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Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin

World Journal of Gastroenterology 2011年第33期17卷 3836-3841页

作者： Mohamed A Fahim Hazem Kataya Rkia El-Kharrag dena am amer Basel al-Ramadi Sherif M Karam Department of Physiology Faculty of Medicine and Health SciencesUAE UniversityAl AinPO Box 17666United Arab Emirates Department of Biology Faculty of ScienceUAE UniversityAl AinPO Box 17666United Arab Emirates Department of Anatomy Faculty of Medicine and Health SciencesUAE UniversityAl AinPO Box 17666United Arab Emirates Department of Microbiology and Immunology Faculty of Medicine and Health SciencesUAE UniversityAl AinPO Box 17666United Arab Emirates

AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)***:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic *** label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before *** stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU ***:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day *** ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined *** analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by *** mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin ***:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation.

关键词： Gastrointestinal cell proliferation Gastrointestinal mucosal damage Ghrelin

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