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Synergistic Effects of Glutamine Deprivation and Metformin in Acute Myeloid Leukemia

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Current Medical Science 2024年第4期44卷 799-808页

作者： Tong-yuan liU Xing FU Ying YANG Jia GU Min XIAO deng-ju li Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective The metabolic reprogramming of acute myeloid leukemia(AML)cells is a compensatory adaptation to meet energy requirements for rapid *** study aimed to examine the synergistic effects of glutamine deprivation and metformin exposure on AML *** SKM-1 cells(an AML cell line)were subjected to glutamine deprivation and/or treatment with metformin or bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide(BPTES,a glutaminase inhibitor)or *** viability was detected by Cell Counting Kit-8(CCK-8)assay,and cell apoptosis and reactive oxygen species(ROS)by flow *** blotting was conducted to examine the levels of apoptotic proteins,including cleaved caspase-3 and poly(ADP-ribose)polymerase(PARP).Moreover,the human long noncoding RNA(lncRNA)microarray was used to analyze gene expression after glutamine deprivation,and results were confirmed with quantitative RT-PCR(qRT-PCR).The expression of metallothionein 2A(MT2A)was suppressed using *** growth and apoptosis were further detected by CCK-8 assay and flow cytometry,respectively,in cells with MT2A *** Glutamine deprivation or treatment with BPTES inhibited cell growth and induced apoptosis in SKM-1 *** lncRNA microarray result showed that the expression of MT family genes was significantly upregulated after glutamine ***2A knockdown increased apoptosis,while proliferation was not affected in SKM-1 *** addition,metformin inhibited cell growth and induced apoptosis in SKM-1 *** glutamine deprivation and metformin enhanced the sensitivity of SKM-1 cells to ***,the combination of glutamine deprivation with metformin exhibited synergistic antileukemia effects on SKM-1 *** Targeting glutamine metabolism in combination with metformin is a promising new therapeutic strategy for AML.

关键词： glutamine metformin acute myeloid leukemia metallothionein

Prognostic Value of D-Dimer in Patients with Diffuse Large B-cell Lymphoma:A Retrospective Study

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Current Medical Science 2019年第2期39卷 222-227页

作者： Yu-di GENG Yi-ren CHEN Jin JIN Xiao-di WANG Shu ZHANG deng-ju li Department of Hematology Tongji HospitalTongji Medical CollegeHua zhong University of Science and TechnologyWuhan 430030China College of Mathematics and Statistics Shenzhen UniversityShenzhen 518060China

This study evaluated the significance of serum D-Dimer for predicting survival of patients with diffuse large B-cell lymphoma(DLBCL).We analyzed the clinical data from 113 patients who were newly diagnosed with DLBCL at Tongji Hospital from January 2012 to January *** results indicated that there were higher levels of D-Dimer in DLBCL patients with the following characteristics:stage HI/IV,lymphocyte monocyte ratio(LMR)upper limit of normal(ULN),albumin(ALB)60 years,stage m/IV,LDH>ULN,LMR*** analysis showed that only LDH>ULN(P=0.038)and age>60 years(P=0.047)were independent adverse prognostic ***,it was suggested that D-Dimer could be regarded as a marker of high tumor burden and a potential prognostic screening tool for patients with DLBCL,not otherwise specified(NOS).

关键词： diffuse large B-cell lymphoma D-Dimer prognosis

Efficacy and Safety of Generic Dasatinib as a Second-line Treatment for Patients with Chronic Myeloid Leukemia:a Multicenter Retrospective Study in Hubei Province,China

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Current Medical Science 2018年第6期38卷 1005-1011页

作者： li-feng CHEN Guo-lin YUAN Zhao-dong ZHONG Ping ZOU deng-ju li Yin BAO Hong-bo REN li MENG Wei-ming li Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Hematology Xiangyang Central HospitalXiangyang 441000China Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology Xiangyang No.1 People's HospitalXiangyang 441000China Department of Hematology the First People's Hospital of JingzhouJingzhou 434000China

Dasatinib is a second-generation tyrosine kinase inhibitor (TKI)and it could be used as a second-line treatment for patients with chronic myeloid leukemia (CML).Yinishu,a generic dasatinib made in China,was approved by the China Food and Drug Administration in 2013 and it costs much less than the patented dasatinib *** present study aimed to examine the efficacy and safety of Yinishu as a second-line treatment for CML by comparing the baseline clinical characteristics,rates of adverse events and efficacy between Yinishu and SPRYCEL groups. The results showed that there were no significant differences in the rates of optimal response between Yinishu and SPRYCEL for patients who started second-line treatment because of treatment *** patients who started second-line treatment because of intolerance of first-line treatment, their levels of BCR-ABL1/ABL1 on the international scale (BCR-ABL^IS)was maintained very low throughout the course of Yinishu ***-related adverse events occurred with the same frequency in these two *** was confirmed that Yinishu was effective and safe as a second- line treatment for CML *** may be more suitable for patients who are economically unable to pay for the patented dasatinib SPRYCEL.

关键词： chronic myeloid leukemia generic dasatinib second-line treatment efficacy safety

Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing li Xiaoge Wang Xiaofan Cao Zhiqun He Chunjun liang Mingxing Chen Jing ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Post-growth mechanism Heterogeneous structure Single-particle spectroscopy Laser irradiation

血管内超声指导介入治疗冠状动脉分叉病变临床研究

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介入放射学杂志 2015年第4期24卷 292-295页

作者：李文庆程志勇魏明霞邓立菊张春芳黑龙江省大庆市龙南医院心内科 163453

目的探讨血管内超声(IVUS)对冠状动脉真性分叉病变介入治疗的指导作用及对远期预后的影响。方法选取2010年4月至2014年1月接受双支架治疗的冠状动脉分叉病变患者62例,随机分为IVUS组(32例)和冠状动脉造影组(30例),比较两组冠状动脉主支... 详细信息

目的探讨血管内超声(IVUS)对冠状动脉真性分叉病变介入治疗的指导作用及对远期预后的影响。方法选取2010年4月至2014年1月接受双支架治疗的冠状动脉分叉病变患者62例,随机分为IVUS组(32例)和冠状动脉造影组(30例),比较两组冠状动脉主支和分支近端和远端最小管腔直径(MLD)、最小管腔横截面积(MLA)、参照管腔直径(RLD)及病变长度、植入支架直径和长度,并记录术后12个月支架内血栓、靶病变血运重建(TLR)、主要不良心血管事件(MACE)。结果 IVUS组主支和分支MLD高于冠状动脉造影组(P>0.05),MLA、RLD、植入支架直径和长度均高于冠状动脉造影组(P0.05)。结论 IVUS指导经皮冠脉介入治疗(PCI)双支架植入治疗冠状动脉分叉病变,有助于优化支架植入,改善PCI远期预后。

关键词：血管内超声冠状动脉分叉病变经皮冠状动脉介入治疗

阿托伐他汀联合依折麦布在冠心病合并高脂血症患者中的应用研究

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中外医疗 2020年第5期39卷 91-93页

作者：刘红果邓立菊山东省沂南县人民医院心内一科山东临沂276300

目的探讨阿托伐他汀联合依折麦布在冠心病合并高脂血症患者中的应用。方法便利选择2017年5月-2018年12月冠心病合并高脂血症患者86例作为对象,随机分为对照组(n=43例)和观察组(n=43例)。对照组采用阿托伐他汀治疗,观察组在对照组基础上... 详细信息

目的探讨阿托伐他汀联合依折麦布在冠心病合并高脂血症患者中的应用。方法便利选择2017年5月-2018年12月冠心病合并高脂血症患者86例作为对象,随机分为对照组(n=43例)和观察组(n=43例)。对照组采用阿托伐他汀治疗,观察组在对照组基础上联合依折麦布治疗,1个月治疗后对患者效果进行评估,比较两组血脂水平、心血管不良事件及药物不良反应发生率。结果观察组治疗后1个月血脂TC为(3.29±0.29)mmol/L、TG(1.21±0.23)mmol/L、LDL-C水平为(2.58±0.23)mmol/L,均低于对照组(t=6.392、8.461、5.309,P<0.05);观察组治疗后1个月HDL-C水平(1.75±0.51)mmol/L,高于对照组(t=5.216,P=0.000);观察组治疗后1个月心源性死亡、心肌梗死、缺血性脑卒中发生率,分别为0.00%、0.00%、2.33%低于对照组6.78%、9.30%、11.63%(χ~2=5.398、7.431、6.412,P=0.025、0.017、0.022)。结论阿托伐他汀联合依折麦布用于冠心病合并高脂血症患者中能降低患者血脂水平,能降低心血管不良事件发生率,未增加药物不良反应发生率。

关键词：阿托伐他汀依折麦布冠心病高脂血症血脂水平

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BP神经网络预测活性染色织物K/S值

印染 2007年第9期33卷 23-24页

作者：姜会钰杨锋王振东邓丽君武汉科技学院化工学院湖北武汉430073

采用人工神经网络方法预测活性染料染色织物的K/S值。将不同的活性染料染色工艺参数和对应的染色织物K/S值输入神经网络作为训练,再输入其它染色参数值,预测其染色织物K/S值。试验表明,BP神经网络预测结果和试验值的相关系数达到了0.995... 详细信息

采用人工神经网络方法预测活性染料染色织物的K/S值。将不同的活性染料染色工艺参数和对应的染色织物K/S值输入神经网络作为训练,再输入其它染色参数值,预测其染色织物K/S值。试验表明,BP神经网络预测结果和试验值的相关系数达到了0.995,说明人工神经网络用于预测活性染料染色织物K/S值是可行的。

关键词：染色活性染料织物

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一种基于成长的物流网络建模方法

华南理工大学学报（自然科学版） 2008年第5期36卷 24-29,37页

作者：陈国荣鄢萍彭军邓菊丽王琦峰重庆大学制造工程研究所重庆400044 重庆科技学院电子信息工程学院重庆400020 重庆工商大学环境与生物工程学院重庆406000 浙江万里学院商学院浙江宁波315100

为解决目前物流网络动态建模中存在的难题,分析了当前流行的物流理论及其建模方法,结合复杂网络理论的最新应用,提出了一种基于成长特性的物流网络基本建模方法NGM.在建模的过程中,首先建立一个原始模型,然后考虑实际物流网络的成长特... 详细信息

为解决目前物流网络动态建模中存在的难题,分析了当前流行的物流理论及其建模方法,结合复杂网络理论的最新应用,提出了一种基于成长特性的物流网络基本建模方法NGM.在建模的过程中,首先建立一个原始模型,然后考虑实际物流网络的成长特性、优先连接特性和赋权边特性等,对原始模型进行了修正和优化,并结合物流配送中心的需要分析了优化后模型的一些特性.仿真结果表明:基于NGM的物流网络能够按照节点的富集程度,形成"一个核心节点,少量中心节点,大量外围节点"的层次型物流网络结构.该结构在经济性、时效性、安全性、沟通性和方便性方面都能使网络的性能动态地达到最优.

关键词：物流网络动态建模小世界网络

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： ju Zheng Yixin li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK