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Gene-modified leucoconcentrate for personalized ex vivo gene therapy in a mini pig model of moderate spinal cord injury

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Neural Regeneration Research 2021年第2期16卷 357-361页

作者： Rustem R.Islamov Farid V.Bashirov Mikhail E.Sokolov Andrei A.Izmailov Filip O.Fadeev Vage A.Markosyan Maria A.Davleeva Olga V.Zubkova Maxim M.Smarov denis yu.logunov Boris S.Naroditskyi Ilnur I.Salafutdinov Albert A.Rizvanov Ramil G.Turaev Kazan State Medical University KazanRussia Gamaleya Research Institute of Epidemiology and Microbiology MoscowRussia Kazan Federal University KazanRussia The Republican Blood Center of the Ministry of Health of the Republic of Tatarstan KazanRussia

We previously demonstrated that gene-modified umbilical cord blood mononuclear cells overexpressing a combination of recombinant neurotrophic factors are a promising therapeutic approach for cell-mediated gene therapy for neurodegenerative diseases,neurotrauma,and *** this study,using a mini pig model of spinal cord injury,we proposed for the first time the use of gene-modified leucoconcentrate prepared from peripheral blood in the plastic blood bag for personalized ex vivo gene *** obtained from mini pig peripheral blood was transduced with a chimeric adenoviral vector(Ad5/35 F)that carried an enhanced green fluorescent protein(EGFP)reporter gene in the plastic blood *** day after blood donation,the mini pigs were subjected to moderate SCI and four hours post-surgery they were intravenously autoinfused with gene-modified leucoconcentrate.A week after gene-modified leucoconcentrate therapy,fluorescent microscopy revealed EGFP-expressing leucocytes in spinal cord at the site of contusion *** the spleen the groups of EGFP-positive cells located in the lymphoid follicles were *** vitro flow cytometry and fluorescent microscopy studies of the gene-modified leucoconcentrate samples also confirmed the production of EGFP by ***,the efficacy of leucocytes transduction in the plastic blood bag and their migratory potential suggest their use for temporary production of recombinant biologically active molecules to correct certain pathological *** paper presents a proof-of-concept of simple,safe and effective approach for personalized ex vivo gene therapy based on gene-modified leucoconcentrate *** animal protocols were approved by the Kazan State Medical University Animal Care and Use Committee(approval No.5)on May 27,2014.

关键词： chimeric Ad5/35F virus enhanced green fluorescent protein gene-modified leucoconcentrate mini pig peripheral blood personalized ex vivo gene therapy plastic blood bag spinal cord injury

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Environmentally Friendly Tannic Acid-Furfuryl Alcohol-Soybean Isolate/Casein Composite Foams Reinforced with Wood Fibers

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Journal of Renewable Materials 2025年第2期13卷 329-347页

作者： Jinxing Li Mustafa Zor Xiaojian Zhou Guanben Du denis Rodrigue Xiaodong(Alice)Wang Department of Wood and Forest Sciences Laval UniversityQuébecG1V 0A6Canada Department of Nanotechnology Zonguldak Bülent Ecevit UniversityZonguldak67900Turkey yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products Southwest Forestry UniversityKunming650224China Department of Chemical Engineering Laval UniversityQuébecG1V 0A6Canada

In this study,two series of foams based on tannic acid(TA),furfuryl alcohol(FA),soybean protein isolate(SPI),and casein(CA),namely TA–FA–SPI(TS series)and TA–FA–CA(TC series)were developed,and their properties were enhanced by adding poplar fibers(WF).From the samples produced,a complete set of characterization was performed including possible crosslinking reactions,morphology,mechanical properties,flame retardancy,thermal insulation and thermal ***-transform infrared spectroscopy(FTIR)revealed possible covalent crosslinking among the components and hydrogen bonding between WF and the *** results indicated that lower prepolymer viscosity led to lower apparent density,while WF addition reduced even more the *** tests showed that the maximum compressive strengths were good,while WF improved the compressive strength by up to 56%.Scanning electron microscopy(SEM)showed uniform cell structures,but small open pores were ***-dimensional(2D)CT scan images confirmed the good compatibility between WF and the matrix,with low anisotropy in the *** tests indicated that WF decreased the pulverization ratio of the materials by up to 42%.Thermogravimetric analysis(TGA)showed good thermal stability of the materials up to 328°*** burning tests showed that the materials were self-extinguishing without residue(dripping).The lowest thermal conductivity was 0.04 W/m·*** results suggest that these novel formaldehyde-free,high biomass content(95%–96%)foams and composite foams have high potential to replace traditional phenolic foams(PF)in applications such as construction,transportation,packaging,and thermal insulation.

关键词： Foam composite tannic acid soybean isolate protein casein poplar fiber compressive strength flame retardancy thermal insulation

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Enhanced efficiency and stability of 3.3 V Cu-Li batteries by tuning the cation-anion interaction in the electrolyte

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Journal of Energy Chemistry 2023年第11期86卷 208-216,I0005页

作者： Kaiming Xue yu Zhao Huimin Wang denis Y.W.yu School of Energy and Environment City University of Hong KongKowloonHong Kong 999077China Research Center for Energy and Environmental Materials(GREEN) National Institute for Materials ScienceTsukubaIbaraki 305-0044Japan

Cu-Li battery with Cu metal cathode and Li metal anode is a candidate for next-generation energy storage *** self-discharge of the battery can be suppressed with an anion exchange membrane,the voltage polarization depends strongly on the ***,when an electrolyte with 3 M LiTFSI(lithium bis(trifluoromethanesulfonyl)imide)in dimethyl carbonate(DMC)is used,overpotential increases with *** this work,we reveal why the voltage polarization changes,and reduce and stabilize it by replacing DMC solvent with a mixed solvent composed of dimethoxyethane(DME)and propylene carbonate(PC).The new electrolyte has higher ionic conductivity and stable solvation structure with more free TFSI-anions upon cycling,which also facilitates uniform plating of metal ions on the metal *** characteristics enable a stable Cu-Li battery with minimal change in overpotential for more than 1500 cycles at a current density of 2 m A cm^(-2).

关键词： Cu-Li battery Metal cathode Electrolyte engineering Solvation structure

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Poly(Ionic Liquid) as an Anion Exchange Membrane for a 3.3 V Copper–Lithium Battery

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Energy & Environmental Materials 2023年第4期6卷 89-97页

作者： Kaiming Xue yu Zhao Pui-Kit Lee denis Y.W.yu School of Energy and Environment City University of Hong Kong83 Tat Chee AveKowloonHong KongChina

Metal–metal battery bears great potential for next-generation large-scale energy storage system because of its simple manufacture process and low production ***,the cross-over of metal cations from the cathode to the anode causes a loss in capacity and influences battery ***,a coating of poly(ionic liquid)(PIL)with poly(diallyldimethylammonium bis(trifluoromethanesulfonyl)imide)(PDADMA^(+)TFSI^(−))on a commercial polypropylene(PP)separator serves as an anion exchange membrane for a 3.3 V copper–lithium *** PIL has a positively charged polymer backbone that can block the migration of copper ions,thus improving Coulombic efficiency,long-term cycling stability and inhibiting self-discharge of the *** can also facilitate the conduction of anions through the membrane and reduce polarization,especially for fast charging/***-Vincent method gives the transport number in the electrolyte to be 0.25 and 0.04 for PP separator without and with PIL coating,*** suggests that the PIL layer reduces the contribution of the internal current due to cation *** use of PIL as a coating layer for commercial PP separator is a cost-effective way to improve overall electrochemical performance of copper–lithium *** to PP and polyacrylic acid(PAA)/PP separators,the PIL/PP membrane raises the Coulombic efficiency to 99%and decreases the average discharge voltage drop to about 0.09 V when the current density is increased from 0.1 to 1 mA cm^(−2).

关键词： anion exchange membrane copper cathode cycle stability ion transport metal-metal battery poly(ionic liquid)

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Study of Ionospheric Anomalies at the Koudougou Station during the Moderate Geomagnetic Activity of Co-Rotation during the Solar Cycle 24

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International Journal of Geosciences 2025年第1期16卷 20-30页

作者： Idrissa Sourabié Abidina Diabaté Emmanuel Wambi Sawadogo Bruno Korgo Christian Zoundi Allain Doua Gnabahou denis Ouédraogo Frédéric Ouattara Laboratoire de Chimie Analytique de Physique Spatiale et nergtique (L@CAPSE) Dpartement de Physique Universit Norbert ZONGO Koudougou Burkina Faso Laboratoire dEnergies Thermiques REnouvelables (L.E.T.RE) Dpartement de Physique Universit Joseph KI-ZERBO Ouagadougou Burkina Faso

This article is part of the ongoing study of the moderate geomagnetic activity of corotation. The aim here is to examine ionospheric anomalies through variations in Total Electronic Content (TEC) recorded at the Koudougou GPS station over solar cycle 24 during periods of corotation activity. Through the diurnal variations by solar phase, we observed a TEC peak at 14:00 TL. The TEC data analysed revealed winter, annual and semi-annual anomalies. However, the equinoctial anomaly was insignificant during corotation activity at the Koudougou station during solar cycle 24.

关键词： Geomagnetic Activity Total Electronic Content Ionospheric Anomalies Equinoctial Corotation Activity

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Microstructure Variation and Hardness Diminution During Low Cycle Fatigue of 55NiCrMoV7 Steel

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Journal of Iron and Steel Research International 2007年第6期14卷 68-73页

作者： ZHANG zhan ping QI yu-hong DELAGNES denis BERNHART Gerard Electro Mechanics and Materials College Dalian Maritime University Dalian 116026 Liaoning China Research Center on Tools Materials and Processes Ecole des Minesd＇Albi Carmaux 81013 Albi CT cedex 09 France

The influence of temperature and hardness level on the cyclic behavior of 55NiCrMoV7 steel, and the mierostrueture variation and hardness diminution during low cycle fatigue behavior were investigated. By means of SEM and XRD, the modality of carbides and the full width half-maximum （FWHM） of martensite （211） [M（211）] of Xray diffraction spectrum in fatigue specimen were studied. The results showed that the cyclic stress response behav ior generally showed an initial exponential softening for the first few cycles, followed by a gradual softening without cyclic softening saturation. The fatigue behavior of the steel is closely related to the hardness level. The hardness diminution and the variation of half-width M（211） are remarkably influenced by the interaction between the cyclic plastic deformation and the thermal loading when the fatigue temperature exceeds the tempering temperature of the steel.

关键词： low cycle fatigue 55NiCrMoV7 steel microstructure hardness half width

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P2-Na_(2/3)Ni_(2/3)Te_(1/3)O_(2)Cathode for Na-ion Batteries with High Voltage and Excellent Stability

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Energy & Environmental Materials 2023年第2期6卷 54-61页

作者： Wenhui Wang Jiaolong Zhang Chaolin Li Xiaohang Kou Baohua Li denis Y.W.yu School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhen 518055China School of Energy and Environment City University of Hong KongHong Kong China School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China Shenzhen Key Laboratory on Power Battery Safety Research and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Air-stable layered structured cathodes with high voltage and good cycling stability are highly desired for the practical application of Na-ion ***,we report a P2-Na_(2/3)Ni_(2/3)Te_(1/3)O_(2) cathode that is stable in ambient air with an average operating voltage of~3.8 V,demonstrating excellent cycling stability with a capacity retention of more than 92.7%after 500 cycles at 20 mA g^(-1) and good rate capability with 91.9%capacity utilization at 500 mA g^(-1) with respect to capacity at 5 mA g^(-1) between 2.0 and 4.0 *** the upper cutoff voltage is increased to 4.4 V,P2-Na_(2/3)Ni_(2/3)Te_(1/3)O_(2) delivers a reversible capacity of 71.9 mAh g^(-1) and retains 91.8%of the capacity after 100 cycles at 20 mA g^(-1).The charge compensation during charge/discharge is mainly due to the redox couple of Ni^(2+)/Ni^(3+)in the host with a small amount of contribution from *** stable structure of the material without phase transformation and with small volume change during charge-discharge allows it to give excellent cycle performance especially when the upper cutoff voltage is not higher than 4.2 V.

关键词： air stability cathode Na_(2)Ni_(2)TeO_(6) Na-ion battery oxygen redox reaction P2 structure

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Facile synthesis of hollow Cu_(3)P for sodium-ion batteries anode

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Rare Metals 2021年第12期40卷 3460-3465页

作者： Jiao-Long Zhang Chao-Lin Li Wen-Hui Wang denis Y.W.yu School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China Shenzhen Key Laboratory on Power Battery Safety Research and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhen 518055China School of Energy and Environment City University of Hong KongHong Kong 999077China

Combining metal to form metal phosphide is a promising strategy to address the fast capacity decay of P rooted from its low electronic conductivity and large volume changes upon cycling. Cu_(3)P, which possesses a high theoretical gravimetric and volumetric capacity of 363 m Ahág^(-1) and 1028 AháL^(-1) and reasonable volume expansion of 156% during sodiation, was investigated as anode material in SIBs. Hollow-structured Cu_(3)P electrode delivers an initial de-sodiation capacity of * 159.0 m Ahág^(-1) with high capacity retention of ~85.1% over 50 cycles at 0.2 C rate and exhibits good rate performance,retaining 70% of the capacity when the current density increases from 0.2 C to 1.6 C. A 3 V-class full cell consisting of P2-Na_(2/3) Ni_(1/3) Mn_(1/2) Ti_(1/6)O_(2) cathode and Cu_(3)P anode was also assembled, which could achieve an energy density of ~189.3 Whákg^(-1)(based on the mass of both electrode materials) and average discharge voltage of~2.91 V when cycled in 1.0-4.3 V at 0.1C.

关键词： Na-ion battery Anode Phosphorus Cu_(3)P Hollow

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Anisotropic nanowire growth via a self-confined amorphous template process： A reconsideration on the role of amorphous calcium carbonate

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Nano Research 2016年第5期9卷 1334-1345页

作者： Li-Bo Mao Lei Xue denis Gebauer Lei Liu Xiao-Fang yu Yang-Yi Liu Helmut Colfen Shu-Hong yu Division of Nanomaterials and Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Collaborative Innovation Center of Suzhou Nano Science and Technology CAS Center for Excellence in Nanoscience Department of Chemistry University of Science and Technology of China Hefei 230026 China Department of Chemistry University of Konstanz Universitatsstrasse 10 Box 714 D-78457 Konstanz Germany

Calcium carbonate crystals with various morphologies have been found in a variety of biospecimens and artificially synthesized structures. Usually, the diversity in morphology can be attributed to different types of interactions between the specific crystal faces and the environment or the templates used for the growth of CaCO3 crystals. On the other hand, isotropic amorphous calcium carbonate （ACC） has been recognized as the precursor of other crystalline calcium carbonate forms for both in vivo and in vitro systems. However, here we propose a self-confined amorphous template process leading to the anisotropic growth of single-crystalline calcite nanowires. Initiated by the assembly of precipitated nanoparticles, the calcite nanowires grew via the continuous precipitation of partly crystallized ACC nanodroplets onto their tips. Then, the crystalline domains in the tip, which were generated from the partly crystallized nanodroplets, coalesced in the interior of the nanowire to form a single-crystalline core. The ACC domains were left outside and spontaneously formed a protective shell to retard the precipitation of CaCO3 onto the side surface of the nanowire and thus guided the highly anisotropic growth of nanowires as a template.

关键词： amorphous calcium carbonate calcite nanowire anisotropic growth self-confined amorphous template

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Hydrogen production from methane and carbon dioxide mixture using all-solid-state electrochemical cell based on a proton-conducting membrane and redox-robust composite electrodes

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Journal of Energy Chemistry 2022年第6期31卷 576-584,I0016页

作者： denis Osinkin Evgeniy Tropin Laboratory of Solid Oxide Fuel Cells Institute of High-Temperature ElectrochemistryYekaterinburg 620137Russian Federation School of Economics and Management Department of Environmental EconomicsUral Federal UniversityYekaterinburg 620002Russian Federation Laboratory of Solid State Chemistry Institute of Solid State Chemistry and MechanochemistryNovosibirsk 630128Russian Federation

In recent years, interest in hydrogen as a fuel has sharply increased in the field of alternative and green energy due to its high energy capability and zero-emission behaviour. As a result, research in the development of new highly efficient methods for producing high-purity hydrogen is relevant. This paper presents, for the first time, the test results of an electrochemical cell with a proton-conducting La_(0.9)Sr_(0.1)ScO_(3-δ) electrolyte and symmetrical Sr_(1.95)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)+ La_(0.9)Sr_(0.1)Sc_(0.9)Co_(0.1)O_(3-δ) electrodes as a hybrid setup for electricity generation in proton ceramic fuel cell mode, for hydrogen separation from H_(2)+ Ar mixture and the production of high-purity hydrogen from methane with simultaneous CO_(2) *** was found that this electrochemical cell generates high flow rates of hydrogen during its separation through a proton-conducting membrane from H_(2)+ Ar mixture, about 500 cm^(3)h^(-1)cm^(-2)at a current density of 0.6 A cm^(-2)as well as about 370 cm^(3) h^(-1)cm^(-2)at a current density of 0.5 A cm^(-2) from CH_(4)+ CO_(2) mixture at 800 ℃ which shows that these cells are promising for hydrogen production.

关键词： Protonic ceramic fuel cell Hydrogen production Symmetrical electrodes Sr_(2)Fe_(1.5)Mo_(0.5)O_(6–δ) CO_(2)utilization

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