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Screening of novel synthetic derivatives of dehydroepiandrosterone for antivirals against flaviviruses infections

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Virologica Sinica 2022年第1期37卷 94-106页

作者： Muhammad Imran Luping Zhang Bohan Zheng Zikai Zhao dengyuan Zhou Shengfeng Wan Zheng Chen Hongyu Duan Qiuyan Li Xueqin Liu Shengbo Cao Shaoyong Ke Jing Ye State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan430070China Key Laboratory of Preventive Veterinary Medicine in Hubei Province College of Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China The Cooperative Innovation Center for Sustainable Pig Production Huazhong Agricultural UniversityWuhan430070China Department of Pathology Faculty of Veterinary ScienceUniversity of AgricultureFaisalabad38040Pakistan Department of Nephrology Henan Provincial Key Laboratory of Kidney Diseases and ImmunologyHenan Provincial People's HospitalZhengzhou450003China Key Laboratory for Animal Health of Jiangxi Province Nanchang330045China Department of Preventive Veterinary Medicine College of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang330045China College of Fisheries Huazhong Agricultural UniversityWuhan430070China National Biopesticide Engineering Research Center Hubei Biopesticide Engineering Research CenterHubei Academy of Agricultural SciencesWuhan430070China

Flaviviruses are important arthropod-borne pathogens that represent an immense global health *** unprecedented epidemic rate and unpredictable clinical features underscore an urgent need for antiviral ***(DHEA)is a natural occurring adrenal-derived steroid in the human body that has been associated in protection against various *** the present study,the plaque assay based primary screening was conducted on 32 synthetic derivatives of DHEA against Japanese encephalitis virus(JEV)to identify potent anti-flaviviral *** on primary screening,HAAS-AV3026 and HAAS-AV3027 were selected as hits from DHEA derivatives that exhibited strong antiviral activity against JEV(IC_(50)=2.13 and 1.98μmol/L,respectively)and Zika virus(ZIKV)(IC_(50)=3.73 and 3.42μmol/L,respectively).Mechanism study indicates that HAAS-AV3026 and HAAS-AV3027 do not exhibit inhibitory effect on flavivirus binding and entry process,while significantly inhibit flavivirus infection at the replication ***,indirect immunofluorescence assay,Western blot analyses,and quantitative reverse transcription-PCR(qRT-PCR)revealed a potent antiviral activity of DHEA derivatives hits against JEV and ZIKV in terms of inhibition of viral infection,protein production,and viral RNA synthesis in Vero *** together,our results may provide a basis for the development of new antivirals against flaviviruses.

关键词： Flaviviruses Japanese encephalitis virus(JEV) Zika virus(ZIKV) Dehydroepiandrosterone(DHEA) Antivirals

双面发电高效率N型Si太阳电池及组件的研制

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太阳能学报 2013年第12期34卷 2146-2150页

作者：宋登元熊景峰光伏材料与技术国家重点实验室英利集团有限公司保定071051

研发双面发电前表面硼发射极高效率N型Si太阳电池及组件。使用大面积(156mm×156mm)碱制绒准方形N型单晶硅片,通过硼磷共扩散在电池前表面形成硼P+发射极以及在背面形成磷N+背面场。PECVD沉积技术在前后表面制备SiNx薄膜起钝化和减反射... 详细信息

研发双面发电前表面硼发射极高效率N型Si太阳电池及组件。使用大面积(156mm×156mm)碱制绒准方形N型单晶硅片,通过硼磷共扩散在电池前表面形成硼P+发射极以及在背面形成磷N+背面场。PECVD沉积技术在前后表面制备SiNx薄膜起钝化和减反射作用。双面丝网印刷金属栅线完成电极的制备,形成双面发电电池结构。这种N型Si太阳电池具有效率高、成本低和双面发电的特点,最高效率达到20.08%。利用该高效率N型Si太阳电池制成的光伏组件具有温度系数小、弱光特性好和输出功率初始衰减小的优点。

关键词：光伏 N型Si 太阳电池组件

Research on Comprehensive Reinforcement Treatment Technology of Tunnel Entrance Slope in Thick Landslide Stratum

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Open Journal of Applied Sciences 2022年第2期12卷 224-234页

作者： Hui Chen Shangyu Han Penheng Zhang dengyuan Kang School of Civil Engineering and Architecture Nanchang Hangkong University Nanchang China

The existence of loose landslides not only poses a huge safety hazard to the construction of tunnel entrances, but also significantly increases the difficulty of site construction. In this paper, we investigate the comprehensive slope reinforcement management technology for tunnel entrances in thick landslide strata, using the finite element analysis software ABAQUS to study the slope safety coefficients, displacements and plastic zone changes under different management conditions, propose a design structure for slope stability enhancement in thick landslide strata, and analyse the effect of the application of slope stability enhancement measures for thick landslide strata. The results show that the enhanced design structure is used to enhance slope stability. The results show that after the landslide treatment with the enhanced design structure, the slope safety factor was increased from 0.961 to 1.512, the maximum horizontal tangential displacement was reduced from 330.2 mm to 32.74 mm, and the area of plastic zone was significantly reduced, and the landslide support effect was remarkable.

关键词： Thick Landslide Stratum Slope Management Landslide Mechanism Improvement Measures

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GaN蓝色激光二极管的研究进展

激光杂志 1999年第6期20卷 1-3,6页

作者：宋登元河北大学电子与信息工程系保定071002

ＧａＮ短波长激光器是最近取得突破性进展而备受关注的光电子学研究新领域。本文简要论述了２０多年来在发展ＧａＮ发光器件过程中所克服的困难，介绍了目前这类激光器在解理法制备谐振腔端面、干法腐蚀和欧姆接触等关键工艺的进展情... 详细信息

ＧａＮ短波长激光器是最近取得突破性进展而备受关注的光电子学研究新领域。本文简要论述了２０多年来在发展ＧａＮ发光器件过程中所克服的困难，介绍了目前这类激光器在解理法制备谐振腔端面、干法腐蚀和欧姆接触等关键工艺的进展情况。最后，综述了在获得室温下脉冲及连续工作的ＧａＮ蓝色激光二极管的研究方面所取得的最新进展。

关键词： GaN 激光二极管解理干法腐蚀二极管

CICQ交换机中一类服务可保障的调度策略研究

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计算机研究与发展 2007年第11期44卷 1873-1880页

作者：李季曾华赟许登元西南交通大学信息科学与技术学院成都610031 重庆交通大学计算机与信息学院重庆400074

具备QoS保障能力的快速调度算法是高速交换机的首选.基于EPFTS(Ethernet-oriented physical frame timeslot switching)和CICQ(combined input-crosspoint-queued)交换技术的特点,提出了一类新的调度策略———TRWFS(ti meslot reservation weighted fair scheduling).为确保各端口对上保障业务的预留带宽,TRWFS以各端口对上保障业务预留时槽数为调度权重,以优先调度保障业务和平衡各保障业务的盈余时槽(surplus timeslot,定义为现实系统和理想系统之间的服务差额)为业务调度准则.基于该调度策略进一步提出了两种实现算法———TRWFS-I和TRWFS-II,总体上使实现TRWFS的时间复杂度降至O(1).性能分析和仿真实验结果均表明两种调度算法都达到了服务保障的设计目标,仿真实验结果还表明CICQ排队方式下与其他调度算法相比,TRWFS和轮询调度综合的调度机制具有交叉缓存容量要求更低的优点.

关键词：调度算法服务质量输入与交叉点综合的排队机制(CICQ) 面向以太网的物理帧时槽交换 (EPFTS) 盈余时槽