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Efficacy of a Diabetes Specific Nutritional Supplement (DSNS) on Glycemic Response in Prediabetic Adults: A Two-Armed, Open-Labelled Randomized Controlled Study

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Food and Nutrition Sciences 2024年第7期15卷 612-643页

作者： deepti Khanna Kejal Joshi Reddy Hema S. Gopalan Jaladhi Bhatt Jayanti gupta Simran Sethi Parth Joshi Manoj Pareek Department of R&D Hindustan Unilever Limited Gurugram India Mumbai India Cliantha Research Ahmedabad India

It is well known that Diabetes Specific Nutritional Supplements (DSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DSNSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose Response (ABGR) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGR of DSNS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of DSNS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. During the 4 weeks intervention phase, the test group received DSNS with lifestyle counselling (DSNS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of DSNS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). DSNS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by DSNS + LC versus LC alone. No other significant changes were reported between groups. It may be concluded that DSNS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.

关键词： Diabetes Specific Nutritional Supplement Prediabetes Acute Blood Glucose Response Incremental Area under Curve Lifestyle Counselling

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Giant Angiomyolipoma of the Kidney Presenting as Anaemia—A Rare Presentation

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Open Journal of Urology 2012年第2期2卷 75-77页

作者： Aparajita Mitra Sudhir Kumar Jain deepti gupta Ram Chandra Murthy Kaza Department of Surgery Maulana Azad Medical College and Lok Nayak Hospital New Delhi India

Angiomyolipoma presenting with severe anaemia is a rare entity. Urgent operative intervention is warranted in such patients especially if the tumour is “Giant” i.e. greater than 10 cm and involves the whole kidney. We chronicle the case of a 35 year old lady who presented with a rapidly enlarging renal lump in the left loin associated with severe anaemia. MRI was highly suggestive of angiomyolipoma. She underwent nephrectomy in view of continuous intratumoral haemorrhage. The tumour measured 18 × 13 × 8 cm and weighed approximately 1.6 kilograms after removing blood and blood clots. The histopathology was suggestive of angiomyolipoma. Angioembolization may be considered for tumours involving a portion of the kidney, as a part of the nephron sparing approach.

关键词： Kidney Angiomyolipoma Anaemia

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关于2—羟基—1,4萘醌的动力学和热力学研究

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国外纺织技术（化纤．染整．环境保护分册） 1995年第4期 27-30页

作者： deepti Bahl gupta 赵涛

引言最近十年表明,人们对天然染料的应用又激发了新的认识。在这期间,已经用这些染料进行了一系列研究,但是大多数研究实际上是以经验为根据的,系统研究天然染料染色的基础理论还相当有限。

关键词：染料 2-羟基-1 4萘醌动力学热力学染色料化学

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Crystal structure,biochemical and biophysical characterisation of NHR1 domain of E3 Ubiquitin ligase neutralized

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Advances in Enzyme Research 2013年第3期1卷 61-75页

作者： deepti gupta Sylvie Beaufils Veronique Vie Gilles Paboeuf Bill Broadhurst Francois Schweisguth Tom L.Blundell Victor M.Bolanos-Garcia Department of Biochemistry University of CambridgeCambridgeUnited Kingdom UMR-CNRS 6251 IPRUniversite de RennesCampus de BeaulieuFrance Institut Pasteur CNRS URA2578ParisFrance Department of Biological and Medical Sciences Oxford Brookes UniversityOxfordEngland

Notch signaling controls diverse developmental decisions of central importance to cell activity. One of the conserved positive regulators of Notch signaling is Neuralized, the E3 Ubiquitin ligase enzyme that regulates signaling activity by endocytosis. Neuralized has two novel repeats, NHR1 and NHR2, with a RING finger motif at the C-terminus. Both endocytosis of the Notch ligand, Delta, and inhibition of Notch signaling by Tom, a bearded family member, require the NHR1 domain. Here we describe the first crystal structure of NHR1 domain from Drosophila melanogaster, solved to 2.1 A resolution by X-ray analysis. Using NMR and other biophysical techniques we define a minimal binding region of Tom, consisting of 12 residues, which interacts with NHR1 and show by interfacial analysis of protein monolayers that NHR1 binds PI4P. Taken together, the studies provide insight into molecular interactions that are important for Notch signaling.

关键词： Notch Signaling Neuralized NHR1 Bearded Tom Endocytosis Neurogenesis

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SAS+R大数据行业应用案例分析

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作者： (印)迪普提·古普塔(deepti gupta)

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天然染料在棉质品上的抗紫外线及抑制微生物的特性

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上海毛麻科技 2009年第4期 37-41页

作者： deepti gupta 新德里[印度] 虞娜（译）刘德钧（译）不详哈尔滨纺织科学研究所哈尔滨

本文对不同粉质的天然染料着色棉质品后的抗紫外线及抑制微生物成长活力的防护特性进行了评估。所有的染料对属于紫外线域内的光谱,都显出有较高的吸收能力。如再使用上媒剂后,就又能增进遮蔽紫外线的效应。对选定的微生物菌种,大多数... 详细信息

本文对不同粉质的天然染料着色棉质品后的抗紫外线及抑制微生物成长活力的防护特性进行了评估。所有的染料对属于紫外线域内的光谱,都显出有较高的吸收能力。如再使用上媒剂后,就又能增进遮蔽紫外线的效应。对选定的微生物菌种,大多数的染料都显出有较好的杀菌活力。随着染料浓度的增加,其活力增强。丹宁基的栎树(***)染料对紫外线和一般微生物都显出有较好的防护性。研究的成果表明:所选定的天然染料可以改进棉织物的抗菌及抗紫外线的特性。

关键词：抑制微生物特性棉质品天然染料防护性的纺织品抗紫外线

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Grover’s Algorithm in a 4-Qubit Search Space

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Journal of Quantum Computing 2021年第4期3卷 137-150页

作者： Saasha Joshi deepti gupta Department of Computer Science and Engineering University Institute of Engineering and TechnologyPanjab UniversityChandigarh160014India

This paper provides an introduction to a quantum search algorithm,known as Grover’s Algorithm,for unsorted search *** algorithm is implemented in a search space of 4 qubits using the Python-based Qiskit SDK by *** providing detailed proof,the computational complexity of the algorithm is generalized to n *** implementation results obtained from the IBM QASM Simulator and IBMQ Santiago quantum backend are analyzed and ***,the paper discusses the challenges faced in implementation and real-life applications of the algorithm ***,the implementation and analysis depict the advantages of this quantum search algorithm over its classical counterparts.

关键词： Grover’s algorithm unsorted search Oracle amplitude amplification quantum computing

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Glycemic Indices of Multiple Oral Nutritional Supplements: A Randomized Cross-Over Study in Indian Adults

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Food and Nutrition Sciences 2023年第10期14卷 941-962页

作者： deepti Khanna Jaladhi Bhatt Jayanti gupta Simran Sethi Parth Joshi Manoj Pareek Divya Agrawal Hindustan Unilever Limited R&D Department Gurugram India Independent Biostatistician & Researcher Mumbai India Cliantha Research Ahmedabad India

Background: A randomized cross-over study was conducted to assess the glycemic index (GI) of seven Oral Nutritional Supplements (ONSs). These ONSs are designed to support the nutritional requirements of different age-groups, physiological states, or health conditions among Indian adults. Methods: The study had two phases viz., phase1 (n = 18) studied two ONSs: A1 and B1 and phase 2 (n = 20) studied five ONSs: A2, B2, C2, D2 & E2. The subjects were healthy, non-diabetic adults, aged between 20 - 44 years with a mean Body Mass Index of 21.2 ± 1.52 kg/m2 (Phase 1) and 21.0 ± 1.45 kg/m2 (Phase 2). All these ONSs were compared with reference drinks (glucose). The carbohydrates in one serving of each ONS were matched to carbohydrates from 25 grams of glucose following ISO 2010 guidelines. Capillary blood was assessed for blood glucose response at baseline, 15, 30, 45, 60, 90 and 120 minutes. GI was calculated as the incremental area under the curve (iAUC) for the test drinks and expressed as a percentage of the average iAUC from glucose. Results: Phase 1 indicated that the high fiber diabetes-specific nutrition supplement A1 with higher protein (23% energy), higher fat (25% energy) and reduced carbohydrates (40% energy) had a significantly (p = 0.002) lower GI [34 (±6)] as compared to B1 [63 (±7)] (protein 19%, fat 7% and carbohydrates 60% energy) even with similar amount (22%) and type of fiber. Phase 2 reported that all test products [A2 (32 ± 5), B2 (37 ± 4), C2 (31 ± 5), D2 (31 ± 5) and E2 (55 ± 4)] had a low GI. As compared to phase 1, ONSs in phase 2 had lower fiber content (1.6% - 4.6% energy). Conclusion: The glycemic index of oral nutrition supplements is influenced not only by their fiber content, but also by the overall macronutrient composition including protein (≥17% energy), fat (≥10% - 27% energy) and carbohydrates (40% - 57.5% energy).

关键词： Glycemic Index Oral Nutritional Supplements Incremental Area under the Curve Diabetes

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Case report on an infant presenting with hypoglycemia,and milky serum

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Asian Pacific Journal of Tropical Biomedicine 2012年第4期2卷 331-332页

作者： Yogesh Kumar gupta Anushre Prasad Pushpa Kini Prashant Naik deepti Choprra Krishnananda Prabhu Department of Paediatrics Kasturba Medical CollegeManipal University Department of Biochemistry Kasturba Medical CollegeManipal University

A 4-month-old male baby who presented in a moribund condition with seizures was found to have hepatomegaly,hypoglycemia and milky *** triglycerides were markedly elevated(3168 mg/dL) with cholesterol being 257 mg/dL and high density lipoprotein levels were low(19 mg/dL).The possibility of glycogen storage disease type Ⅰ was considered in the *** with glycogen storage disease type Ⅰ may present like *** association of hepatomegaly, hypoglycemia and abnormal lipid profile stated above should alert the physician to consider glycogen storage disease type Ⅰ in the diagnosis.

关键词： Hypertriglyceridemia Hypoglycemia Glycogen storage disorder type Ⅰ Milky serum

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Prevalence and Antibiotic Resistance Pattern among the Mastitis Causing Microorganisms

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Open Journal of Veterinary Medicine 2018年第4期8卷 54-64页

作者： Karanvir Singh Mudit Chandra Gurpreet Kaur deepti Narang Dhiraj Kumar gupta Department of Veterinary Microbiology College of Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India Department of Veterinary Clinical Medicine College of Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University Ludhiana Punjab India

Mastitis is one of the most commonly occurring diseases of dairy animals. It is the most important cause of economic losses to the dairy industry in India and throughout the world. In the present study prevalence of microorganisms isolated from mastitic milk and their antibiotic resistance was studied. A total of sixty nine milk samples from mastitic animals (clinical and subclinical) were tested using sodium lauryl sulphate test and those positive were selected and transported to the laboratory for isolation and identification of the causative agent. Out of these samples fifty samples yielded bacterial growth when tested on selective/non selective medium. Of these fifty samples, seven samples had single bacterial growth whereas rest of the 43 samples had mixed growth. Among the bacterial isolates it was found that the highest prevalence was of Streptococcus agalactiae and Staphylococcus aureus followed by E. coli and Klebsiella pneumoniae. Antibiotic sensitivity test revealed that Streptococcus agalactiae revealed the highest sensitivity to ofloxacin, ciprofloxacin, gentamicin and resistance to amoxicillin and doxycycline;Staphylococcus aureus revealed the highest sensitivity to ciprofloxacin, doxycycline, azithromycin and sparfloxacin and resistance to amoxycillin and gentamicin. Similarly, E. coli revealed the highest sensitivity to azithromycin and chloramphenicol and resistance to amoxicillin and teicoplanin, and Klebsiella pneumoniae revealed highest sensitivity to azithromycin, gentamicin and resistance to amoxicillin, teicoplanin and erythromycin. Thus, from the present study it could be concluded that Streptococcus agalactiae, Staphylococcus aureus, E. coli and Klebsiella pneumoniae were the most frequently isolated organisms from mastitic animals and azithromycin and the third generation fluoroquinolones (ciprofloxacin, sparfloxacin and ofloxacin) were the most sensitive drugs.

关键词： Mastitis Milk Antibiotic Bacteria Resistance

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