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P2X7 receptor blockade decreases inflammation,apoptosis,and enteric neuron loss during Clostridioides difficile toxin A-induced ileitis in mice

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World Journal of Gastroenterology 2022年第30期28卷 4075-4088页

作者： Ana A Q A santos deiziane v s costa Danielle A Foschetti Antoniella s G Duarte Conceicao s Martins Pedro M G soares Patricia Castelucci Gerly A C Brito Department of Morphology School of MedicineFederal University of CearaFortaleza 60430-170CearaBrazil Department of Physiology and Pharmacology School of MedicineFederal University of CearáFortaleza 60430-170CearaBrazil Department of Pathology and Legal Medicine School of MedicineFederal University of CearaFortaleza 60430-170CearaBrazil Department of Morphology(UFC) Federal University of CearaFortaleza 60430-170CearaBrazil Department of Anatomy Institute of Biomedical SciencesUniversity of São PauloSao Paulo 05508-270Brazil Department of Morphology Federal University of CearaFortaleza 60140-170CearaBrazil

Clostridioides difficile(***)is the most common pathogen causing health care-associated *** TcdA and TcdB have been shown to activate enteric neurons;however,what population of these cells is more profoundly influenced and the mechanism underlying these effects remain *** To characterize a specific population of TcdA-affected myenteric neurons and investigate the role of the P2X7 receptor in TcdA-induced ileal inflammation,cell death,and the changes in the enteric nervous system in *** swiss mice were used to model TcdA-induced ileitis in ileal loops exposed to TcdA(50μg/Loop)for 4 *** investigate the role of the P2X7 receptor,Brilliant Blue G(50 mg/kg,i.p.),which is a nonspecific P2X7 receptor antagonist,or A438079(0.7μg/mouse,i.p.),which is a competitive P2X7 receptor antagonist,were injected one hour prior to TcdA *** samples were collected to analyze the expression of the P2X7 receptor(by quantitative real-time polymerase chain reaction and immunohistochemistry),the population of myenteric enteric neurons(immunofluorescence),histological damage,intestinal inflammation,cell death(terminal deoxynucleotidyltransferasemediated dUTP-biotin nick end labeling),neuronal loss,and s100B synthesis(immunohistochemistry).REsULTs TcdA upregulated(Pssion of the P2X7 receptor gene in the ileal tissues,increasing the level of this receptor in myenteric neurons compared to that in control *** with the control mice indicated that TcdA promoted(Pss of myenteric calretinin+(Calr)and choline acetyltransferase+neurons and increased the number of nitrergic+and Calr+neurons expressing the P2X7 *** of the P2X7 receptor decreased TcdAinduced intestinal damage,cytokine release[interleukin(IL)-1β,IL-6,IL-8,and tumor necrosis factor-α],cell death,enteric neuron loss,and s100B synthesis in the mouse *** Our findings demonstrated that TcdA induced the upregulation of the P

关键词： Clostridioides difficile Clostridioides difficile toxin A P2X7 receptor Enteric nervous system Enteric neuron Enteric glia

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Complexed amino acid minerals ***-glycinate chelated minerals:Impact on the performance of old laying hens

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Animal Nutrition 2024年第1期16卷 395-408页

作者： Marcos J.B.santos Maria C.M.M.Ludke Leandro M.silva Carlos B.v.Rabello Mércia R.Barros Fabiano s.costa Clariana s.santos Jamille s.s.Wanderley Department of Animal science Rural Federal University of PernambucoRecifePEBrazil Department of veterinary science Rural Federal University of PernambucoRecifePEBrazil

The present study was to evaluate the effect of trace minerals(Zn,Mn,and Cu)from complexed amino acid minerals(ZMCAA)and bis-glycinate chelated minerals(ZMCGly)in laying hen diets on performance,internal and external egg quality,yolk mineral deposition,intestinal morphometry,and bone *** 78 to 98 weeks of age,400 White LsL-Lite strain laying hens were distributed in a randomized design with 4 treatments with 10 replicates per *** were distributed in a 2×2 factorial arrangement using either Zn,Mn,and Cu of ZMCAA or ZMCGly source at 2 levels:low(20,20,and 3.5 mg/kg of Zn,Mn,and Cu,respectively)or high(40,40,and 7 mg/kg of Zn,Mn,and Cu,respectively).The analysis of variance was performed,and in cases where differences were observed,the means were compared using Tukey?s test(Psource and level of trace mineral supplementation had a significant impact on the performance of laying *** fed ZMCAA had higher egg production(P=0.01),egg weight(P=0.02),egg mass(P=0.01),and lower feed conversion ratio(P=0.05)compared to those fed *** ZMCAA supplementation showed higher albumen height(P=0.01),albumen weight(P=0.01),and eggshell thickness(Psition of Zn(Ps greater for hens received *** weight(P=0.04)and bone densitometry(Psmall intestine,ZMCAA resulted in longer villi(P=0.02)and shorter crypt depth(P=0.01)in the *** and ileum measurements were influenced by the level and source of trace minerals(Ps fed ZMCAA exhibited superior performance,egg quality,deposition of trace minerals in the egg yolk,and bone density compared to hens fed *** this study,older laying hens supplemented with ZMCAA at lower levels demonstrated adequate levels of supplementation.

关键词： Bis-glycinates Metal-amino acids Radiodensity Trace minerals

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Changes in calcium accumulation and utilization efficiency and their impact on recycling, immobilization, and export across the oil palm cycle

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Oil Crop science 2024年第3期9卷 143-150页

作者： viégas I.D.J.M. souza L.C.D. Ferreira E.v.D.O. costa M.G. Nogueira G.A.D.s. Nascimento v.R.D. Oliveira Neto C.F.D. Capanema Campus Federal Rural University of the Amazon (UFRA) Av. Barão de Capanema Caixa D'agua 5514-6434 Pará Brazil Center of Agricultural and Environmental sciences Federal University of Maranhão (UFMA) Chapadinha BR-222 km 04 SN Boa Vista 65500000 Maranhão Brazil Capitão Poço Campus Federal Rural University of the Amazon (UFRA) Tv. Pau Amarelo S/n - Vila Nova Capitão Poço 68650-000 Pará Brazil Department of soil science São Paulo State University (Unesp) School of Agricultural and Veterinarian Sciences Jaboticabal Via de Acesso Prof. Paulo Donato Castelane Castellane - S/N - Vila Industrial São Paulo 14884-900 Brazil Institute of Agricultural sciences (ICA) Federal Rural University of the Amazon (UFRA) Estr. Principal da Ufra 2150 Curió-Utinga Belém 66077-580 Pará Brazil

Effective calcium (Ca) management is crucial for optimizing oil palm cultivation and enhancing crop yield. This study aimed to gain insights into the dynamics of Ca concentration, accumulation, exportation, immobilization, and recycling in various oil palm organs relative to plant age. The experiment was conducted at the Agropalma enterprise site in the northeastern region of Pará state, Brazil, evaluating seven plant age treatments: 2, 3, 4, 5, 6, 7, and 8 years old. Employing a completely randomized design with four replications. The results demonstrated an age-related increase in Ca concentration in petioles, rachis, arrows, male inflorescences, peduncles, and fruits. Furthermore, Ca accumulation exhibited an upward trend in all organs with progressing plant age. Notably, the study revealed an enhanced Ca use efficiency across all plant organs in correlation with the age of oil palm cultivation. These findings underscore the dynamic nutritional demands of oil palm, influencing Ca immobilization, cycling, and export throughout its developmental stages. © 2024 the Oil Crop Research Institute, Chinese Academy of Agriculture sciences

关键词： Amazon Ca cycling Ca export Ca immobilization Ca use efficiency Elaeis guineensis Jacq. Plant nutrition

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香椿的树木年轮宽度与超年生殖行为的相互关系:对树轮学研究的警示

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Journal of Plant Ecology 2024年第1期17卷 165-171页

作者： Monique silva costa Thaís Jorge de vasconcellos Claudio sergio Lisi Arno Fritz Neves Brandes Mario Tomazello-Filho Cátia Henriques Callado Instituto de Aplicação Fernando Rodrigues da silveira Universidade do Estado do Rio de JaneiroRua Barão de Itapagipe96.Rio Comprido 20261-005Rio de JaneiroBrazil Laboratório de Anatomia vegetal Universidade do Estado do Rio de JaneiroRua São Francisco Xavier524Maracanã20550-013Rio de JaneiroBrazil Departamento de Biologia Universidade Federal de SergipeAv.Marechal Rondon s/n-Rosa Elze.São Cristóvão 49100-000SergipeBrazil Departamento de Biologia Geral Universidade Federal FluminenseRua Prof.Marcos Waldemar de Freitas ReisS/N.Gragoatá24210-201Rio de JaneiroBrazil Escola superior de Agricultura Luiz de Queiroz Universidade de São PauloAv.Pádua Dias11.Piracicaba 13418-900São PauloBrazil

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的... 详细信息

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的树木年轮宽度与超年生殖行为相关联。总体而言,生殖结构的发育发生在湿润的年份,在生长季初期没有出现水分亏缺。然而,在这些年份,树木年轮宽度较小。这些结果可能与树木年轮宽度与当地气候之间缺乏相关性有关。因此,我们强调在径向生长研究中纳入生殖数据的重要性,以扩大对热带森林生长变异性的理解。

关键词：植物生长策略树木年轮学树木生态学生殖权衡

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Iron-Deficiency Anemia Management in Gynecological surgery: A Review of Current Evidence and Best Practices

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1223-1241页

作者： Aline Evangelista santiago Artur Lima sendin víctor Nilo Nogueira Rogério Adão Braga Admilson Lemos costa Filho Eduardo Batista Cândido Agnaldo Lopes silva Filho Department of Gynecology and Obstetrics Faculty of Medicine Santo Amaro University (UNISA) So Paulo Brazil Department of Gynecology and Obstetrics Federal University of Minas Gerais (UFMG) Belo Horizonte Brazil Department of Gynecology and Obstetrics Faculty of Medicine So Paulo State University (UNESP) So Paulo Brazil

Purpose: Due to the high prevalence of iron deficiency anemia in women undergoing gynecological surgeries and its association with worse postoperative results, it is necessary to identify and treat anemia preoperatively. However, although anemia and iron deficiency are significant global health problems, there are still disparities in the recognition and implementation of “Patient Blood Management” (PBM) as a comprehensive approach to mitigating the risks associated with these diseases. The purpose of the study is to review best practices for the treatment of anemia based on the Enhanced Recovery After surgery (ERAs) protocol and PBM recommendations. Methods: This study reviewed the literature on preoperative iron deficiency anemia in patients undergoing gynecological surgery. We identified references through searches in PubMed using relevant search terms. Results: Among the various strategies used in PBM, perhaps the most important is the early detection and management of anemia. In gynecological surgery, there are several approaches to reducing perioperative blood loss, highlighting the use of gonadotropin-releasing hormone (GnRH) agonists (aGnRh) and antifibrinolytics. Oral and intravenous iron supplementation can be performed in addition to blood transfusion to treat anemia. Conclusion: Addressing preoperative and postoperative anemia through systematic correction, following the guidelines of the ERAs protocol and PBM guidelines, is essential to improving perioperative outcomes in women undergoing gynecological surgery.

关键词： Anemia Gynecological surgery Iron supplementation Iron Deficiency

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Enhancement of the Antigenotoxic and Antioxidant Actions of Eugenol from spice Clove and the stabilizer Gum Arabic on Colorectal Carcinogenesis

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Food and Nutrition sciences 2024年第1期15卷 71-100页

作者： Nayanna de Oliveira Ramos Melo Lucas Gabriel da costa Marques Humberto Maia costa Neto Matheus De sousa silva Francisco vagnaldo Fechine Jamacaru Bruno Coêlho Cavalcanti Antônio Adailson De sousa silva Conceição Aparecida Dornelas Postgraduate Program in Medical-surgical sciences School of Medicine Federal University of Ceará Fortaleza Brazil school of Medicine Federal University of Ceará Fortaleza Brazil Nucleus of Research and Development of Medicines (NPDM) Laboratory of Pharmacology and Preclinical Research School of Medicine Federal University of Ceará Fortaleza Brazil Nucleus for Research and Development of Medicines (NPDM) National Laboratory of Experimental Oncology Federal University of Ceará Fortaleza Brazil Postgraduate Program in Pathology and Medical-surgical sciences School of Medicine Federal University of Ceará Fortaleza Brazil

spices are defined as any aromatic condiment of plant origin used to alter the flavor and aroma of foods. Besides flavor and aroma, many spices have antioxidant activity, mainly related to the presence in cloves of phenolic compounds, such as flavonoids, terpenoids and eugenol. In turn, the most common uses of gum arabic are in the form of powder for addition to soft drink syrups, cuisine and baked goods, specifically to stabilize the texture of products, increase the viscosity of liquids and promote the leavening of baked products (e.g., cakes). Both eugenol, extracted from cloves, and gum arabic, extracted from the hardened sap of two species of the Acacia tree, are dietary constituents routinely consumed virtually throughout the world. Both of them are also widely used medicinally to inhibit oxidative stress and genotoxicity. The prevention arm of the study included groups: Ia, IIa, IIIa, Iva, v, vI, vII, vIII. Once a week for 20 weeks, the controls received saline s.c. while the experimental groups received DMH at 20 mg/kg s.c. During the same period and for an additional 9 weeks, the animals received either water, 10% GA, EUG, or 10% GA + EUG by gavage. The treatment arm of the study included groups Ib, IIb, IIIb e Ivb, IX, X, XI, XII). Once a week for 20 weeks, the controls received saline s.c. while the experimental groups received DMH at 20 mg/kg s.c. During the subsequent 9 weeks, the animals received either water, 10% GA, EUG or 10% GA + EUG by gavage. The novelty of this study is the investigation of their use alone and together for the prevention and treatment of experimental colorectal carcinogenesis induced by dimethylhydrazine. Our results show that the combined use of 10% gum arabic and eugenol was effective, with antioxidant action in the colon, as well as reducing oxidative stress in all colon segments and preventing and treating genotoxicity in all colon segments. Furthermore, their joint administration reduced the number of aberrant crypts and th

关键词： Eugenol Gum Arabic Carcinogenesis Oxidative stress Genotoxicity

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Numerical simulation of non-Darcian flow through a porous medium

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Particuology 2009年第3期7卷 193-198页

作者： Duoxing Yang Yipeng Yang v.A.F. costa Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Crustul Dynamics Chinese Earthquake Administration Beijing 100085 China Ministry of Environmentul Protection of the People's Republic of China. Beijing 100035 China Departamento de Engenharia Mecenica. Universidade de Aveiro Campus Universiterio de Santiago 3810-193 Aveiro Portugal

This work reports on fluid flow in a fluid-saturated porous medium, accounting for the boundary and inertial effects in the momentum equation. The flow is simulated by Brinkman-Forchheimer-extended Darcy formulation （DFB）, using MAC （Marker And Cell） and Chorin pressure iteration method. The method is validated by comparison with analytic results. The effect of Reynolds number, Darcy number, porosity and viscosity ratio on velocity is investigated. As a result, it is found that Darcy number has a decisive influence on pressure as well as velocity, and the effect of viscosity ratio on velocity is very strong given the Darcy number. Additional key findings include unreasonable choice of effective viscosity can involve loss of important physical information.

关键词： MAC Pressure Darcy law Porous media Permeability viscosity ratio

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Oxidative stress in N88s seipinopathy:novel insights into the mechanisms of neurodegeneration and therapeutic avenues

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中国神经再生研究：英文版 2023年第8期18卷 1719-1720页

作者： vítor costa vitor Teixeira i3s-Instituto de Investigação e Inovação em saúde Universidade do PortoPortoPortugal Yeast signalling Networks IBMC-Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal ICBAs Instituto de Ciências Biomédicas Abel SalazarUniversidade do PortoPortoPortugal

Lipid droplets (LDs) are ubiquitous cellular orga nelles that perform functions mostly dedicated to energy homeostasis and lipid *** neutral lipid depots (triacylglycerol,sterol esters),they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy,a specific form of autophagy devoted to consumption of LDs inside the lysosome.

关键词： hydrolysis insight devoted

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Communities of saprobic fungi on leaf litter of vismia guianensis in remnants of the Brazilian Atlantic Forest

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Journal of Forestry Research 2017年第1期28卷 163-172页

作者： Loise Araujo costa Luís Fernando Pascholati Gusmao Laboratorio de Micologia Av Transnordestina Departamentode Ciências BiológicasUniversidade Estadual de Feira deSantanas/nNovo HorizonteFeira de SantanaBA 44031-460Brazil

We examined the mycobiota associated with vismia guianensis leaf litter in three Atlantic Forest remnants of Brazil＇ s semiarid region. Among the study sites, two remnants were protected forest reserves, whereas the third was influenced by major anthropogenic activities. Eighteen litter samples were collected in wet and dry seasons and were processed by particle filtration technique. A total of 4750 fungal isolates of 142 taxa were identified. species richness was higher in litter samples collected during wet season. Nonmetric multidimensional scaling multivariate analysis showed differences in the composition of fungal communities among the sampling sites and the seasons. Analysis of similarity showed that the differences were statistically significant （R = 0.85; P = 0.0001）. Our findings revealed that spatial and temporal heterogeneity, and human activities had significant impacts on the saprobic fungi of v. guianensis leaf litter.

关键词： Biodiversity Conservation seasonality spatial heterogeneity Tropical fungi

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Journal of Energy Chemistry 2022年第10期31卷 88-113,I0003页

作者： Magno B.costa Moisés A.de Araújo Marcos v.de Lima Tinoco Juliana F.de Brito Lucia H.Mascaro Departamento de Química Universidade Federal de São CarlosRodovia Washington Luizkm 235São CarlosSão Paulo 13565-905Brazil Instituto de Química de são Carlos Universidade de São PauloAvenida Trabalhador Sancarlense400São CarlosSão Paulo 13566-590Brazil Instituto de Química Universidade Estadual PaulistaRua Professor Francisco Degnis/nAraraquaraSão Paulo 14800-900Brazil

This review shows the importance of WO_(3)photoanode as a potentially low-cost,efficient,stable,and photoactive material for light-driven water *** such,this manuscript aims to review the most recent publications regarding the strategies to improve the phoelectroactivity of WO_(3)films for water *** addition,this review aims to graphically highlight and discuss the general trendings of the photocurrent density response and stability test of the recent outstanding studies in the literature for photoelectrochemical water splitting *** strategies covered in this review will not only concern the WO_(3)morphology and crystal plane growth,but also the many arrangements possibilities to improve the WO_(3)efficiency for water photoelectrooxidation,such as defect engineering based on oxygen vacancies,doping,decorations,and homo and *** these strategies are compared by the photocurrent density results and by the stability of these *** best results in this sense were observed in cases where the use of heterojunction was applied together with a desired morphology and crystal plane of the WO_(3)***,the modifications that caused a decrease in the photocurrent density reaching values that are even lower than the pure WO_(3)were also *** this way,this review intends to improve the knowledge about the synthesis and design of WO_(3)photoanodes to further obtain an efficient photocatalyst to minimize the recombination losses or losses across the interfaces and improve the photoelectroactivity for water splitting in the large-scale application.

关键词： solar energy H_(2)production N-type semiconductor Photoelectrode design Oxygen evolution reaction

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