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Biomarkers for response to immune checkpoint inhibitors in gastrointestinal cancers

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 19-37页

作者： Meng Li denis Kaili Lei Shi School of Life Sciences Chongqing UniversityChongqing 400044China Department of Surgery Wexner Medical CenterThe Ohio State UniversityColumbusOH 43210United States

Gastrointestinal(GI)cancers account for a large proportion of cancer deaths worldwide and pose a major public health *** is considered to be one of the prominent and successful approaches in cancer treatment in recent *** them,immune checkpoint inhibitor(ICI)therapy,has received widespread attention,and many clinical findings support the feasibility of ICIs,with sustained responses and significantly prolonged lifespan observed in a wide range of ***,patients treated with ICIs have not fully benefited,and therefore,the identification and development of biomarkers for predicting ICI treatment response have received further attention and *** tumor genome to molecular interactions in the tumor microenvironment,and further expanding to circulating biomarkers and patient characteristics,the exploration of biomarkers is evolving with high-throughput sequencing as well as *** large-scale prospective and specific studies are needed to explore biomarkers in GI *** this review,we summarize the known biomarkers used in ICI therapy for GI *** addition,some ICI biomarkers applied to other tumors are included to provide insights and further validation for GI ***,we present single-cell analysis and machine learning approaches that have emerged in recent *** there are no clear applications yet,it can be expected that these techniques will play an important role in the application of biomarker prediction.

关键词： Immunotherapy Immune checkpoint inhibitor Biomarker Predictive response Gastrointestinal cancer

retinal detachment repair through multifocal intraocular lens-overcoming visualization challenge of the peripheral retina

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 1008-1010页

作者： Amir Hadayer denis Jusufbegovic Shlomit Schaal Department of Ophthalmology and Visual Sciences University of Louisville Louisville Kentucky 40202 US

Sir Nicholas Harold Lloyd ridley has revolutionized the practice of ophthalmology by performing the firstintraocular lens （IOL） implantation in 1949. His scientific achievement was acknowledged thirty years later, which led to US Food and Drug Administration approval in 1981. Although the basic principles of IOL implantation have not changed since, many efforts have been invested in perfecting IOL design during the past decades.

关键词： IOL retinal detachment repair through multifocal intraocular lens-overcoming visualization challenge of the peripheral retina PPV

Improved Methods for In-situ Measurement railway Noise Barrier Insertion Loss

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 58-68页

作者： Li Qiutong Duhamel denis Luo Yanyun Yin Honoré Université Paris-Est Laboratoire NavierENPC-IFSTTAR-CNRS Institute of railway Transit Tongji University

Many countries which seek to understand the acoustic performance of railway noise barriers have established standards for the conduct of in-situ ***,there are no universally acknowledged receiver positions for the evaluation of the barrier performance,a fact which may be leading to uncertainty over the noise reduction capabilities of available *** terms of the descriptor of the barrier performance,the general recommendation is the A-weighted sound pressure level,although the latter is considered to underestimate low frequencies for railway noise ***,in this study,the comparison of receiver positions and the descriptors among existing Chinese,ISO and European standards were *** upon a combination of diffraction theory and standards,a rearrangement of receiver positions and one-third-octave-band analysis were *** addition,in line with improved methods,an in-situ measurement of insertion loss for a 1.5 mhigh railway noise barrier was designed and *** results of the experiment validate as effective and applicable the new receiver *** results also suggest that one-third-octave-band analysis is indispensable.

关键词： railway noise noise barrier in-situ experiment A-weighting insertion loss one-third-octave-band analysis grid receiver positions

Advances in quantum dots for classical and non-classical light sources Invited Paper

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Chinese Optics Letters 2008年第10期6卷 718-723页

作者： Yasuhiko Arakawa Satoshi Iwamoto Satoshi Kako Masahiro Nomura denis Guimard research Center for Advanced Science and Technology Institute for Nano Quantum Information ElectronicsThe University of Tokyo4-6-1 Meguro-ku153-8505 TokyoJapan

recent advances in quantum dots （QDs） for classical and non-classical light sources are presented. We have established metal organic chemical vapor deposition （MOCVD） technology for InAs-based QD lasers at 1.3 μm and achieved ultralow threshold in QD lasers with photonic crystal （PhC） nanocavity. In addition, single photon emitters at 1.55 μm, GaN-based single photon sources operating at 200 K, and high-Q PhC nanocavity have been demonstrated.

关键词： QDs Advances in quantum dots for classical and non-classical light sources Invited Paper AIN InAs

Pseudo-static stability analysis of rock slopes reinforced by passive bolts using the generalized Hoek-Brown criterion

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Journal of rock Mechanics and Geotechnical Engineering 2017年第4期9卷 659-670页

作者： Mounir Belghali Zied Saada denis Garnier Samir Maghous Laboratoire de Génie Civil ENIT Université de Tunis El Manar Tunis Tunisia Université Paris-Est Laboratoire Navier (UMR8205) ENPC-IFSTTAR-CNRS Marne-la-Vallée France Department of Civil Engineering Federal University of Rio Grande do Sul Av. Osvaldo Aranha 99 Porto Alegre RS 90350-190 Brazil

The stability analysis of passive bolt-reinforced rock slopes under seismic loads is investigated within the framework of the kinematic approach of limit analysis theory.A pseudo-static method is adopted to account for the inertial forces induced in the rock mass by seismic *** strength properties of the rock material are described by a modified Hoek-Brown strength criterion,whereas the passive bolts are modeled as bar-like inclusions that exhibit only resistance to tensile-compressive *** advantage of the ability to compute closed-form expressions for the support functions associated with the modified Hoek-Brown strength criterion,a rotational failure mechanism is implemented to derive rigorous lower bound estimates for the amount of reinforcement strength to prevent slope *** approach is then applied to investigating the effects of relevant geometry,strength and loading parameters in light of a preliminary parametric *** accuracy of the approach is assessed by comparison of the lower bound estimates with finite element limit analysis solutions,thus emphasizing the ability of the approach to properly predict the stability conditions and to capture the essential features of deformation localization ***,the extension of the approach to account for slipping at the interface between reinforcements and surrounding rock mass is outlined.

关键词： reinforced rock slope Modified Hoek-Brown criterion Seismic loading Limit analysis rotational failure mechanism

Measurement of electrical charges carried by airborne bacteria laboratory-generated using a single-pass bubbling aerosolizer

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Particuology 2015年第1期13卷 179-185页

作者： Xavier Simon Sébastien Bau denis Bémer Philippe Duquenne Institut National de recherche et de Securite(INrS)

Widely used bioaerosol generators like Collison nebulizer probably produce electrostatically charged par- ticles, but the electrical charges carried by laboratory-generated airborne microorganisms using bubbling aerosolizers are poorly understood. In this study, we measured the fraction of neutral particles and num- ber of elementary charges per particle as a function of the aerodynamic diameter of airborne bacteria （Escherichia coli and Enterococcus hirae）. Bioaerosols were produced by a liquid sparging aerosolizer-type bubbling generator, with particle sizes ranging from roughly 0.6 to 2 p^m. The experimental setup included an electrostatic precipitator and real-time devices including an electrometer, aerodynamic particle sizer, and electrical low-pressure impactor. Experimental results obtained for various operating conditions showed that aerosols produced with a higher bubbling airflow contained a larger proportion of neutral particles （from around 30% to 50%） and that bacteria carried a greater average absolute number of elementary charges （from around -10 to -60 elementary units） than those under lower airflow. Under the investigated conditions, a neutralization step is unnecessary because it may have a negative effect on the viability of sensitive microorganisms. Our results suggest that the neutral fraction can be used down- stream of an electrostatic precipitator, and that this setup may have advantages over bipolar neutralizers.

关键词： Bubbling generator Bioaerosol Electrical charge Electrostatic precipitator Escherichia coil Enterococcus hirae

responses of jointed rock masses subjected to impact loading

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Journal of rock Mechanics and Geotechnical Engineering 2018年第4期10卷 624-634页

作者： Shabnam Aziznejad Kamran Esmaieli John Hadjigeorgiou denis Labrie Lassonde Institute of Mining University of Toronto CanmetMINING Natural Resources Canada

Impact-induced damage to jointed rock masses has important consequences in various mining and civil engineering applications. This paper reports a numerical investigation to address the responses of jointed rock masses subjected to impact loading. It also focuses on the static and dynamic properties of an intact rock derived from a series of laboratory tests on meta-sandstone samples from a quarry in Nova Scotia, Canada. A distinct element code(PFC2D) was used to generate a bonded particle model(BPM) to simulate both the static and dynamic properties of the intact rock. The calibrated BPM was then used to construct large-scale jointed rock mass samples by incorporating discrete joint networks of multiple joint intensities into the intact rock matrix represented by the BPM. Finally, the impact-induced damage inflicted by a rigid projectile particle on the jointed rock mass samples was determined through the use of the numerical model. The simulation results show that joints play an important role in the impactinduced rock mass damage where higher joint intensity results in more damage to the rock mass. This is mainly attributed to variations of stress wave propagation in jointed rock masses as compared to intact rock devoid of joints.

关键词： Jointed rock mass Impact loading Microcracks rock damage

Plasma-enabled healing of graphene nano-platelets layer

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 350-359页

作者： Xiuqi Fang Carles Corbella denis B.Zolotukhin Michael Keidar Department of Mechanical & Aerospace Engineering George Washington UniversityWashingtonDC 20052USA Department of Physics Tomsk State University of Control Systems and RadioelectronicsTomsk 634050Russia

Graphene platelet networks (GPNs) were deposited onto silicon substrates by means of anodic arc discharge ignited between two graphite *** temperature and pressure of helium atmosphere were optimized for the production of the carbon *** samples were modified or destroyed with different methods to mimic typical environments responsible of severe surface *** emulated conditions were performed by four surface treatments,namely thermal oxidation,substrate overheating,exposition to glow discharge,and metal coating due to arc *** the next step,the samples were regenerated on the same substrates with identical deposition *** and re-growth of GPN samples were systematically characterized by scanning electron microscopy and raman *** full regeneration of the structural and morphological properties of the samples has proven that this healing method by arc plasma is adequate for restoring the functionality of2D nanostructures exposed to harsh environments.

关键词： graphene platelet networks anodic arc discharge plasma healing scanning electron microscopy raman spectroscopy

Hybrid BWO-IACO Algorithm for Cluster Based routing in Wireless Sensor Networks

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Computers, Materials & Continua 2021年第10期69卷 433-449页

作者： r.Punithavathi Chinnarao Kurangi S.P.Balamurugan Irina V.Pustokhina denis A.Pustokhin K.Shankar Department of Information Technology M.Kumarasamy College of EngineeringKarur639113India Department of Computer Science Pondicherry UniversityPuducherry605014India Department of Computer and Information Science Faculty of ScienceAnnamalai UniversityChidambaram608002India Department of Entrepreneurship and Logistics Plekhanov Russian University of EconomicsMoscow117997Russia Department of Logistics State University of ManagementMoscow109542Russia Department of Computer Applications Alagappa UniversityKaraikudi630001India

Wireless Sensor Network(WSN)comprises a massive number of arbitrarily placed sensor nodes that are linked wirelessly to monitor the physical parameters from the target *** the nodes in WSN operate on inbuilt batteries,the energy depletion occurs after certain rounds of operation and thereby results in reduced network *** enhance energy efficiency and network longevity,clustering and routing techniques are commonly employed in *** paper presents a novel black widow optimization(BWO)with improved ant colony optimization(IACO)algorithm(BWO-IACO)for cluster based routing in *** proposed BWO-IACO algorithm involves BWO based clustering process to elect an optimal set of cluster heads(CHs).The BWO algorithm derives a fitness function(FF)using five input parameters like residual energy(rE),inter-cluster distance,intra-cluster distance,node degree(ND),and node *** addition,IACO based routing process is involved for route selection in inter-cluster *** IACO algorithm incorporates the concepts of traditional ACO algorithm with krill herd algorithm(KHA).The IACO algorithm utilizes the energy factor to elect an optimal set of routes to BS in the *** integration of BWO based clustering and IACO based routing techniques considerably helps to improve energy efficiency and network *** presented BWO-IACO algorithm has been simulated using MATLAB and the results are examined under varying aspects.A wide range of comparative analysis makes sure the betterment of the BWO-IACO algorithm over all the other compared techniques.

关键词： Clustering routing wireless sensor network energy efficiency black widow optimization