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Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation

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Neural Regeneration Research 2022年第10期17卷 2102-2107页

作者： Liang Liu Quan-jun deng Department of Neurosurgery Tianjin Institute of NeurologyTianjin Medical University General HospitalTianjinChina

Extracellular vesicles are composed of fragments of exfoliated plasma membrane,organelles or nuclei and are released after cell activation,apoptosis or ***-derived extracellular vesicles are the most abundant type of extracellular vesicle in the blood of patients with traumatic brain *** laboratory and clinical evidence shows that platelet-derived extracellular vesicles play an important role in coagulopathy and inflammation after traumatic brain *** review discusses the recent progress of research on platelet-derived extracellular vesicles in coagulopathy and inflammation and the potential of platelet-derived extracellular vesicles as therapeutic targets for traumatic brain injury.

关键词： angiogenesis clotting factors coagulopathy delivery inflammation platelet-derived extracellular vesicles review target traumatic brain injury

Auto-ignition and stabilization mechanism of diluted H_2 jet flame

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第2期12卷 154-161页

作者： Wei FENG Zhi-jun WU jun deng Li-guang LI Key Laboratory for Power Machinery and Engineering of Ministry of Education Shanghai Jiao Tong University Shanghai 200030 China School of Automotive Studies Tongji University Shanghai 200092 China

The controllable active thermo-atmosphere combustor(CATAC) has become a utilizable and effective facility because it benefits the optical diagnostics and modeling. This paper presents the modeling research of the auto-ignition and flames of the H2/N2(H2/CH4/N2,or H2/H2O2/N2) mixture on a CATAC,and shows curves varying with temperatures of auto-ignition delay,the height of the site of auto-ignition of lifted flames,and flame lift-off height. The results of auto-ignition delay and the lift-off height are compared the experimental results to validate the model. A turning point can be seen on each curve,identified with criterion temperature. It can be concluded that when the co-flow temperature is higher than the criterion temperature,the auto-ignition and lifted flame of the mixture are not stable. Conversely,below the criterion temperature,the mixture will auto-ignite in a stable fashion. Stabilization mechanisms of auto-ignition and lifted flames are analyzed in terms of the criterion temperature.

关键词： Simulation Combustor Auto-ignition Jet flame Stabilization mechanism

基于TOPSIS法综合评价法半夏抗慢性阻塞性肺疾病的品质研究

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中国药理学通报 2025年第1期41卷 138-146页

作者：邓军黄先菊李竣李啟恩麦合苏木·艾克木申李丹中南民族大学药学院湖北武汉430074 青海大学藏医药研究中心藏医学院藏药新药开发国家重点实验室青海西宁840016 新疆医科大学维吾尔医学院新疆乌鲁木齐830017

目的通过离散型逼近理想解排序法(technique for order preference by similarity to an ideal solution,TOPSIS)评估6批法半夏醇提物的体外抗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)作用,建立法半夏综合品质评价新方法。方法采用香烟烟雾提取物(cigarette smoke extract,CSE)和脂多糖(lipopolysaccharide,LPS)构建Beas-2b人正常肺细胞的COPD模型,并使用MTT法测定生半夏及6批法半夏醇提取物的毒性和药效浓度,同时计算EC 50、IC 50;再由qRT-PCR、超氧化物歧化酶(superoxide dismutase,SOD)试剂盒测定相关指标;最后通过TOPSIS法对生半夏和法半夏进行多指标综合评价。结果根据IC 50值,得出各批次样品如下毒性排序:生半夏>法半夏④>法半夏①>法半夏⑤>法半夏③>法半夏⑥>法半夏②。通过qRT-PCR法验证得出,与模型组对比,各半夏给药组的TNF-α、IL-6和IL-8的表达均有不同程度的下调;并且在给药后所有给药组的SOD的含量均降低。将所有数据进行归一化处理,通过TOPSIS分析,得到药效综合排序结果如下:法半夏⑥>法半夏⑤>法半夏②>法半夏①>法半夏③>法半夏④>生半夏。结论不同半夏醇提物均可抑制LPS和CSE诱导的炎症和氧化应激,综合评价第⑥批法半夏的质量最好,且TOPSIS法可以作为一种药材的综合品质评定方法,为市面上参差不齐的药材质量提供质控思路。

关键词：法半夏生半夏 COPD Beas-2b细胞 TOPSIS 香烟烟雾提取物

Influence of aeration and initial water thickness on axial velocity attenuation of jet flows

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第5期14卷 362-370页

作者： Wang-ru WEI jun deng Bin LIU State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Hydro-China Kunming Engineering Corporation

With the development of ski-jump energy dissipation for high and large discharge among the hydraulic projects,the effects of characteristics of water flow on energy dissipation are increasingly *** the present study,the effects of aeration and the initial water thickness on axial velocity attenuation of jet flow were analyzed,using variance analysis and numerical calculated *** the analysis of test data,both of the air concentration and initial water thickness are sensitive factors for the axial velocity attenuation of jet flow along the axial way,and there is no significant interaction effect between the aeration and initial water *** has a more significant effect on the axial velocity attenuation of jet *** the initial water thickness of jet flow can reduce the length of jet core,and make the initial position of axial velocity attenuation closer to the nozzle *** numerical calculation results show that aeration can contribute to the enhancement of entrainment ability of jet flow,which may improve the interaction between jet flow and *** ski-jump energy dissipation among the hydraulic projects,combining aeration with decreasing initial water thickness of jet flow is an effective way to enhance the rate of axial velocity attenuation.

关键词： Velocity Aeration Initial water thickness Jet flows

Biological identity of nanomaterials:Opportunities and challenges

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Science China Chemistry 2013年第11期56卷 1533-1541页

作者： deng jun YU DaHai GAO ChangYou MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

The emergence of nanoparticles(NPs)has attracted tremendous interest of the scientific community for decades due to their unique properties and potential applications in diverse areas,including drug delivery and *** novel NPs have been synthesized and used to reduce drug toxicity,improve bio-availability,prolong circulation time,control drug release,and actively target to desired cells or ***,clinical translation of NPs with the goal of treating particularly challenging diseases,such as cancer,will require a thorough understanding of how the NP properties influence their fate in biological systems,especially in *** efforts have been paid to studying the interactions and mechanisms of NPs and *** deliberately designed,the NPs in contact with biological fluids are rapidly covered by a selected group of biomolecules especially proteins to form a corona that interacts with biological *** this view,the recent development of NPs in drug delivery and the interactions of NPs with cells and proteins are *** understanding the protein-NP interactions,some guidelines for safety design of NPs,challenges and future perspectives are discussed.

关键词： nanoparticles carriers cellular uptake protein corona

A Modified Landweber Iteration for General Sideways Parabolic Equations

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 727-738页

作者： Jin-bo LIU You-jun deng Department of Mathematics Changsha University of Science and Technology Changsha 410076 China School of Mathematical Sciences and Computing Technology Central South University Changsha Hunan 410075China

Abstract In this paper, we introduce a modified Landweber iteration to solve the sideways parabolic equation, which is an inverse heat conduction problem （IHCP） in the quarter plane and is severely ill-posed. We shall show that our method is of optimal order under both a priori and a posteriori stopping rule. Furthermore, if we use the discrepancy principle we can avoid the selection of the a priori bound. Numerical examples show that the computation effect is satisfactory.

关键词： inverse heat conduction problem sideways parabolic equation Landweber iteration,discrepancy principle

Estimation of time-varying channels for pilot-assisted OFDM systems

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The Journal of China Universities of Posts and Telecommunications 2007年第2期14卷 94-98页

作者： TANG Tian deng Gang JIANG jun School of Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

Orthogonal frequency division multiplexing （OFDM） systems encounter performance degradations because of the time-varying （TV） channels common in wireless environments. The channel variations within one OFDM symbol introduce intercarrier interference. In this case, the frequency domain channel matrix is no longer diagonal, hence the corresponding channel estimation is challenging. In this article, two novel TV channel estimation approaches are proposed for the pilot-assisted OFDM systems, where the channel is approximated by the high-order linear model or the piece-wise linear model in time domain. The least square estimation is derived for the two kinds of channel approximations. The simulation is performed based on realistic TV channels with a fairly high Doppler spread. The results show the significant decreasing of the estimation mean square error using the proposed approaches.

关键词： OFDM pilot-assisted modulation TV channels channel estimation

Characteristics of air flow driven by the free surface of the open channel

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Journal of Hydrodynamics 2022年第1期34卷 69-75页

作者： Jing Gong jun deng Wang-ru Wei Wei-wei Li State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065China

Spillway tunnels are a key structure in large-scale water conservancies. The high-head water inlet makes the water surface-velocity extremely high, and the air is driven by the free surface of the water to move downstream. This paper studies the air velocity distribution above the water surface through the model tests, under the assumption that the airflow is a turbulent boundary layer with a rough interface, and the influence of the water depth and the water velocity on the air velocity distribution is analyzed. It is shown that the air velocity is in an exponential distribution. As the measured position moves upward, the air velocity gradually decreases, and the gradient decreases. When the water depth increases, the air velocity increases but with the same distribution form. With the increase of the water surface-velocity, the air velocity at the same measuring point increases, the variation range near the water surface is large, the air boundary layer height increases slightly, and the index coefficient of the air velocity distribution function decreases. Through numerical fitting, the calculation formula of the air boundary layer thickness at different water surface velocities is obtained, along with the numerical value of the index coefficient.

关键词： Open channel air velocity distribution air boundary layer height index coefficient

An Innovative Argon/Miller Power Cycle for Internal Combustion Engine: Thermodynamic Analysis of its Efficiency and Power Density

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Automotive Innovation 2023年第1期6卷 76-88页

作者： Chenxu Wang Shaoye Jin jun deng Liguang Li School of Automotive Studies Tongji UniversityShanghai 200092China

Increasing efficiency and reducing emissions are fundamental approaches to achieving peak carbon emissions and carbon neutrality for the transportation and power *** Argon power cycle(APC)is a novel concept for high efficiency and zero ***,APC faces the challenges of severe knock and low power density at high *** elevate efficiency and power density simultaneously of APC,the Miller cycle is applied and combined with *** calculation method is based on a modification of the previous thermodynamic *** mixture of hydrogen and oxygen is controlled in the stoichiometric *** results indicate that to obtain a thermal conversion efficiency of 70%,in the Otto cycle,the compression ratio and the AR(argon molar ratio in the argon-oxygen mixture)could be 9 and 95%,*** comparison,for the Miller cycle,these two parameters only need to be 7 and 91%.A lower compression ratio can reduce the negative effect of knock,and a reduced AR increases the power density by 66%with the same *** improvement effect is significant when the expansion-compression ratio is ***,increasing the expansion-compression ratio is more effective in the argon-oxygen mixture than in the nitrogen–oxygen *** the next-generation Argon/Miller power cycle engine,the feasible design to achieve the indicated thermal efficiency of 58.6%should be a compression ratio of 11,an expansion-compression ratio of 1.5,and an AR of 91%.

关键词： Argon power cycle engine Miller cycle Hydrogen Thermal conversion efficiency Power density