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search for the rare decay B^(0)→J/ψФ

Chinese Physics C 2021年第4期45卷 47-60页

作者： R.Aaij C.Abellin Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnial C.A.Aidala s.Aiola Z.Ajaltouni s.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle s.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier s.Bachmann M.Bachmaver J.J.Back s.Baker P.Baladron Rodriguez v.Balagura W.Baldinit J.Baptista Leite R.J.Barlow s.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschis I.Bediaga A.Beiter v.Belavin s.Belin v.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko s.Bhasin J.Bhom L.Bian M.s.Bieker s.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Biorn M.P.Blago T.Blake F.Blanc s.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar s.Borghi M.Borisyak M.Borsato J.T.Borsuk s.A.Bouchiba T.J.v.Bowcock A.Boyer C.Bozzi M.J.Bradley s.Braun A.Brea Rodriguezs M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Burschee A.Butkevich J.s.Butter J.Buytaert W.Byczynski s.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz s.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada s.Capelli L.Capriotti A.Carbonel G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais vidal G.Casse M.Cattaneo G.Cavallero s.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen s.Chen A.Chernov s.-G.Chitic v.Chobanova s.Cholak M.Chrzaszcz A.Chubykin v.Chulikov P.Ciambrone M.F.Cicala X.Cid vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.v.Cliff J.Closier J.L.Cobbledick v.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.costa sobral B.Couturier D.C.Craik J.Crkovska M.Cruz Centro Brasileiro de Pesquisas Fisicas(CBPF) Riode JaneiroBrazil Universidade Federal do Riode Janeiro(UFRJ) Riode JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina school of Physics state Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of sciences BeijingChina Institute Of High Energy Physics(IHEP) BejingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universitq Paris-saclay CNRS/IN2P3IJCLabOrsayFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut fir Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany school of Physics University College DublinDublinIreland INFN sezione di Bari BariItaly INFN sezione di Bologna BolognaItaly INFN sezione di Ferrara FerraraItaly INFN sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati Frascatiltaly INFN sezione di Genova GenovaItaly INFN sezione di Milano Bicocca Milanolaly INFN sezione di Milano MilanoItaly INFN sezione di Cagliari Monserratoltaly Universita degli studi di Padova Universita e INFNPadovaPadovaItaly INFN sezione di Pisa PisaItaly INFN sezione di Roma Tor vergata RomaItaly INFN sezione di Roma La sapienza RomaItaly Nikhef National Institute for subatomic Physics AmsterdamNetherlands Nikhef National Institute for subatomic Physics and vU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of sciences KrakowPoland AGH-University of science and Technology Faculty of Physics and Applied Computer Science

A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 Tev,corresponding to an integrated luminosity of9 *** significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is set on the branching fraction.

关键词： B physics flavour physics rare decay ω-Фmixing branching fraction

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Deep Learning with Backtracking search Optimization Based skin Lesion Diagnosis Model

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Computers, Materials & Continua 2022年第1期70卷 1297-1313页

作者： C.s.s.Anupama L.Natrayan E.Laxmi Lydia Abdul Rahaman Wahab sait Jose Escorcia-Gutierrez Margarita Gamarra Romany F.Mansour Department of Electronics&Instrumentation Engineering V.R.Siddhartha Engineering CollegeVijayawada520007India Department of Mechanical Engineering Saveetha School of EngineeringSIMATSChennai602105India Department of Computer science and Engineering Vignan’s Institute of Information TechnologyVisakhapatnam530049India Department of Archives and Communication King Faisal University31982Kingdom of Saudi Arabia Electronic and Telecommunicacions Program Universidad Autonoma del CaribeBarranquilla08001Colombia Department of Computational science and Electronic Universidad de la CostaCUCBarranquilla08001Colombia Department of Mathematics Faculty of ScienceNew Valley UniversityEl-Kharga72511Egypt

Nowadays,quality improvement and increased accessibility to patient data,at a reasonable cost,are highly challenging tasks in healthcare *** of Things(IoT)and Cloud Computing(CC)architectures are utilized in the development of smart healthcare *** entities can support real-time applications by exploiting massive volumes of data,produced by wearable sensor *** advent of evolutionary computation algorithms andDeep Learning(DL)models has gained significant attention in healthcare diagnosis,especially in decision making *** cancer is the deadliest disease which affects people across the *** skin lesion classification model has a highly important application due to its fine-grained variability in the presence of skin *** current research article presents a new skin lesion diagnosis model i.e.,Deep Learning with Evolutionary Algorithm based Image segmentation(DL-EAIs)for IoT and cloud-based smart healthcare ***,the dermoscopic images are captured using IoT devices,which are then transmitted to cloud servers for further ***,Backtracking search optimization Algorithm(BsA)with Entropy-Based Thresholding(EBT)i.e.,BsA-EBT technique is applied in image *** by,shallow Convolutional Neural Network(sCNN)model is utilized as a feature *** addition,Deep-Kernel Extreme LearningMachine(D-KELM)model is employed as a classification model to determine the class labels of dermoscopic *** extensive set of simulations was conducted to validate the performance of the presented method using benchmark *** experimental outcome infers that the proposed model demonstrated optimal performance over the compared techniques under diverse measures.

关键词： Intelligent models skin lesion dermoscopic images smart healthcare internet of things

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Knockdown of MLO genes reduces susceptibility to powdery mildew in grapevine

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Horticulture Research 2016年第1期3卷 248-256页

作者： stefano Pessina Luisa Lenzi Michele Perazzolli Manuela Campa Lorenza Dalla costa simona Urso Giampiero valè Francesco salamini Riccardo velasco Mickael Malnoy Research and Innovation Centre Fondazione Edmund Machvia Edmund Mach 1San Michele all’Adige38010Italy Wageningen UR Plant Breeding Wageningen University and Research CentrePO Box 386Wageningen6700AJThe Netherlands Department of Ecological and Biological sciences Universitàdella TusciaVia San Camillo de LellisViterbo01100Italy Council for Agricultural Research and Economics(CREA) Rice Research UnitS.S.11 per Torino km 25Vercelli13100Italy Council for Agricultural Research and Economics(CREA) Genomics Research CentreVia San Protaso302Fiorenzuola d’Arda29017PiacenzaItaly

Erysiphe necator is the causal agent of powdery mildew(PM),one of the most destructive diseases of *** is controlled by sulfur-based and synthetic fungicides,which every year are dispersed into the *** is why PM-resistant varieties should become a priority for sustainable grapevine and wine *** resistance can be achieved in other crops by knocking out susceptibility s-genes,such as those residing at genetic loci known as MLO(Mildew Locus O).All MLO s-genes of dicots belong to the phylogenetic clade v,including grapevine genes vvMLO7,11 and 13,which are upregulated during PM infection,and vvMLO6,which is not *** adopting a gene-editing approach to knockout candidate s-genes,the evidence that loss of function of MLO genes can reduce PM susceptibility is *** paper reports the knockdown through RNA interference of vvMLO6,7,11 and *** knockdown of vvMLO6,11 and 13 did not decrease PM severity,whereas the knockdown of vvMLO7 in combination with vvMLO6 and vvMLO11 reduced PM severity up to 77%.The knockdown of vvMLO7 and vvMLO6 seemed to be important for PM resistance,whereas a role for vvMLO11 does not seem *** wall appositions(papillae)were present in both resistant and susceptible lines in response to PM *** genes involved in defense were less upregulated in infected mlo plants,highlighting the early mlo-dependent disruption of PM invasion.

关键词： MLO crops mildew

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Comparative carbon emission assessments of recycled and natural aggregate concrete: Environmental influence of cement content

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Geoscience Frontiers 2021年第6期12卷 72-81页

作者： Marian sab?u Dan v.Bompa Luis F.O.silva Department of Civil and Environmental Engineering Universidad de la Costa Department of Civil and Environmental Engineering University of Surrey Departamento de Ingeniería Civil y Arquitectura Universidad de Lima

This work examines the environmental and geochemical impact of recycled aggregate concrete production with properties representative for structural applications. The environmental influence of cement content, aggregate production, transportation, and waste landfilling is analysed by undertaking a life cycle assessment and considering a life cycle inventory largely specific for the region. To obtain a detailed insight into the optimum life cycle parameters, a sensitivity study is carried out in which supplementary cementitious materials, different values of natural-to-recycled aggregate content ratio and case-specific transportation distances were considered. The results show that carbon emissions were between 323 and 332 kg CO2e per cubic metre of cement only natural aggregate concrete. These values can be reduced by up to 17% by replacing 25% of the cement with fly ash. By contrast, carbon emissions can increase when natural coarse aggregates are replaced by recycled aggregates in proportions of 50% and 100%, and transportation is not included in analysis. However, the concrete with 50% recycled aggregate presented lower increase, only 0.3% and 3.4% for normal and high strength concrete, respectively. In some cases, the relative contribution of transportation to the total carbon emissions increased when cement was replaced by fly ash in proportions of 25%, and case-specific transportation distances were considered. In absolute values, the concrete mixes with 100% recycled aggregates and 25% fly ash had lower carbon emissions than concrete with cement and natural aggregates only. Higher environmental benefits can be obtained when the transportation distances of fly ash are relatively short(15–25 km) and the cement replacement by fly ash is equal or higher than 25%, considering that the mechanical properties are adequate for practical application. The observations from this paper show that recycled aggregate concrete with strength characteristics representative for s

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situations of Domestic violence against Children and Adolescents in a Northeastern Brazilian Capital

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Open Journal of Nursing 2016年第9期6卷 633-642页

作者： Eliane santos Cavalcante Francisco Arnoldo Nunes de Miranda Lannuzya v. e Oliveira Glauber W. dos santos silva Gustavo Ávila Dias Romeika C. F. de sena suerda Lillian da Fonseca Lins Cleonice A. A. Cavalcante Izaura Luzia silvério Freire João E. da costa Health school Federal University of Rio Grande do Norte Natal Brazil Nursing Department Postgraduate Program in Nursing Federal University of Rio Grande do Norte Natal Brazil Natal Health City Department Natal Brazil

Objective: To describe the epidemiological profile of children and adolescents who are victims of domestic violence. Method: This is a cross sectional and descriptive study, following a quantitative approach, conducted from september to December 2013, at the sOs CHILD service, in the city of Natal, Rio Grande do Norte, Brazil. The research protocol was approved by CEP/UFRN under CAAE 0166.***.051.000-11. Results: In the analysis of 69 children, the results were presented from three points of view: 1) the victim—female (56.5%), aged one to 11 years old (66.7%) and lived with one of the parents (43.5%);2) the abuser—female (60.9%) in the 14 - 23 years old and 34 - 43 years old, with the same percentage (24.6%), history of alcohol use and abuse (42.0%), the mother was the one who attacked the most (34.7%);3) types of violence, among the physical ones, the most frequent were slaps (43.2%) and punches (18.9%);the prevalence, among the psychological violence, were curses (35.4%) and abuse (27.8%);negligence, omission of care (73.5%), deprivation of care for personal appearance (18.4%);among sexual violence: sexual caresses (57.1%) and forced sex (42.9%). Conclusion: Children and adolescents placed in an unfavorable social-economic context, under the care of mothers with a history of use and abuse of alcohol and other drugs, are more vulnerable to intra-domiciliary violence.

关键词： Exposure to violence Domestic violence Child Health Adolescent Health

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Adhesion studies of Diamond-Like Carbon Films Deposited on Ti6Al4v Alloy after Carbonitriding

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Open Journal of Metal 2012年第1期2卷 1-7页

作者： Deiler Antonio Lima-Oliveira Romina Paula Castro costa Gislene valdete Martins Evaldo JoséCorat vladimir Jesus Trava-Airoldi Anderson Oliveira Lobo Fernanda Roberta Marciano Instituto Nacional de Pesquisas Espaciais Sao Josédos CamposSão PauloBrazil Faculdade de Ciencia e Tecnologia da Universidade de Coimbra CoimbraPortugal Clorovale Diamantes Indústria e Comércio s.A. Sao Josédos CamposSao PauloBrazil Universidade do vale do Paraíba Sao Josédos CamposSao PauloBrazil

Diamond-like Carbon (DLC) coatings have attracted significant attention due to their low friction coefficient, high degree of hardness, chemical inertness, and high wear resistance as well as and their many possible uses in metallurgical, aeronautical, and biomedical applications. However, DLC has low adhesion strength to metallic substrates. Carbonitriding was performed before DLC deposition to improve this adherence. Different concentration of nitrogen in the gas mixture was used during the carbonitriding of Ti6Al4v alloy. DLC films were subsequently grown from methane using plasma enhanced chemical vapor deposition. The samples were characterized with Raman scattering spectroscopy, nanoindentation, and tribological tests. Films from 80.0% N2 had the best friction coefficient (0.07) and a critical load of ~22 N. In the scratching test, these films had adhesive failure and they completely detached from the substrate only in the end of the tests. sEM images show carbonitring promoted a significant increase in the surface defects (homogeneously distributed) but without the presence of microcracks. EDX analysis indicated that nitrogen element was diffused throughout the thickness of the samples. Hydrogen and carbon atoms from carbonitriding formed a diffusion-barrier layer that can be used as the first step for DLC deposition. This carbonitriding can also provide a carbide layer, which serves as the precursor for the nucleation and growth of DLC films.

关键词： Diamond-Like Carbon Carbonitriding Ti6Al4v Alloy

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Resolutive Results with Oral Corticosteroids for Patients with COvID-19 in Pulmonary Inflammatory Phase. successful Outpatient Experience during the Collapse of Belem Do Para Health system—Brazil

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Health 2021年第8期13卷 830-838页

作者： Roberto s. Zeballos Luciana N. L. Cruz vânia C. R. Brilhante Adriana v. Lima Carlliane L. L. P. Martins Karla N. A. Lima Michele C. G. L. Leão Belinete L. Cruz Alessandra B. Dysarz Paulo C. B. Lobato Erika s. Almeida Rute A. P. costa Klevison C. Araújo Augusto C. C. Almeida Leônidas B. D. Junior Kathia O. Harada Rita H. v. s. Araújo Elaine X. Prestes Ivete M. s. souza Avany M. P. Pereira Antônio B. M. A. Rocha Iracema A. Estevão Fagnei I. C. Carvalho Paulo M. P. Melo Clinical Care Sao Paulo Brazil Instituto de Ciencias da saude Faculdade de Medicina Universidade Federal do Para Belem Brazil Fundacao Publica Estadual Hospital de Clinicas Gaspar vianna Belem Brazil Hospital da Policia Militar do Para Belem Brazil Imunoclinic Belem Brazil Universidade Estadual do Para Fundacao Santa Casa de Misericordia do Para Belem Brazil Clinica Barros Cirurgia Plastica Belem Brazil secretaria de Estado de saude Publica Castanhal Brazil Centro de Tratamento Oncologico Belem Brazil sociedade Brasileira de valorizaç ã o das sociedades Medicas—sOBEMED S&#227 o Paulo Brazil Clinica de Nutrologia Sao Luiz Brazil Hospital Nipo Brasileiro de Olhos Belem Brazil Centro de Ciencias Biologicas e da saude Universidade do Estado do Para Belem Brazil Hospital Regional do Baixo Amazonas Santarem Brazil Clinica vallinoto secretaria de saude de Barcarena Barcarena Brazil Estrategia saude da Familia secretaria Municipal de saude de Ananindeua Centro Universitario do Estado do Para Belem Brazil A. M. P. Endocrinologia Belem Brazil Instituto Avertano Rocha Belem Brazil Departamento de Neurocirurgia Hospital Militar de Area De Sao Paulo Sao Paulo Brazil

In the face of new diseases, medicine needs to reinvent itself in order to contain and control epidemics, such as the one we have recently faced, COvID-19, a disease with a wide spectrum of clinical severity. A new moment has been established, since the application of well-known, effective and safe medications for other diseases, has shown high success rates in the treatment of COvID-19. Thereunto, studies with early intervention are needed, which can change the unfavorable outcome of patients. In this article, we report the successful experience using an oral strategy during the collapse of Belem (Para, Brazil) Health system. Two hundred and ten patients were diagnosed with respiratory failure due to COvID-19, with no option of hospital treatment due to lack of beds and resources. These patients were then started on therapeutic regimen consisting of 40 mg prednisolone, 40 mg enoxaparin and macrolides (500 mg clarithromycin, 500 mg axetylcefuroxime) associated and followed in outpatient facilities. Two hundred and eight patients had an excellent therapeutic response and there were only two fatalities. These results push research boundaries, valuing outpatient treatment with early use of prednisolone in the initial pulmonary phase, preventing severe COvID-19 pneumonitis. Adoption of the proposed treatment intends to reduce the need for hospitalization, as well as lethality, with social robust benefits and incalculable economic savings since involves the use of accessible, safe and not expensive medications.

关键词： COvID-19 Corticosteroids Pulmonary Inflammatory Phase Collapse Brazil

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Correction of Acidity of a Brazilian Cerrado Oxisol with Limestone and Wood Ash on the Initial Growth of Cowpea

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Agricultural sciences 2019年第7期10卷 841-851页

作者： Edna Maria Bonfim-silva Alisson silva costa Jefferson vieira José André Pereira Freire Ferraz Ana Paula Alves Barreto Damasceno Tonny José Araújo da silva Department of Agricultural and Environmental Engineering Institute of Agricultural Sciences and Technology Federal University of Mato Grosso Rondonópolis Brazil

Among Brazilian soils orders, there are some of it classified as acid soils, which need correction to guarantee crop productivity. Currently, limestone is the most used soil corrective and wood ash has been a sustainable alternative to this process. Thus, the objective was to evaluate the effect of two correctives of soil acidity on an Oxisol collected in the Brazilian Cerrado area using limestone and wood ash and the effect of soil correction on initial growth of cowpea. Two greenhouse experiments were carried out: 1) with limestone, using base saturation levels (v%) of 0, 20, 40, 60 and 80;and 2) wood ash, with doses of 0, 8, 16, 24 and 32 g⋅dm−3, both in five randomized blocks. At 40 days after sowing, it was verified that pH values were within the range considered ideal for soil (pH of 5 to 7), according to the increase of base saturation levels and wood ash doses, but limestone provided faster results. Initial growth of cowpea was positively influenced by soil correction with use of both correctives. Wood ash and limestone increased soil pH to adequate values and resulted in better initial crop development.

关键词： vigna unguiculata solid Waste Disposal Alternative soil Corrective soil pH

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Research and development of the back-end electronics for the two-dimensional improved resistive plate chambers in CMs upgrade

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Radiation Detection Technology and Methods 2021年第2期5卷 181-191页

作者： P.Cao Z-A.Liu J.Zhao H.Kou J.Tao J.song W.Gong N.Wang A.samalan M.Tytgat N.Zaganidis G.A.Alves F.Marujo F.Torres.Da.s.ilva.De.Araujo E.M.Da costa D.De Jesus Damiao H.Nogima A.santoro s.Fonseca De souza A.Aleksandrov R.Hadjiiska P.Iaydjiev M.Rodozov M.shopova G.sultanov M.Bonchev A.Dimitrov L.Litov B.Pavlov P.Petkov A.Petrov s.J.Qian C.Bernal A.Cabrera J.Fraga A.sarkar s.Elsayed Y.Assran M.El sawy M.A.Mahmoud Y.Mohammed X.Chen C.Combaret M.Gouzevitch G.Grenier I.Laktineh L.Mirabito K.shchablo I.Bagaturia D.Lomidze I.Lomidze v.Bhatnagar R.Gupta P.Kumari J.singh v.Amoozegar B.Boghrati M.Ebraimi R.Ghasemi M.Mohammadi Najafabadi E.Zareian M.Abbrescia R.Aly W.Elmetenawee N.De Filippis A.Gelmi G.Iaselli s.Leszki F.Loddo I.Margjeka G.Pugliese D.Ramos L.Benussi s.Bianco D.Piccolo s.Buontempo A.Di Crescenzo F.Fienga G.De Lellis L.Lista s.Meola P.Paolucci A.Braghieri P.salvini P.Montagna C.Riccardi P.vitulo B.Francois T.J.Kim J.Park s.Y.Choi B.Hong K.s.Lee J.Goh H.Lee J.Eysermans C.Uribe Estrada I.Pedraza H.Castilla-valdez A.sanchez-Hernandez C.A.Mondragon Herrera D.A.Perez Navarro G.A.Ayala sanchez s.Carrillo E.vazquez A.Radi A.Ahmad I.Asghar H.Hoorani s.Muhammad M.A.shah I.Crotty Department of Physics and Astronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium Centro Brasileiro Pesquisas Fisicas R.Dr.Xavier Sigaud150-UrcaRio de JaneiroRJ 22290-180Brazil Dep.de Fisica Nuclear e Altas Energias Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524BR-Rio de Janeiro 20559-900RJBrazil Bulgarian Academy of sciences Inst.for Nucl.Res.and Nucl.EnergyTzarigradsko shaussee Boulevard 721784 SofiaBulgaria Faculty of Physics University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria school of Physics Peking UniversityBeijing 100871China Institute of High Energy Physics UCAS/CAS19(B)Yuquan RoadShijingshan DistrictBeijing 100049China Universidad de Los Andes Apartado Aereo 4976Carrera 1Eno.18A 10BogotaCOColombia Egyptian Network for High Energy Physics Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt The British University in Egypt(BUE) P.O.Box 43Elsherouk CitySuez Desert RoadCairo 11837Egypt suez University Elsalam CitySuez-Cairo RoadSuez 43522Egypt Department of Physics Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Center for High Energy Physics Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance Georgian Technical University 77 Kostava Str.Tbilisi 0175Georgia Department of Physics Panjab UniversityChandigarh 160014India school of Particles and Accelerators Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531TehranIran school of Engineering Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso Univ.Monte S.AngeloVia Cintia80126 NaplesItaly INFN Sezione di PaviaVia Bassi 6PaviaItaly INFN Sezione di Pavia and University of PaviaVia Bassi 6PaviaItaly Hanyang University 222 Wangsimni-roSageun-dongSeongdong

Purpose To complement and ensure redundancy in the endcap muon system of the Compact Muon solenoid(CMs)detector and to extend the Resistive Plate Chamber(RPC)system coverage,improved RPCs(iRPCs)with either orthogonal layer strips with one-end electronics or single layer strips with two-end electronics providing more precise time measurement will be installed in the very forward pseudorapidity region of|η|system needs to support twodimensional(2D)or two-end *** addition,it must combine detector data with Timing,Trigger and fast Control(TTC)and slow Control(sC)into one data stream over a bi-directional optical link with a line rate of 4.8 Gb/s between the Front-End Electronics(FEE)and the Back-End Electronics(BEE).To fulfill these requirements,a prototype BEE for the iRPC 2D chamber has been researched and *** A Micro-Telecommunication and Computing Architecture(μTCA)-based processing card was designed in this study to establish a prototype system together with aμTCA *** Giga-Bit Transceiver(GBT)protocol is integrated to provide bi-directional communication between the FEE and BEE.A server is connected with the BEE by a Gigabit Ethernet(GbE)link for sC and a 10-GbE link for Data AcQuisition(DAQ).Results The Bit Error Rate(BER)test of the back-end board and a joint test with the iRPC 2D prototype chamber were *** less than 1.331×10−16 was *** timemeasurement with a resolution of 3.05 nswas successfully realized,and detector efficiencies of 97.7%for longitudinal strips and 96.0%for orthogonal strips were *** results demonstrate the correctness and reliability of the prototype *** The BEE prototype satisfies the requirements for the iRPC 2D chamber,and it worked stably and reliably during a long-term joint test run.

关键词： CMs iRPC TTC sC BEE μTCA GBT DAQ

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Evaluation of Antinociceptive and Anti-Inflammatory Effects of synthetic O-Prenylated Phenolic Derivatives

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Pharmacology & Pharmacy 2012年第3期3卷 348-357页

作者： Niraldo Paulino Amarilis scremin Paulino Priscila vautier Laura Pisco Carolina Passarelli Jose Matheus de Freitas costa Dirk Michalik Paulo Celso Pardi Jose Agustín Quincoces suarez Grupo de Pesquisa e Desenvolvimento de Biomedicamentos(BIOMED) Programa de Mestrado Profissional em FarmaciaUniversidade Bandeirante de Sao PauloSao PauloBrasil Programa de Pos-Graduacao em Farmacia Universidade Federal de Santa CatarinaFlorianopolisBrasil Laboratorio de síntese Organica Universidade Bandeirante de Sao PauloSao PauloBrasil Leibniz-Institut für Katalyse an der Universitat Rostock RostockGermany

This work describes the synthesis, antinociceptive and anti-inflammatory effect of O-prenyl derivatives: O-prenyl derivatives 2-(3-methylbut-2-enyloxy)acetophenone (L1) and 3-methoxy-4-(3-methylbut-2-enyloxy)benzaldehyde (v1). Treatment with L1- or v1-produced antinociceptive effect on classical pain models: acetic acid abdominal contortions and formalin test (first and second phases), and in hot plate or tale flick models in mice without changing the locomotors performance, and anti-oedematogenic or anti-inflammatory effect in vivo: carrageenan-induced paw oedema and peritonitis in mice. In addition, L1 and v1 derivatives reduced nitric oxide production on RAW 264.7 cells stimulated with lipopolysaccharide without changing the cell viability. Taken together, our results show for the first time that L1 and v1 can produce antinociception and modulate inflammatory response when administered in mice.

关键词： Anti-Inflammatory Antinociception synthesis O-Prenyl Compounds

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