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急性血糖波动对N末端B型利钠肽前体评估心功能的影响

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河北医药 2024年第15期46卷 2316-2319页

作者：刘阔呼海娟刘德敏王倩张力辉崔炜河北医科大学第二医院河北省心脑血管病研究所心内一科石家庄市050000 河北医科大学第二医院河北省心脑血管病研究所内分泌科石家庄市050000

目的研究短时间内血糖浓度波动对NT-proBNP水平的影响。方法选取2019年9~10月进行OGTT试验的住院患者32例。分别检测每位患者在空腹时、OGTT试验开始后30 min、60 min、120 min和180 min时血浆NT-proBNP、血糖、胰岛素和C-肽的水平。... 详细信息

目的研究短时间内血糖浓度波动对NT-proBNP水平的影响。方法选取2019年9~10月进行OGTT试验的住院患者32例。分别检测每位患者在空腹时、OGTT试验开始后30 min、60 min、120 min和180 min时血浆NT-proBNP、血糖、胰岛素和C-肽的水平。通过Pearson和Spearman相关分析探究个体NT-proBNP水平与血糖浓度的相关性,应用单因素重复测量方差分析和广义线性混合模型进一步分析检测时间、血糖、胰岛素和C-肽对NT-proBNP水平的影响。结果相关分析表明,在32例患者中,只有5例患者的NT-proBNP水平与血糖浓度有相关性(P0.05)。结论急性血糖浓度波动不影响NT-proBNP水平从而不影响NT-proBNP对心功能的评估。

关键词： N末端B型利纳肽血糖心功能

Jellyfish bio-inspired Fe@CNT@CuNC derived from ZIF-8 for cathodic oxygen reduction

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Nano Research 2024年第4期17卷 2352-2359页

作者： Kai Cheng Zequan liu demin Jiang Min Song Yuqiao Wang Research Center for Nano Photoelectrochemistry and Devices School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China Yangtze River Delta Carbon Neutrality Strategy Development Institute Southeast UniversityNanjing 210096China School of Energy and Environment Southeast UniversityNanjing 210096China

Biomimetics provides guidance to design and synthesize advanced catalysts for oxygen reduction reaction in microbial fuel cells(MFCs).Herein,jellyfish-inspired Fe clusters on carbon nanotubes connected with CuNC(Fe@CNT@CuNC)were designed and prepared by using zeolitic imidazolate framework(ZIF)-8 precursors to imitate the organic texture and function of *** antibacterial effect of Cu^(+)ions depressed the growth of cathode biofilm to ensure rapid mass *** clusters and CuNC connected by CNTs accelerated the electron transfer from Fe to *** optimization of oxygen adsorption was caused by electron redistribution between sites of Fe and ***-like catalysts achieved a half-wave potential of 0.86 V and onset potential of 0.95 V *** hydrogen electrode(RHE).MFCs gained the maximum power density of 1600 mW·m^(-2) after 500 h *** work provides insights into the special design of advanced catalysts based on bio-inspiration and biomimetics.

关键词： bio-inspiration oxygen reduction reaction antibacterial ability microbial fuel cells density functional theory(DFT)rational design

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青藏高原形成演化动力机制及其远程效应

地学前缘 2024年第1期31卷 154-169页

作者：刘德民王杰姜淮赵悦郭铁鹰杨巍然中国地质大学(武汉)地球科学学院湖北武汉430074 中国地震局地震研究所湖北武汉430071 湖北省地震局湖北武汉430071

作为第三极的青藏高原的形成是新生代以来的地球节律构造事件中最典型、最显著的新构造运动的结果,其构造地貌特征及其重要性,内部单元组成,构造演化历程及动力机制,以及对周边盆地乃至整个中国大陆的影响及远程效应至今一直是学术关注... 详细信息

作为第三极的青藏高原的形成是新生代以来的地球节律构造事件中最典型、最显著的新构造运动的结果,其构造地貌特征及其重要性,内部单元组成,构造演化历程及动力机制,以及对周边盆地乃至整个中国大陆的影响及远程效应至今一直是学术关注的焦点。本文重新圈定了青藏高原构造地貌范围,确立了其在全球构造中的地位。青藏高原的远程效应向南北两侧延伸,北到北冰洋,南到太平洋,总体上围绕东经105°经线穿越了整个亚洲大陆,本文采用东经105°所在经线大圆作为划分东西半球的分界线,该线以东为东半球,以西为西半球。青藏高原处于全球最大、最重要的南北向构造和东西向构造的交汇处,其内部的帕米尔高原更是区域构造的中流砥柱。青藏高原起源于帕米尔高原,它是一个印支期的热穹窿,晚期转化出一条直径200 km的异常重力柱,垂直下沉至600 km,构成一个垂向上的挤压-伸展构造,完成于白垩纪。以它为中心向东西扩展,东边三条、西边一条水平方向挤压-伸展构造。喜山期它还遭受到岩体的侵入,白垩系基本上未变形。古近纪,印度陆块与亚洲陆块碰撞,形成先压后升的雄伟的喜马拉雅造山带。以它为中心向北扩展,第四纪3个地幔枝上升,导致整个青藏高原上升。青藏高原形成与演化的深部动力机制模型:早期表现为地质体在垂向上的离心运动和在水平上的伸展运动;后期是以挤压为主的阶段,表现为地质体在垂向上的向心运动和水平上的挤压运动。从驱动力的角度,早期以热能为主驱动力,后期以重力势能为主驱动力。青藏高原的隆升及其形成演化是欧亚陆块新生代最令人瞩目的地质事件,其直接影响到岩石圈浅部及地壳表层与人类生存发展息息相关的地形地貌、能源、资源、生态、环境和灾害等,产生了具有举足轻重的近区及远程效应。3个远程效应分别是贝加尔湖裂谷、汾渭裂谷以及东非三叉裂谷的形成。本文最后对印支运动的命名和穿时问题、印支运动起止时间和类型、青藏高原是研究各类造山带的最佳基地、喜马拉雅造山带东西构造结的确定和帕米尔高原四维动力学模型的探索等5个问题进行了简单讨论。

关键词：青藏高原帕米尔高原地热能地幔枝动力机制构造演化远程效应

CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice

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Signal Transduction and Targeted Therapy 2021年第7期6卷 2172-2185页

作者： Lu Gan demin liu Jing liu Erya Chen Chan Chen Lian liu Hang Hu Xiaohui Guan Wen Ma Yanzi Zhang Yarong He Bofu liu Songling Tang Wei Jiang Jianxin Xue Hongbo Xin Research Laboratory of Emergency Medicine Department of Emergency MedicineNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduPeopled Republic of China Cardiology Department The Second Hospital of Hebei Medical UniversityShijiazhuangPeopled Republic of China Department of Endocrinology The Second Hospital of Shanxi Medical UniversityTaiyuanPeople’s Republic of China Department of Anesthesiology Laboratory of Anesthesia and Critical Care MedicineTranslational Neuroscience CenterWest China HospitalSichuan UniversityChengduPeople's Republic of China The National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational MedicineNanchang UniversityNanchangPeople's Republic of China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduPeopled Republic of China Department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduPeople’s Republic of China

CD38 is the main enzyme for nicotinamide adenine dinucleotide(NAD)degradation in mammalian *** NAD levels are closely related to metabolic syndromes and aging-related *** study showed that CD38 deficiency significantly alleviated angiotensin II(Ang ll)-induced vascular remodeling in mice,as shown by decreased blood pressures;reduced vascular media thickness,media-to-lumen ratio,and collagen deposition;and restored elastin ***,our bone marrow transplantation assay showed that CD38 deficiency in lymphocytes led to lack of protection against Ang ll-induced vascular remodeling,suggesting that the effects of CD38 on Ang ll-induced vascular remodeling might rely primarily on vascular smooth muscle cells(VSMCs),not *** addition,we observed that CD38 deficiency or NAD supplementation remarkably mitigated Ang ll-induced vascular senescence by suppressing the biogenesis,secretion,and internalization of senescence-associated small extracellular vesicles(SA-sEVs),which facilitated the senescence of neighboring non-damaged ***,we found that the protective effects of CD38 deficiency on VSMC senescence were related to restoration of lysosome dysfunction,particularly with respect to the maintenance of sirtuin-mediated mitochondrial homeostasis and activation of the mitochondria-lysosomal axis in *** conclusion,our findings demonstrated that CD38 and its associated intracellular NAD decline are critical for Ang ll-induced VSMC senescence and vascular remodeling.

关键词： CD38 Ang remodeling

Investigation of Matrix Metalloproteinase -1,2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

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Journal of Nanjing Medical University 2007年第3期21卷 159-164页

作者： Rong liu demin Pu Dan Yang Department of Obstetrics and Gynecology of Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 China

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and *** from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.

关键词： endometriosis MMP-1 MMP-2 TIMP-1 in-situ hybridization Western blot

Frontier research of ultra-high-speed ultra-large-capacity and ultra-long-haul optical transmission

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Frontiers of Optoelectronics 2016年第2期9卷 123-137页

作者： Daojun XUE Shaohua YU Qi YANG Nan CHI Lan RAO Xiangjun XIN Wei LI Songnian FU Sheng CUI demin liu Zhuo LI Aijun WEN Chongxiu YU Xinmei WANG State Key Laboratory of Optical Communication Technologies and Networks Wuhan Research Institute of Posts and Telecommunications Wuhan 430074 China School of Information Science and Technology Fudan University Shanghai 200433 China State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications Beijing 100876 China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China School of Optics and Electronic Information Huazhong University of Science and Technology Wuhan 430074 China State Key Laboratory of Integrated Services Networks Xidian University Xi'an 710126 China

Ultra-high-speed, ultra-large-capacity and ultra-long-haul （3U） are the forever pursuit of optical communication. As a new mode of optical communication, 3U transmission can greatly promote next generation optical internet and broadband mobile communication network development and technological progress, therefore it has become the focus of international high-tech intellectual property competition ground. This paper introduces the scientific problems, key technologies and important achievements in 3U transmission research.

关键词： ultra-high-speed ultra-large-capacity ultra-long-haul optical transmission high spectral efficiency,parametric amplification dispersion management

Macrophages in Ischemic Heart Failure:Yesterday,Today,and Tomorrow

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Cardiology Discovery 2021年第2期1卷 128-134页

作者： demin liu Wenjun Yan Jingwen Huang Jianli Zhao Houston Kilby Theodore AChristopher Bernard Lopez Ling Tao Xinliang Ma Guoqiang Gu Yajing Wang Department of Cardiology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000China Xijing Hospital Fourth Military Medical UniversityXi’an 710032China Department of Medicine and Department of Emergency Medicine Thomas Jefferson UniversityPhiladelphiaPennsylvania 19107USA.

With continually improving reperfusion strategies and patient care,the overall mortality of acute myocardial infarction(AMI)has been significantly reduced during the past two ***,this success is a double-edged sword,as many patients surviving an AMI will progress towards ischemic heart failure(HF)over *** pathologic causes of ischemic HF are undoubtedly ***,the inflammatory response is considered one of the most important causes of pathological remodeling because it spans the whole process of HF *** macrophage-mediated inflammatory response was once considered a purely harmful factor leading to pathological remodeling and ***,growing evidence demonstrates that multiple subgroups of macrophage exist and contribute differently to ischemic HF *** macrophage populations and how they contribute to post-MI remodeling and consequent ischemic HF is,therefore,critical to understanding and treating the *** review focuses on different macrophage populations that regulate post-MI cardiac injury and how immunoregulation therapy may benefit patients with ischemic HF.

关键词： Acute myocardial infarction Heart failure Immunoregulation therapy Inflammation Macrophages

circPVT1 promotes silica-induced epithelial-mesenchymal transition by modulating the miR-497-5p/TCF3 axis

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Journal of Biomedical Research 2024年第2期38卷 163-174,I0011-I0015页

作者： Siyun Zhou Yan Li Wenqing Sun Dongyu Ma Yi liu demin Cheng Guanru Li Chunhui Ni Department of Occupational Medical and Environmental Health Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Biomedical Publications Center Nanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversityNanjingJiangsu 211166China

Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary ***,whether circRNA is involved in the process remains *** present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying *** found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial *** isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the *** immunoprecipitation assay and RNA pull-down experiment indicated that cytoplasmic-localized circPVT1 was capable of binding to ***,we found that miR-497-5p attenuated the silica-induced EMT process by targeting transcription factor 3(TCF3),an E-cadherin transcriptional repressor,in the silica-treated epithelial ***,these results reveal a novel role of the circPVT1/miR-497-5p/TCF3 axis in the silica-induced EMT process in lung epithelial *** validated,this finding may provide a potential theoretical basis for the development of interventions and treatments for pulmonary fibrosis.

关键词： silicosis epithelial-mesenchymal transition circPVT1 miR-497-5p TCF3

采用MICP加固不同掺砂比例粉土的试验研究

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东南大学学报（自然科学版） 2023年第2期53卷 270-277页

作者：赵志峰刘德民南京林业大学土木工程学院南京210037

针对微生物诱导碳酸钙沉积(MICP)处理对象多为单一级配土体的现状,开展颗粒级配对MICP加固效果影响的试验研究.通过在粉土中掺入不同比例的标准砂来配置5种不同级配的土样.选用巴氏芽孢杆菌作为微生物,尿素和氯化钙作为胶结液来进行MIC... 详细信息

针对微生物诱导碳酸钙沉积(MICP)处理对象多为单一级配土体的现状,开展颗粒级配对MICP加固效果影响的试验研究.通过在粉土中掺入不同比例的标准砂来配置5种不同级配的土样.选用巴氏芽孢杆菌作为微生物,尿素和氯化钙作为胶结液来进行MICP处理.由于制样的密实程度会影响加固效果,将每种级配试样的干密度控制为5个水平.通过试验研究掺砂比例、密实水平等对加固效果的影响.结果表明:试样经过MICP处理得到了整体加固,在粉土中掺入一定比例砂土有助于提高水稳定性.掺砂比例和密实水平对CaCO_(3)生成量和无侧限抗压强度都有影响.在粉土中掺入适量的砂土颗粒有利于提高加固强度;但当砂土掺量过高时,对加固效果有不利影响.增加制样干密度在一定程度上有助于获得更高的强度,但加固强度并不完全取决于初始干密度或孔隙比.

关键词：微生物诱导碳酸钙沉积粉土掺砂比例加固强度