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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia qin Lingyan Liang Yichen Wei qingping Zhang Xiaocheng Li Haixia qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

Distributed Communication-Sliding Mirror-Descent Algorithm for Nonsmooth Resource Allocation Problem

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Journal of Systems Science & Complexity 2022年第4期35卷 1244-1261页

作者： WANG Yinghui tu Zhipeng qin Huashu School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Key Lab of Systems and Control Academy of Mathematics and Systems ScienceBeijing100190China University of Chinese Academy of Sciences Beijing100190China

This paper considers a distributed nonsmooth resource allocation problem of minimizing a global convex function formed by a sum of local nonsmooth convex functions with coupled constraints.A distributed communication-efficient mirror-descent algorithm,which can reduce communication rounds between agents over the network,is designed for the distributed resource allocation *** employing communication-sliding methods,agents can find aε-solution in O(1/ε)communication rounds while maintaining O(1/ε^(2))subgradient evaluations for nonsmooth convex functions.A numerical example is also given to illustrate the effectiveness of the proposed algorithm.

关键词： Distributed resource allocation problem mirror-descent algorithm nonsmooth functions

平衡强化训练对住院老年精神分裂症患者平衡能力的影响:一项随机对照试验

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中国全科医学 2025年第2期28卷 193-199页

作者：秦伟涂刚英万小梅王芳江西省精神卫生中心护理部江西省南昌市330029 南昌大学附属精神病医院护理部江西省南昌市330029 江西省精神卫生中心老年科江西省南昌市330029

背景住院老年精神疾病患者跌倒发生率呈上升趋势,而运动不足和久坐不动的生活方式成为住院老年患者的现状,平衡训练可以有效减少跌倒已被证实,但在精神科运用甚少。目的探讨平衡强化训练对住院老年精神分裂症患者平衡能力的影响。方法选... 详细信息

背景住院老年精神疾病患者跌倒发生率呈上升趋势,而运动不足和久坐不动的生活方式成为住院老年患者的现状,平衡训练可以有效减少跌倒已被证实,但在精神科运用甚少。目的探讨平衡强化训练对住院老年精神分裂症患者平衡能力的影响。方法选取2023年江西省某三级甲等精神专科医院老年科住院精神分裂症患者72例作为研究对象,采用随机数字表法分为试验组(36例)和对照组(36例)。对照组采用常规康复训练,试验组在对照组基础上采用平衡强化训练方案进行干预,在干预前及干预4、12周后,使用Berg平衡量表(BBS)和中文版Barthel指数(BI)以及国际版跌倒效能量表(FES-I)对两组患者进行评估。结果共62例患者完成训练,其中试验组30例,对照组32例。两因素重复测量方差分析显示,组别与时间对BBS、BI评分存在交互作用(P0.05),时间对BBS、BI评分主效应均显著(P0.05);时间对FES-I总分及室内、室外活动评分主效应均显著(P<0.05)。干预12周,试验组FES-I总分及室内、室外活动评分高于对照组(P<0.05)。组内比较显示,试验组干预4周FES-I总分及室内、室外活动评分均高于干预前(P<0.05);试验组干预12周FES-I总分及室内、室外活动评分均高于干预前、干预4周(P<0.05)。结论平衡强化训练方案可有效提高住院老年精神分裂症患者平衡能力、生活自理能力及跌倒自我效能,降低跌倒风险。

关键词：精神分裂症老年人平衡强化训练平衡能力跌倒随机对照试验

Distributed stochastic mirror descent algorithm for resource allocation problem

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Control Theory and Technology 2020年第4期18卷 339-347页

作者： Yinghui Wang Zhipeng tu Huashu qin Key Lab of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China

In this paper,we consider a distributed resource allocation problem of minimizing a global convex function formed by a sum of local convex functions with coupling *** on neighbor communication and stochastic gradient,a distributed stochastic mirror descent algorithm is designed for the distributed resource allocation *** convergence to an optimal solution of the proposed algorithm is given when the second moments of the gradient noises are summable.A numerical example is also given to illustrate the effectiveness of the proposed algorithm.

关键词： Distributed Resource allocation problem Stochastic gradient Mirror descent

Validation of a RANS transition model using a high-order weighted compact nonlinear scheme

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Science China(Physics,Mechanics & Astronomy) 2013年第4期56卷 805-811页

作者： tu GuoHua deng XiaoGang MAO MeiLiang State Key Laboratory of Aerodynamics China Aerodynamics Research & Development Center Science and Technology on Scramjet Laboratory Hypervelocity Aerodynamics Institute of CARDC National University of Defense Technology Computational Aerodynamics Institute China Aerodynamics Research & Development Center

A modified transition model is given based on the shear stress transport (SST) turbulence model and an intermittency transport equation. The energy gradient term in the original model is replaced by flow strain rate to saving computational costs. The model employs local variables only, and then it can be conveniently implemented in modern computational fluid dynamics codes. The fifth-order weighted compact nonlinear scheme and the fourth-order staggered scheme are applied to discrete the governing equations for the purpose of minimizing discretization errors, so as to mitigate the confusion between numerical errors and transition model errors. The high-order package is compared with a second-order TVD method on simulating the transitional flow of a flat plate. Numerical results indicate that the high-order package give better grid convergence property than that of the second-order method. Validation of the transition model is performed for transitional flows ranging from low speed to hypersonic speed.

关键词： hypersonic boundary layer transition transition model intermittency factor high-order schemes

Effect of RANS turbulence Model on Aerodynamic Behavior of Trains in Crosswind

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Chinese Journal of Mechanical Engineering 2019年第5期32卷 145-156页

作者： Tian Li deng qin Jiye Zhang State Key Laboratory of Traction Power Southwest Jiaotong University

The numerical simulation based on Reynolds time-averaged equation is one of the approved methods to evaluate the aerodynamic performance of trains in ***,there are several turbulence models,trains may present different aerodynamic performances in crosswind using different turbulence *** order to select the most suitable turbulence model,the inter-city express 2(ICE2)model is chosen as a research object,6 different turbulence models are used to simulate the flow characteristics,surface pressure and aerodynamic forces of the train in crosswind,respectively.6 turbulence models are the standard k-ε,Renormalization Group(RNG)k-ε,Realizable k-ε,Shear Stress Transport(SST)k-ω,standard k-ωand Spalart-Allmaras(SPA),*** numerical results and the wind tunnel experimental data are *** results show that the most accurate model for predicting the surface pressure of the train is SST k-ω,followed by Realizable k-ε.Compared with the experimental result,the error of the side force coefficient obtained by SST k-ωand Realizable k-εturbulence model is less than 1%.The most accurate prediction for the lift force coefficient is achieved by SST k-ω,followed by RNG k-ε.By comparing 6 different turbulence models,the SST k-ωmodel is most suitable for the numerical simulation of the aerodynamic behavior of trains in crosswind.

关键词： turbulence model Crosswind High speed train Numerical simulation Aerodynamic

Stabilized seventh-order dissipative compact scheme using simultaneous approximation terms

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Applied Mathematics and Mechanics(English Edition) 2019年第6期40卷 823-836页

作者： Jiaxian qin Yaming CHEN Xiaogang deng College of Aerospace Science and Engineering National University of Defense Technology

To ensure time stability of a seventh-order dissipative compact finite difference scheme, fourth-order boundary closures are used near domain boundaries previously. However, this would reduce the global convergence rate to fifth-order only. In this paper, we elevate the boundary closures to sixth-order to achieve seventh-order global accuracy. To keep the improved scheme time stable, the simultaneous approximation terms (SATs) are used to impose boundary conditions weakly. Eigenvalue analysis shows that the improved scheme is time stable. Numerical experiments for linear advection equations and one-dimensional Euler equations are implemented to validate the new scheme.

关键词： high-order scheme compact scheme time stability simultaneous approximation term (SAT)

Reactivation of a huge ancient landslide by surface water infiltration

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Journal of Mountain Science 2019年第4期16卷 806-820页

作者： tu Guo-xiang HUANG Da deng Hui State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology School of Civil and Transportation Engineering Hebei University of Technology

An ancient landslide, situated in Deqin County, Yunnan Province, China, was used to investigate the reactivation by water infiltration. This study considers the infiltration process and landslide stability using finite-element method(FEM)-based models. The results show that the reactivation of old landslide deposit was triggered by the long-term leakage of diversion ditch before October 2012, and the reactivation was triggered again by the intense rainfall on 7-9 October 2012. The old cracks, which formed in the earlier reactivation of landslide, played a key role for the rainfall infiltration. They offered a preferential path for much more rainfall to infiltrate fast into deep soil, and caused wetting front to move down faster in landslide. The old slip zone with lower permeability was another important factor to cause the infiltrated water to accumulate and form a high pore water pressure above slip zone. Then the high pore water pressure decreased the shear strength of slip zone and triggered the reactivation of the old landslide deposit again.

关键词： Landslide Rainfall infiltration Soil stability Finite-element-method Leakage of diversion ditch