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疗效评价标准及其在淋巴瘤中的应用:第一部分

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中华核医学与分子影像杂志 2019年第3期39卷 187-192页

作者： Mateen C.Moghbel Laie Kostakoglu Katherine Zukotynski delphine L.Chen Helen Nadel Ryan Niederkohr Erik Mittra 李慧玲(译) 兰晓莉刘振(审校) Stanford University Medical Center Stanford California Mount Sinai Medical Center New York New York McMaster University Hamilton Ontario Canada Washington University St. Louis Missouri University of British Columbia Vancouver British Columbia Canada Kaiser Permanente Santa Clara California 华中科技大学同济医学院附属协和医院核医学科武汉430022

无论对于个体患者还是人群.癌症治疗的有效性都需要一种系统的、可重复的疗效评价方法。为满足这一需求,学界制定了一些评估疗效的指导原则,主要从解剖和代谢方面来量化治疗后的变化。过去几年针对特定的肿瘤组织制定了相应的疾病疗效... 详细信息

无论对于个体患者还是人群.癌症治疗的有效性都需要一种系统的、可重复的疗效评价方法。为满足这一需求,学界制定了一些评估疗效的指导原则,主要从解剖和代谢方面来量化治疗后的变化。过去几年针对特定的肿瘤组织制定了相应的疾病疗效分类标准迄今为止,恶性淋巴瘤可能是疾病疗效分类应用最普遍的肿瘤类型.该文对现有的淋巴瘤疗效评价标准进行概述,重点介绍这些评价标准各自的方法及其适用性。针对阻碍疗效评价标准化发展的问题,该文也对其中许多标准的技术复杂度和主观阈值判定的内容进行了评述。

关键词：淋巴瘤 PET CT RECIST PERCIST

Management of renal replacement therapy among adults in French intensive care units: A bedside practice evaluation

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Journal of Intensive Medicine 2023年第2期3卷 147-154页

作者： Florian Jolly Marine Jacquier delphine Pecqueur Marie Labruyère Christophe Vinsonneau Isabelle Fournel Jean-Pierre Quenot The READIAL Study group Service de Médecine Intensive-Réanimation CHU Dijon-BourgogneDijon 21000France Equipe Lipness Centre de recherche INSERM UMR1231 et LabEx LipSTICUniversitéde Bourgogne-Franche ComtéDijon 21000France INSERM CIC 1432Module Epidémiologie CliniqueDijon 21000France CHU Dijon-Bourgogne Centre d’Investigation CliniqueModule Epidémiologie Clinique/Essais CliniquesDijon 21000France Service de Médecine Intensive Réanimation-Unitéde Sevrage Ventilatoire et Réhabilitation CH de BethuneBethune 62408France 不详

Background:This study aimed to investigate renal replacement therapy (RRT) practices in a representative nationwide sample of French intensive care units (ICUs).Methods:From July 1 to October 5 2021, 67 French ICUs provided data regarding their ICU and RRT implementation. We used an online questionnaire to record general data about each participating ICU, including the type of hospital, number of beds, staff ratios, and RRT implementation. Each center then prospectively recorded RRT parameters from 5 consecutive acute kidney injury (AKI) patients, namely the indication, type of dialysis catheter used, type of catheter lock used, type of RRT (continuous or intermittent), the RRT parameters initially prescribed (dose, blood flow, and duration), and the anticoagulant agent used for the ***:A total of 303 patients from 67 ICUs were analyzed. Main indications for RRT were oligo-anuria (57.4%), metabolic acidosis (52.1%), and increased plasma urea levels (47.9%). The commonest insertion site was the right internal jugular (45.2%). In 71.0% of cases, the dialysis catheter was inserted by a resident. Ultrasound guidance was used in 97.0% and isovolumic connection in 90.1%. Citrate, unfractionated heparin, and saline were used as catheter locks in 46.9%, 24.1%, and 21.1% of cases, ***:Practices in French ICUs are largely compliant with current national guidelines and international literature. The findings should be interpreted in light of the limitations inherent to this type of study.

关键词： Renal replacement therapy Acute kidney injury Intensive care unit Practice evaluation Bedside

Management of Non-Traumatic Urological Emergencies at Souro Sanou University Teaching Hospital of Bobo-Dioulasso (Burkina Faso)

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Open Journal of Urology 2023年第9期13卷 353-362页

作者： Ouattara Adama Paré Abdoul-Karim Yé delphine Simporé Moahmed Babagana Mustapha Abubakar Rouamba Mickael Kaboré Aristide Fasnewindé Kambou Timothée Division of Urology Souro Sanou University Teaching Hospital Bobo-Dioulasso Burkina Faso Department of Surgery Federal Medical Center Nguru Yobe State Nigeria Division of Urology Yalgado Ouedraogo University Teaching Hospital Ouagadougou Burkina Faso

Background: Generally, urological emergencies are assumed not to be very common, however, recent reports showed that they constitute an important aspect of the day-to-day urological practice. If not well and promptly managed, they may lead to serious morbidity or mortality. Objectives: To study the pattern of presentation, diagnosis and outcome of management of non-traumatic urological emergencies seen at the Emergency Department of Souro Sanou University Hospital in Bobo-Dioulasso. Patients and Methods: This was a retrospective and descriptive study over four years. It included patients of all ages and both sexes, admitted for non-traumatic urological emergencies in the surgical emergency department of Souro Sanou University Hospital. It took place from January 1, 2017 to December 31, 2020. Results: A total of 584 patients were reviewed in our study. Non-traumatic urological emergencies account for 6.3% of all surgical emergencies seen during the study period. The male-to-female ratio was 9.2 to 1. The mean age of the patients was 51.9 ± 23.9 years. Forty-five per cent of the patients presented within 48 hours of symptoms. The vast majority of the patients presented with difficulties with passing urine (41.6%), followed by cases of hematuria (18.4%). On admission, 154 patients (26.4%) presented with severe conditions such as anemia as seen in 40.9% of the cases and deterioration in the general health condition as seen in 34.4% of the patients. Leukocytosis was noted in 18.7% of the patients and anemia in 17.9%. Urine culture was positive in 15.4% of the patients and Escherichia coli was the most common pathogen found (40.6%). Ultrasound was the most requested examination (81.2%), followed by a computerized tomography (CT) scan (22%). The most frequent diagnoses were urine retention (42.9%), hematuria (16.9%) and renal colic (10.1%). Emergency interventions were carried out in 525 patients (89.9%) who include bladder catheterization (46.1%), bladder lavage and/or bl

关键词： Non-Traumatic Urological Emergency Acute Urine Retention Renal Colic Hematuria

Impact of Smart Valley on Soil Moisture Content and Rice Yield in Some Lowlands in Burkina Faso

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Agricultural Sciences 2020年第9期11卷 860-868页

作者： Bama Nati Aïssata delphine Dossou Yovo Elliott Gbané Mahanat Vanessa Gnépi Elvire Soulama Issa Ibrahima Ouedraogo Adama Ouédraogo Institut de l’Environnement et de Recherches Agricoles Département de Production Végétale INERA Ouagadougou Burkina Faso Africa Rice Center (AfricaRice) Cotonou Benin Institut International d’Ingénierie de l’Eau et de l’Environnement Laboratoire Eaux Hydro-Systèmes et Agriculture Ouagadougou Burkina Faso Centre Agricole Polyvalent de Martourkou Bobo-Dioulasso Burkina Faso

To reduce the impact of rainfall variability on lowland rice yields, Burkina Faso state develops lowlands for small rice farmers. However, the high cost of these infrastructures makes impossible to duplicate them to satisfy the needs which are enormous. The Smart-Valley technology which is actually popularized in certain coastal countries of West Africa would therefore be a boon to increase the productivity of the Sudanese lowlands if it well regulates runoff. The object of this study was therefore to know if smart valley technology could increase soil moisture in order to mitigate the impact of drought’s pockets on rice cultivation in the Sudanese lowlands. The experiment takes place in three lowlands during the rainy seasons 2018 and 2019. The climatic data comes from the meteorological stations in the study areas as well as those installed on the sites. The infiltration measurements were carried out using the double Muntz ring. The soil moisture measurement device consisted of a smart valley area of 5 ha and an undeveloped area of 5 ha per site. Sixteen tubes were installed per lowland allowing the humidity to be measured at a depth of 10, 20, 30, 40 cm using a probe. Four rice varieties, Orylux6, FKR62N, FKR19 and FKR64 were tested on plots of 0.25 ha per variety in the smart valley and undeveloped parts. The results showed that the humidity level was 12% higher in the smart-valley plots throughout the cycle compared to the unmanaged area. In addition, humidity decreases rapidly in unmanaged plots as rain becomes increasingly scarce. Finally, the smart-valley development allowed an average increase in rice yields of 21% compared to the average yield of undeveloped plots.

关键词： Smart Valley Soil Moisture Lowland Development Rice Productivity Rain

Perception and Management Strategies of the Fall Armyworm, Spodoptera frugiperda J.E. Smith (1797) (Lepidoptera: Noctuidae) on Maize, Millet and Sorghum by Farmers in Western Burkina Faso

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Advances in Entomology 2023年第3期11卷 204-222页

作者： Innocent S. Yaméogo delphine Ouattara Rémi Dabiré Arthur Ki Lakpo Agboyi Olivier Gnankiné Marc Kenis Souleymane Nacro Science and Technology Doctoral School Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Centre Ré gional de Recherches Environnementales et Agricoles de l’Ouest Bobo-Dioulasso Burkina Faso Centre Agricole Polyvalent de Matourkou Bobo Dioulasso Burkina Faso Centre International d’Agriculture et de Biosciences (CABI) CSIR Campus Cantonments Ghana Centre International d’Agriculture et de Biosciences (CABI) Delé mont Switzerland Centre Ré gional de Recherches Environnementales Agricoles et de Formation de Kamboinsé Ouagadougou Burkina Faso

Since it was first detected in Africa in early 2016, the fall armyworm (FAW), Spodoptera frugiperda Smith (Lepidoptera: Noctuidae), has spread to over 50 African countries, including Burkina Faso. This insect pest attacks important cereals, such as maize, millet and sorghum, which are the staple food in Burkina Faso. Since the invasion of the FAW in Africa, data on farmers’ knowledge and their perceptions of this insect’s pest are scarce and fragmented in Burkina Faso. Although this issue has been already addressed in some African countries, farmers’ perceptions of this invasive insect pest may differ from one country to another. This reality justifies our study, the main objective of which is to assess the perception and level of knowledge of farmers on this new invasive insect pest and the consequences of its damage to cereal production in western Burkina Faso. To do this, a stratified survey was conducted among 355 farmers in two important agricultural regions of Burkina Faso, namely the Hauts-Bassins and the Cascades. At the end of these surveys, it was found that the age of the people surveyed varied from 18 to 80 years. People between the ages of 41 and 50 and 31 and 40 were the most numerous, with 31.27% and 30.14% of the target population, respectively. In addition, the majority of the farmers were male, 94.08% of them being men and 5.92% being women. More than half (50.42%) of this population was non-literate. Almost all of the farmers surveyed (97.46%) said they had heard of S. frugiperda and 80.85% of them said they could identify the insect pest. The date of appearance of the FAW was variously perceived by the farmers of the study area. According to these cereals growers, the years 2016, 2017, 2018, and 2019 were to be remembered in terms of the insect pest’s appearance. While for sorghum and millet the change in yields from 2010 to 2019 seemed slight, it was quite remarkable for maize according to the farmers. The average maize yield in 2016 and 2017 wa

关键词： Spodoptera frugiperda Cereals Yield Losses Burkina Faso

Direct Visual Internal Urethrotomy (DVIU) in the Management of Male Urethral Strictures. A Single Center Experience about 44 Patients

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Open Journal of Urology 2023年第8期13卷 293-301页

作者： Adama Ouattara Abdoul-Karim Paré Tioulé Mamadou Traoré delphine Yé Moahmed Simporé Mickael Rouamba Fasnéwindé Aristide Kaboré Timothée Kambou Division of Urology Souro Sanou University Hospital Bobo-Dioulasso Burkina Faso Department of Surgery Regional University Hospital Ouahigouya Burkina Faso Division of Urology Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso

Introduction: Male urethral stricture is one of the oldest urological disorders. Many techniques have been proposed to treat them, including endoscopic internal urethrotomy (DVIU). Material and Methods: To evaluate the contribution of this technique in the treatment of urethra narrowing, a retrospective study on the records of patients with urethral stricture treated with endoscopic internal urethrotomy between January 2014 and December 2021 in the urology division of the Souro Sanou University Teaching Hospital. Results: A total of 44 male patients with urethral stricture were treated with this technique and 48 procedures were performed. The average age of the patients was 53.2 ± 18.2 years. The etiology of the stricture was dominated by iatrogenic, infectious, traumatic and idiopathic causes in 43.2% (n = 19), 27.3% (n = 12), 20.4 % (n = 9), and 9.1% (n = 4) respectively. The location of the stricture was bulbar in 72.7%, and the anterior penile urethra in 15.9%. The overall success rate was 72.7% with satisfactory urination without dysuria, evaluated after removal of the urinary catheter, at three months this rate fell to 69.1%, and at 6 months this rate was 67.5%. Five cases (5) of extravasation of blood or irrigation fluid into the scrotum were reported and managed conservatively as well as two (2) cases of false routes with postoperative oedema of the penis were observed. Conclusion: DVIU is a simple technique, free of major morbidity and requiring only short-term hospitalization. It can be proposed as a first-line treatment for urethral stricture.

关键词： Internal Urethrotomy Urethral Stricture Outcomes Complications

Postharvest Adaptation Strategies to the Effects of Temperature Variations and Farmer-Miller Practices on the Physical Quality of Rice in Cameroon

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American Journal of Climate Change 2014年第2期3卷 178-192页

作者： Sali Atanga Ndindeng delphine Lamare Mapiemfu Wilson Fantong Valentine P. Nchinda Zachée Ambang John T. Manful Centre for Hydrological Research Institute of Mining & Geological Research (IRGM) Yaoundé Cameroon Department of Plant Biology University of Yaoundé-I Yaoundé Cameroon Food Science and Technology Laboratory Institute of Agricultural Research for Development (IRAD) Yaoundé Cameroon Grain Quality and Postharvest Unit Africa Rice Center Cotonou Benin

In order to develop simple and adaptable measures to reduce the impact of changing climatic conditions and poor postharvest practices on grain quality, data on temperature and postharvest practices were collected and correlated with physical grain quality parameters for 3 rice development hubs (Ndop, Lagdo and Mbam) in Cameroon. Inter-annual variations in temperature and thermal amplitudes were the highest in Ndop followed by Mbam and the least in Lagdo. When the same rice variety was grown in the hubs and milled with a laboratory hand dehusker, the mean chalky score was highest in Ndop (18%) and least in Mbam (11%). In addition, Ndop recorded higher grain fissures and broken fractions compared to Mbam or Lagdo. Positive correlations were observed between thermal amplitudes, grain fissures and the proportion of broken fractions. However, rice milled using commercial mills located in the hubs recorded the highest broken fractions in Mbam (54% - 63%), followed by Lagdo (43% - 52%) and the least in Ndop (35% - 38%). The type of mills in the hubs was responsible for these differences as Mbam had only Engelberg types mills that recorded higher broken fractions than in Ndop where only rubber roll mills were present (P < 0.05). Lagdo had a mixture of Engelberg and rubber roll mills and recorded intermediate broken fractions. Proper parboiling, recovery and processing of poorly filled and immature grains during parboiling and processing of low-grade and fine broken rice into product generally accepted by the local population were demonstrated as simple adaptation strategies to mitigate the adverse effects of changing climatic conditions and poor postharvest practices on the physical quality of rice especially in sub-Saharan African countries.

关键词： Postharvest Loss Thermal Amplitude Temperature Variations Climate Change Practices Grain Quality

小麦挥发物对蚜虫及其天敌的行为影响——田间有效挥发性信息化合物的筛选(英文)

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应用昆虫学报 2014年第6期51卷 1470-1478页

作者：解海翠 Durieux delphine 范佳刘勇 Bragard Claude Haubruge Eric 孙京瑞 Francis Frédéric 陈巨莲中国农业科学院植物保护研究所、植物病虫害生物学国家重点实验室北京100193 比利时列日大学让布鲁农业科学与生物工程学院昆虫功能与进化学系让布鲁5030 山东农业大学植物保护学院泰安271018 比利时鲁汶大学地球与生命研究所植物病理系鲁汶1348

【目的】植物挥发性信息化合物能够影响植食性昆虫及其他天敌行为,因此,在植物-植食性昆虫-天敌互作系统中具有重要地位。目前,小麦[Triticum aestivum L.(Gramineae)]中多种挥发物已被鉴定,为明确其对蚜虫及其天敌的行为影响。【方法... 详细信息

【目的】植物挥发性信息化合物能够影响植食性昆虫及其他天敌行为,因此,在植物-植食性昆虫-天敌互作系统中具有重要地位。目前,小麦[Triticum aestivum L.(Gramineae)]中多种挥发物已被鉴定,为明确其对蚜虫及其天敌的行为影响。【方法】本试验利用四臂嗅觉仪和风洞测定4种不同浓度的小麦挥发物(水杨酸甲酯、3-己酰醋酸酯、己烯醇和1-己醇)对麦长管蚜Sitobion avenae(Fabricus)及其两种重要天敌,异色瓢虫[Harmonia axyridis(Pallas)(Coleoptera:Coccinellidae)]和黑带食蚜蝇[(Episyrphus balteatus(De Geer)(Diptera:Syrphidae)]的行为反应。【结果】结果显示,水杨酸甲酯仅吸引异色瓢虫。3-己酰醋酸酯和己烯醇吸引麦长管蚜及异色瓢虫,但随其浓度增加对蚜虫的吸引作用降低,对异色瓢虫吸引作用增强。3-己酰醋酸酯对黑带食蚜蝇也具有吸引作用。另外,与天敌相比,1-己醇对麦长管蚜吸引作用更强。【结论】总之,本试验明确除1-己醇外,水杨酸甲酯、3-己酰醋酸酯、己烯醇可以作为吸引天敌,控制蚜虫的潜在用于推-拉策略的挥发物性化学信息物。

关键词：小麦挥发物蚜虫天敌行为

Fast-GC Quantification of Harmonine,the Major Defense Alkaloid of the Multicolored Asian Ladybird Harmonia axyridis(Pallas)

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American Journal of Analytical Chemistry 2012年第1期3卷 67-75页

作者： Christophe Y.Fischer Pascal Laurent Stephanie Heuskin delphine Durieux Eric Haubruge Francois J.Verheggen Georges C.Lognay Department of Analytical Chemistry Gembloux Agro-Bio TechLiege UniversityLiegeBelgium Department of General and Organic Chemistry Gembloux Agro-Bio TechLiege UniversityLiegeBelgium Department of Biological and Industrial Chemistry Gembloux Agro-Bio TechLiege UniversityLiegeBelgium Department of Functional and Evolutionary Entomology Gembloux Agro-Bio TechLiege UniversityLiegeBelgium

These last few years the multicolored Asian ladybird, Harmonia axyridis (Pallas), previously introduced in Europe and North America as a biological control agent, has swiftly spread out on those territories and turns out to be a pest in several ways. In order to improve understanding of several key points of the biology of this ladybird, a novel fast-GC method of quantification of harmonine, the main defense alkaloid of H. axyridis, has been designed and validated using the accuracy profile concept for concentrations ranging from 13 to 264 μg/individual. This method allows quantifying harmonine in a single insect with a maximal error risk of 20%. For ladybirds collected in spring, mean harmonine concentration observed was 106.6 μg/individual with a very high standard deviation of 80.2 μg/individual, which can easily be explained by the strong asymmetry of the results distribution. Males and females seem equally chemically protected as the harmonine concentration did not significantly differ between sexes. This method is currently used to improve our comprehension of several key points of H. axyridis biology including aggregation behavior and aposematism.

关键词： Alkaloid Harmonine Harmonia axyridis Fast-GC Validation