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Reflectivity and thickness analysis of epiretinal membranes using spectral-domain optical coherence tomography

International Journal of Ophthalmology(English edition) 2016年第1期9卷 93-98页

作者： Ajay E.Kuriyan delia cabrera debuc William E.Smiddy Department of Ophthalmology Bascom Palmer Eye InstituteMiller School of Medicine University of Miami

AIM：To compare thickness and reflectivity spectral domain optical coherence tomography（SD-OCT）findings in patients with idiopathic epiretinal membranes（ERMs）,before and after ERM peeling surgery,with normal controls.·METHODS：A retrospective study analyzing SD-OCTs of eyes with ERMs undergoing ERM peeling surgery by one surgeon from 2008 to 2010 and normal control ***-OCTs were analyzed using a customized algorithm to measure reflectivity and *** relationship between the SD-OCT findings and best corrected visual acuity（BCVA）outcomes was also studied.·RESULTS：Thirty-four ERM eyes and 12 normal eyes were *** eyes had high reflectivity and thickness of the group of layers from the internal limiting membrane（ILM）to the retinal pigment epithelium（RPE）and the group of layers from the ILM to the external limiting membrane（ELM）.The values of reflectivity of these two groups of layers decreased postoperatively,but were still higher than normal *** contrast,preoperative eyes had lower reflectivity of two10×15 pixel regions of interest（ROIs）incorporating：1）ELM＋outer nuclear layer（ONL）and 2）photoreceptor layer（PRL）＋RPE,compared to *** values of reflectivity of these ROIs increased postoperatively,but were still lower than normal controls.A larger improvement in BCVA postoperatively was correlated with a greater degree of abnormal preoperative reflectivity and thickness findings.·C ONCLUSION：Quantitative differences in reflectivity and thickness between preoperative,postoperative,and normal SD-OCTs allow assessment of changes in the retina secondary to *** study identified hyperreflective inner retina changes and hyporeflective outer retina changes in patients with ***-OCT quantitative measures of reflectivity and/or thickness of specific groups of retinal layers and/or ROIs correlate with improvement in BCVA.

关键词： epiretinal membranes optical coherencetomography reflectivity retina imaging vitrectomy

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Exploratory study of non-invasive,high-resolution functional macular imaging in subjects with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 57-63页

作者： Thalmon R.Campagnoli Gábor Márk Somfai Jing Tian delia cabrera debuc William E.Smiddy Bascom Palmer Eye Institute Miller School of MedicineUniversity of MiamiMiamiFL 33136USA Department of Ophthalmology Semmelweis UniversityFaculty of MedicineBudapestHungary

AIM:To evaluate a high-resolution functional imaging device that yields quantitative data regarding macular blood flow and capillary network features in eyes with diabetic retinopathy(DR).METHODS:Prospective,cross-sectional comparative case-series in which blood flow velocities(BFVs)and noninvasive capillary perfusion maps(nCPMs)in macular vessels were measured in patients with DR and in healthy controls using the Retinal Functional Imager(RFI)***:A total of 27 eyes of 21 subjects were studied[9 eyes nonproliferative diabetic retinopathy(NPDR),9 eyes proliferative diabetic retinopathy(PDR)and 9 controls].All diabetic patients were type *** patients with NPDR and 5 eyes with PDR also had diabetic macular edema(DME).The NPDR group included eyes with severe(n=3)and moderate NPDR(n=6),and were symptomatic.A significant decrease in venular BFVs was observed in the macular region of PDR eyes when compared to controls(2.61±0.6 mm/s and 2.92±0.72 mm/s in PDR and controls,respectively,P=0.019)as well as PDR eyes with DME compared to NPDR eyes(2.36±0.51 mm/s and 2.94±1.09 mm/s in PDR with DME and NPDR,respectively,P=0.01).CONCLUSION:The RFI,a non-invasive imaging tool,provides high-resolution functional imaging of the retinal microvasculature and quantitative measurement of BFVs in visually impaired DR *** isolated diminish venular BFVs in PDR eyes compared to healthy eyes and PDR eyes with DME in comparison to NPDR eyes may indicate the possibility of more retinal vein compromise than suspected in advanced DR.

关键词： macular blood flow capillary perfusion map non-invasive vascular imaging high-resolution imaging diabetic retinopathy retinal function imager

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Investigation of changes in thickness and reflectivity from layered retinal structures of healthy and diabetic eyes with optical coherence tomography

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Journal of Biomedical Science and Engineering 2011年第10期4卷 657-665页

作者： Wei Gao Erika Tatrai Veronika Olvedy Boglarka Varga Lenke Laurik Aniko Somogyi Gabor Mark Somfai delia cabrera debuc Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiUSA Semmelweis University Department of OphthalmologyBudapestHungary Semmelweis University 2^(nd) Department of Internal MedicineBudapestHungary

OCT is usually employed for the measurement of retinal thickness. However, coherent reflected light carries more information characterizing the optical properties of tissue. Therefore, optical property changes may provide further information regarding cellular layers and early damage in ocular diseases. We investigated the possibility of OCT in detecting changes in the optical backscattered signal from layered retinal structures. OCT images were obtained from diabetic patients without retinopathy (DM, n = 38 eyes) or mild diabetic retinopathy (MDR, n = 43 eyes) and normal healthy subjects (n = 74 eyes). The thickness and reflectivity of various layered structures were assessed using a custom-built algorithm. In addition, we evaluated the usefulness of quantifying the reflectivity of layered structures in the detection of retinal damage. Generalized estimating equations considering within-subject inter-eye relations were used to test for differences between the groups. A modified p value of <0.001 was considered statistically significant. Receiver operating characteristic (ROC) curves were constructed to describe the ability of each parameter to discriminate between the eyes of DM, MDR and healthy eyes. Thickness values of the GCL + IPL and OPL showed a significant decrease in the MDR eyes compared to controls. Significant decreases of total reflectance average values were observed in all layers in the MDR eyes compared with controls. The highest AUROC values estimated for the total reflectance were observed for the GCL+IPL, OPL and OS when comparing MDR eyes with controls. Total reflectance showed a better discriminating power between the MDR eyes and healthy eyes compared to thickness values. Our results suggest that the optical properties of the intraretinal layers may provide useful information to differentiate pathological from healthy eyes. Further research is warranted to determine how this approach may be used to improve diagnosis of early retinal neurodegene

关键词： Optical Coherence Tomography Rerina Diabetic Retinopathy Segmentation Image Processing

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An Overview of Leptin and the Th1/Th2 Balance

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Open Journal of Immunology 2014年第2期4卷 42-50页

作者： Buenaventura Brito Diaz Itahisa Marcelino Rodriguez delia Almeida Gonzalez María del Cristo Rodríguez Pérez Antonio cabrera de León Research Unit University Hospital Nuestra Senora de Candelaria TenerifeSpain Immunology Unit University Hospital Nuestra Senora de Candelaria TenerifeSpain University of La Laguna TenerifeSpain

Adipocytes produce hormones and adipokines, among others leptin, with metabolic and inflammatory responses. The role of leptin involves different subsets of the immune system. Low levels of serum leptin concentrations are associated with bacterial infections and produce susceptibility to allergic diseases and type Th2 autoimmune diseases. High levels of leptin are associated with Th1 autoimmune diseases via inflammatory responses. Leptin resistance, that happens in obesity, is characterized by the presence of high levels of serum leptin itself accompanied by a clinical situation of a Th2 response. There is a relationship between obesity, leptin resistance, altered immunity and sex hormones. Serum leptin concentration (Th1 response) in women is higher than in men maybe to achieve the balance Th1/Th2 because of the high level of estrogenic hormones (Th2 response) in women.

关键词： Obesity Leptin Resistance Autoimmunity Sex Hormones

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