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Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 38-51页

作者： Xuejun Chen Ziqing Li Chunrong yang degong yang Department of Pharmacy Shantou University Medical CollegeShantou 515041China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology Shantou University Medical CollegeShantou 515041China

Ionic liquids (ILs) have been proven to be an effective technology for enhancing drug transdermal absorption. However, due to the unique structural components of ILs, the design of efficient ILs and elucidation of action mechanisms remain to be explored. In this review, basic design principles of ideal ILs for transdermal drug delivery system (TDDS) are discussed considering melting point, skin permeability, and toxicity, which depend on the molar ratios, types, functional groups of ions and inter-ionic interactions. Secondly, the contributions of ILs to the development of TDDS through different roles are described: as novel skin penetration enhancers for enhancing transdermal absorption of drugs;as novel solvents for improving the solubility of drugs in carriers;as novel active pharmaceutical ingredients (API-ILs) for regulating skin permeability, solubility, release, and pharmacokinetic behaviors of drugs;and as novel polymers for the development of smart medical materials. Moreover, diverse action mechanisms, mainly including the interactions among ILs, drugs, polymers, and skin components, are summarized. Finally, future challenges related to ILs are discussed, including underlying quantitative structure-activity relationships, complex interaction forces between anions, drugs, polymers and skin microenvironment, long-term stability, and in vivo safety issues. In summary, this article will promote the development of TDDS based on ILs.

关键词： Transdermal drug delivery system Ionic liquid Quantitative structure-activity relationship Intermolecular interaction

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Mechanistic insights of the controlled release capacity of polar functional group in transdermal drug delivery system:the relationship of hydrogen bonding strength and controlled release capacity

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Acta Pharmaceutica Sinica B 2020年第5期10卷 928-945页

作者： Zheng Luo Chao Liu Peng Quan degong yang Hanqing Zhao Xiaocao Wan Liang Fang Department of Pharmaceutical Sciences School of PharmacyShenyang Pharmaceutical Universityshenyang 110016China

Background:Hydrogen bonding interaction was considered to play a critical role in controlling drug release from transdermal ***,the quantitative evaluation of hydrogen bonding strength between drug and polar functional group was rarely reported,and the relationship between hydrogen bonding strength and controlled release capacity of pressure sensitive adhesive(PSA)was not well *** present study shed light on this ***:Acrylate PSAs with amide group were synthesized by a free radical-initiated solution *** drugs,i.e.,etodolac,ketoprofen,gemfibrozil,zolmitriptan,propranolol and lidocaine,were selected as model *** vitro drug release and skin permeation experiments and in vivo pharmacokinetic experiment were *** correlation analysis,fourier-transform infrared spectroscopy and molecular simulation were conducted to provide molecular details of drug-PSA *** test,rheology study,and modulated differential scanning calorimetry study were performed to scrutinize the free volume and molecular mobility of ***:Release rate of all six drugs from amide PSAs decreased with the increase of amide group concentrations;however,only zolmitriptan and propranolol showed decreased skin permeation *** was found that drug release was controlled by amide group through hydrogen bonding,and controlled release extent was positively correlated with hydrogen bonding ***:From these results,we concluded that drugs with strong hydrogen bond forming ability and high skin permeation were suitable to use amide PSAs to regulate their release rate from patch.

关键词： Controlled release Polar functional group Hydrogen bonding strength Pharmacokinetics Pressure sensitive adhesive Hydrogen bonding interaction Transdermal patch Stratum corneum

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液压伺服预紧的电磁发射轨道振动频率和幅值特性研究

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兵工学报 2019年第1期40卷 29-34页

作者：王振春杨德功张玉燕燕山大学电气工程学院河北秦皇岛066004 燕山大学工业计算机控制工程河北省重点实验室河北秦皇岛066004 燕山大学测试计量技术及仪器河北省重点实验室河北秦皇岛066004

为提高电磁轨道发射装置的稳定性,提出在电磁发射装置身管上施加预紧压力,利用液压伺服的液压自稳定性来平衡电磁冲击力引起的振动。在发射装置上3个不同位置安装具有抗电磁干扰的压电加速度传感器实时采集轨道的振动信号,应用虚拟仪器... 详细信息

为提高电磁轨道发射装置的稳定性,提出在电磁发射装置身管上施加预紧压力,利用液压伺服的液压自稳定性来平衡电磁冲击力引起的振动。在发射装置上3个不同位置安装具有抗电磁干扰的压电加速度传感器实时采集轨道的振动信号,应用虚拟仪器技术对比分析轨道振动频率和幅值变化。施加液压伺服预紧后大幅值振动时间明显缩短,并且在不同位置施加液压伺服预紧,发射装置呈现不同的振动特性。试验结果表明,施加液压伺服预紧能够有效缩短轨道的振动持续时间,提高电磁轨道发射装置的稳定性。

关键词：电磁发射振动特性液压伺服预紧幅值谱图

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高速滑动电接触构件表面损伤参数计算方法

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中国激光 2017年第5期44卷 170-175页

作者：张玉燕郭全丽杨德功王振春燕山大学电气工程学院河北秦皇岛066004 燕山大学测试计量技术及仪器河北省重点实验室河北秦皇岛066004 燕山大学国防科学技术学院河北秦皇岛066004

提出了一种基于3D点云深度信息的函数拟合与三角剖分相结合的方法,构建了高速滑动电接触构件的表面损伤特征提取模型,将损伤区域3D特征数据进行三角剖分,计算了构件表面损伤体积和质量。实验结果表明,该算法计算准确度可达97.3%。

关键词：测量 3D点云深度损伤特征三角剖分损伤质量

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电磁轨道推进接触温度的特性研究

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高压物理学报 2018年第6期32卷 161-169页

作者：王振春杨德功张玉燕战再吉燕山大学电气工程学院河北秦皇岛066004 燕山大学工业计算机控制工程河北省重点实验室河北秦皇岛066004 燕山大学测试计量技术及仪器河北省重点实验室河北秦皇岛066004

在电磁轨道推进过程中,固体电枢和轨道接触面温度是衡量接触状态的重要指标之一,能够在一定程度上表征在电磁轨道推进过程中影响轨道推进性能和推进效率的轨道损伤程度。针对电磁轨道推进的电枢和轨道接触面温度特性,进行相关仿真分析... 详细信息

在电磁轨道推进过程中,固体电枢和轨道接触面温度是衡量接触状态的重要指标之一,能够在一定程度上表征在电磁轨道推进过程中影响轨道推进性能和推进效率的轨道损伤程度。针对电磁轨道推进的电枢和轨道接触面温度特性,进行相关仿真分析与测量实验研究。根据电接触的基本理论,对电枢和轨道接触面的温度热源进行分析,建立温度模型,结合仿真研究,得出在几种热源作用下电枢和轨道接触面温度的变化情况。以电磁轨道推进装置为试验平台,采用基于红外辐射测温原理的测量系统,对电磁轨道推进装置电枢和轨道接触面温度进行测量,得出了几个典型位置的温度和典型加载电流下的温度数据。结果表明,测量温度在幅值上和趋势上与仿真模拟结果具有一致性。轨道损伤分析也反映了电枢和轨道接触面温度升高加速了轨道表面的烧蚀。

关键词：电磁轨道推进接触温度场红外辐射测温轨道损伤

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HPLC-FLD法同时测定丁酸氯维地平及其代谢物

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中国药科大学学报 2015年第3期46卷 328-332页

作者：荣景宏刘宇王芳李艺杨德功陈立江辽宁大学药学院沈阳110036

研究丁酸氯维地平脂微球(CDB-LM)注射液在小鼠体内的药代动力学过程,探讨丁酸氯维地平(CDB)在体内的代谢规律。采用HPLC-FLD法同时测定CDB及其代谢物氯维地平酸(MI)在小鼠全血样品中的浓度。色谱柱Waters C18(4.6 mm×150 mm,5μm);流动... 详细信息

研究丁酸氯维地平脂微球(CDB-LM)注射液在小鼠体内的药代动力学过程,探讨丁酸氯维地平(CDB)在体内的代谢规律。采用HPLC-FLD法同时测定CDB及其代谢物氯维地平酸(MI)在小鼠全血样品中的浓度。色谱柱Waters C18(4.6 mm×150 mm,5μm);流动相:乙腈-甲醇-磷酸盐缓冲液(2∶1∶2);FLD检测波长:激发波长358 nm,发射波长440 nm。采用DAS 2.0软件分析计算出CDB和MI的药代动力学参数,所得参数采用PASW Statistics 18软件进行统计分析。结果表明,CDB和MI的半衰期分别在4 min和20 min左右。低剂量组和高剂量组的药代动力学参数依次为:CDB的CL为4.21和2.72 L·min-1·kg-1,AUC0-t为3.86和6.43 mg/L·min,MRT0-t为7.09和6.17 min。MI的CL为0.34和0.22 L·min-1·kg-1,AUC0-t为52.23和74.90 mg/L·min,MRT0-t为201.24和217.33 min。采用乙腈沉淀蛋白法处理全血样品,操作简单快速,全血中内源性杂质无干扰,方法准确可靠。体内研究结果表明,建立的HPLC-FLD法简便、灵敏,可同时测定CDB和MI的血药浓度。高、低两剂量组的血药浓度-时间曲线趋势相同,CDB在体内迅速代谢为MI。

关键词：丁酸氯维地平氯维地平酸脂微球药代动力学 HPLC-FLD法

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中医药从瘀血论治偏头痛研究近况

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现代中西医结合杂志 2011年第1期20卷 114-116页

作者：付秋菊杨德功徐重白南京中医药大学江苏南京210028 江苏省中西医结合医院江苏南京210028

偏头痛是一种伴有神经系统和非神经系统表现的反复发生的头痛综合征。流行病学显示,中国的患病率为985.2/10万,发病率为79.7/10万,女性高于男性,发病年龄集中在25—55岁。偏头痛发作虽不能猝然致命,但长期反复发作会影响人们的生命质量... 详细信息

偏头痛是一种伴有神经系统和非神经系统表现的反复发生的头痛综合征。流行病学显示,中国的患病率为985.2/10万,发病率为79.7/10万,女性高于男性,发病年龄集中在25—55岁。偏头痛发作虽不能猝然致命,但长期反复发作会影响人们的生命质量。有研究表明,[第一段]

关键词：中医药偏头痛血瘀证辨证论治客观

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Supportive tactics for innovative and sustainability performance in emerging SMEs

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Financial Innovation 2021年第1期7卷 1824-1854页

作者： Farid Ullah Ma degong Muhammad Anwar Saddam Hussain Rizwan Ullah School of Economics Sichuan UniversityChengduChina Department of Economics ROKHAN Institute of Higher EducationJalalabadAfghanistan Head of Financial Engineering Department School of EconomicsSichuan UniversityChengduChina Witten Institute for Family Business Witten/Herdecke UniversityWittenGermany Institute of Management Studies University of PeshawarPeshawarPakistan Capital University of Science and Technology IslamabadPakistan

For this research,we examined the influence of access to domestic and international financing on sustainability performance with a mediating role of innovative performance and a moderating role of access to government *** were collected from 317 small and medium-sized enterprises(SMEs)through structured *** results indicated that access to domestic and international financing significantly contributes to sustainability and innovative ***,we found a partial mediating role of innovative performance between access to domestic financing and sustainability performance as well as between access to international financing and sustainability *** to government support significantly moderates the relationship between access to domestic finances and innovative performance as well as between access to international finances and innovative *** and policymakers should encourage national and international financial institutions and banks to facilitate SMEs by lending them funds for innovative activities and sustainability ***,the government should support SMEs,so that they can contribute to economic growth and the gross domestic *** implications from these matters will be further discussed in this paper.

关键词： Domestic finance Government support International finance Foreign direct investment Innovative performance Sustainability SMEs

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Modulation of electronic state in copper-intercalated 1T-TaS_(2)

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Nano Research 2022年第5期15卷 4327-4333页

作者： Wenhao Zhang degong Ding Jingjing Gao Kunliang Bu Zongxiu Wu Li Wang Fangsen Li Wei Wang Xuan Luo Wenjian Lu Chuanhong Jin Yuping Sun Yi Yin Zhejiang Province Key Laboratory of Quantum Technology and Device Department of PhysicsZhejiang UniversityHangzhou 310027China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China Vacuum Interconnected Nanotech Workstation(Nano-X) Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123China High Magnetic Field Laboratory HFIPSChinese Academy of SciencesHefei 230031China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Intercalation is an effective method to modify physical properties and induce novel electronic states of transition metal dichalcogenide(TMD)***,it is difficult to reveal the microscopic electronic state evolution in the intercalated *** we successfully synthesize the copper-intercalated 1T-TaS_(2) and characterize the structural and electronic modification combining resistivity measurements,atomic-resolution scanning transmission electron microscopy(ADF-STEM),and scanning tunneling microscopy(STM).The intercalated Cu atom is determined to be directly below the Ta atom and suppresses the commensurate charge density wave(CCDW)*** specific electronic modulations are discovered in the near-commensurate(NC)CDW phase:the electron doping state near the defective star of Davids(SDs)in metallic domains and the spatial evolution of the Mott gap in insulating *** modulations reveal that intercalated Cu atoms act as a medium to enhance the interaction between intralayer SDs,in addition to the general charge transfer *** also solidifies the Mott foundation of the insulating gap in pristine *** intriguing electronic evolution in Cu-intercalated 1T-TaS_(2) will motivate further exploration of novel electronic states in the intercalated TMD materials.

关键词： intercalation scanning tunneling microscopy Mott insulator charge transfer electron doping

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Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering

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Journal of Molecular Cell Biology 2016年第2期8卷 174-177页

作者： Yi yang Kepin Wang Han Wu Qin Jin degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine South China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China School of Life Sciences University of Science and Technology of ChinaHefei 230027China Leon H Charney Division of Cardiology New York University School of Medicine522 First AvenueNew YorkNY 10016USA Key Laboratory for Major Obstetric Diseases of Guangdong Province Key Laboratory of Reproduction and Genetics of Guangdong Higher Education InstitutesThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150China Jilin Provincial Key Laboratory of Animal Embryo Engineering Institute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchun 130062China

Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the *** disease can be treatedby either insulin injection or islet *** transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control.

关键词： islet injection expressing

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