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Cytotoxic and antiproliferative activity of kanchnar guggulu,an Ayurvedic formulation

Journal of Integrative Medicine 2018年第6期16卷 411-417页

作者： Prachi Tomar Yadu Nandan Dey deepti sharma Manish Motiram Wanjari Sudesh Gaidhani Ankush Jadhav Department of Biotechnology Komla Roja Girls Government Postgraduate Autonomous CollegeCwalior 474009Madhya PradeshIndia Regional Ayurveda Research Institute for Drug Development AamkhoGwalior 474009Madhya PradeshIndia Central Council for Research in Ayurvedic Sciences New Delhi 110058India

Objective： Kanchnar guggulu is a compound Ayurvedic formulation used in clinical practice for the treat- ment of benign and malignant tumors. The present study investigates its cytotoxic and antiproliferative ***： The hydro-alcoholic （50%） extract of kanchnar guggulu was prepared. Its antimitotic activity was assessed in an Allium cepa assay, while its antiproliferative effects were studied in a yeast prolifer- ation model. Methotrexate was used as a standard anticancer ***： In the Allium assay, all concentrations of the extract （1, 2 and 3 mg/mL） and methotrexate （0.02 mg/mL） significantly inhibited the division ofA. cepa root cells, decreasing root growth and mitotic index compared to control; this effect was concentration-dependent for kanchnar guggulu extract. In the antiproliferative studies, treatment with the hydro-alcoholic extract of kanchnar guggulu （1, 5 and 10 mg/mL） and methotrexate （0.025, 0.05 and 0.1 mg/mL） resulted in marked reduction of dividing Saccharornyces cerevisiae cells and inhibition of cell viability compared to control. The cytotoxicity of the hydro-alcoholic extract of kanchnar guggulu, shown by its antimitotic and antiproliferative effects, may be due to the presence of flavonoids and ***： Kanchnar guggulu exhibited a cytotoxic effect by inhibiting cell division （antimitotic） and reducing cell proliferation. These results substantiate its potential for the treatment of cancer and support its traditional use in the treatment of cancer.

关键词： BAUHINIA-VARIEGATA CANCER-CELLS ALLIUM TEST AGENTS

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Non-Native English Speaker Readability Metric: Reading Speed and Comprehension

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Journal of Applied Mathematics and Physics 2017年第6期5卷 1257-1268页

作者： Aissa Boudjella Mukti sharma deepti sharma Department of Information Technology and Computer Science American University of Afghanistan Kabul Afghanistan Department of Electrical Engineering Bircham International University Madrid Spain General Education KIC Abu Dhabi United Arab Emirates BML Munjal University Gurgaon India

This paper presents an investigation to evaluate the reading speed and reading comprehension of non-native English speaking students by presenting a simple analytical model. For this purpose, various readability softwares were used to estimate the average grade level of the given texts. The relationship between the score obtained by the students and their reading speed under average grade level 9 and 14 using font size 12 and 14 is presented. The experimental results show that the reading speed and the score versus the students may be explained by a linear regression. Reading speed decreases as the score decreases. The students with a higher magnitude of reading speed scored better marks. More importantly, we find that the reading speed of our students is lower than the native English speakers. This approach of modeling the readability in linear form significantly simplifies the readability analysis.

关键词： Readability Reading Speed Software Readability Flesch-Kincaid Grade Level Gunning-Fog Score Coleman-Liau Index Smog Index Automatic Readability Index Linear Regression

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Tobacco Exposed Buccal Mucosa Graft—A Potential Carcinogen for Scrotal Cancer

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Surgical Science 2012年第2期3卷 87-88页

作者： Chaitanya H. Raut Atul Kumar Fanindra Singh Solanki Shabbir Hussain deepti B. sharma Dhananjay sharma Department of Surgery NSCB Medical College Jabalpur India

Squamous cell carcinoma of scrotum is not common. It was the first cancer directly associated with a specific occupation i.e. chimney sweeps. We report a case of squamous cell carcinoma of scrotum developed in a patient of stricture urethra with multiple perineal urinary fistulas treated with lay open urethra with buccal mucosal graft. Tobacco exposed buccal mucosa graft can act as a carcinogen for scrotal cancer in patients with multiple fistula and poor hygiene.

关键词： Buccal Mucosa Scrotal Malignancy Tobacco

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Improvement of phosphorus uptake,phosphorus use efficiency,and grain yield of upland rice(Oryza sativa L.)in response to phosphate-solubilizing bacteria blended with phosphorus fertilizer

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Pedosphere 2022年第5期32卷 752-763页

作者： Pratibha RAWAT Anita sharma deepti SHANKHDHAR Shailesh Chandra SHANKHDHAR Department of Plant Physiology College of Basic Sciences&HumanitiesGovind Ballabh Pant University of Agriculture&TechnologyPantnagar-263145(India) Department of Microbiology College of Basic Sciences&HumanitiesGovind Ballabh Pant University of Agriculture&TechnologyPantnagar-263145(India)

Phosphorus(P)limitation in soil is a major concern for crop ***,the use of chemical fertilizer is hazardous to the environment and ***,the use of phosphate-solubilizing bacteria(PSB)is an eco-friendly approach for a sustainable agricultural *** the present study,a field trial was conducted for two consecutive years to study the effects of three PSB strains isolated,Bacillus licheniformis,Pantoea dispersa,and Staphylococcus sp.,with different P fertilizer rates on P uptake,P use efficiency(PUE),and grain yield of *** activities of soil enzymes were also studied in relation to PSB *** analysis of the yield and biochemical parameters revealed that inoculation of PSB consortium could reduce almost 50%of the recommended P dose in rice *** PSB strains in combination with 50%P dose was most effective and showed the highest increases in P uptake and PUE as compared to the uninoculated ***,the PSB consortium combined with 50%P dose contributed to 50.58%and35.64%yield increases compared to the uninoculated control for 2018 and 2019,*** increases in the activities of soil dehydrogenase,alkaline phosphatase,and acid phosphatase were also recorded under PSB treatment.

关键词： bacterial inoculation enzyme activity phosphate solubilization index recommended P dose soil dehydrogenase soil phosphatase

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Genetics on early onset inflammatory bowel disease:An update

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Genes & Diseases 2020年第1期7卷 93-106页

作者： Johnson Nameirakpam Rashmi Rikhi Sanjay Singh Rawat Jyoti sharma deepti Suri Pediatric Allergy and Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Inflammatory bowel disease(IBD)is more common in adults than in *** of IBD before 17 years of age is referred as pediatric onset IBD and is further categorized as very early onset IBD(VEO-IBD)for children who are diagnosed before 6 years of age,infantile IBD who had the disease before 2 years of age and neonatal onset IBD for children less than 28 days of *** presenting with early onset disease may have a monogenic *** and awareness of the clinical manifestations facilitates early evaluation and *** generation sequencing is helpful in making the genetic *** of childhood IBD is difficult;targeted therapies and hematopoietic stem cell transplantation form the *** this review we aim to summarize the genetic defects associated with IBD *** describe genetic location and functions of various genetic defect associated with VEO-IBD with their key clinical *** also provide clinical clues to suspect these conditions and approaches to the diagnosis of these disorders and suitable treatment options.

关键词： Il-10 signalling defect IPEX Next generation sequencing Targeted therapy Very early onset inflammatory bowel disease

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