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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin Meng Li Weibin chen Pei Liu Tao Huang Zhencheng Huang Yuying Liu Jiaojiao deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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改进型髋关节挡板在全髋关节置换术中的应用

齐鲁护理杂志 2012年第17期18卷 4-5页

作者：陈红云郭达邓晨辉广东省中医院

目的:探讨改进型髋关节挡板在全髋关节置换术中的应用。方法:预实验时,模拟髋关节手术体位摆放,观察改进型髋关节挡板与传统体位摆放方法的组装时间、固定后前、后倾角度被动丢失角度、操作人员满意度4个项目;临床验证时将56例全髋关节... 详细信息

目的:探讨改进型髋关节挡板在全髋关节置换术中的应用。方法:预实验时,模拟髋关节手术体位摆放,观察改进型髋关节挡板与传统体位摆放方法的组装时间、固定后前、后倾角度被动丢失角度、操作人员满意度4个项目;临床验证时将56例全髋关节置换术患者随机分成两组,分别记录两组术前体位摆放所用时间、术中需要再次调整体位的次数、患者术中舒适度。结果:预实验和临床验证中两种体位摆放方法效果的差异具有统计学意义(P<0.01)。结论:改进型髋关节挡板较传统体位摆放方法更适用于全髋关节置换术患者,可进行推广。

关键词：全髋关节置换术改进型髋关节挡板体位固定

Rational design of lipid-activatable NIR-II probes for precisely imaging atherosclerotic plaque

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Science China Chemistry 2025年

作者： Xinyu Xu Yuan Ma hui Cao Li Xu Haoming chen Sulai Liu Wei Sun Guosheng Song Xiaobing Zhang State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan University Department of Hepatobiliary Surgery/Central Laboratory Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University) Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical University Shenzhen Research Institute of Hunan University

Atherosclerosis(AS) is a prevalent condition associated with cardiovascular and cerebrovascular diseases, featuring lipid-laden plaque; however, the insufficient resolution and low sensitivity of traditional medical imaging techniques limit their application in lipid imaging. Currently, the second near-infrared(NIR-II) fluorescence imaging offers promising sensitivity and convenience. However, existing probes have limitations in terms of signal-to-background ratio, penetration depth, and tissue scattering. Herein, we use a molecular regulatory strategy to design a lipid-activatable probe Rh-965 with high specificity and NIR-II emission for improved imaging potential in deep tissues. The potential of Rh-965 for imaging plaque lipids in mice with AS is demonstrated by localizing carotid artery plaques using NIR-II imaging. The development of more stable lipid-activated NIR-II probes can significantly enhance atherosclerosis diagnosis and facilitate in vivo imaging in deeper tissues.

关键词：

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成年病人万古霉素治疗药物监测软件的研发

中国药学杂志 2014年第10期49卷 881-885页

作者：邓晨辉季双敏王思媛李良周田彦卢炜北京大学药学院北京100191 北京大学天然药物与仿生药物国家重点实验室北京100191

目的研制开发成年病人的万古霉素治疗药物监测软件,帮助临床进行万古霉素个体化用药。方法系统地检索PubMed数据库中发表于2012年9月前的文献,提取成年病人万古霉素群体药动学模型并结合笔者建立的模型构建万古霉素治疗药物监测模型集... 详细信息

目的研制开发成年病人的万古霉素治疗药物监测软件,帮助临床进行万古霉素个体化用药。方法系统地检索PubMed数据库中发表于2012年9月前的文献,提取成年病人万古霉素群体药动学模型并结合笔者建立的模型构建万古霉素治疗药物监测模型集。根据建立的群体药动学模型和Bayesian原理,在Microsoft Visual Studio 2005集成开发环境中采用C++语言研发治疗药物监测软件。结果构建的治疗药物监测模型集包含14个群体药动学模型。基于模型开发的软件可根据病人信息的多寡分别进行群体、亚群体和个体预测,为临床万古霉素个体化给药提供帮助。结论本实验研发的软件涵盖了当前报道的万古霉素药动学模型,医生可以根据病人的实际情况选择适当的模型,具有较广的适用性。

关键词：万古霉素成年病人群体药物动力学治疗药物监测软件研制

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急性胰腺炎并发胰性脑病的临床观察与护理

实用护理杂志 2001年第10期17卷 25-27页

作者：邓蓓陈惠蓉王世萍陈增蓉四川大学华西医学中心附属第一医院普外三病房四川成都610041

目的　总结急性胰腺炎并发胰性脑病 (PE)的临床特点并探讨相关护理问题。方法　回顾性分析了急性胰腺炎并发PE患者 19例。结果　全组中 18例系重症急性胰腺炎 ,总的病死率 5 2 6% ,稍低于文献报道的水平( 66 7%～ 10 0 % )。结论　PE... 详细信息

目的　总结急性胰腺炎并发胰性脑病 (PE)的临床特点并探讨相关护理问题。方法　回顾性分析了急性胰腺炎并发PE患者 19例。结果　全组中 18例系重症急性胰腺炎 ,总的病死率 5 2 6% ,稍低于文献报道的水平( 66 7%～ 10 0 % )。结论　PE可能是在胰酶对大脑损害作用的基础上多种因素综合致病的结果 ,中西医结合治疗有一定疗效。护理工作中多器官功能不全的观察与护理最为关键。

关键词：胰性脑病急性胰腺炎护理并发症临床观察

穴位贴敷复合耳穴疗法对气管插管全麻患者术后咽痛疗效的临床观察

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中华中医药杂志 2017年第11期32卷 5237-5239页

作者：洪晓燕邓晨晖邓华梅邓金莹司俊丽单葵顺李文霞董晶晶广州中医药大学第二附属医院麻醉科广州510120 广州中医药大学第二临床医学院广州510120

目的:探讨醋调吴茱萸薄荷粉穴位贴敷天突、内关、合谷联合耳穴疗法对气管插管全麻术后咽痛临床疗效。方法:将符合条件的2016年11月-2017年3月于广东省中医院施行气管插管全麻的患者100例按随机数字表法分为观察组和对照组,各50例。观察... 详细信息

目的:探讨醋调吴茱萸薄荷粉穴位贴敷天突、内关、合谷联合耳穴疗法对气管插管全麻术后咽痛临床疗效。方法:将符合条件的2016年11月-2017年3月于广东省中医院施行气管插管全麻的患者100例按随机数字表法分为观察组和对照组,各50例。观察组于术前1d进行耳穴贴压取穴位:神门、交感、咽喉、屏间前,并于手术当天麻醉开始前给予吴茱萸薄荷贴敷天突、双侧内关、双侧合谷穴,观察比较两组术后清醒(0h)及术后24h患者的咽痛及伴随症状疗效。结果:观察组患者全麻术后清醒时(0h)及术后24h恶心、呕吐次数明显少于对照组,24h咽痛评分低于对照组,术后舒适评分高于对照组(P<0.01,P<0.05)。结论:醋调吴茱萸薄荷粉穴位贴敷联合耳穴疗法有利于缓解气管插管全麻术后患者的咽痛及咽喉伴随症状,增加术后舒适感,对全麻术后咽痛患者有预防及干预效果。

关键词：气管插管全麻咽痛穴位贴敷耳穴疗法疗效吴茱萸薄荷粉

定量药理学在新药研发及临床治疗药物监测方面的应用

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中国药科大学学报 2010年第1期41卷 91-96页

作者：尚德为王曦培邓晨辉毕姗姗管峥周田彦卢炜北京大学天然药物及仿生药物国家重点实验室北京100191

定量药理学是上个世纪末在传统的药动学基础之上形成的新型学科,其主要运用数学及统计学的方法定量描述、解释和预测药物在体内的作用行为。近年来定量药理学中涉及的模型化和仿真预测在新药研发、治疗药物监测和临床个体化用药等方面... 详细信息

定量药理学是上个世纪末在传统的药动学基础之上形成的新型学科,其主要运用数学及统计学的方法定量描述、解释和预测药物在体内的作用行为。近年来定量药理学中涉及的模型化和仿真预测在新药研发、治疗药物监测和临床个体化用药等方面得到了广泛的重视和研究。本文主要从新药研发和临床治疗药物监测这两个方面综述了定量药理学国内外研究进展。

关键词：定量药理学新药研发治疗药物监测个体化给药

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-hui Jiang hui-Li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

靶向抑制巨噬细胞Act1表达对溃疡性结肠炎的作用

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中国实验动物学报 2016年第6期24卷 585-590页

作者：郐一贺王丽京邓慧君陈佳园顾取良广东药科大学基础学院血管生物学研究所广州510006 广东药科大学健康学院广州510006

目的探讨巨噬细胞NF-κB活化因子1(nuclear factor kappa B activator 1,Act1)在炎症性肠病中的作用。方法以巨噬细胞Act1表达被靶向抑制的小鼠(anti-Act1)为研究对象,利用葡聚糖硫酸钠(dextran sodium sulfate,DSS)诱导溃疡性结肠炎模... 详细信息

目的探讨巨噬细胞NF-κB活化因子1(nuclear factor kappa B activator 1,Act1)在炎症性肠病中的作用。方法以巨噬细胞Act1表达被靶向抑制的小鼠(anti-Act1)为研究对象,利用葡聚糖硫酸钠(dextran sodium sulfate,DSS)诱导溃疡性结肠炎模型,通过检测小鼠体重变化、便血情况、粪便黏稠度等进行疾病活动指数评分,对结直肠组织进行HE染色评价炎症严重程度,免疫组化方法分析白细胞和巨噬细胞等的浸润情况并用RT-q PCR法检测相关细胞因子的表达变化。结果在DSS诱导7 d后与C57小鼠相比,anti-Act1小鼠结直肠炎症指标评分较低,巨噬细胞等浸润数量较少,TNF-α、IL-1β和IL-6 mRNA表达较低。结论靶向抑制巨噬细胞Act1表达能够减轻DSS诱导的溃疡性结肠炎。

关键词： Act1 基因工程小鼠溃疡性结肠炎巨噬细胞