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Discovery and preclinical development of ⅢM-160, a Bergenia ciliatabased anti-inflammatory and anti-arthritic botanical drug candidate

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Journal of Integrative Medicine 2019年第3期17卷 192-204页

作者： Sandip B.Bharate Vikas Kumar Sonali S.Bharate Bikarma singh Gurdarshan singh Amarinder singh Mehak Gupta deepika singh Ajay Kumar Surjeet singh Ram A.Vishwakarma Medicinal Chemistry Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research PK-PD Toxicology & Formulation Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research Biodiversity and Applied Botany Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research Quality Control and Quality Assurance Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research

Objective: Bergenia ciliata(Haw.) Sternb. is used in the Indian traditional system of medicine to treat various ailments including rheumatism and to heal wounds. The objective of the present study was to perform a preclinical characterization of the B. ciliata-based botanical extract ***: ⅢM-160 was chemically standardized and analyzed for heavy metal content, aflatoxins,pesticides and microbial load. The in vitro and in vivo efficacies were determined in suitable models of inflammation, arthritis and nociception. An acute oral toxicity study was performed in Swiss albino mice.A suitable oral formulation was developed and ***: Bergenin was found to be the major component(9.1% w/w) of ⅢM-160. The botanical lead displayed inhibition of lipopolysaccharide-induced production of proinflammatory cytokines in THP-1 cells, with selectivity toward interleukin-6(IL-6) and had an excellent safety-window. It showed anti-inflammatory, anti-arthritic and antinociceptive activity in animal models and was not toxic at oral doses up to 2 g/kg in Swiss-albino mice. The gastroretentive, sustained-release capsule formulation showed sustained-release of the bergenin over the period of 24 h, resulting in improved plasma-exposure of bergenin in Sprague–Dawley ***: The dual-activity of IL-6 inhibition and antinociception marks the suitability of ⅢM-160 for treating rheumatoid arthritis. This study will serve as the benchmark for further research on this botanical formulation.

关键词： Botanical preclinical candidate UIM-160 Bergenia ciliata Arthritis Gastroretentive sustained release formulation Bergenin

Charged current quasi-elastic scattering of vμoff^12C

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Chinese Physics C 2018年第12期42卷 25-31页

作者： deepika Grover Kapil Saraswat Prashant Shukla Venktesh singh Department of Physics Institute of ScienceBanaras Hindu UniversityVaranasi 221005India Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Homi Bhabha National Institute Anushakti NagarMumbai 400094India

In this work, we study charged current quasi-elastic scattering （QES） of vμ off nucleon and nucleus using a formalism based on the Llewellyn Smith （LS） model. Parameterizations by Galster et al. are used for electric and magnetic Sach＇s form factors of the nucleons. We use the Fermi gas model along with the Pauli suppression condition to take into account the nuclear effects in the anti-neutrino-nucleus QES. We calculate vμ-p and vμ-^12C charged current quasi-elastic scattering differential and total cross sections for different values of axial mass MA, and compare the results with data from the GGM, SKAT, BNL, NOMAD, MINERVA and MiniBooNE experiments. The present theoretical approach gives a good description of differential cross section data. The calculations with axial mass MA =0.979 and 1.05 GeV are compatible with data from most of the experiments.

关键词： cross section quasi-elastic scattering axial mass form factors

Defect induced room-temperature ferromagnetism and enhanced photocatalytic activity in Ni-doped ZnO synthesized by electrodeposition

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Chinese Physics B 2020年第10期29卷 566-572页

作者： deepika Raju Kumar Ritesh Kumar Kamdeo Prasad Yadav Pratyush Vaibhav Seema Sharma Rakesh Kumar singh Santosh Kumar College o f Commerce Arts and SciencePatna.BiharIndia Jaypee University o f Engineering and Technology GunaMadhya PradeshIndia Anugrah Narayan College PatnaBiharIndia Aryabhatta Knowledge University PatnaBiharIndia

Zn0.90Ni0.10O nanoparticles have been synthesized by single-bath two-electrode electrodeposition at constant voltage. X-ray diffraction, UV vis and photoluminescence studies reveal that a single-phase polycrystalline hcp wurtzite crystal structure of ZnO is evolved. The material consists of a large number of defects such as oxygen vacancy (Ov) and zinc interstitial (Zi). The magnetization study reveals that the sample exhibits room-temperature global ferromagnetism and the ferromagnetic ordering seems to be defect induced via bound magnetic polaron mechanism, and double exchange is also expected to have played role. Interesting optoelectronic properties have been found in the synthesized sample and the material seems to be a potential candidate to be used as a UV sensor. Such a transition metal doped ZnO based dilute magnetic semiconducting system exhibiting room-temperature ferromagnetism is likely to be first of its kind in the sense that such materials have not yet been reported to be synthesized by the simple method of electrodeposition to the best of our knowledge on the basis of ample literature review.

关键词： dilute magnetic semiconductors(DMS) bound magnetic polaron photoluminescence ferromagnetism

Phytochemistry and ethnomedicinal qualities of metabolites from Phyllanthus emblica L.:A review

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BIOCELL 2023年第5期47卷 1159-1176页

作者： VIJAY KUMAR PRAVEEN C.RAMAMURTHY SIMRANJEET singh DALJEET singh DHANJAL PARUL PARIHAR deepika BHATIA RAM PRASAD JOGINDER singh Central Ayurveda Research Institute JhansiUttar Pradesh284003India Interdisciplinary Centre for Water Research Indian Institute of SciencesBangalore560012India Department of Biotechnology Lovely Professional UniversityPhagwaraPunjab144411India Department of Botany Lovely Professional UniversityPhagwaraPunjab144411India Department of Biotechnology Baba Farid CollegeBathindaPunjab151001India Department of Botany Mahatma Gandhi Central UniversityMotihari845401India Department of Microbiology Lovely Professional UniversityPhagwaraPunjab144411India

Phyllanthus emblica or Indian gooseberry is an integrated part of Ayurvedic and Traditional Chinese *** several decades,the well-known ancient herb has been extensively utilized in traditional medicine to cure diseases like fever,diabetes,constipation,jaundice,ulcers,biliousness,anemia,anorexia,and *** the traditional system,Indian gooseberry has various ethnomedicinal *** the Ayurvedic system,different methods of administration(anupan)have shown different ethnomedicinal properties of Indian *** well-known chemical components in Indian gooseberry have been identified through phytochemical evaluation,among which the flavonoids and phenols are most *** the toxicity perspective,it is considered a safe herb in India,and is taken as a food supplement in European *** wide-spectrum pharmacological activities of the crude extracts and isolates of Indian gooseberry are attributed to the predominance of phenols and ***,it is important to study the exact mechanism of the activity of the phytochemicals in Indian gooseberry,especially in anti-cancer *** of Indian gooseberry enhances proliferation in several cancer cells in vitro,including stem cells like ovarian cancer(OC)cells,and also has been observed to possess anti-proliferative characteristics in *** review intends to explore the therapeutic potential of Indian gooseberry based on scientific reports and attempts to find the gaps for future research.

关键词： Phyllanthus emblica Amla Vitamin C Antioxidant Stem cells Phytochemistry Pharmacology

Benzimidazole derivatives: search for GI-friendly anti-inflammatory analgesic agents

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Acta Pharmaceutica Sinica B 2015年第4期5卷 337-342页

作者： Monika Gaba Punam Gaba deepika Uppal Neelima Dhingra Malkeet singh Bahia Om Silakari Chander Mohan Department of Pharmaceutical Sciences ASBASJSM College of Pharmacy Research Scholar Punjab Technical University University Institute of Pharmaceutical Sciences Panjab University Department of Pharmaceutical Sciences and Drug Research Punjabi University Rayat-Bahra Institute of Pharmacy Hoshiarpur Affiliated to Punjab Technical University

Non-steroidal anti-inflammatory drugs(NSAIDs) have been successfully used for the alleviation of pain and inflammation in the past and continue to be used daily by millions of patients worldwide. However, gastrointestinal(GI) toxicity associated with NSAIDs is an important medical and socioeconomic problem. Local generation of various reactive oxygen species plays a significant role in the formation of gastric ulceration associated with NSAIDs therapy. Co-medication of antioxidants along with NSAIDs has been found to be beneficial in the prevention of GI injury. This paper describes the synthesis and biological evaluation of N-1-(phenylsulfonyl)-2-methylamino-substituted-1H-benzimidazole derivatives as anti-inflammatory analgesic agents with lower GI toxicity. Studies in vitro and in vivo demonstrated that the antioxidant activity of the test compounds decreased GI toxicity.

关键词： Benzimidazole Analgesic Gastrointestinal toxicity Antioxidant activity

Deep Learning Based Automated Detection of Diseases from Apple Leaf Images

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Computers, Materials & Continua 2022年第4期71卷 1849-1866页

作者： Swati singh Isha Gupta Sheifali Gupta deepika Koundal Sultan Aljahdali Shubham Mahajan Amit Kant Pandit Department of Electronics and Communication Engineering University Institute of TechnologyHimachal Pradesh UniversityShimla171005India Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjabIndia Department of Systemics School of Computer ScienceUniversity of Petroleum and Energy StudiesDehradunIndia Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia School of Electronics&Communication Shri Mata Vaishno Devi UniversityKatra185320India

In Agriculture Sciences, detection of diseases is one of the mostchallenging tasks. The mis-interpretations of plant diseases often lead towrong pesticide selection, resulting in damage of crops. Hence, the automaticrecognition of the diseases at earlier stages is important as well as economicalfor better quality and quantity of fruits. Computer aided detection (CAD)has proven as a supportive tool for disease detection and classification, thusallowing the identification of diseases and reducing the rate of degradationof fruit quality. In this research work, a model based on convolutional neuralnetwork with 19 convolutional layers has been proposed for effective andaccurate classification of Marsonina Coronaria and Apple Scab diseases fromapple leaves. For this, a database of 50,000 images has been acquired bycollecting images of leaves from apple farms of Himachal Pradesh (H.P)and Uttarakhand (India). An augmentation technique has been performedon the dataset to increase the number of images for increasing the *** performance analysis of the proposed model has been compared with thenew two Convolutional Neural Network (CNN) models having 8 and 9 layersrespectively. The proposed model has also been compared with the standardmachine learning classifiers like support vector machine, k-Nearest Neighbour, Random Forest and Logistic Regression models. From experimentalresults, it has been observed that the proposed model has outperformed theother CNN based models and machine learning models with an accuracy of99.2%.

关键词： Deep learning convolutional neural network apple leaves apple scab support vector machine

Quantization error in stereo imaging system with noise distributions

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第5期11卷 86-117页

作者： deepika Saini Sanjeev Kumar Department of Mathematics Graphic Era Deemed to be University Dehradun Uttarakhand 248002India Department of Mathematics Indian Institute of Technology Roorkee Roorkee 247667India

The problem of estimating quantization error in 2D images is an inherent problem in computer *** outcome of this problem is directly related to the error in reconstructed 3D position coordinates of an *** estimation of quantization error has its own importance in stereo *** the quantization error cannot be controlled fully,still statistical error analysis helps us to measure the performance of stereo systems that relies on the imaging ***,it is assumed that the quantization error in 2D images is distributed uniformly that need not to be true from a practical *** this paper,we have incorporated noise distributions(Triangular and Trapezoidal)for the stochastic error analysis of the quantization error in stereo imaging *** the validation of the theoretical analysis,the detailed simulation study is carried out by considering different cases.

关键词： Quantization error stereo images noise distributions range estimation error range error magnitude relative range error

Biomineralized and chemically synthesized magnetic nanoparticles:A contrast

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Frontiers of Materials Science 2020年第4期14卷 387-401页

作者： Tanya NANDA Ankita RATHORE deepika SHARMA Present adress:School of Biological and Health Systems Engineering Ira A.Fulton Schools of EngineeringArizona State UniversityTempeAZ 85281USA Present address:Academy of Scientific and Innovative Research(AcSir) CSIR-National Institute of Science Communication and Information Resources(NISCAIR)New Delhi 110067India Institute of Nano Science and Technology Habitat CentreSector 64Mohali 160062India

Magnetic nanoparticles(MNPS)have widely been synthesized through chemical processes for biomedical applications over the past few ***,a new class of MNPs,known as bacterial magnetosomes,has been isolated from magnetotactic bacteria,a natural *** magnetosomes are magnetite or greigite nanocrystals which are biomineralized in the bacterial cell and provide magnet-like properties to *** to MNPs,bacterial magnetosomes are biocompatible,lower in toxicity,and can be easily cleared from the body due to the presence of a phospholipid bilayer around *** also do not demonstrate aggregation,which makes them highly *** this review,we have provided an in-depth comparative account of bacterial magnetosomes and chemically synthesized MNPs in terms of their synthesis,properties,and biomedical *** addition,we have also provided a contrast on how magnetosomes might have the potential to successfully substitute synthetic MNPs in therapeutic and imaging applications.

关键词： bacterial magnetosomes magnetic nanoparticles iron nanoparticles magnetotactic bacteria magnetosomes

Diversity and species composition of microbiota associated with dengue mosquito breeding habitats:A cross-sectional study from selected areas in Udapalatha MOH division,Sri Lanka

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Asian Pacific Journal of Tropical Medicine 2023年第8期16卷 363-370页

作者： Yashoda Kumari deepika Amarasinghe Koshila Ranasinghe Department of Zoology and Environmental Management Faculty of ScienceUniversity of KelaniyaDalugamaKelaniya GQ 11600Sri Lanka

Objective:To determine the diversity of microbiota associated with different breeding habitats of dengue vector mosquitoes Aedes(Ae.)aegypti and *** and to identify any parasitic,epibiont,pathogenic,competitive or predatory ***:Sampling was performed from a variety of breeding habitats using dipping,pipetting and siphoning *** in water samples were preserved using Rose Bengal solution and Lugol's iodine,and were *** samples of microbiota were kept under laboratory conditions to observe any pathogenic or parasitic microbiota interacting with ***:A total of eleven microbiota species(Canthocamptus staphylinus,Canthocamptus microstaphylinus,Parastenocaris brevipes,Lepadella ovalis,Lepadella patella,Rotatoria rotatoria,Rotatoria macrura,Asplanchna brightwelli,Trichocerca rattus,Euglena variabilis,and Flagilaria capucina)belonging to four(4)phyla(Arthropoda,Rotifera,Euglenozoa,and Ochrophyta)and 8 microbiota species belonged to four phyla(Arthropoda,Rotifera,Euglenozoa,and Ochrophyta)were identified from *** and *** breeding habitats *** was a higher percentage(54.54%)of larval habitats positive for the secondary vector *** than through the primary vector *** in the Gampola urban area indicating higher possibility of transmitting the dengue virus through the secondary ***,no pathogenic or parasitic ciliates on mosquito larvae were encountered in the present *** findings may be due to sampling maingly from temporary container-type breeding ***:The relative distribution of microbiota associated with mosquito species differed significantly among *** and *** overall findings of this study could help in implementing novel eco-friendly vector-control strategies in the study area.

关键词： Aedes Biological Mosquito-control Vectors