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A COMPLETE CHARACTERIZATION OF THE ROBUST ISOLATED CALMNESS OF NUCLEAR NORM REGULARIZED CONVEX OPTIMIZATION PROBLEMS

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Journal of Computational Mathematics 2018年第3期36卷 441-458页

作者： Ying Cui defeng sun The Daniel J. Epstein Department of Industrial and Systems Engineering University of Southern California Los Angeles California USA Department of Applied Mathematics The Hong Kong Polytechnic University Hung Hom Hong Kong

In this paper, we provide a complete characterization of the robust isolated calmness of the Karush-Kuhn-Tucker （KKT） solution mapping for convex constrained optimization problems regularized by the nuclear norm function. This study is motivated by the recent work in [8], where the authors show that under the Robinson constraint qualification at a local optimal solution, the KKT solution mapping for a wide class of conic programming problems is robustly isolated calm if and only if both the second order sufficient condition （SOSC） and the strict Robinson constraint qualification （SRCQ） are satisfied. Based on the variational properties of the nuclear norm function and its conjugate, we establish the equivalence between the primal/dual SOSC and the dual/primal SRCQ. The derived results lead to several equivalent characterizations of the robust isolated calmness of the KKT solution mapping and add insights to the existing literature on the stability of nuclear norm regularized convex optimization problems.

关键词： Robust isolated calmness Nuclear norm Second order sufficient condition Strict Robinson constraint qualification

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日间手术麻醉规范化管理策略

实用医学杂志 2024年第3期40卷 283-288页

作者：孙德峰大连医科大学附属第一医院麻醉科辽宁大连116011

日间手术具有床位周转快、患者满意度高、医疗费用少、院内感染率低等优势,是目前国内外大力探索和发展的一种手术模式。安全是日间手术开展的底线,舒适是日间手术的核心追求,二者的保障均离不开对高质量的围术期麻醉管理。因此,在快速... 详细信息

日间手术具有床位周转快、患者满意度高、医疗费用少、院内感染率低等优势,是目前国内外大力探索和发展的一种手术模式。安全是日间手术开展的底线,舒适是日间手术的核心追求,二者的保障均离不开对高质量的围术期麻醉管理。因此,在快速周转的日间手术模式下,本文就如何实施规范化的麻醉管理策略,分别从日间手术麻醉临床路径的制定、硬件设施以及人员的配备,麻醉术前评估与术前准备,麻醉方式的选择,围术期疼痛管理,术后恶心呕吐(postoperative nausea and vomiting,PONV)管理,麻醉后监测治疗,术后随访几方面加以阐述。

关键词：日间手术麻醉规范化管理围术期疼痛术后恶心呕吐

A UNIFIED ALGORITHMIC FRAMEWORK OF SYMMETRIC GAUSS-SEIDEL DECOMPOSITION BASED PROXIMAL ADMMS FOR CONVEX COMPOSITE PROGRAMMING

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Journal of Computational Mathematics 2019年第6期37卷 739-757页

作者： Liang Chen defeng sun Kim-Chuan Toh Ning Zhang College of Mathematics and Econometrics Hunan UniversityChangsha 410082China Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong KongChina Department of Mathematics and Institute of Operations Research and AnalyticsNational University of Singapore10 Lower Kent Ridge RoadSingapore School of Computer Science and Technology Dongguan University of TechnologyDongguanChina

This paper aims to present a fairly accessible generalization of several symmetric Gauss-Seidel decomposition based multi-block proximal alt ernating direction met hods of multipliers(ADMMs)for convex composite optimization problems.The proposed method unifies and refines many constructive techniques that were separately developed for the computational efficiency of multi-block ADMM-type algor计hms.Specifically,the majorized augmented Lagrangian functions,the indefinite proximal terms,the inexact symmetrie Gauss-Seidel decomposition theorem,the tolerance criteria of approximately solving the subproblems,and the large dual step-lengths,are all incorporated in one algoi?计hmic framework,which we named as sGS-imiPADMM.From the popularity of convergent variants of multi-block ADMMs in recent years,especially for high-dimensional multi-block convex composite conic programming problems,the unification presen ted in this paper,as well as the corresponding convergence results,may have the great potential of facilitating the implemen tation of many multi-block ADMMs in various problem set tings.

关键词： Convex optimization Multi-block Alternating direction method of multipliers Symmetric Gauss-Seidel decomposition Majorization

星状神经节阻滞改善术后认知功能障碍研究进展

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实用医学杂志 2024年第11期40卷 1500-1504页

作者：薛茹月李悦娴孙德峰大连医科大学附属第一医院麻醉科辽宁大连116011

术后认知功能障碍(postoperative cognitive dysfunction,POCD)是老年患者麻醉后常见的并发症。POCD的特点是手术后注意力、学习能力和记忆力的急性或持续性损害。这种认知障碍不仅可能导致术后并发症增加、住院时间延长,还会增加社会... 详细信息

术后认知功能障碍(postoperative cognitive dysfunction,POCD)是老年患者麻醉后常见的并发症。POCD的特点是手术后注意力、学习能力和记忆力的急性或持续性损害。这种认知障碍不仅可能导致术后并发症增加、住院时间延长,还会增加社会负担并造成医疗资源的浪费。星状神经节阻滞(stellate ganglion block,SGB)是一种临床上常用的神经阻滞技术,主要通过注射局部麻醉药物来阻断星状神经节的神经信号,从而实现疼痛控制或治疗某些疾病的目的。本文总结了SGB改善POCD的作用机制,尤其是围绕调节脑血管、氧化应激及炎症反应等方面进行综述,以期为老年患者提供更加安全和有效的术后恢复途径,也可能为缓解POCD的负担开辟新的治疗途径。

关键词：星状神经节阻滞术后认知功能障碍氧化应激炎症

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加速术后康复理念下术后镇痛管理策略

实用医学杂志 2022年第17期38卷 2123-2127页

作者：孙德峰大连医科大学附属第一医院麻醉科辽宁大连116011

加速术后康复(ERAS)是以循证医学为基础,通过外科、麻醉、护理、营养等多科室合作,通过优化围术期各种临床路径来达到减少术后并发症、缩短住院时间及促进患者康复的目的。近年来因其极大程度上解决了我国医疗资源分布不均的问题,ERAS... 详细信息

加速术后康复(ERAS)是以循证医学为基础,通过外科、麻醉、护理、营养等多科室合作,通过优化围术期各种临床路径来达到减少术后并发症、缩短住院时间及促进患者康复的目的。近年来因其极大程度上解决了我国医疗资源分布不均的问题,ERAS理念及路径在我国得到迅速的普及和推广。有效镇痛是ERAS理念的核心内容,通过采用多模式、预防性、低阿片化及个体化的镇痛方法等来提高患者生活质量及满意度。本文将对ERAS理念下术后镇痛管理策略进行述评。

关键词： ERAS理念术后疼痛低阿片化

Molecular mechanism of the inhibitory effect of methylation outside the recognition sequence of restriction endonuclease Pvu Π on its cleavage activity

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Chinese Science Bulletin 1998年第1期43卷 47-52页

作者： CHEN defeng, sun Mei, LIU Yingmiao, SHI Guoli and CHEN Yawen Institute of Molecular Biology, Nankai University, Tianjin 300071, China Institute of Molecular Biology Nankai University Tianjin China

In 1991, we found that methylation outside the PvuⅡ recognition sequence could partially inhibit its cleavage activity. To clarify the molecular mechanism, three plasmids with different methylation states were constructed. Then, together with the original one, four plasmids were digested with different amounts of PvuⅡ. Results show that methylation on both sites results in 90% inhibition; moving the methylated site one base further away decreases the inhibitory effect to about 30%; with the adjacent dam methylation site eliminated, the inhibitory effect disappears. The data suggest that the inhibition of cleavage activity caused by outside methylation is not "all or none", and the degree of inhibition is dependent on the position and the number of methylated bases.

关键词： methylation outside the recognition sequence molecular mechanism PCR sitespecific mutation restriction endonuclease PvuⅡ.

Effects of Phytochemicals Sulforaphane on Uridine Diphosphate-Glucuronosyltransferase Expression as well as Cell-Cycle Arrest and Apoptosis in Human Colon Cancer Caco-2 Cells

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Effects of Phytochemicals Sulforaphane on Uridine Diphosphat...

不同剂量酒石酸布托啡诺预防性镇痛对妇科腹腔镜手术术后疼痛的影响

山东省医学会第十一次老年医学分会学术会

作者： Min Wang Shuo Chen Shuai Wang defeng sun Jian Chen Yanqing Li Wei Han Xiaoyun Yang Hai-qing Gao Department of Geriatrics and Gastroenterology Qi-Lu Hospital of Shandong University Key Laboratory of Proteomics of Shandong Province Department of Gastroenterology Qi-Lu Hospital of Shandong University

＜正＞Our study investigated the effects of the chemopreventive agent sulforaphane（SFN） on human colon cancer Caco-2 cells and potential underlying mechanisms of the effects.When treated with SFN at hypotoxic levels,UDP-glucuronosyltransferase 1A（UGT1A） was induced in a dose-dependent manner.SFN at 25μM showed the highest UGT1A-induction activity,inducing UGT1A1,UGT1A8,and UGT1A10 mRNA expression,and increasing UGT-mediated N-hydroxy-PhIP glucuronidation.SFN-induced UGT1A expression may have resulted from Nrf2 nuclear translocation or activation.At higher concentrations,e.g.75μM,SFN caused G1/G2 cell cycle arrest and induced apoptosis possibly through reducing anti-apoptotic bcl-2 expression and increasing apoptosis-inducing bax expression in Caco-2 cells.Taken together,these results demonstrated the chemopreventive effects of SFN on human colon cancer Caco-2 cells may have been partly attributed to Nrf2-mediated UGT1A induction and apoptosis induction,and our studies provided theoretic and experimental basis for clinical application of SFN to human colon cancer prevention.

关键词： Caco-2 cell line sulforaphane colon cancer apoptosis UDP-glucuronosyltransferase

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中国医师杂志 2023年第11期25卷 1630-1634,1639页

作者：张明杰孙忠良孙德峰大连医科大学附属第一医院麻醉科大连116011

目的观察预注射三种不同剂量酒石酸布托啡诺对妇科腹腔镜手术术后疼痛的影响。方法前瞻性选取2022年4月至12月于大连医科大学附属第一医院择期行全麻下妇科腹腔镜手术的患者172例,按随机数字表法将患者分为B1、B2、B3三组,分别于术前15 ... 详细信息

目的观察预注射三种不同剂量酒石酸布托啡诺对妇科腹腔镜手术术后疼痛的影响。方法前瞻性选取2022年4月至12月于大连医科大学附属第一医院择期行全麻下妇科腹腔镜手术的患者172例,按随机数字表法将患者分为B1、B2、B3三组,分别于术前15 min予以10、20、30μg/kg酒石酸布托啡诺组。记录患者给药后10 min时的Ramsay镇静评分;术后2、6、12、24、48 h静息状态及活动状态的疼痛数字评估量表(NRS)评分,舒适度评分(BCS);术中不同时点的血流动力学参数;术后辅助镇痛药物使用情况、患者自控静脉镇痛(PCIA)有效按压次数;术后不良反应发生率。结果三组患者一般特征比较差异无统计学意义(均P>0.05)。给药后10 min时,B2组、B3组的Ramsay评分与B1组差异有统计学意义(均P0.05)。三组术后追加镇痛药物率比较差异有统计学意义(均P<0.05)。结论妇科腹腔镜手术术前15 min静脉注射30μg/kg酒石酸布托啡诺预防性镇痛可达到较好的镇痛作用,不良反应较少,可作为妇科腹腔镜手术预防性镇痛的优先剂量。

关键词：妇科外科手术腹腔镜检查疼痛,手术后布托啡诺镇痛

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S-氯胺酮镇痛作用的临床应用进展

实用医学杂志 2023年第2期39卷 180-185页

作者：李俊杰冯艳孙德峰大连医科大学附属第一医院麻醉科辽宁大连116011

氯胺酮是一种N-甲基-D-天冬氨酸(NMDA)受体的非竞争性拮抗药,是左旋及右旋两种对映异构体的消旋体。S-氯胺酮为氯胺酮的右旋异构体,与NMDA受体的亲和力是外消旋氯胺酮的2倍,因此镇痛效价更强、不良反应更少。研究证明NMDA受体与急性疼... 详细信息

氯胺酮是一种N-甲基-D-天冬氨酸(NMDA)受体的非竞争性拮抗药,是左旋及右旋两种对映异构体的消旋体。S-氯胺酮为氯胺酮的右旋异构体,与NMDA受体的亲和力是外消旋氯胺酮的2倍,因此镇痛效价更强、不良反应更少。研究证明NMDA受体与急性疼痛的产生和慢性疼痛的发展相关,在围术期使用S-氯胺酮是一种可取的策略,提供了镇痛的非阿片机制途径,但其最佳的使用途径及方法仍需要进行不断的研究。

关键词： S-氯胺酮疼痛治疗