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Neutrophil extracellular traps mediate neuro-immunothrombosis

Neural Regeneration Research 2024年第8期19卷 1734-1740页

作者： Jianbo Lou Jianning Zhang Quanjun deng Xin Chen Department of Neurosurgery Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institute Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjinChina

Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammato ry *** extracellular trap formation occurs through lytic and non-lytic pathways that can be further classified by formation ***,von Willebrand factor,fibrin,and many other factors participate in the interplay between inflammation and *** summarizes the intricate interplay between inflammation and thrombosis during neural development and the pathogenesis of neurological diseases,providing cutting-edge insights into post-neurotrauma thrombotic *** blood-brain barrier defends the brain and spinal cord against external assaults,and neutrophil extracellular trap involvement in blood-brain barrier disruption and immunothrombosis contributes substantially to secondary injuries in neurological *** research is needed to understand how neutrophil extracellular traps promote blood-brain barrier disruption and immunothrombosis,but recent studies have demonstrated that neutrophil extracellular traps play a crucial role in immunothrombosis,and identified modulators of ***,these neurological diseases occur in blood vessels,and the mechanisms are unclear by which neutrophil extracellular traps penetrate the blood-brain barrier to participate in immunothrombosis in traumatic brain *** review discusses the role of neutrophil extracellular traps in neuro-immunothrombosis and explores potential therapeutic interventions to modulate neutrophil extracellular traps that may reduce immunothrombosis and improve traumatic brain injury outcomes.

关键词： inflammation neuro-immunothrombosis neurologic diseases neurotrauma neutrophil extracellular traps platelet thrombosis traumatic brain injury

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A general descriptor for guiding the electrolysis of CO_(2)in molten carbonate

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Green Energy & Environment 2024年第4期9卷 748-757页

作者： Zhengshan Yang Bowen deng Kaifa Du Huayi Yin Dihua Wang School of Resource and Environmental Sciences Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and EnergyWuhan UniversityWuhan430072China

Molten carbonate is an excellent electrolyte for the electrochemical reduction of CO_(2)to carbonaceous ***,the electrolyte–electrode-reaction relationship has not been well ***,we propose a general descriptor,the CO_(2)activity,to reveal the electrolyte–electrode-reaction relationship by thermodynamic calculations and experimental *** studies agree well with theoretical predictions that both cations(Li^(+),Ca^(2+),Sr^(2+)and Ba^(2+))and anions(BO_(2)^(-),Ti_(5)O_(14)^(8-),SiO_(3)^(2-))can modulate the CO_(2)activity to control both cathode and anode reactions in a typical molten carbonate electrolyzer in terms of tuning reaction products and *** this regard,the reduction of CO_(3)^(2-)can be interpreted as the direct reduction of CO_(2)generated from the dissociated CO_(3)^(2-),and the CO_(2)activity can be used as a general descriptor to predict the electrode reaction in molten ***,the CO_(2)activity descriptor unlocks the electrolyte–electrode-reaction relationship,thereby providing fundamental insights into guiding molten carbonate CO_(2)electrolysis.

关键词： Molten carbonate CO_(2)activity CO_(2)RR Electrolyte engineering Carbon

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Glymphatic system:a gateway for neuroinflammation

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Neural Regeneration Research 2024年第12期19卷 2661-2672页

作者： Kailu Zou Qingwei deng Hong Zhang Changsheng Huang Department of Anesthesiology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Xiangya School of Medicine Central South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

The glymphatic system is a relatively recently identified fluid exchange and transpo rt system in the *** evidence indicates thatglymphatic function is impaired not only in central nervous system disorders but also in systemic *** diseases can trigger the inflammatory responses in the central nervous system,occasionally leading to sustained inflammation and functional disturbance of the central nervous *** review summarizes the current knowledge on the association between glymphatic dysfunction and central nervous system *** addition,we discuss the hypothesis that disease conditions initially associated with peripheral inflammation ove rwhelm the performance of the glymphatic system,thereby triggering central nervous system dysfun ction,chronic neuroinflammation,and *** research investigating the role of the glymphatic system in neuroinflammation may offer innovative therapeutic approaches for central nervous system disorders.

关键词： aquaporin-4 central nervous system disease cerebrospinal fluid chronic neuroinflammation glymphatic dysfunction neurodegeneration peripheral nerve injury perivascular space systemic disease vicious cycle

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Robot trajectory planning for autonomous 3D reconstruction of cockpit in aircraft final assembly testing

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Chinese Journal of Aeronautics 2024年第3期37卷 332-350页

作者： Yanzhe WANG Zemin PAN Qian YANG Changxi deng Yanding WEI The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China School of Information Science and Engineering NingboTech UniversityNingbo 315100China AVIC Xi’an Aircraft Industry(Group)Company Ltd. Xi’an 710089China Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China

The trend towards automation and intelligence in aircraft final assembly testing has led to a new demand for autonomous perception of unknown cockpit operation scenes in robotic collaborative airborne system *** address this demand,a robotic automated 3D reconstruction cell which enables to autonomously plan the robot end-camera’s trajectory is developed for image acquisition and 3D modeling of the cockpit operation scene.A continuous viewpoint path planning algorithm is proposed that incorporates both 3D reconstruction quality and robot path quality into optimization *** metrics for viewpoint position paths and orientation paths are introduced together for the first time in 3D *** ensure safe and effective movement,two spatial constraints,Domain of View Admissible Position(DVAP)and Domain of View Admissible Orientation(DVAO),are implemented to account for robot reachability and collision *** using diffeomorphism mapping,the orientation path is transformed into 3D,consistent with the position *** orientation and position paths can be optimized in a unified framework to maximize the gain of reconstruction quality and path smoothness within DVAP and *** reconstruction cell is capable of automatic data acquisition and fine scene modeling,using the generated robot C-space *** and physical scene experiments have confirmed the effectiveness of the proposed method to achieve highprecision 3D reconstruction while optimizing robot motion quality.

关键词： Aircraft assembly testing Aircraft cockpit 3D modeling Camera viewpoint Robot trajectory planning

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Numerical simulation and parameter optimization of Coriolis force scale measurement process based on DEM

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Particuology 2024年第7期90卷 128-139页

作者： Haiting Liu Yong Yang Xiangliang Wang Jiewen deng Bingbing Wang School of Energy and Power Engineering Northeast Electric Power UniversityJilin132012China CNBM Hefei Mechanical&Electrical Engineering Technology Co.Ltd Hefei230051China

The Coriolis force method is a recently developed and highly regarded direct measurement technique that enables high-precision measurement of bulk *** operational parameters and variations thereof directly influence the measurement accuracy of the *** this study,a measurement correction coefficient is introduced to improve the calculation method for mass flow rate of the *** DEM is employed to simulate the motion of particle groups within the Coriolis force scale under different parameters,and the effects of various structural and operational parameters on the measurement results are *** research findings indicate that a lower rotational speed leads to more stable instantaneous measurement results,although the measurement error is relatively *** the rotational speed exceeds 300 rpm,the measurement error remains within 15%.For materials with a radius of 1–2 mm,the variation range of precision error is approximately 0.4%.Among the structural parameters,the radius of the measurement wheel has the most significant impact on the measurement results,wherein a larger measurement wheel radius corresponds to a smaller measurement *** horizontal angle of the blades follows as the next influential parameter,with a clockwise rotation and a horizontal angle of 30°resulting in a measurement error below 2%.

关键词： Parameter optimization Discrete element method Coriolis force scale Measurement error Numerical simulation

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Enhanced Fenton-like process over Cu/L(+)-ascorbic acid co-doping mesoporous silica for toxicity reduction of emerging contaminants

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 49-60页

作者： Yuhang Liu Wenxuan deng Xiaojun Wu Chun Hu Lai Lyu Key Laboratory for Water Quality and Conservation of the Pearl River Delta(Ministry of Education) Institute of Environmental Research at Greater BayGuangzhou UniversityGuangzhou 510006China

Effective removal of emerging contaminants(ECs)to minimize their impacts on human health and the natural environment is a global *** the removal of ECs in water,we fabricated a seaweed spherical microsphere catalyst with Cu cation-πstructures by in situ doping of Cu species and ascorbic acid in mesoporous silica(Cu-C-MSNs)via a hydrothermal *** results indicate that bisphenol A(BPA)is substantially degraded within 5 min under natural conditions,with its biological toxicity considerably ***,industrial wastewater could also be effectively purified by Cu-C-MSNs/H_(2)O_(2) *** presence of metal sites and the complexation of ECs via cation-πinteraction andπ-πstacking on the catalyst surface were directly responsible for the polarization distribution of electrons,thus activating H_(2)O_(2) and dissolved oxygen(DO).The removal of contaminants could be attributed primarily to 1)the activation of H_(2)O_(2) into ^(·)OH to attack the contaminants and 2)self-cleavage because of the transfer of electrons from the contaminants to the *** study provides an innovative solution for the effective treatment of ECs and has positive implications for easing global environmental crises.

关键词： Cation-πstructures Polarization electric field Fenton-like process Contaminants cleavage

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Interfacial/bulk synergetic effects accelerating charge transferring for advanced lithium-ion capacitors

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Chinese Chemical Letters 2024年第6期35卷 168-175页

作者： Chang Liu Zirui Song Xinglan deng Shihong Xu Renji Zheng Wentao deng Hongshuai Hou Guoqiang Zou Xiaobo Ji School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-Containing Mineral Resources School of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China

The exploration of advanced materials through rational structure/phase design is the key to develop highperformance lithium-ion capacitors(LICs).However,high complexity of material preparation and difficulty in quantity production largely hinder the further ***,Cu_(5)FeS_(4-x)/C(CFS@C)heterojunction with rich sulfur vacancies has successfully achieved from natural bornite,presenting low costeffective and bulk-production *** functional theory(DFT)calculations indicate that rich vacancies in bulk phase can decrease band gap of bornite and thus improve its intrinsic electron conductivity,as well as the heterojunction spontaneously evokes a built-in electric field between its interfacial region,largely reducing the migration barrier from 1.27 e V to 0.75 e *** from these merits,the CFS@C electrodes deliver outperformed lithium storage performance,e.g.,high reversible capacity(822.4m Ah/g at 0.1 A/g),excellent cycling stability(up to 820 cycles at 2 A/g and 540 cycles at 5 A/g with respective capacity retention of over or nearly 100%).With CFS@C as anode and porous carbon nanosheets(PCS)as cathode,the assembled CFS@C//PCS LIC full cells exhibit high energy/power density characteristics of 139.2 Wh/kg at 2500 W/*** work is expected to offer significant insights into structure modifications/devising toward natural minerals for advanced energy-storage systems.

关键词： Bulk/interfacial modification Heterostructure Sulfur vacancies Lithium ion capacitors Capacitors

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Air target intention recognition and causal effect analysis combining uncertainty information reasoning and potential outcome framework

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Chinese Journal of Aeronautics 2024年第1期37卷 287-299页

作者： Yu ZHANG Fanghui HUANG Xinyang deng Mingda LI Wen JIANG School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China

Recognizing target intent is crucial for making decisions on the ***,the imperfect and ambiguous character of battlefield situations challenges the validity and causation analysis of classical intent recognition *** with the challenge,a target intention causal analysis paradigm is proposed by combining with an Intervention Retrieval(IR)model and a Hybrid Intention Recognition(HIR)*** target data acquired by the sensors are modelled as Basic Probability Assignments(BPAs)based on evidence theory to create uncertain ***,the HIR model is utilized to recognize intent for a tested sample from uncertain ***,the intervention operator under the evidence structure is utilized to perform attribute intervention on the tested *** retrieval is performed in the sample database based on the IR model to generate the intention distribution of the pseudo-intervention samples to analyze the causal effects of individual sample *** simulation results demonstrate that our framework successfully identifies the target intention under the evidence structure and goes further to analyze the causal impact of sample attributes on the target intention.

关键词： Causal effect analysis Hybrid intention recognition Intervention retrieval Target intention Uncertainty reasoning

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Design of a Bio-inspired,Two-winged,Flapping-wing Micro Air Vehicle with High-lift Performance

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Journal of Bionic Engineering 2024年第3期21卷 1191-1207页

作者： Kai Hu Huichao deng Shengjie Xiao Gongyu Yang Yuhong Sun Space Robot Laboratory The School of Mechanical EngineeringBeihang UniversityBeijing100191China

In this paper,we present the development of our latest flapping-wing micro air vehicle(FW-MAV),named Explobird,which features two wings with a wingspan of 195 mm and weighs a mere 25.2 g,enabling it to accomplish vertical take-off and hover *** devised a novel gear-based mechanism for the flapping system to achieve high lift capability and reliability and conducted extensive testing and analysis on the wings to optimise power matching and lift *** Explobird can deliver a peak lift-to-weight ratio of 1.472 and an endurance time of 259 s during hover flight powered by a single-cell LiPo *** the inherent instability of the prototype,we discuss the derivatives of its longitudinal system,underscoring the importance of feedback control,position of the centre of gravity,and increased *** demonstrate the effect of damping enhancement on stability,we also designed a passive stable ***,the vehicle is actively stabilised in roll by adjusting the wing root bars and in pitch through high-authority tail control,whereas yaw is passively *** a series of flight tests,we successfully demonstrate that our prototype can perform vertical take-off and hover flight under wireless *** promising results position the Explobird as a robust vehicle with high lift capability,paving the way towards the use of FW-MAVs for carrying load equipment in multiple tasks.

关键词： Flapping wing Biologically inspired robots Mechanical design Flight dynamics Damping enhancement

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Ameliorating the Strength-Modulus Synergy in GNPs Reinforced Mg-Zn-Zr Composites via Multidirectional Forging and Hot Extrusion Deformation

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 425-437页

作者： Yuhao Chen Kaibo Nie Kunkun deng Zhilong Liu Quanxin Shi College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China State Key Laboratory of Compressor Technology(Compressor Technology Laboratory of Anhui Province) Hefei 230031China Instrumental Analysis Center Taiyuan University of TechnologyTaiyuan 030024China

The integration of lightweight and high-modulus magnesium-based materials is becoming increasingly valued as structural materials due to the complexity and intelligence of industrial products like automobiles and *** this study,the graphene nanoplatelets(GNPs)/Mg-Zn-Zr composites with 0.5 wt%GNPs were successfully prepared by the combination of multidirectional forging(MDF)and hot extrusion(Ex).The newly-developed composites after multi-step deformation possessed excellent strength and modulus,with a tensile strength exceeding 375 MPa and an elastic modulus reaching 54 *** results revealed that the stripping and thinning of GNPs bands parallel to the extrusion direction occurred after MDF+Ex,which promoted the dynamic recrystallization and the formation of numerous fine *** significant improvement in comprehensive mechanical performances of the composites could be primarily ascribed to the refinement of grain size caused by the optimized distribution of GNPs,and efficient load transfer facilitated by the tight interface.

关键词： Magnesium matrix composites Graphene nanoplatelets(GNPs) Multi-step deformation Microstructure Strength-modulus

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