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针刺通过增加前额叶皮层突触蛋白的表达对两种抑郁症动物模型的快速抗抑郁作用

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World Journal of Acupuncture-Moxibustion 2024年第2期34卷 117-129页

作者：宁百乐王志芳杨晴吴倩邓启粤高静傅文邓颖吴炳鑫黄熙畅王聪符文彬广州中医药大学第二附属医院广州510120 广州中医药大学广州510006 河南中医药大学第一附属医院郑州45000

Objective:To investigate the effect of acupuncture onset time and synaptic structure in two different models of depression.Methods:A total of 150 healthy male adult SPF C57BL/6J mice were divided into five time-point groups:1 h,3 h,6 h,12 h and 24 h.Each time-point group was further divided into three groups:the model,scopolamine and acupuncture groups with 10 rats each.Rats were given forced swimming stimulation(15 min,once)before the intervention.A total of 200 healthy male adult specific pathogen-free(SPF)Sprague-Dawley(SD)rats were divided into 30 normal rats,and 170 modelling ones.A total of 90 rats were successfully modeled,and were randomly divided into three time-point groups:1 h,6 h and 24 h.And each time-point group was further divided into the normal,model,scopolamine,and acupuncture group.Chronic unpredictable mild stress(CUMS)combined with individual feeding was used to establish the depressed rat model.The sucrose preference test(SPT)and open field test(OFT)were used to evaluate the success of the model.There were 10 rats in each group.The acupuncture intervention was performed once for 20 min on"Baihui(GV20)","Yintang(GV29)","Hegu(LI4)",and"Taichong(LR3)"without any other operations for the corresponding animals.Other groups were given corresponding medications.According to different time points,the forced swimming test(FST)was conducted in mice,and the FST and novelty-suppressed feeding test(NSFT)were measured in rats.Monoamine neurotransmitters(NE,DA,DOPAC,5-HT,5-HIAA,HVA)in the prefrontal cortex and hippocampus were detected with high performance liquid chromatography(HPLC).The expression of synapsin I,PSD95,p-mTOR,mTOR,and BDNF in the prefrontal cortex and hippocampus was determined by western blot.Results:At the 1 h time point,compared with the model group,the immobility time was significantly decreased in the acupuncture group(P<0.05).At 3 h,6 h,12 h,and 24 h,compared with the model group,the immobility time was significantly reduced in both scopolamine and acupuncture groups(P<0.05).At the 1

关键词： Depression Acupuncture Rapidantidepressanteffect Synaptic proteins Prefrontal cortex

扬子陆块北缘大洪山地区莲沱组底部凝灰岩锆石U-Pb定年及其地层学意义

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地质通报 2024年第2期43卷 363-375页

作者：宁括步邓奇崔晓庄汪正江任光明杨青雄中国地质调查局成都地质调查中心(西南地质科技创新中心) 四川成都610218 自然资源部沉积盆地与油气资源重点实验室四川成都610218 湖北省地质调查院湖北武汉430034

扬子陆块北缘莲沱组是华南新元古代的重要地层单元之一,但其沉积时限、区域对比关系、沉积环境与沉积期古地理存在诸多争论。对大洪山地区莲沱组底部的凝灰岩进行了LA-ICP-MS锆石U-Pb定年,获得凝灰岩样品的形成年龄为798.4±4.5 Ma(MSWD... 详细信息

扬子陆块北缘莲沱组是华南新元古代的重要地层单元之一,但其沉积时限、区域对比关系、沉积环境与沉积期古地理存在诸多争论。对大洪山地区莲沱组底部的凝灰岩进行了LA-ICP-MS锆石U-Pb定年,获得凝灰岩样品的形成年龄为798.4±4.5 Ma(MSWD=0.40,n=13)。结合前人研究成果,将莲沱组的沉积时限限定为800~714 Ma,区域上可与板溪群及其相当地层中上部、休宁组、澄江组、开建桥组、武当群和随县群进行对比,为“晋宁造山运动”不整合面之上、南华冰期之下的一套裂谷充填产物,代表了裂谷盆地全面打开,沉积范围快速扩大的充填序列,其主体为冲积扇、河流及滨浅海沉积。莲沱沉积时期,扬子陆块北缘形成了一个向北逐渐变深的裂谷盆地,此时大洪山地区的莲沱组为围绕鄂北古隆起分布的冲积扇沉积,向北则变为以随县群为代表的滨浅海—半深海沉积。

关键词：扬子陆块北缘莲沱组凝灰岩锆石U-Pb定年新元古代地质调查工程

针刺对干眼兔角膜形态学及角膜组织NF-κB信号通路的影响

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眼科新进展 2024年第3期44卷 173-177页

作者：丁宁韦庆波刘成勇邓伟民徐倩高卫萍南京中医药大学江苏省南京市210008 南京中医药大学附属医院江苏省南京市210029 东南大学附属中大医院江苏省南京市210029

目的探讨针刺对干眼兔角膜形态学及角膜组织NF-κB信号通路的影响,分析针刺对干眼的作用机制。方法取雌雄不拘的健康新西兰兔24只,随机分为空白组、模型组、针刺组、假针刺组,每组6只。空白组为正常对照组,不加任何处理;其余3组动物每... 详细信息

目的探讨针刺对干眼兔角膜形态学及角膜组织NF-κB信号通路的影响,分析针刺对干眼的作用机制。方法取雌雄不拘的健康新西兰兔24只,随机分为空白组、模型组、针刺组、假针刺组,每组6只。空白组为正常对照组,不加任何处理;其余3组动物每天800、 1100、1400和1800时于皮下注射氢溴酸东莨菪碱2.0 mg·kg-1,连续35 d直至实验结束。假针刺组:于造模后第22天给予假针刺治疗(睛明BL1、攒竹BL2、丝竹空SJ23、太阳穴EX-HN5、瞳子髎GB1),钝针头点刺穴位,不刺进穴位,每天1次,连续14 d。针刺组:于造模成功后第22天给予针刺治疗,穴位同假针刺组。造模后第0、21、28、35天分别进行角膜荧光素染色,第35天进行角膜共焦显微镜检查,之后处死动物,在光学显微镜、透射电子显微镜下观察角膜形态学变化,采用Western blot检测角膜组织NF-κB蛋白的表达。结果与模型组相比,造模后第28、35天,针刺组、空白组兔角膜荧光素染色评分均减小,差异均有统计学意义(均为P<0.05)。造模后第35天共焦显微镜检查结果显示,模型组和假针刺组与其他组相比,兔角膜基质层出现大量球状免疫细胞和边界不清大小不规律的活化基质层细胞,可见具有不规则细胞间间隙的区域,存在炎症;针刺组基质层细胞形态得到改善,细胞呈轻微激活状态,角膜神经形态未见明显异常。造模后第35天光学显微镜检查结果显示,模型组和假针刺组兔角膜组织表面可见角化过度的扁平上皮细胞,淋巴细胞浸润,局灶上皮细胞层数增多,表面上皮细胞脱落;针刺组角膜上皮有接近4~6层上皮细胞,上皮脱落减少,与模型组相比,淋巴细胞浸润减少。造模后第35天透射电子显微镜检查结果显示,模型组和假针刺组兔角膜上皮细胞出现异常的微绒毛结构和上皮细胞缺失,细胞间隙增宽,粗面内质网严重扩张,桥粒解体伴随线粒体肿胀;针刺组上皮细胞微绒毛结构稀疏且短,仍见局部缺失,粗面内质网轻度扩张,线粒体未见明显肿胀。造模后第35天Western blot检测结果显示,与空白组相比,模型组、假针刺组p-NF-κB p65表达均上调(均为P<0.05);与模型组、假针刺组相比,针刺组p-NF-κB p65表达均下调(均为P<0.05)。结论针刺可以抑制NF-κB信号通路从而发挥抗炎作用,改善兔干眼模型角膜炎症和损伤。

关键词：针刺干眼角膜形态学 NF-κB信号通路

基于循证医学原则探讨针刺双盲试验装置与举例

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中华中医药杂志 2024年第3期39卷 1566-1569页

作者：宁百乐邓启粤吴倩王舢泽梁雪松符文彬广州中医药大学第二临床医学院广州510120 广东省中医院广州510120

循证医学中强调随机对照临床试验是目前评估医学干预措施临床效果最严谨、最可靠的科学方法,但目前针刺试验面临着棘手的问题——如何设计规范的安慰针对照组。针对此问题,本团队研发了一款针刺临床双盲试验装置,该装置有如下特点:安慰... 详细信息

循证医学中强调随机对照临床试验是目前评估医学干预措施临床效果最严谨、最可靠的科学方法,但目前针刺试验面临着棘手的问题——如何设计规范的安慰针对照组。针对此问题,本团队研发了一款针刺临床双盲试验装置,该装置有如下特点:安慰组与治疗组所用装置外观一致,操作简易,对操作者及受试者都有良好的蒙蔽作用;装置由针管与球体的螺纹连接,其可实现360°试验角度,满足斜刺等多角度针刺试验;装置可调节针刺深度,也满足留针要求,可应用于针刺手法临床试验;可配合已有针具,一根针一个器具使用,降低针刺感染等风险,适用范围广。本装置可在临床试验研究中推广应用,为针刺双盲试验中安慰针组设计提供思路。

关键词：临床随机试验安慰组针刺循证医学双盲试验装置

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铁尾矿中重金属释放的矿物学影响研究

环境科学学报 2024年第5期44卷 457-465页

作者：邓金环宁寻安邱国强张鼎元崔喜庆叶文盛彭岱王逸广东工业大学环境科学与工程学院广州510006 广东省环境催化与健康风险控制重点实验室广州510006

铁尾矿中重金属的迁移转化会对环境构成长期威胁,矿物学因素与尾矿中重金属的稳定性密切相关.本研究以广东某多金属铁尾矿为研究对象,采用自动矿物解离分析仪(MLA)、连续提取和模拟浸出试验,从矿物学角度揭示了尾矿中有害金属释放的潜... 详细信息

铁尾矿中重金属的迁移转化会对环境构成长期威胁,矿物学因素与尾矿中重金属的稳定性密切相关.本研究以广东某多金属铁尾矿为研究对象,采用自动矿物解离分析仪(MLA)、连续提取和模拟浸出试验,从矿物学角度揭示了尾矿中有害金属释放的潜在影响因素.结果表明,褐铁矿(59.56%)和赤铁矿(22.15%)等含铁矿物为主要矿物相,与重金属矿物连生关系复杂.在模拟浸出中,铅和锰在酸雨、植物吸收和人体吸收等情境下释放潜力较高,尤其是细粒部分,分别含有46.98%和43.26%的潜在可利用态.含铅、锰的主要矿物为水磷铁铅石、砷铅铁矿和硬锰矿.褐铁矿对锌和铜的固定起关键作用,超过90%的锌和铜以类质同象的形式被束缚于褐铁矿中,限制其迁移浸出.本研究结果为库区铁尾矿污染控制和风险管理提供了重要依据.

关键词：铁尾矿矿物学有害金属矿物解离释放潜能

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智慧校园信息共享服务平台的设计与应用

信息与电脑 2024年第3期36卷 235-238页

作者：农嘉韦宁梁婷邓力文广西生态工程职业技术学院广西柳州1545001

智慧校园信息共享服务平台是现代教育体系的重要组成部分,能够为学校和教育工作者提供全方位的信息支持。文章重点探讨了智慧校园信息共享服务平台的设计与应用,以期促进教育信息化的进一步发展。

关键词：智慧校园信息共享服务平台

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2022年中国粉末涂料行业年度报告

涂层与防护 2024年第2期45卷 57-64页

作者：吴向平宁波李馨邓凯徐萍中国化工学会涂料涂装专业委员会全国涂料工业信息中心江苏常州213016

以中国化工学会涂料涂装专业委员会和全国涂料工业信息中心的行业统计数据、国家统计局发布的数据及行业调研为基础,阐述了2022年我国粉末涂料行业运行概况,并提出了未来行业发展建议。

关键词：粉末涂料行业调研统计数据固化体系涂装专利建议

Photovoltaic,thermoelectric and electromagnetic generation technologies applied in power systems for mobile unmanned systems

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Science China(Technological Sciences) 2023年第3期66卷 599-629页

作者： DING ning WANG XiangYang XIAN XiaoYang CAI YeYun LIU DaoMing deng Fang Key Laboratory of Intelligent Control and Decision of Complex Systems School of AutomationBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

Unmanned systems are increasingly adopted in various fields,becoming an indispensable technology in daily life.Power systems are the lifeblood of unmanned systems,and affect the working time and task complexity.However,traditional power systems,such as batteries and fuels have a fixed capacity.Therefore,once the power supply is exhausted and cannot be replenished in time,the unmanned systems will stop working.Hence,researchers have increasingly begun paying attention to renewable energy generation technologies.The principles,advantages,and limitations of renewable energy generation technologies are different,and their application effects in different unmanned systems are also uneven.This paper presents a comprehensive study of the application and development status of photovoltaic,thermoelectric,and magnetoelectric generation technologies in four kinds of unmanned systems,including space,aviation,ground,and water,and then summarizes the adaptability and limitations of the three technologies to different systems.Moreover,future development directions are predicted to enhance the reliability of renewable energy generation technologies in unmanned systems.This is the first study to conduct a comprehensive and detailed study of renewable energy generation technologies applied in unmanned systems.The present work is critical for the development of renewable energy generation technologies and power systems for unmanned systems.

关键词： unmanned system renewable energy generation technology photovoltaic generation thermoelectric generation electromagnetic generation

Hydrogel-based catalysts for hydrogen generation by the hydrolysis of B–H compounds under external physical fields

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Journal of Energy Chemistry 2023年第11期86卷 518-535,I0011页

作者： Chunling Qin Wenliu Wu Hassanien Gomaa Shuai Wu Cuihua An Qibo deng ning Hu Key Laboratory of Hebei Province on Scale-span Intelligent Equipment Technology School of Mechanical Engineeringand School of Materials Science and EngineeringHebei University of TechnologyTianjin 300401China State Key Laboratory of Reliability and Intelligence Electrical Equipment Hebei University of TechnologyTianjin 300130China Advanced Equipment Research Institute Co. Ltd.Of HEBUTTianjin 300401China

Hydrogen is a popular clean high-energy-density fuel.However,its utilization is limited by the challenges toward low-cost hydrogen production and safe hydrogen storage.Fortunately,these issues can be addressed using promising hydrogen storage materials such as B–H compounds.Hydrogen stored in B–H compounds can be released by hydrolysis at room temperature,which requires catalysts to increase the rate of the reaction.Recently,several effective approaches have been developed for hydrogen generation by catalyzing the hydrolysis of B–H compounds.This review summarizes the existing research on the use of nanoparticles loaded on hydrogels as catalysts for the hydrolysis of B–H compounds.First,the factors affecting the hydrolysis rate,such as temperature,p H,reactant concentration,and type of nano particles,were investigated.Further,the preparation methods(in situ reduction,one-pot method,template adsorption,etc.)for the hydrogel catalysts and the types of loaded catalysts were determined.Additionally,the hydrogel catalysts that can respond to magnetic fields,ultrasound fields,optical fields,and other physical fields are introduced.Finally,the issues and future developments of hydrogel-based catalysts are discussed.This review can inspire deeper investigations and provide guidance for the study of hydrogel catalysts in the field of hydrogen production via hydrolysis.

关键词： Hydrogel Nanoparticlec atalyst B-H compounds Hydrolysis reaction External physical field