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circPVT1 promotes silica-induced epithelial-mesenchymal transition by modulating the miR-497-5p/TCF3 axis

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Journal of Biomedical Research 2024年第2期38卷 163-174,I0011-I0015页

作者： Siyun Zhou Yan Li Wenqing Sun Dongyu Ma Yi liu demin Cheng Guanru Li Chunhui Ni Department of Occupational Medical and Environmental Health Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Biomedical Publications Center Nanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversityNanjingJiangsu 211166China

Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary fibrosis.However,whether circRNA is involved in the process remains unclear.The present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying mechanisms.We found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial cells.The isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the cytoplasm.RNA immunoprecipitation assay and RNA pull-down experiment indicated that cytoplasmic-localized circPVT1 was capable of binding to miR-497-5p.Furthermore,we found that miR-497-5p attenuated the silica-induced EMT process by targeting transcription factor 3(TCF3),an E-cadherin transcriptional repressor,in the silica-treated epithelial cells.Collectively,these results reveal a novel role of the circPVT1/miR-497-5p/TCF3 axis in the silica-induced EMT process in lung epithelial cells.Once validated,this finding may provide a potential theoretical basis for the development of interventions and treatments for pulmonary fibrosis.

关键词： silicosis epithelial-mesenchymal transition circPVT1 miR-497-5p TCF3

Paleo-Earthquakes along the Zheduotang Fault,Xianshuihe Fault System,Eastern Tibet:Implications for Seismic Hazard Evaluation

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Journal of Earth Science 2022年第5期33卷 1233-1245页

作者： Guifan Chen Mervin Bartholomew demin liu Kai Cao Minxuan Feng Dun Wang School of Earth Sciences China University of GeosciencesWuhan 430074China Three Gorges Geotechnical Consultants Co. Ltd.Wuhan 430074China Department of Earth Sciences University of MemphisMemphisTN38152USA Xi’an Center of Geological Survey China Geological SurveyXi’an710054China

The Kangding City in eastern Tibet is at high risk due to frequent strong earthquakes along the Xianshuihe sinistral strike-slip fault bounding the Chuandian Block to the northeast.The knowledge of paleo-seismicity recurrence along this fault system is key to the evaluation of earthquake hazards in this region;thus,more accurate paleoseismic information are required.We examined the paleo-seismicity along the Zheduotang fault in the central segment of the Xianshuihe fault system by applying the field investigation,trenching,and Quaternary dating methods(e.g.,OSL and ^(14)C).Field observations found~8.5 m offset of stream by sinistral slip along the Zheduotang fault.We trenched the central fault zone of the Zheduotang fault and found that the colluvial wedges and five buried,discontinuous,A-soil horizons progressively have been offset in the shallow graben on the SW-side of the main fault indicative of the paleo-earthquakes.The dating results of OSL and ^(14)C,in line with existing data,enable us to establish the paleo-seismic history of the Zheduotang fault.It shows at least eight surface ruptures in the last 7500 years identified from displaced buried soils,colluvial wedges and terraces.Our study reveals~100 years minimum paleo-earthquake recurrence,suggesting potential large earthquakes in the Kangding area in the future.

关键词： Tibetan Plateau Xianshuihe fault system paleo-seismicity trench recurrence geophysics

Mixed finite element for two-dimensional incompressible convective Brinkman-Forchheimer equations

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Applied Mathematics and Mechanics(English Edition) 2019年第6期40卷 889-910页

作者： demin liu Kaitai LI College of Mathematics and System Sciences Xinjiang UniversityUrumqi 830046China School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049China

In this work, the two-dimensional convective Brinkman-Forchheimer equa- tions are considered. The well-posedness for the variational problem and its mixed finite element approximation is established, and the error estimates based on the conforming approximation are obtained. For the computation, a one-step Newton (or semi-Newton) iteration algorithm initialized using a fixed-point iteration is proposed. Finally, numerical experiments using a Taylor-Hood mixed element built on a structured or unstructured triangular mesh are implemented. The numerical results obtained using the algorithm are compared with the analytic data, and are shown to be in very good agreement. Moreover, the lid-driven problem at Reynolds numbers of 100 and 400 is considered and analyzed.

关键词： Brinkman-Forchheimer equations finite element method Newton iteration

Experimental Investigation of Inter-Blade Vortices in a Model Francis Turbine

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Chinese Journal of Mechanical Engineering 2017年第4期30卷 854-865页

作者： demin liu Xiaobing liu Yongzhi ZHAO Key Laboratory of Fluid and Power Machinery of Ministry of Education Xihua University Dongfang Electric Machinery Co. Ltd

The inter-blade vortex in a Francis turbine becomes one of the main hydraulic factors that are likely to cause blade erosion at deep part load operating con- ditions. However, the causes and the mechanism of inter- blade vortex are still under investigation according to present researches. Thus the causes of inter-blade vortex and the effect of different hydraulic parameters on the inter-blade vortex are investigated experimentally. The whole life cycle of the inter-blade vortex is observed by a high speed camera. The test results illustrate the whole life cycle of the inter-blade vortex from generation to separation and even to fading. It is observed that the inter- blade vortex becomes stronger with the decreasing of flow and head, which leads to pressure fluctuation. Meanwhile, the pressure fluctuations in the vane-less area and the draft tube section become stronger when inter-blade vortices exist in the blade channel. The turbine will be damaged if operating in the inter-blade vortex zone, so its operating range must be far away from that zone. This paper reveals the main cause of the inter-blade vortex which is the larger incidence angle between the inflow angle and theblade angle on the leading edge of the runner at deep part load operating conditions.

关键词： Inter-blade vortex Francis turbine Highspeed photography

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冠状动脉钙化调控机制及评估技术的研究进展

中华心血管病杂志 2024年第3期52卷 303-310页

作者：陈雪宁金晓雪崔术刘德敏河北医科大学第二医院心内一科石家庄050000 河北省医学考试中心石家庄050000

血管钙化广泛存在于心血管疾病、糖尿病等疾病中,是导致心血管并发症的重要因素。随着钙化评估和诊断技术的发展,钙化过程为主动炎症过程的观点逐渐被接受,而调控冠状动脉钙化(CAC)的信号通路也被进一步探索。CAC的评估技术在不断革新,... 详细信息

血管钙化广泛存在于心血管疾病、糖尿病等疾病中,是导致心血管并发症的重要因素。随着钙化评估和诊断技术的发展,钙化过程为主动炎症过程的观点逐渐被接受,而调控冠状动脉钙化(CAC)的信号通路也被进一步探索。CAC的评估技术在不断革新,以期更清晰地显示斑块结构,评估斑块的钙化程度及预测术后并发症的风险。该文主要对CAC的分子调控机制及相关评估技术的研究进展作一综述,旨在结合目前的检测技术更好地识别病变,全面了解CAC的发生发展过程。

关键词：冠状动脉成骨样细胞转化平滑肌细胞内皮细胞光学相干断层成像

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基于双惯导协同的误差参数估计与融合算法

中国惯性技术学报 2024年第4期32卷 319-325,335页

作者：贾继超祁帅夏家和寇得民刘鑫航天科技集团九院16所西安710100 西安飞行自动控制研究所西安710065

针对无外界参考信息的双惯导系统长期使用后系统参数发生变化导致导航精度降低,且系统间缺少信息融合的问题,提出了一种同等精度双惯导协同误差估计与信息融合算法。首先以两套旋转式惯导间相对速度误差与位置误差作为观测量,建立包含... 详细信息

针对无外界参考信息的双惯导系统长期使用后系统参数发生变化导致导航精度降低,且系统间缺少信息融合的问题,提出了一种同等精度双惯导协同误差估计与信息融合算法。首先以两套旋转式惯导间相对速度误差与位置误差作为观测量,建立包含陀螺和加速度计零偏的导航误差模型。然后分析了不同转序下各状态量的可观测性,采用Kalman滤波对各参数进行有效估计,估计完成后对双惯导系统进行误差补偿及信息融合。仿真结果表明,所提算法对陀螺零偏估计精度优于0.002(°)/h,加速度计零偏估计精度优于4μg,在抑制误差发散的同时,提高了旋转式惯导导航精度。

关键词：双惯导系统旋转调制误差估计数据融合

替格瑞洛对血清尿酸水平的影响及其机制的研究进展

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中国心血管杂志 2024年第3期29卷 263-268页

作者：周子涵刘德敏崔炜河北医科大学第二医院心内科、河北省心脑血管病研究所石家庄050000

高尿酸血症是导致心血管疾病患者预后不良的重要原因。研究表明,替格瑞洛会引起不同程度的血清尿酸水平升高,可能与肾尿酸转运体功能障碍和红细胞腺苷再摄取减少相关。本文就替格瑞洛引起尿酸升高的发生率、危险因素和潜在机制等研究现... 详细信息

高尿酸血症是导致心血管疾病患者预后不良的重要原因。研究表明,替格瑞洛会引起不同程度的血清尿酸水平升高,可能与肾尿酸转运体功能障碍和红细胞腺苷再摄取减少相关。本文就替格瑞洛引起尿酸升高的发生率、危险因素和潜在机制等研究现状进行综述,旨在为替格瑞洛相关高尿酸血症的防治提供策略。

关键词：替格瑞洛尿酸高尿酸血症研究进展

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Late Jurassic Intracontinental Extension and Related Mineralisation in Southwestern Fujian Province of SE China:Insights from Deformation and Syn-Tectonic Granites

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Journal of Earth Science 2021年第1期32卷 158-173页

作者： Rui Cao Xinghua Ma Leon Bagas Yongbao Gao demin liu Zailai Mou Kay Laboratory of Earth Exploration and Information Techniques Ministry of educationChengdu University of TechnologyChengdu 610059China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 100083China Xi'an Center of China Geological Survey Xi'an 710054China Centre for Exploration Targeting the University of Western AustraliaCrawley WA 6009Australia MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China School of Earth Sciences China University of GeosciencesWuhan 430074China

Late Mesozoic igneous intrusions and extensional structures in Carboniferous to Permian sequences in the SW Fujian region acted as important controls on the localisation of Fe-polymetallic de-posits.Here we document the identification of extensional deformation at shallow crustal levels and syn-tectonic granites related to normal faults.Based on spatial distribution and structural features,the extensional deformation can be divided into cover-only and basement-intersecting styles.A series of syn-tectonic plutons were emplaced into the footwall of normal faults.Representative samples of the Tangquan Granite have high SiO2(66.4 wt.%-73.9 wt.%)assays and Mg#values(37-59).The samples also have relatively homogenous initial 87Sr/86Sr(0.7083-0.7089)andεNd(-9.2--10.2)values.Geochemical and isotopic evidences indicate that the Tangquan granite originates from a hybrid source including lower crustal-derived felsic and lithospheric mantle-derived mafic magmas.Zircon U-Pb dating indicates that the granodiorite phase from the pluton crystallised at 161±4 Ma and the monzogranite phase crystallised at 159±1 Ma.Combined with the granitic rocks in a wider region of SE China,the widespread granitic magmatism and polymetallic mineralisation have been synchronous during the Late Mesozoic,probably resulting from extensional tectonics related to the lithospheric thinning.

关键词： extensional tectonic intracontinental deformation granitic magmatism mineralisation SE China

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青藏高原形成演化动力机制及其远程效应

地学前缘 2024年第1期31卷 154-169页

作者：刘德民王杰姜淮赵悦郭铁鹰杨巍然中国地质大学(武汉)地球科学学院湖北武汉430074 中国地震局地震研究所湖北武汉430071 湖北省地震局湖北武汉430071

作为第三极的青藏高原的形成是新生代以来的地球节律构造事件中最典型、最显著的新构造运动的结果,其构造地貌特征及其重要性,内部单元组成,构造演化历程及动力机制,以及对周边盆地乃至整个中国大陆的影响及远程效应至今一直是学术关注... 详细信息

作为第三极的青藏高原的形成是新生代以来的地球节律构造事件中最典型、最显著的新构造运动的结果,其构造地貌特征及其重要性,内部单元组成,构造演化历程及动力机制,以及对周边盆地乃至整个中国大陆的影响及远程效应至今一直是学术关注的焦点。本文重新圈定了青藏高原构造地貌范围,确立了其在全球构造中的地位。青藏高原的远程效应向南北两侧延伸,北到北冰洋,南到太平洋,总体上围绕东经105°经线穿越了整个亚洲大陆,本文采用东经105°所在经线大圆作为划分东西半球的分界线,该线以东为东半球,以西为西半球。青藏高原处于全球最大、最重要的南北向构造和东西向构造的交汇处,其内部的帕米尔高原更是区域构造的中流砥柱。青藏高原起源于帕米尔高原,它是一个印支期的热穹窿,晚期转化出一条直径200 km的异常重力柱,垂直下沉至600 km,构成一个垂向上的挤压-伸展构造,完成于白垩纪。以它为中心向东西扩展,东边三条、西边一条水平方向挤压-伸展构造。喜山期它还遭受到岩体的侵入,白垩系基本上未变形。古近纪,印度陆块与亚洲陆块碰撞,形成先压后升的雄伟的喜马拉雅造山带。以它为中心向北扩展,第四纪3个地幔枝上升,导致整个青藏高原上升。青藏高原形成与演化的深部动力机制模型:早期表现为地质体在垂向上的离心运动和在水平上的伸展运动;后期是以挤压为主的阶段,表现为地质体在垂向上的向心运动和水平上的挤压运动。从驱动力的角度,早期以热能为主驱动力,后期以重力势能为主驱动力。青藏高原的隆升及其形成演化是欧亚陆块新生代最令人瞩目的地质事件,其直接影响到岩石圈浅部及地壳表层与人类生存发展息息相关的地形地貌、能源、资源、生态、环境和灾害等,产生了具有举足轻重的近区及远程效应。3个远程效应分别是贝加尔湖裂谷、汾渭裂谷以及东非三叉裂谷的形成。本文最后对印支运动的命名和穿时问题、印支运动起止时间和类型、青藏高原是研究各类造山带的最佳基地、喜马拉雅造山带东西构造结的确定和帕米尔高原四维动力学模型的探索等5个问题进行了简单讨论。

关键词：青藏高原帕米尔高原地热能地幔枝动力机制构造演化远程效应