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Pathologically relevant aldoses and environmental aldehydes cause cilium disassembly via formyl group-mediated mechanisms

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Journal of Molecular Cell Biology 2024年第1期16卷 15-28页

作者： Te Li Min Liu Fan Yu Song Yang Weiwen Bu Kai Liu Jia Yang Hua Ni Mulin Yang Hanxiao yin Renjie Hong dengwen Li Huĳie Zhao Jun Zhou Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Protein ScienceCollege of Life SciencesNankai UniversityTianjin 300071China Laboratory of Tissue Homeostasis Haihe Laboratory of Cell EcosystemTianjin 300462China Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of ShandongShandong Provincial Key Laboratory of Animal Resistance BiologyCollege of Life SciencesShandong Normal UniversityJinan 250014China

Carbohydrate metabolism disorders(CMDs),such as diabetes,galactosemia,and mannosidosis,cause ciliopathy-like multiorgan ***,the mechanistic link of cilia to CMD complications is still poorly ***,we describe significant cilium disassembly upon treatment of cells with pathologically relevant aldoses rather than the corresponding sugar ***,environmental aldehydes are able to trigger cilium disassembly by the steric hindrance effect of their formyl *** studies reveal that aldehydes stimulate extracellular calcium influx across the plasma membrane,which subsequently activates the calmodulin-Aurora A-histone deacetylase 6 pathway to deacetylate axonemal microtubules and triggers cilium *** vivo experiments further show that Hdac6 knockout mice are resistant to aldehyde-induced disassembly of tracheal cilia and sperm *** findings reveal a previously unrecognized role for formyl group-mediated cilium disassembly in the complications of CMDs.

关键词： carbohydrate metabolism disorder aldose aldehyde cilium disassembly formyl group calcium influx HDAC6

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Relationship between Expression of CEA,E-cadherin and Liver Metastasis in Colorectal Cancer

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Chinese Journal of Clinical Oncology 2008年第6期5卷 429-432页

作者： Ning Li Xiaobing Chen Xiangbin Wan Suxia Luo Lili Han Mengqiang Zhou dengwen yin Li Zhang Department of Oncologic Medicine Henan Tumor Hospital Zhengzhou 450003 Henan Province China Zhengzhou University Cancer Center Zhengzhou 450000 Henan Province China Department of Surgery Henan Tumor Hospital Zhengzhou 450003 Henan ProvinCe China Department of Oncologic Medicine Sun YatSen University Cancer Center Guangzhou 510000 Guangdong Province China

OBJECTIVE To investigate the expression of E-cadherin andCEA in serum in colorectal carcinoma and their relationship withliver *** CEA level was measured post-operativelyby radioimmunoassay of 60 patients with colorectal *** analysis was used to evaluate theexpression of *** In liver metastasis group,24 patients (24/26,92.3%)were high level of CEA,but only 9 patients in non-liver *** difference is significant (P=0.004).Expression ofE-cadherin significantly correlated with differentiation,but wasnot associated with Tstage or N *** metastatic rate innegative expression was higher than that in positive *** the survival analysis showed that time of liver metastasis wassignificant different in two groups (P<0.05).CONCLUSION The expression of CEA in serum can be usedto predict liver mestatasis of colorectal cancer after operation.E-cadherin,associated with tumor differentiation,is also a hopefulindicator for the prediction of liver metastasis in patients withcolorectal cancer.

关键词： colorectal cancer liver metastasis E-cadherin CEA.

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