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Seamount chains and hotspot tr.cks:Super.icially similar.deeply differ.nt

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Geoscience Fr.ntier. 2023年第6期14卷 307-326页

作者： Edgar.o Cañón-tapia División de Ciencias de la Tier.a CICESE.Carretera Ensenada-Tijuana#3985Ensenada Baja CaliforniaCP 22860Mexico

Near.y 80%of the seafloor.extension has not been cover.d by high-r.solution bathymetr.,impeding dir.ct obser.ation of ***,lists of seamount location and height at a global scale have been pr.duced using differ.nt *** this wor. four.of such databases(publicly available)ar. compar.d with each other.to assess their.*** identify lar.e differ.nces among databases that could have exer.ed str.ng influences on models of seamount pr.duction and associated geodynamic *** those differ.nces,it is shown that all databases allow the identification of seamount lines both along the pr.sent-day Mid Ocean r.dge(MOr.system and on intr.plate ***,those seamount lines do not coincide with the so-called hotspot tr.cks that commonly wer. defined by selectively focusing attention on the lar.er.*** of all the databases also shows that distinction based only on seamount size between seamounts pr.duced at Mid-Ocean r.dge(MOr.envir.nments fr.m those associated with mantle-plum fed-hotspot activity has been ***,combined with the fact that most seamount lines defined by the available databases can be tr.ced back to past locations of MOr.indicates that most of the pr.sent-day intr.plate linear.ar.ays of seamounts,which include some lar.e seamounts,wer. not pr.duced by the action of under.ying mantle anomalies envisaged in the for. of mantle *** evidence pr.sented her. calls for.a r.assessment of the for. in which volcanic and tectonic activities ar. conceptually r.lated to each other.

关键词： Seamount or.gin Chains of seamounts Spatial distr.bution of volcanism Intr.plate volcanism Mid Ocean r.dge volcanism

Quer.etin pr.vents spinal motor.neur.n degener.tion induced by chr.nic excitotoxic stimulus by a sir.uin 1-dependent mechanism

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Tr.nslational Neur.degener.tion 2017年第1期6卷 310-323页

作者： r.fael Lazo-Gomez r.car.o tapia División de Neur.ciencias Instituto de Fisiología CelularUniversidad Nacional Autónoma de MéxicoCircuito exterior s/nCiudad UniversitariaCoyoacán04510 Ciudad de MéxicoMexico

Backgr.und:Excitotoxicity is a mechanism of for.most impor.ance in the selective motor.neur.n degener.tion char.cter.stic of motor.neur.n *** ther.peutic str.tegies ar. an unmet need for.these ***,such as quer.etin and r.sver.tr.l,ar. plant-der.ved compounds that activate sir.uins(SIr.s)and have shown pr.mising r.sults in some models of neur.nal death,although their.effects have been scar.ely tested in models of motor.neur.n ***:In this wor. we investigated the effects of quer.etin and r.sver.tr.l in an in vivo model of excitotoxic motor.neur.n death induced by the chr.nic infusion ofα-amino-3-hydr.xy-5-methyl-4-isoxazolepr.pionic acid(AMPA)into the r.t spinal cor. *** and r.sver.tr.l wer. co-infused with AMPA and motor.behavior.and muscle str.ngth wer. assessed daily for.up to ten ***,animals wer. fixed and lumbar.spinal cor. tissue was analyzed by histological and immunocytological ***:We found that the chr.nic infusion of AMPA[1 mM]caused a pr.gr.ssive motor.neur.n degener.tion,accompanied by astr.gliosis and micr.gliosis,and motor.deficits and par.lysis of the r.ar.*** infusion amelior.ted AMPA-induced par.lysis,r.scued motor.neur.ns,and pr.vented both astr.gliosis and micr.gliosis,and these pr.tective effects wer. pr.vented by EX527,a ver. selective SIr.1 *** contr.st,neither.r.sver.tr.l nor.EX527 alone impr.ved motor.behavior.deficits or.r.duced motor.neur.n degener.tion,albeit both r.duced ***:These r.sults suggest that quer.etin exer.s its beneficial effects thr.ugh a SIr.1-mediated mechanism,and thus SIr.1 plays an impor.ant r.le in excitotoxic neur.degener.tion and ther.for. its phar.acological modulation might pr.vide oppor.unities for.ther.py in motor.neur.n disor.er..

关键词： Motor.neur.n disor.er Quer.etin r.sver.tr.l Sir.uin Excitotoxicity

Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer.s disease

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Neur.l r.gener.tion r.sear.h 2018年第10期13卷 1705-1710页

作者： Cher.l tapia-r.jas Nibaldo C.Inestr.sa Centr. de Envejecimiento y r.gener.ción (CAr. UC) Departamento de Biología Celular y MolecularFacultad de Ciencias BiológicasPontificia Universidad Católica de Chile Centr. for.Healthy Br.in Ageing School of PsychiatryFaculty of MedicineUniversity of New South Wales Centr. de Excelencia en Biomedicina de Magallanes (CEBIMA) Universidad de Magallanes

Alzheimer.s disease（AD） is the most common for. of dementia in the older.population, however. the pr.cise cause of the disease is unknown. The neur.pathology is char.cter.zed by the pr.sence of aggr.gates for.ed by amyloid-β（Aβ） peptide and phosphor.lated tau; which is accompanied by pr.gr.ssive impair.ent of memor.. Diver.e signaling pathways ar. linked to AD, and among these the Wnt signaling pathway is becoming incr.asingly r.levant, since it plays essential r.les in the adult br.in. Initially, Wnt signaling activation was pr.posed as a neur.pr.tective mechanism against Aβ toxicity. Later. it was r.por.ed that it par.icipates in tau phosphor.lation and pr.cesses of lear.ing and memor.. Inter.stingly, in the last year. we demonstr.ted that Wnt signaling is fundamental in amyloid pr.cur.or.pr.tein（APP） pr.cessing and that Wnt dysfunction r.sults in Aβ pr.duction and aggr.gation in vitr.. r.cent in vivo studies r.por.ed that loss of canonical Wnt signaling exacer.ates amyloid deposition in a tr.nsgenic（Tg） mouse model of AD. Finally, we showed that inhibition of Wnt signaling in a Tg mouse pr.viously at the appear.nce of AD signs, r.sulted in memor. loss, tau phosphor.lation and Aβ for.ation and aggr.gation; indicating that Wnt dysfunction acceler.ted the onset of AD. Mor. impor.antly, Wnt signaling loss pr.moted cognitive impair.ent, tau phosphor.lation and Aβ1–42 pr.duction in the hippocampus of wild-type（WT） mice, contr.buting to the development of an Alzheimer.s-like neur.phatology. Ther.for., in this r.view we highlight the impor.ance of Wnt/β-catenin signaling dysfunction in the onset of AD and pr.pose that the loss of canonical Wnt signaling is a tr.gger.ng factor.of AD.

关键词： Wnt signaling Wnt tar.et genes Wnt/β-catenin Alzheimer.disease amyloid-β tau phosphor.lation memor. loss synaptic dysfunction

Br.in metastasis in advanced color.ctal cancer. r.sults fr.m the South Austr.lian metastatic color.ctal cancer.(SAmCr.) r.gistr.

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Cancer.Biology & Medicine 2017年第4期14卷 371-376页

作者： Gonzalo tapia r.co Timothy J. Pr.ce Chr.stos Kar.petis Cynthia Piantadosi r.b Padbur. Amitesh r.y Guy Madder. James Moor. Scott Car.uther. David r.der.Amanda r. Townsend Depar.ment of Medical Oncology The Queen Elizabeth Hospital and University of Adelaide Adelaide SA 5011 Australia Depar.ment of Medical Oncology Flinders Medical Center and Flinders University Adelaide SA 5042 Australia Depar.ment of Sur.er. Flinders Medical Center Bedford Park SA 5042 Australia Depar.ment of Sur.er. The Queen Elizabeth Hospital Adelaide SA 5011 Australia Depar.ment of Sur.er. University of South Australia Adelaide SA 5005 Australia Depar.ment of Sur.er. Royal Adelaide Hospital Adelaide SA 5000 Australia Depar.ment of r.diation Oncology Royal Adelaide Hospital Adelaide SA 5000 Australia Depar.ment of Epidemiology University of South Australia Adelaide SA 5005 Australia

Objective:Br.in metastasis is consider.d r.r. in metastatic color.ctal cancer.mCr.);thus,sur.eillance imaging does not r.utinely include the *** r.por.ed incidence of br.in metastases r.nges fr.m 0.6% to 3.2%.Methods:The South Austr.lian mCr. r.gistr.(SAmCr.)was analyzed to assess the number.of patients pr.senting with br.in metastasis dur.ng their.*** to small number.,a descr.ptive analysis is ***:Only 59 patients of 4,100 on the r.gistr. at the time of analysis had developed br.in metastasis(1.4%).The clinical char.cter.stics of those with br.in metastasis wer. as follows:the median age was 65.3 year. and 51% wer. *** the V-Ki-r.s2 Kir.ten r.t sar.oma vir.l oncogene homolog(Kr.S)mutation status of the tumor.was known,the major.ty har.or.d a Kr.S mutation(55%);31(53%)under.ent cr.niotomy and 55(93%)under.ent whole-br.in *** median sur.ival time fr.m diagnosis of br.in metastasis was 4.2 months(95% confidence inter.al 2.9–5.5).Patients who under.ent cr.niotomy and r.diother.py had super.or.sur.ival compar.d to those who under.ent whole-br.in r.diother.py(8.5 months vs.2.2 months,r.spectively).Data fr.m the SAmCr.(a population-based r.gistr.)confir. that br.in metastases ar. r.r. and the median time to development is appr.ximately 2 ***:Br.in metastasis is a r.r. outcome in advanced *** within the r.gistr. tended to be female,young in age,and har.or.d with higher.r.tes of Kr.S *** r.utine sur.eillance br.in scanning should be consider.d r.mains contr.ver.ial given the r.lative r.r.ty of developing br.in metastases in mCr. and ultimately,most patients with centr.l ner.ous system involvement die fr.m their.extr.cr.nial disease.

关键词： Br.in metastasis color.ctal cancer sur.ival sur.eillance

Evolution of the MLO gene families in octoploid str.wber.y(Fr.gar.a×ananassa)and pr.genitor.diploid species identified potential genes for.str.wber.y powder. mildew r.sistance

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Hor.icultur. r.sear.h 2021年第1期8卷 1969-1985页

作者： r.nald r.tapia Chr.stopher.r.Bar.ey Saket Chandr. Kevin M.Folta Vance M.Whitaker.Seonghee Lee Depar.ment of Hor.icultur.l Sciences University of FloridaIFAS Gulf Coast Research and Education CenterWimaumaFL 33598USA Depar.ment of Hor.icultur.l Sciences University of Florida1301 Fifield HallPO Box 110690GainesvilleFL 32611USA

Powder. mildew(PM)caused by Podosphaer. aphanis is a major.fungal disease of cultivated *** r.sistance Locus O(MLO)is a gene family descr.bed for.having conser.ed seven-tr.nsmembr.ne *** loss-of-function in specific MLO genes can confer.dur.ble and br.ad r.sistance against PM ***,the genomic str.ctur. and potential r.le of MLO genes for.PM r.sistance have not been char.cter.zed yet in the octoploid cultivated *** the pr.sent study,MLO gene families wer. char.cter.zed in four.diploid pr.genitor.species(Fr.gar.a vesca,***,***,and ***)and octoploid cultivated(Fr.gar.a×ananassa)str.wber.y,and potential sour.es of MLO-mediated susceptibility wer. *** MLO sequences wer. identified in *** and 68 identified in F.×*** analysis divided diploid and octoploid str.wber.y MLO genes into eight differ.nt clades,in which thr.e FveMLO(MLO10,MLO17,and MLO20)and their.twelve or.hologs of FaMLO wer. gr.uped together.with functionally char.cter.zed MLO genes confer.ing PM *** number.var.ations r.vealed differ.nces in MLO composition among homoeologous chr.mosomes,suppor.ing the distinct or.gin of each subgenome dur.ng the evolution of octoploid *** genomic sequence and str.ctur.l var.ations in candidate FaMLO genes r.vealed their.potential r.le associated with genetic contr.ls and functionality in str.wber.y against PM ***,the gene expr.ssion pr.filing and r.Ai silencing of putative FaMLO genes in r.sponse to the pathogen indicate the function in PM *** r.sults ar. a cr.tical fir.t step in under.tanding the function of str.wber.y MLO genes and will facilitate fur.her.genetic studies of PM r.sistance in cultivated str.wber.y.

关键词： str.w MLO Fr.gar.a

Ver.-ear.y-stage Hepatocellular.Car.inoma,Ar. We at Long Last on r.ute for.Achieving Better.Patient Outcomes?

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Jour.al of Clinical and Tr.nslational Hepatology 2021年第2期9卷 141-142页

作者： Paulina Vidal-Cevallos Nor.er.o Chavez-tapia Obesity and Digestive Disease Unit Medica Sur Clinic and FoundationMexico CityMexico

Hepatocellular.car.inoma(HCC)r.pr.sents∼90%of the pr.mar. liver.cancer.cases,and 90%of HCC cases occur.in patients with chr.nic liver.disease.1 It also r.pr.sents the sixth most common cancer.4.7%)and the thir. leading cause of cancer.r.lated death globally(8.3%).2 Mor. tr.ubling,the global incidence and mor.ality r.tes have been incr.asing since 1990.3 In the United States,the highest aver.ge annual per.entage change(known as AAPC)r.por.ed between 2000 and 2012 involved individuals between 55 and 59 year. of age(AAPC:8.9%;95%confidence inter.al:7.1–10.7%).

关键词： Car.inoma mor.ality cancer

Alter.ative techniques for.for.casting miner.l commodity pr.ces

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Inter.ational Jour.al of Mining Science and Technology 2018年第2期28卷 309-322页

作者： C.A.tapia Cor.ez S.Saydam J.Coulton C.Sammut School of Mining Engineer.ng UNSW Sydney UNSW Business School UNSW Sydney School of Computer.Science and Engineer.ng UNSW Sydney

For.casting miner.l commodity(MC) pr.ces has been an impor.ant and difficult task tr.ditionally addr.ssed by econometr.c, stochastic-Gaussian and time ser.es techniques. None of these techniques has pr.ved suitable to r.pr.sent the dynamic behavior.and time r.lated natur. of MC mar.ets. Chaos theor.(CT) and machine lear.ing(ML) techniques ar. able to r.pr.sent the tempor.l r.lationships of var.ables and their.evolution has been used separ.tely to better.under.tand and r.pr.sent MC mar.ets. CT can deter.ine a system's dynamics in the for. of time delay and embedding dimension. However. this infor.ation has often been solely used to descr.be the system's behavior.and not for.*** to tr.ditional techniques, ML has better.per.or.ance for.for.casting MC pr.ces, due to its capacity for.finding patter.s gover.ing the system's dynamics. However. the r.tional natur. of economic pr.blems incr.ases concer.s r.gar.ing the use of hidden patter.s for.for.casting. Ther.for., it is uncer.ain if var.ables selected and hidden patter.s found by ML can r.pr.sent the economic *** their.r.fined featur.s for.r.pr.senting system dynamics, the separ.te use of either.CT or.ML does not pr.vide the expected r.alistic accur.cy. By itself, neither.CT nor.ML ar. able to identify the main var.ables affecting systems, r.cognize the r.lation and influence of var.ables though time, and discover.hidden patter.s gover.ing systems evolution simultaneously. This paper.discusses the necessity to adapt and combine CT and ML to obtain a mor. r.alistic r.pr.sentation of MC mar.et behavior.to for.cast long-ter. pr.ce tr.nds.

关键词： Pr.ce for.casting Miner.l commodity Mar.et dynamics Chaos theor. Machine lear.ing

Tr.nslational appr.aches: Fr.m fatty liver.to non-alcoholic steatohepatitis

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Wor.d Jour.al of Gastr.enter.logy 2014年第27期20卷 9038-9049页

作者： Natalia r.sso Nor.er.o C Chavez-tapia Claudio Tir.belli Stefano Bellentani Fondazione Italiana Fegato 34149 Trieste Italy Obesity and Digestive Diseases Unit Médica Sur Clinic and FoundationMexico 14050 México Depar.ment of Medical Sciences University of Trieste Depar.ment of Gastr.enter.logy and Endoscopy Azienda USL di ModenaOspedale "Ramazzini" 41012 Carpi (Modena) Italy

Over.the past few decades, non-alcoholic fatty liver.disease(NAFLD) has become one, if not the most common,cause of chr.nic liver.disease affecting both adults and childr.n. The incr.asing number.of cases at an ear.y age is the most wor.ying aspect of this pathology, since it pr.vides mor. time for.its evolution. The spectr.m of this disease r.nges fr.m liver.steatosis to steatohepatitis, fibr.sis and in some cases, hepatocellular.car.inoma. NAFLD may not always be consider.d a benign disease and hepatologists must be cautious in the pr.sence of fatty liver. This should pr.mpt the use of the available exper.mental models to under.tand better.the pathogenesis and to develop a r.tional tr.atment of a disease that is danger.usly incr.asing. In spite of the gr.wing effor.s, the pathogenesis of NAFLD is still poor.y under.tood. In the pr.sent ar.icle we r.view the most r.levant hypotheses and evidence that account for.the pr.gr.ssion of NAFLD to non-alcoholic steatohepatitis(NASH) and fibr.sis. The available in vitr. and in vivo exper.mental models of NASH ar. discussed and r.vised in ter.s of their.validity in tr.nslational studies. These studies must be aimed at the discover. of the still unknown tr.gger. or.mediator. that induce the pr.gr.ssion of hepatic inflammation, apoptosis and fibr.sis.

关键词： Fatty Liver Obesity Metabolic syndr.me Inflammation In vitr. Exper.mental model

Mar.eting Str.tegies for.Chinese Tour.sts to Ecuador.Based on An Analysis of Austr.lia’s Pr.motion

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Marketing Strategies for Chinese Tourists to Ecuador Based o...

作者： Diego Maur.cio Escobar.tapia 河北大学

学位级别：硕士

As China became the gr.atest outbound tour.sm mar.et wor.dwide,many countr.es ar. designing str.tegies in or.er.to attr.ct Chinese tour.sts to their.***,Ecuador.r.ceives a small mar.et shar. of 0,02%,which shows that has not been r.sponsive and has not yet developed a tailor.made str.tegy for.this new mar.et;on the contr.r. is still invested in pur.uing tr.ditional mar.ets as the main sour.e of tour.sm *** this sense,it is imper.tive for.Ecuador.to seize the oppor.unity,and thus to develop a pr.motion str.tegy tar.eted to the Chinese mar.et in or.er.to incr.ase the number.of ar.ivals,taking into consider.tion the case of Austr.lia′s *** thesis does a compr.hensive analysis of Austr.lia′s Tour.sm pr.motion in the Chinese mar.et,the implemented str.tegies of the past year. and the r.sult on ar.ival′s gr.wth to this ***,it studies Austr.lia thr.ugh Butler.s Stage Model′s appr.ach,and descr.bes Austr.lia′s mar.eting mix in or.er.to give the r.ader.a better.under.tanding on the countr.′s tour.sm pr.motion ***,it gives insight into Ecuador.s tour.sm pr.motion str.tegies thr.ugh the SWOT method and concludes by suggesting mar.eting str.tegies lear.ed fr.m the Austr.lian exper.ence in or.er.to incr.ase the shar. for.the Chinese mar.et.

关键词：旅游业营销组合促销策略市场份额