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circPVT1 promotes silica-induced epithelial-mesenchymal transition by modulating the miR-497-5p/TCF3 axis

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Journal of Biomedical Research 2024年第2期38卷 163-174,I0011-I0015页

作者： Siyun Zhou Yan Li Wenqing Sun Dongyu Ma Yi Liu demin cheng Guanru Li Chunhui Ni Department of Occupational Medical and Environmental Health Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Biomedical Publications Center Nanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversityNanjingJiangsu 211166China

Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary ***,whether circRNA is involved in the process remains *** present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying *** found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial *** isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the *** immunoprecipitation assay and RNA pull-down experiment indicated that cytoplasmic-localized circPVT1 was capable of binding to ***,we found that miR-497-5p attenuated the silica-induced EMT process by targeting transcription factor 3(TCF3),an E-cadherin transcriptional repressor,in the silica-treated epithelial ***,these results reveal a novel role of the circPVT1/miR-497-5p/TCF3 axis in the silica-induced EMT process in lung epithelial *** validated,this finding may provide a potential theoretical basis for the development of interventions and treatments for pulmonary fibrosis.

关键词： silicosis epithelial-mesenchymal transition circPVT1 miR-497-5p TCF3

Fe/C微电解耦合H_2O_2氧化处理页岩气钻井废水

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环境工程学报 2016年第11期10卷 6473-6478页

作者：杨德敏夏宏程方平袁建梅国土资源部页岩气资源勘查重点实验室(重庆地质矿产研究院) 重庆400042 重庆市页岩气资源与勘查工程技术研究中心(重庆地质矿产研究院) 重庆400042 油气资源与探测国家重点实验室重庆页岩气研究中心重庆400042

采用Fe/C微电解耦合H_2O_2工艺对经复合混凝处理后的某页岩气井钻井废水进行处理,考察了Fe/C质量比、Fe/C投加量、溶液pH值、气水比、H_2O_2(30%)投加量和反应时间对COD去除率的影响。结果表明,耦合工艺最佳实验条件为Fe/C质量比1∶1、F... 详细信息

采用Fe/C微电解耦合H_2O_2工艺对经复合混凝处理后的某页岩气井钻井废水进行处理,考察了Fe/C质量比、Fe/C投加量、溶液pH值、气水比、H_2O_2(30%)投加量和反应时间对COD去除率的影响。结果表明,耦合工艺最佳实验条件为Fe/C质量比1∶1、Fe/C投加量500 g·L-1、溶液pH值2.5、气水比20∶1、H_2O_2(30%)投加量6 m L·L-1、反应时间120 min。最佳工艺条件下,页岩气钻井废水经处理后,出水COD质量浓度为89.54 mg·L^(-1),去除率达到81.60%。

关键词： Fe/C微电解 H2O2 页岩气钻井废水耦合工艺

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页岩气压裂返排废水的混凝处理效能研究

工业水处理 2016年第9期36卷 32-34页

作者：杨德敏夏宏程方平国土资源部页岩气资源勘查重点实验室(重庆地质矿产研究院) 重庆400042 重庆市页岩气资源与勘查工程技术研究中心(重庆地质矿产研究院) 重庆400042 油气资源与探测国家重点实验室重庆页岩气研究中心重庆400042

对页岩气压裂返排废水进行了混凝处理,研究了聚合氯化铝、硫酸亚铁等不同混凝剂对压裂返排废水COD的去除效果,考察了p H、混凝剂投加量和助凝剂投加量对COD去除率的影响。结果表明:在复配混凝剂为硫酸亚铁和聚合氯化铝(质量比为1∶1),... 详细信息

对页岩气压裂返排废水进行了混凝处理,研究了聚合氯化铝、硫酸亚铁等不同混凝剂对压裂返排废水COD的去除效果,考察了p H、混凝剂投加量和助凝剂投加量对COD去除率的影响。结果表明:在复配混凝剂为硫酸亚铁和聚合氯化铝(质量比为1∶1),混凝剂投加量为12 000 mg/L,p H为8.5,助凝剂投加量为10 mg/L的最佳混凝处理条件下,压裂返排废水的COD去除率为62.49%,出水COD由1 984.32 mg/L降至744.32 mg/L。

关键词：页岩气压裂返排废水复配混凝化学需氧量

Jellyfish bio-inspired Fe@CNT@CuNC derived from ZIF-8 for cathodic oxygen reduction

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Nano Research 2024年第4期17卷 2352-2359页

作者： Kai cheng Zequan Liu demin Jiang Min Song Yuqiao Wang Research Center for Nano Photoelectrochemistry and Devices School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China Yangtze River Delta Carbon Neutrality Strategy Development Institute Southeast UniversityNanjing 210096China School of Energy and Environment Southeast UniversityNanjing 210096China

Biomimetics provides guidance to design and synthesize advanced catalysts for oxygen reduction reaction in microbial fuel cells(MFCs).Herein,jellyfish-inspired Fe clusters on carbon nanotubes connected with CuNC(Fe@CNT@CuNC)were designed and prepared by using zeolitic imidazolate framework(ZIF)-8 precursors to imitate the organic texture and function of *** antibacterial effect of Cu^(+)ions depressed the growth of cathode biofilm to ensure rapid mass *** clusters and CuNC connected by CNTs accelerated the electron transfer from Fe to *** optimization of oxygen adsorption was caused by electron redistribution between sites of Fe and ***-like catalysts achieved a half-wave potential of 0.86 V and onset potential of 0.95 V *** hydrogen electrode(RHE).MFCs gained the maximum power density of 1600 mW·m^(-2) after 500 h *** work provides insights into the special design of advanced catalysts based on bio-inspiration and biomimetics.

关键词： bio-inspiration oxygen reduction reaction antibacterial ability microbial fuel cells density functional theory(DFT)rational design

Sodium fluoride induces apoptosis through reactive oxygen species-mediated endoplasmic reticulum stress pathway in Sertoli cells

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Journal of Environmental Sciences 2015年第4期27卷 81-89页

作者： Yang Yang Xinwei Lin Hui Huang demin Feng Yue Ba Xuemin cheng Liuxin Cui Department of Environmental Health College of Public Health Zhengzhou University Department of Nephrology 152 Hospital of PLA

Excessive fluoride exposure is known to contribute to reproductive system dysfunction,ultimately leading to pathological damage and apoptosis in cells. Although both oxidative and endoplasmic reticulum（ER） stresses have been implicated in fluorosis, the signaling pathways and their roles in sodium fluoride（Na F）-induced apoptosis of Sertoli cells have been sparsely described. In this study, oxidative damage, ER stress, and apoptosis were analyzed after Sertoli cells were treated with varying doses of Na F for 24 hr. Moreover, the antioxidant N-acetylcysteine（NAC） and pro-apoptotic transcription factor CHOP knockdown were used to clarify the precise interplay between reactive oxygen species（ROS）, ER stress and their roles in NaF-induced apoptosis in Sertoli cells. The present study indicated that NaF significantly decreased cell viability and induced apoptosis in Sertoli cells. In addition, NaF exposure facilitated the accumulation of ROS and increased nuclear translocation of nuclear factor erythroid 2-related factor 2（Nrf2） in Sertoli cells. Treatment with NAC caused remarkable recovery from these NaF-induced responses. Meanwhile, excessive NaF triggered ER stress as evidenced by up-regulated glucose-regulated protein 78 k Da（GRP78）, PKR-like ER kinase（PERK）, phosphorylation of eukaryotic translation initiation factor 2α（p-eI F2α） and CCAAT/enhancer-binding protein-homologous protein（CHOP）, without affecting total eukaryotic translation initiation factor 2α（e IF2α）. NAC effectively blocked the activation of ER stress, suggesting that Na F-induced ROS is an early event that triggers ER stress. Taken together, the results demonstrate that the ROS-mediated ER stress pathway is the crucial mechanistic event involved in NaF-induced apoptosis of Sertoli cells.

关键词： Sodium fluoride Apoptosis Reactive oxygen species Endoplasmic reticulum stress Sertoli cell

Experimental Study on Interaction Between Degrees of Freedom in a Wave Buoy

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Journal of Ocean University of China 2019年第6期18卷 1256-1264页

作者： HUANG Shuting SHI Hongda CAO Feifei TAN Junzhe cheng Haixun LI demin LIU Shangze GONG Haoxiang TAO Ji College of Engineering Ocean University of ChinaQingdao 266100China Shandong Provincial Key Laboratory of Ocean Engineering Qingdao 266100China

Increasing degrees of freedom(DOFs)is a useful way to raise the power capture efficiency of oscillating wave energy ***,this study proposes a buoy with three DOFs,which are surge,heave,and *** hydrodynamic performance and power capture efficiency of the buoy is physically *** of unidirectional and coupled motions are compared to analyze the interaction effect between freedoms under conditions with and without power take-off *** capture width ratio and corresponding growth rates are also *** show that the buoy makes a periodic sinusoidal(or approximate)movement in every *** effect can cause an increase in the amplitude in one DOF and a decrease in the amplitudes of the *** phenomenon shows that the kinematic energy of the buoy redistributes to all DOFs compared with the unidirectional *** DOFs can improve the power absorption of the buoy in most cases,but the number of DOFs is not the more the better.

关键词： wave energy oscillating buoy multiple degrees of freedom

Clinical significance of germline copy number variation in susceptibility of human diseases

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Journal of Genetics and Genomics 2018年第1期45卷 3-12页

作者： Liwen Hu Xinyue Yao Hairong Huang Zhong Guo Xi cheng Yang Xu Yi Shen Biao Xu demin Li Department of Cardiothoracic Surgery Jinling Hospital School of Clinical Medicine Nanjing University Institute of Laboratory Medicine Jinling Hospital School of Clinical Medicine Nanjing University

Germline copy number variation （CNV） is considered to be an important form of human genetic poly- morphisms. Previous studies have identified amounts of CNVs in human genome by advanced technologies, such as comparative genomic hybridization, single nucleotide genotyping, and high-throughput sequencing. CNV is speculated to be derived from multiple mechanisms, such as nonallelic homologous recombination （NAHR） and nonhomologous end-joining （NHEJ）. CNVs cover a much larger genome scale than single nucleotide polymorphisms （SNPs）, and may alter gene expression levels by means of gene dosage, gene fusion, gene disruption, and long-range regulation effects, thus affecting individual phenotypes and playing crucial roles in human pathogenesis. The number of studies linking CNVs with common complex diseases has increased dramatically in recent years. Here, we provide a comprehensive review of the current understanding ofgermline CNVs, and summarize the association of germline CNVs with the susceptibility to a wide variety of human diseases that were identified in recent years. We also propose potential issues that should be addressed in future studies.

关键词： Copy number variation Susceptibility Risk Cancer Neuropsychological disorders

Mg AmorphousZr_(0.9)Ti_(0.1)(Ni_(0.57)Mn_(0.28)V_(0.1)Co_(0.05))_(2.1)Composite for Hydrogen Storage

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Journal of Materials Science & Technology 2003年第2期19卷 141-144页

作者： Haiyan LENG, demin CHEN, Manqi LU, Haifeng ZHANG, Huiming cheng and Ke YANGInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

The reactive mechanical alloying (RMA) method was used to produce Mg-40 wt pet amorphous Zr0.9Ti0.1(Nio.57-Mn0.28\/***.o5)2.i composite in this study, and the absorption/desorption property of the composite was improved remarkably. The composite possessed excellent kinetic properties even at moderate temperature (393 K) without activation. Owing to the formation of the embrittle MgH2, the reactive mechanical milling process reduced the particle size of Mg and made the composite phase being highly efficiently distributed, which determined the excellent hydriding properties of the composite.

关键词： Mg Hydrogen storage material RMA Amorphous

An amorphous carbon-graphite composite cathode for long cycle life rechargeable aluminum ion batteries

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Journal of Materials Science & Technology 2018年第6期34卷 983-989页

作者： Jiang Wei Wei Chen demin Chen Ke Yang University of Chinese Academy of Sciences Beijing 100049 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Natural graphite is investigated as the cathode for aluminum ion batteries in recent years. However, some drawbacks of the natural graphite such as severe volume swelling shorten its lifetime, In this work, we prepared a composite material by depositing an amorphous carbon on the graphite paper, The composite was used as a cathode to study the electrochemical performance in aluminum ion batteries. The charge/discharge results showed that the composite could exhibit a longer cycle life than the graphite paper, Electrochemical analyses demonstrated that the interface between the amorphous carbon and the graphite paper made a major contribution to the improvement of the cycling stability.

关键词： Amorphous carbon Graphite paper Aluminum ion batteries Cathode Ionic liquid Interface Phase equilibrium