterized, their catabolism in plants is not yet completely understood. We previously characterized the branched chain amino acid transaminase gene family in tomato, revealing both the subcellular localization and kinetic properties of the enzymes encoded by six genes. Here, we examined possible functions of the enzymes during fruit development. We further characterized transgenic plants differing in the expression of branched chain amino acid transaminases I and 3, evaluating the rates of respiration in fruits deficient in BCAT1 and the levels of volatiles in lines overexpressing either BCAT1 or BCAT3. We quantitatively tested, via precursor and isotope feeding experiments, the importance of the branched chain amino acids and their corresponding keto acids in the formation of fruit volatiles. Our results not only demonstrate for the first time the importance of branched chain amino acids in fruit respiration, but also reveal that keto acids, rather than amino acids, are the likely precursors for the branched chain flavor volatiles.

关键词： alternative electron transport metabolic regulation molecular physiology nitrogen metabolism volatiles tomato.

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偏移速度分析:考虑横向速度的影响

国外油气勘探 1996年第2期8卷 187-200,206页

作者： Hans J.tieman 徐焱东大庆物探公司研究所

迭代剖面偏移、聚焦分析、叠加能量分析等这些最常用的偏移速度分析算法都是以特定的地下假设条件为依据的,在横向速度变化的情况下这些假设会导致这些算法的失败。一般地说,或者假定地下速度为常速或最多假定速度是随深度变化的。最近... 详细信息

迭代剖面偏移、聚焦分析、叠加能量分析等这些最常用的偏移速度分析算法都是以特定的地下假设条件为依据的,在横向速度变化的情况下这些假设会导致这些算法的失败。一般地说,或者假定地下速度为常速或最多假定速度是随深度变化的。最近的一些改进,包括使用旅行时反演原理来反演求取偏移后同相轴所表现出的曲率与炮检距的函数关系的偏移测量值。旅行时反演无需对地下地质情况做任何假设,但却是一个相当不稳定的方法。因此,一个重要的问题是:"在什么样的条件下,传统的方法会失败,而必须使用旅行时反演法?" 将常用的偏移分析与层析成象结合在一组方程中,虽然根据偏移值算出修正量有用,但对于回答上面的问题来讲是太复杂了。然而,如果限定地下为低起伏的构造,并且假定波以小角度传播,那么这些校正的方程式就可以用等同于传统的校正方程式的形式来近似,不同的只是差一个系数,这个系数取决于可能的横向速度变化的大小、位置和空间波长。这些简单的方程式表明,甚至较长波长的异常也能使校正指向错误方向、使迭代过程发散、并在一定条件下使这些校正的精度大大降低。

关键词：偏移速度模型横向速度地震勘探地震数据

Monteggia Bilateral Fracture: A Case Study

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Surgical Science 2019年第8期10卷 297-301页

作者： Louis Traore Moussa Sidibe Abdoulkadri Moussa tieman Coulybali Rabat Faculty of Medicine and Pharmacy Orthopedic Trauma Mohammed V University Rabat Morocco

The authors report a rare case of Monteggia bilateral fracture combining bifocal fracture of the left ulna to a mid-shaft fracture of the radius with dislocation of the radial head and on the right;a fractured ulna with dislocation of the radial head occurring in a patient of 31 years after an accident of the public highway. In emergency, the treatment consisted of a fixation with radius special plates and a left pin ulnar upper radio. The evolution was marked by a good consolidation and after six months the patient had resumed operations.

关键词： Fracture Monteggia Bilateral

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不用扫描法的叠加速度分析

国外油气勘探 1995年第2期7卷 211-222页

作者： Hans J.tieman 马作彬石油地球物理勘探局物探地质研究院

叠加速度可直接由地震资料估算,而不依赖于多速度叠加和许多近代常规程序中包含的研究技术。估算步骤包括:(1)用零炮检距时间和速度的初始估计值对地震资料(一个给定的共中点道集时窗内)进行动校正(NMO);(2)对全部炮检距应用两个不同的... 详细信息

叠加速度可直接由地震资料估算,而不依赖于多速度叠加和许多近代常规程序中包含的研究技术。估算步骤包括:(1)用零炮检距时间和速度的初始估计值对地震资料(一个给定的共中点道集时窗内)进行动校正(NMO);(2)对全部炮检距应用两个不同的加权函数并相加求和获得两个叠加结果;(3)将两个叠加结果互相关;(4)将时移转换成速度和时间校正值。对上述过程迭代地进行直到收敛为止。这种方法称为ARAMVEL(美国专利号4813027),是通过交互连续速度分析技术最佳实现的。这种方法虽然简单,但是不论在经验研究或理论分析方面都已证明它所确定的速度精度比基于扫描的常规方法获得的速度精度高。该法收敛快,通常仅需一两次迭代。该法实用,因为最初仅需近似信息。实际资料研究结果证明,对于处理具有不可忽视的横向速度变化的地区资料,该法能经济地给出细致的速度控制,并能提供旅行时信息,以便精确地进行层速度和深度转换。

关键词：地震数据处理速度分析叠加速度迭代法

Can Video Conferencing Be as Easy as Telephoning?—A Home Healthcare Case Study

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E-Health Telecommunication Systems and Networks 2016年第1期5卷 8-18页

作者： Alan Taylor Greg Morris Jennifer tieman David Currow Michael Kidd Colin Carati Faculty of Medicine Nursing and Health Sciences Flinders University Adelaide Australia

In comparison with almost universal adoption of telephony and mobile technologies in modern day healthcare, video conferencing has yet to become a ubiquitous clinical tool. Currently telehealth services are faced with a bewildering range of video conferencing software and hardware choices. This paper provides a case study in the selection of video conferencing services by the Flinders University Telehealth in the Home trial (FTH Trial) to support healthcare in the home. Using pragmatic methods, video conferencing solutions available on the market were assessed for usability, reliability, cost, compatibility, interoperability, performance and privacy considerations. The process of elimination through which the eventual solution was chosen, the selection criteria used for each requirement and the corresponding results are described. The resulting product set, although functional, had restricted ability to directly connect with systems used by healthcare providers elsewhere in the system. This outcome illustrates the impact on one small telehealth provider of the broader struggles between competing video conferencing vendors. At stake is the ability to communicate between healthcare organizations and provide public access to healthcare. Comparison of the current state of the video conferencing market place with the evolution of the telephony system reveals that video conferencing still has a long way to go before it can be considered as easy to use as the telephone. Health organizations that are concerned to improve access and quality of care should seek to influence greater standardization and interoperability though cooperation with one another, the private sector, international organizations and by encouraging governments to play a more active role in this sphere.

关键词： Telehealth Home Care Video Conferencing Standards Interoperability

Building an Architectural Component Model for a Telehealth Service

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E-Health Telecommunication Systems and Networks 2015年第3期4卷 35-44页

作者： Alan Taylor Greg Morris Jennifer tieman David Currow Michael Kidd Colin Carati Faculty of Medicine Nursing and Health Sciences Flinders University Adelaide Australia

Models of services, processes and technology are useful tools for conceptualizing complex systems such as healthcare. The application of a component architecture helps illustrate the processes and technologies that are important to the operation of a health service and conceptualize the relationships between each component. Telehealth services are relatively recent and have characteristics that do not fit neatly into established models of health services. This paper analyzes the components used to build a telehealth in the home service in South Australia and the design choices that were taken. The service used commodity-based devices and systems to deliver simple to use, low-cost in the home care. Building on this analysis, the components required in an architectural component model of a telehealth service are identified enabling a provisional architecture for telehealth services to be derived from an existing internationally recognized architectural model for eHealth systems. Situated within the broad family of eHealth architectures, a Telehealth Architectural Model of telehealth processes, software, devices, common systems and ICT infrastructure is proposed that represents the components required to support telehealth and allows for customization of services according to clinical models of care.

关键词： Architectural Models eHealth Telehealth in the Home Healthcare Processes Infrastructure Infostructure Governance

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非扫描叠加速度分析法

石油物探译丛 1994年第2期 1-14页

作者： Hans J.tieman 张伯君

我们可以从地震数据直接估算出叠加速度,而不必求助于目前流行的多速度叠加和其它研究方法。直接从地震数据中估测速度的步骤是:(1)首先用零偏移距上时间和速度的初始估算值对资料做正常时差校正(在一个数据时窗上针对某一特定的共中心... 详细信息

我们可以从地震数据直接估算出叠加速度,而不必求助于目前流行的多速度叠加和其它研究方法。直接从地震数据中估测速度的步骤是:(1)首先用零偏移距上时间和速度的初始估算值对资料做正常时差校正(在一个数据时窗上针对某一特定的共中心点道集);(2)在使用不同的加权函数后,在偏移距上对数据求和,得出二次叠加;(3)将二次叠加数据互相关;(4)把时间延迟转换成速度和时间校正值。迭代处理直到收敛为止。 ARAMVEL算法(美国专利号:4,813,027)被认为是交互式连续速度分析的最理想的方法。这种方法虽然简单易懂,但理论分析和实践研究都表明,它在确定速度方面比常规的速度扫描方法更为精确。其特点是收敛速度快,只需一二次迭代即可实现。由于这种方法最初只需要近似信息,所以很稳妥。实际资料的结果表明,这种方法可以在处理横向速度变化大的地区资料时廉价地提供所需的详细的速度控制,此外还能提供用于复杂的层速度和深度反演的地震波旅行时信息。

关键词：叠加速度分析地震数据地震波

开放源码计划拒绝IIPA反对开源的特殊要求

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图书情报工作动态 2010年第6期 9-12页

作者： Michael tieman 魏剑（编译）庞弘燊（校对）

摩尔定律、磁盘定律和光纤定律创造了经济增长的引擎，有希望在可预见的未来极大地提高计算、存储和网络的性能。然而，2003年UNCTAD（联合国贸易和发展会议，简称贸发会议）的报告指出，“软件行业中并不存在摩尔定律”，实际上，这是... 详细信息

摩尔定律、磁盘定律和光纤定律创造了经济增长的引擎，有希望在可预见的未来极大地提高计算、存储和网络的性能。然而，2003年UNCTAD（联合国贸易和发展会议，简称贸发会议）的报告指出，“软件行业中并不存在摩尔定律”，实际上，这是因为软件导致计算机系统变得更加昂贵，更加复杂，

关键词：开放源码摩尔定律开源 UNCTAD 软件行业计算机系统经济增长联合国