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scEMAIL: Universal and Source-free Annotation Method for scRNA-seq Data with Novel Cell-type Perception

Genomics, Proteomics & Bioinformatics 2022年第5期20卷 939-958页

作者： hui Wan Liang chen Minghua deng School of Mathematical Sciences Peking UniversityBeijing 100871China Huawei Technologies Co. Ltd.Beijing 100080China Center for Statistical Science Peking UniversityBeijing 100871China Center for Quantitative Biology Peking UniversityBeijing 100871China

Current cell-type annotation tools for single-cell RNA sequencing(sc RNA-seq)data mainly utilize well-annotated source data to help identify cell types in target ***,on account of privacy preservation,their requirements for raw source data may not always be *** this case,achieving feature alignment between source and target data explicitly is ***,these methods are barely able to discover the presence of novel cell types.A subjective threshold is often selected by users to detect novel *** propose a universal annotation framework for sc RNA-seq data called sc EMAIL,which automatically detects novel cell types without accessing source data during *** new cell-type identification,a novel cell-type perception module is designed with three ***,an expert ensemble system measures uncertainty of each cell from three complementary ***,based on this measurement,bimodality tests are applied to detect the presence of new cell ***,once assured of their presence,an adaptive threshold via manifold mixup partitions target cells into‘‘known”and‘‘unknown”*** adaptation is then conducted to alleviate the batch *** gather multi-order neighborhood messages globally and impose local affinity regularizations on‘‘known”*** constraints mitigate wrong classifications of the source model via reliable self-supervised information of *** EMAIL is accurate and robust under various scenarios in both simulation and real *** is also flexible to be applied to challenging single-cell ATAC-seq data without loss of *** source code of sc EMAIL can be accessed at https://***/aster-ww/sc EMAIL and https://***/biocode/tools/BT007335/releases/v1.0.

关键词： Cell-type annotation Transfer learning Privacy preservation Single-cell RNA sequencing Gene expression

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Synthesis of dihydrocapsaicin and dihydrocapsiate exclusively from lignocellulosic platform chemicals

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Green Energy & Environment 2022年第3期7卷 519-524页

作者： Yan-Bing Li hui-Ying Guo chen-Qiang deng Jin deng Hefei National Laboratory for Physical Sciences at the Microscale IChemCAS Key Laboratory of Urban Pollutant ConversionAnhui Province Key Laboratory of Biomass Clean EnergyDepartment of ChemistryUniversity of Science and Technology of ChinaHefeiAnhui230026China CAS Key Laboratory of Renewable Energy Guangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhouGuangdong510640China

Biorefinery is pivotal to the sustainability of modern chemical ***,since biomass is oxygen-enriched,new and green chemical strategies are required for expanding the biomass derived chemical *** this work,synthesis of natural products dihydrocapsaicin and dihydrocapsiate was achieved exclusively from lignocellulosic platform *** products dihydrocapsaicin and dihydrocapsiate were synthesized exclusively from lignocellulosic platform chemicals,using furfural(from hemicellulose)and methyl isopropyl ketone(from cellulose)through aldol condensation-hydrolysis-hydrodeoxygenation to synthesize 8-methylnonanoic acid and then combined with vanillin derivates(from lignin).This synthesis demonstrates the feasibility of constructing natural products entirely from renewable biomass platform through green *** utilization of inherent functional groups of biomass demonstrates their potential to open up chemical space.

关键词： space synthesis hydrolysis

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秦岭植被覆盖时空变化及其对气候变化与人类活动的双重响应

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自然资源学报 2018年第3期33卷 425-438页

作者：邓晨晖白红英高山刘荣娟马新萍黄晓月孟清西北大学城市与环境学院西安710127 陕西继续教育大学西安710004 西安市气象局西安710016

论文基于MODIS-NDVI数据、DEM及气象数据,辅以趋势分析、多元回归残差法、偏最小二乘回归法,反演了秦岭地区2000—2015年植被覆盖度及分析了其"格局—过程—趋势"的变化特征,探究了其对气候变化与人类活动的双重响应机制。结果表明:1)... 详细信息

论文基于MODIS-NDVI数据、DEM及气象数据,辅以趋势分析、多元回归残差法、偏最小二乘回归法,反演了秦岭地区2000—2015年植被覆盖度及分析了其"格局—过程—趋势"的变化特征,探究了其对气候变化与人类活动的双重响应机制。结果表明:1)秦岭地区近16 a来植被覆盖度呈显著上升趋势,增速为2.77%/10 a,呈"中间高、周边低,西部高、东部低,南坡高、北坡低"的空间格局,植被覆盖度随海拔的升高在2 200 m左右达到最大,700~3 200 m达0.7以上,1 300~2 700 m达0.9以上,3 400 m以上为0.5以下的低值区;2)秦岭地区的植被覆盖与气候因子的响应关系存在明显的空间差异,对气温的响应总体上没有明显的时滞效应,而与降水的响应存在以滞后1个月为主的时滞效应;3)人类活动对秦岭地区植被变化的作用日趋增强,且以正向作用为主,主要分布在东部地区,而负向作用则分布于中部和西部地区;4)秦岭地区植被变化是气候变化和人类活动共同作用的结果,影响因子对植被覆盖变化的解释能力依次为人类活动>降水>气温>潜在蒸散量。

关键词：植被覆盖度气候变化人类活动双重响应秦岭地区

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FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

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Science China Life Sciences 2025年

作者： Rongmei Gao Kanchao chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei Xie Shangda Yang Yanling Lü Qian Ren Fei Liu Song chen Fengxia Ma Tao cheng hui cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HSPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHL2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

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党的自我革命的基因生成与制度建构:基于新民主主义革命时期的阐释

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河南社会科学 2025年第1期33卷 25-36页

作者：邓蓉敬陈宏彩中共浙江省委党校图书馆浙江杭州311121 中共浙江省委党校全面从严治党研究中心浙江杭州311121 中共浙江省委党校公共管理教研部浙江杭州311121

新民主主义革命时期党的自我革命遵循了“革命”的基本原理和一般规律,是价值管理、组织变革、行动再造三个因素相互作用、良性互动的结果,也是实践和制度相互转化的结果。根据这一规律,可以从新的视角出发,建立党的自我革命的阐释性分... 详细信息

新民主主义革命时期党的自我革命遵循了“革命”的基本原理和一般规律,是价值管理、组织变革、行动再造三个因素相互作用、良性互动的结果,也是实践和制度相互转化的结果。根据这一规律,可以从新的视角出发,建立党的自我革命的阐释性分析框架,并运用这一框架对新民主主义革命时期党的自我革命进行梳理和反思。新民主主义革命时期党在自我革命中形成的原创性、初始性制度安排和实践经验,对深入推进党的自我革命、建设长期执政的马克思主义政党具有奠基意义和示范价值。

关键词：党的自我革命基因新民主主义革命分析框架制度建构

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竞争环境下资金约束企业的召回风险管理策略

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管理工程学报 2025年第2期39卷 262-281页

作者：陈静杨艺郑朝南邓开洋东南大学经济管理学院江苏南京211189 上海财经大学商学院上海200433 香港中文大学社会科学学院中国香港999077

基于绩效进行采购订单分配是引入供应商竞争、提升零部件质量的一种常见手段。然而资金约束供应商为了避免后期财务困境的发生,很可能在初期削弱其质量投资以增加流动资金的持有量。由资金约束引发的质量竞争失效问题可能在制造商基于... 详细信息

基于绩效进行采购订单分配是引入供应商竞争、提升零部件质量的一种常见手段。然而资金约束供应商为了避免后期财务困境的发生,很可能在初期削弱其质量投资以增加流动资金的持有量。由资金约束引发的质量竞争失效问题可能在制造商基于保障零部件质量而实施的惩罚机制下更为严重。为此,越来越多的制造商采用保险机制提升供应商的财务能力。本文考虑召回成本随机分布,通过构建供应商的质量竞争模型,研究惩罚机制与保险机制对供应商质量竞争行为的影响。研究发现,相较于惩罚机制,保险机制使资金约束供应商更容易在低采购价格下进入市场并参与竞争。此外,惩罚机制或具有较高赔付限额的保险机制会产生“价格黑洞”。当采购价格位于“价格黑洞”中时,提高采购价格反而会带来更低的零部件质量。当保险赔付限额较低时,保险机制可形成非对称均衡,此时仅一家供应商能够进入市场。

关键词：资金约束质量竞争召回风险惩罚与保险

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带扇叶形锚固板钢筋机械锚固性能试验研究

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工程力学 2025年第1期42卷 74-82页

作者：吴琛姚鹏飞陈真锋邓芬福建理工大学福建省土木工程新技术与信息化重点实验室福州350118 锦曦控股集团有限公司福州350017

为避免型钢混凝土节点钢筋锚固时导致的大量型钢穿孔或钢筋焊接，设计一种新型扇叶形锚固板，并通过带扇叶形锚固板钢筋中心拔出试验，分析锚固板形式、钢筋直径、锚固长度对带锚固板钢筋机械锚固性能的影响。试验结果表明：带扇叶型锚... 详细信息

为避免型钢混凝土节点钢筋锚固时导致的大量型钢穿孔或钢筋焊接，设计一种新型扇叶形锚固板，并通过带扇叶形锚固板钢筋中心拔出试验，分析锚固板形式、钢筋直径、锚固长度对带锚固板钢筋机械锚固性能的影响。试验结果表明：带扇叶型锚固板钢筋可避开抗剪栓钉，具有施工方便的优点，同时拥有良好的锚固性能;当钢筋锚固长度为5d~7d时，发生混凝土劈裂破坏，当锚固长度为8d~12d时，发生钢筋拉断破坏，且钢筋的锚固系数大于1.25，具有良好的锚固性能;带扇叶形锚固板钢筋极限粘结强度随钢筋直径、钢筋锚固长度增大而减小，建议钢筋的锚固长度取为8d;提出了适用于带扇叶形锚固板钢筋极限粘结强度的计算公式，能较准确地反映扇叶形锚固板对混凝土产生的挤压和劈裂作用。

关键词：扇叶型锚固板中心拔出试验机械锚固性能极限粘结强度型钢混凝土节点

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Nondeterministic Fuzzy Simulation and Bisimulation

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Chinese Journal of Electronics 2020年第2期29卷 297-303页

作者： deng hui LI Zhi School of Electro-Mechanical Engineering Xidian University

As the abstraction and equivalent technologies, simulation and bisimulation have been applied to the simplifications of some classical and uncertain models structures. The studies of the more generalized simulation and bisimulation technologies have not proceeded *** this problem in mind, we introduce the concepts,lemmas, theorems of nondeterministic fuzzy simulation and bisimulation, as well as the relevant proofs. According to the definitions of nondeterministic fuzzy simulation and bisimulation, we propose nondeterministic fuzzy quotients and a series of quotienting algorithms to generate the minimization of nondeterministic fuzzy simulation and bisimulation. By comparison with previous quotienting algorithms, we show that our quotienting algorithms are more generalized. This kind of quotienting algorithms not only suit for Nondeterministic fuzzy Kripke structure(NFKS), but also Fuzzy Kripke structure(FKS)and classical Kripke structure.

关键词： Nondeterministic fuzzy kripke structure(NFKS) Nondeterministic fuzzy simulation Nondeterministic fuzzy bisimulation Nondeterministic fuzzy quotient

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The role of flavonoids in mitigating food originated heterocyclic aromatic amines that concerns human wellness

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Food Science and Human Wellness 2023年第4期12卷 975-985页

作者： hui Teng Hongting deng Chang Zhang hui Cao Qun Huang Lei chen College of Food Science and Technology Guangdong Ocean UniversityGuangdong Provincial Key Laboratory of Aquatic Product Processing and SafetyGuangdong Province Engineering Laboratory for Marine Biological ProductsGuangdong Provincial Engineering Technology Research Center of SeafoodKey Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education InstitutionZhanjiang 524088China Faculty of Food Science and Technology University of VigoVigo 36310Spain Meat Processing Key Laboratory of Sichuan Province School of Food and Biological EngineeringChengdu UniversityChengdu 610106China

Meat products are an important part in our daily diet,providing valuable nutrients for the human ***,heating processes cause the meat to become more appetizing with changes in texture,appearance,flavor,and chemical properties by the altering of protein structure and other *** one kind of cooking-induced contaminants,heterocyclic aromatic amines(HAAs)are widely present in protein aceous food products with strong carcinogenic and mutagenic *** order to promote the safety of traditional meat products,this review focused on the formation,metabolism,biological monitoring and inhibitory mechanism of *** overview of the formation pathways,hazards,and control methods of HAAs during food processing in recent years was studied,aiming to provide some valuable information for exploring effective methods to inhibit the production of associated hazards during food *** selection of different types of flavonoids to explore their effects on the formation of HAAs in an actual barbecue system can provide theoretical reference for effectively controlling the formation of HAAs and reducing their harm to human health.

关键词： Heterocyclic aromatic amines Flavonoids Hazardous control Precursors

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Effects of bolt profile and grout mixture on shearing behaviors of bolt-grout interface

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第2期12卷 242-255页

作者： Chuanqing Zhang Guojian Cui Xiangrong chen hui Zhou Liang deng State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China PowerChina Huadong Engineering Corporation Limited Hangzhou310014China College of Civil Engineering and Architecture China Three Gorges UniversityYichang443002China

Shearing behavior and failure mechanism of bolt-grout interface are of great significance for load transfer capacity and design of rock bolting *** this paper,direct shear tests on bolt-grout interfaces under constant normal load(CNL) conditions were conducted to investigate the effects of bolt profile(*** spacing and rib height) and grout mixture on the bolt-grout interface in terms of mechanical behaviors and failure *** results showed that the peak shear strength and the deformation capacity of the bolt-grout interface are highly dependent on the bolt profile and grout mixture,suggesting that bolt performances can be optimized,which were unfortunately ignored in the previous studies.A new interface failure mode,i.e.'sheared-crush' mode,was proposed,which was characterized by progressive crush failure of the grout asperities between steel ribs during *** was shown that the interface failure mode mainly depends on the normal stress level and rib spacing,compared with the rib height and grout mixture for the range of tested parameters in this study.

关键词： Bolt-grout interface Direct shear test Shear behavior Failure mode Bolt profiles

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