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米索前列醇在发展中国家引产中的应用:几内亚的一项前瞻性研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 8-9页

作者： Yolande H. Namory K. delphine F. T. Patrick 张丽娟 Human Fertility Research Group-Reproductive Health in Developing Countries H.opital Paule de Viguier Toulouse University 330 Avenue de Grande Bretagne 31059 Toulouse Cedex 09 France

Background: The purpose of this study was to assess the efficacy, side effects and cost of misoprostol regimens in various obstetrical situations frequently occurring in deve-loping countries. Study design: One hundred and four parturient women with indications for labor induction received different regimens of misoprostol in the range of 50-800 μg according to their gestational age. Misoprostol was administered by the vaginal route, every 6 h without exceeding four doses. Results: All indications for labor induction concerned women with a gestational age of more than 30 weeks, except in the intrauterine death cases. The mean overall duration of labor was 7.8 h (±4.6 h). The mean amount of misoprostol used was 226 μg (±196 μg). The difference in the mean labor duration between the four indications for induction was statistically significant (P < 0.01). It was also significant for the mean total dose of misoprostol used. Total dose of misoprostol and Bishop score were inversely proportional. Two caesarean deliveries and two uterine ruptures were recorded, but no maternal deaths. The mean Apgar score was 8.0 (±1) at 1 min and 9.5 (±0.8) at 5 min. In our series, four fetal deaths occurred. The mean cost of misoprostol for labor induction was around US＄1, with a range of ＄0.05-4. Conclusions: The use of vaginal misoprostol appears to be relevant in developing countries in cases where labor induction is indicated. Nevertheless, the advantages of misoprostol (low cost, facility of storage) are counter-balanced by side-effects (C-section, uterine rupture) which can be harmful for the mother and also for the newborn.

关键词：引产指征阴道给药剖宫产术胎死宫内子宫破裂总产程临产妇产科疾病 Bishop 研究设计

MALDI质谱成像技术用于皮肤T细胞淋巴瘤疾病标记物研究

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MALDI质谱成像技术用于皮肤T细胞淋巴瘤疾病标记物研究

Identification of quantitative trait loci and candidate genes for primary metabolite content in strawberry fruit

中华医学会第十八次全国皮肤性病学术年会

作者： Liu Jie Marven El Osta Caroline Truntzer delphine Pecqueur Tony Petrella Patrick Ducoroy Beijing Union Medical College Hospital Dermatology CLIPP(Clinical Innovation Proteomic Platform) IFR 100 Sante STICUniversite de Bourgogne1 rue Professeur Marion21079 Dijon.100730

目的原发性皮肤淋巴瘤是以皮肤损害为初发或首要表现的淋巴瘤,占结外非霍奇金淋巴瘤的第二位,仅次于胃肠道,估计年发病率为1:100,000。皮肤T细胞淋巴瘤是最常见的原发性皮肤淋巴瘤,蕈样肉芽肿(mycosis fungoides,MF)是其中最具代表性的...

目的原发性皮肤淋巴瘤是以皮肤损害为初发或首要表现的淋巴瘤,占结外非霍奇金淋巴瘤的第二位,仅次于胃肠道,估计年发病率为1:100,000。皮肤T细胞淋巴瘤是最常见的原发性皮肤淋巴瘤,蕈样肉芽肿(mycosis fungoides,MF)是其中最具代表性的疾病类型,占所有原发性皮肤淋巴瘤的50%。MF发病初期临床表现类似良性炎症性皮肤病,缺乏特异性,而MF晚期患者病情发展呈侵袭性,患者平均寿命明显缩短。目前尚无高度特异的MF早期肿瘤标记物,早期诊断仍有困难。近期基

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Horticulture Research 2019年第1期6卷 1638-1654页

作者： JoséG.Vallarino delphine M.Pott Eduardo Cruz-Rus Luis Miranda Juan J.Medina-Minguez Victoriano Valpuesta Alisdair R.Fernie JoséF.Sánchez-Sevilla Sonia Osorio Iraida Amaya Department of Molecular Biology and Biochemistry Instituto de Hortofruticultura Subtropical y Mediterránea“La Mayora”University of Málaga–Consejo Superior de Investigaciones Científicas(IHSM-UMA-CSIC)Campus de Teatinos29071 MálagaSpain Max-Planck-Institut für Molekulare Pflanzenphysiologie Am Mühlenberg 114476 Potsdam-GolmGermany Genómica y Biotecnología Centro de MálagaInstituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)29140 MálagaSpain Ingeniería y Tecnología Agroalimentaria Centro Las Torres-TomejilInstituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)Alcaládel RíoSevillaSpain Ingeniería y Tecnología Agroalimentaria Centro de HuelvaInstituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)HuelvaSpain

Improvement of nutritional and organoleptic quality of fruits is a key goal in current strawberry breeding *** ratio of sugars to acids is a determinant factor contributing to fruit liking,although different sugars and acids contribute in varying degrees to this complex trait.A segregating F1 population of 95 individuals,previously characterized for several fruit quality characters,was used to map during 2 years quantitative trait loci(QTL)for 50 primary metabolites,L-ascorbic acid(L-AA)and other related traits such as soluble solid content(SSC),titratable acidity(TA),and pH.A total of 133 mQTL were detected above the established thresholds for 44 *** 12.9%of QTL were detected in the 2 years,suggesting a large environmental influence on primary metabolite *** objective of this study was the identification of key metabolites that were associated to the overall variation in SSC and *** it was observed in previous studies,a number of QTL controlling several metabolites and traits were co-located in homoeology group V(HG V).mQTL controlling a large variance in raffinose,sucrose,succinic acid,and L-AA were detected in approximate the same chromosomal regions of different homoeologous linkage groups belonging to HG *** genes for selected mQTL are proposed based on their co-localization,on the predicted function,and their differential gene expression among contrasting F1 progeny ***-seq analysis from progeny lines contrasting in L-AA content detected 826 differentially expressed genes and identified Mannose-6-phosphate isomerase,FaM6PI1,as a candidate gene contributing to natural variation in ascorbic acid in strawberry fruit.

关键词： straw breeding trait

Survival of dental implants in patients with bone dysplasia:A systematic review

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Discussion of Clinical Cases 2021年第4期8卷 8-13页

作者： Alexandre Perez Sarah Dib Andreij Terzic delphine Courvoisier Paolo Scolozzi Division of Oral and Maxillofacial Surgery University of GenevaSwitzerland

Objective:This study used published studies to assess the survival rate of dental implants placed in patients with bone dysplasia of the maxillofacial *** and methods:An electronic search without a specified date range was performed using the MEDLINE,PubMed,EMBASE,Web of Science,and Cochrane *** gender or age restrictions were ***:Eighteen publications were found that met the study’s criteria,reporting data on 18 patients with bone dysplasia including cleidocranial dysplasia(CDD),fibrous dysplasia(FD),florid cemento-osseous dysplasia(FCOD),and odonto-maxillary segmental dysplasia(SOMD),who received a total of 130 implants,an average of 7.2 implants/patient(range 1 to 16).The mean age of the patients was 36.7 years(range 15 to 70 years).For implants placed in bone dysplasia,the survival rates were 100% for patients with CDD(n=8),FD(n=5),SOMD(n=2),FCOD with implants inserted far from the lesions(n=2)and 0% for dental implants inserted within FCOD(n=1).The mean follow-up was 38.2 months(min 6,max 60).Conclusions:Dental implants placed in patients with dysplastic bone lesions show high survival rates,similar to those in the general population for CDD,FD,and *** FCOD,the failure rate was 100%.

关键词： Dental implants Bone Osseous dysplasia Fibrous dysplasia Florid cemento-osseous dysplasia Bone diseases Treatment outcome Osteomyelitis

Upper Gastrointestinal Endoscopy at University Hospital Souro Sanou Bobo-Dioulasso (Burkina Faso), about 1022 Cases: Signs and Lesions Observed

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Open Journal of Gastroenterology 2017年第11期7卷 287-296页

作者： Mali Koura delphine Passolguewindé Zongo Napon Zanga Damien Ouattara Kounpiélimé Sosthène Somda Aboubacar Coulibaly Steve Léonce Zoungrana Christine Couna Somé Bere Sandrine Hema Soudré Euloges Bébar Kamboulé Nogogna Zouré Honoré Zougmoré Inoussa Adama Zampou Appolinaire Sawadogo Gastroenterology Service of the University Hospital Souro Sanou Bobo-Dioulasso Burkina Faso Regional University Hospital of Ouahigouya Ouahigouya Burkina Faso Gastroenterology Service of the University Hospital Yalgado Ouédraogo Ouagadougou Burkina Faso Regional Hospital Kaya Kaya Burkina Faso National Hospital Blaise Compaoré Ouagadougou Burkina Faso

Upper gastrointestinal endoscopy is an excellent way for the diagnosis of high digestive pathology. We report the results of 1022 upper gastrointestinal endoscopy performed at Bobo-Dioulasso CHU-SS, in western Burkina Faso (West Africa). The aim of this study was to document the indications and lesions found in high endoscopy at the CHUSS. Patients and Methods: It was a cross-sectional study, prospective to describe the results of gastroscopy performed from 1st January 2015 to 30th June 2016 at the digestive endoscopy unit CHU-Souro Sanou Bobo-Dioulasso. Results: In the study period, 1022 upper gastrointestinal endoscopies were performed. The main indications were: The epigastric pain (48.6%), portal hypertension (10.7%) and gastroesophageal reflux disease (9.9%). The pathologies observed were dominated by gastropathies (48.11%), peptic ulcer (27%) and oesophageal varices (9.68%). Epigastralgias were the main circumstance for the discovery of: 52.3% of esophagitis, 49.17% of gastropathies and 46.12% of peptic ulcers. Histopathologically, the results of the 236 biopsies were dominated by gastritis (88.56%), stomach cancers (7.63%) and esophagus (3.81%). Conclusion: The main indication of the UGIE at the CHU-Souro Sanou in Bobo-Dioulasso was epigastralgia. The pathologies observed were dominated by gastropathy, esophagitis and PUD.

关键词： Upper Gastrointestinal Endoscopic Indications Lesions Observed Bobo-Dioulasso

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推板

中国住宅设施 2014年第11期 8-17页

作者： Winy Maas Jacob van Rijs Nathalie de Vries Frans de Witte Bertrand Schippan Catherine Drieux Victor Perez delphine Borg Billy Guidoni MVRDV

“推板”办公楼位于两片完全不同的城市肌理之间：北部是高密度的城市街区；南部的肌理较为松散，包含规划清晰直观的基础设施。基于办公和节能的要求，设计将成熟的节能技术应用到独立的办公楼层和室外空间--例如庭院，阳台和花园。建... 详细信息

“推板”办公楼位于两片完全不同的城市肌理之间：北部是高密度的城市街区；南部的肌理较为松散，包含规划清晰直观的基础设施。基于办公和节能的要求，设计将成熟的节能技术应用到独立的办公楼层和室外空间--例如庭院，阳台和花园。建筑内部的三个核心筒和一座中央大堂为办公区域的灵活划分提供了最大的可能；可以在保持结构不变的情况下满足单个或多个租户的空间要求。

关键词：推板城市肌理室外空间节能技术城市街区基础设施办公区域高密度

Telaprevir- and boceprevir-based tritherapies in real practice for F3-F4 pretreated hepatitis C virus patients

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World Journal of Hepatology 2014年第9期6卷 660-669页

作者： delphine Bonnet Matthieu Guivarch Anais Palacin Laurent Alric Emilie Bérard Jean-Marc Combis Andre Jean Remy Andre Glibert Jean-Louis Payen Sophie Metivier Karl Barange Herve Desmorat Florence Nicot Florence Abravanel Internal Medicine-Digestive Department Purpan University Hospital31059 Toulouse cedex 9France UMR152 IRD Toulouse III University 31400 ToulouseFrance Department of Epidemiology Health Economics and Public HealthToulouse University Hospital31073 ToulouseFrance UMR-1027 INSERM-Toulouse III University 31062 ToulouseFrance Clinique Ambroise Pare 31300 ToulouseFrance Perpignan General Hospital 66000 PerpignanFrance Tarbes General Hospital 65000 TarbesFrance Montauban General Hospital 82000 MontaubanFrance Hepatogastroenterology-Digestive Department Purpan University Hospital31059 Toulouse cedex 9France Clinique du Parc 31078 Toulouse Cedex 4France Virology Unit INSERM U1043 31059 Toulouse cedex 9France

AIM:To assess,in a routine practice setting,the sus-tained virologic response(SVR) to telaprevir(TPV) or boceprevir(BOC) in hepatitis C virus(HCV) nullresponders or relapsers with severe liver ***:One hundred twenty-five patients were treated prospectively for 48 wk with TPV or BOC + pegylated-interferon(peg-INF) α2a + ribavirin(PR) according to standard treatment schedules without *** patients were treated in routine practice settings in 10 public or private health care centers,and the data were prospectively *** patients with severe liver fibrosis(Metavir scores of F3 or F4 upon liver biopsy or liver stiffness assessed by elastography),genotype 1 HCV and who were null-responders or relapsers to prior PR combination therapy were included in this ***:The Metavir fibrosis scores were F3 in 35(28%) and F4 in 90(72%) of the *** total,62.9% of the patients were null-responders and 37.1% relapsers to the previous PR *** overall SVR rate at 24 wk post-treatment withdrawal was 59.8%.The SVR was 65.9% in the TPV group and 44.1% in the BOC *** predictive factors of an SVR included a response to previous treatment,relapsers vs null-responders [OR = 3.9;(1.4,10.6),P = 0.0084],a rapid virological response(RVR) [OR 6.9(2.6,18.2),P = 0.001] and liver stiffness lower than 21.3 kPa [OR = 8.2(2.3,29.5),P = 0.001].During treatment,63 patients(50.8%) had at least one severe adverse event(SAE) of grade 3 or 4.A multivariate analysis identified two factors associated with SAEs:female gender [OR = 2.4(1.1,5.6),P = 0.037] and a platelet count below 150 × 103/ mm3 [OR = 5.3(2.3,12.4),P ≤ 0.001].CONCLUSION:More than half of these difficult-to-treat patients achieved an SVR and had SAEs in an actual practice *** SVR rate was influenced by the response to previous PR treatment,the RVR and liver stiffness.

关键词： Hepatitis C virus Hepatitis C Antiviral therapy Protease inhibitors Fibroscan Liver stiffness Cirrhosis Boceprevir Telaprevir Ribavirin

二甲双胍单药控制不佳的2型糖尿病患者联合达格列净治疗的长期有效性

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二甲双胍单药控制不佳的2型糖尿病患者联合达格列净治疗的长期有...

Epidemiological and Clinical Characteristics of Renal Diseases Diagnosed by Biopsies in Ivory Coast

中华医学会糖尿病学分会第十六次全国学术会议

作者： Clifford J.Bailey Jorge L.Gross delphine Hennicken Nayyar Iqbal Traci A.Mansfield James F.List Life and Health Sciences Aston UniversityBirminghamUK Endocrine Division Universidade Federal do Rio Grande do SulPorto AlegreBrazil

目的达格列净(DAPA)是选择性2型钠-葡萄糖协同转运蛋白(SGLT2)抑制剂,通过增加肾脏的葡萄糖清除这一非胰岛素依赖方式来降低血糖。先前已报道了二甲双胍(MET)单药控制欠佳的2型糖尿病患者(n=546)加用DAPA[主要终点:第24周的糖化血红蛋白...

目的达格列净(DAPA)是选择性2型钠-葡萄糖协同转运蛋白(SGLT2)抑制剂,通过增加肾脏的葡萄糖清除这一非胰岛素依赖方式来降低血糖。先前已报道了二甲双胍(MET)单药控制欠佳的2型糖尿病患者(n=546)加用DAPA[主要终点:第24周的糖化血红蛋白(HbA1c)水平]的随机、双盲、安慰剂对照试验(MB102014)的24周的短期治疗效果;而本研究将报道扩展治疗至102周的结果。

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Open Journal of Pathology 2022年第3期12卷 100-113页

作者： Kouame Justin N’Dah Weu Melanie Tia Alain Didier Abouna Ibrahiman Toure Amelie delphine Lagou Monley Cyr Guei Ibrahim Cherif Moussa Traore Eyram Amekoudi Attaah Ange Rebecca Kobenan Sery Patrick Olivier Diopo Kouame Hubert Yao N’Guessan Clement Ackoundou Koffi Laurence Adonis Dazé Apolinaire Gnionsahié Mohenou Isidore Jean Marie Diomande Department of Anatomic Pathology University Teaching Hospital of Bouake Bouake Ivory Coast Department of Nephrology University Teaching Hospital of Bouake Bouake Ivory Coast Department of Anatomic Pathology University Teaching Hospital of Cocody Abidjan Ivory Coast Department of Nephrology University Teaching Hospital of Yopougon Abidjan Ivory Coast Department of Nephrology University Teaching Hospital of Donka Conakry Guinea Department of Nephrology Sylvanus Olympio University Teaching Hospital Lomé Togo Department of Nephrology University Teaching Hospital of Treichville Abidjan Ivory Coast Department of Pediatric Nephrology University Teaching Hospital of Yopougon Abidjan Ivory Coast

Renal biopsy is an invasive procedure used to evaluate the activity and the therapeutic management of kidney disease and kidney transplantation. Objective: The aim of this study was to describe the epidemiological, clinical, and pathological features of kidney disease diagnosed by biopsy in the Ivory Coast. Materials and Methods: This was a descriptive and prospective study conducted between January 2015 and December 2018 in the Department of Anatomy and Cytology of the Pathology of Cocody (Abidjan) and Bouake. Specimens were obtained from the nephrology department of Ivory Coast and from teaching hospitals in Togo, Guinea, Burkina Faso, and Mali. Samples were analyzed according to standard renal biopsy procedures. One kidney fragment was fixed in acetic acid formalin (AAF) for optical microscopy examination. The other fragment, soaked in physiological water, was immediately sent for immunofluorescence examination. All renal pathologies were included in this study. The study parameters were frequency, age, sex, origin, occupation, clinical and biological signs, and pathological aspects with optical microscopy, and immunofluorescence. Results: 153 cases (2.23%) of kidney biopsies were examined on a total of 10,573 specimens. Ivory Coast specimens accounted for 91.5% of cases (n = 140). Nephrotic syndrome (49%) was the most common clinical sign and indication for renal biopsy, followed by acute renal failure (16.3%), chronic renal failure (19.6%), and a combination of chronic renal failure with hypertension (11.18%) and glomerulonephritis (4%). Mean proteinuria was 3.03 g/24h (range, 0.14 to 11.5 g/24h). Histologically, 90.8% (n = 139) were glomerular nephropathies, including 26.6% HIV-associated nephropathy, 17.3% focal segmental glomerulosclerosis, 13.6% nephroangiosclerosis, 11.5% post-infectious glomerulonephritis, 9.3% membranous glomerulonephritis, and 21.6% miscellaneous glomerular nephropathies (n = 30). The incidence of various tubulo-interstitial lesions was

关键词： Kidney Biopsy Disease Pathology Ivory Coast