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Surface-modified elastomeric nanofluidic devices for single nanoparticle trapping

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Microsystems & Nanoengineering 2021年第3期7卷 185-196页

作者： deepika sharma Roderick Y.H.Lim Thomas Pfohl Yasin Ekinci Swiss Nanoscience Institute 4056BaselSwitzerland Biozentrum University of Basel4056BaselSwitzerland Laboratory for Micro and Nanotechnology Paul Scherrer Institut5232VilligenSwitzerland Institute of Physics University of FreiburgD-79104FreiburgGermany

Our work focuses on the development of simpler and effective production of nanofluidic devices for high-throughput charged single nanoparticle trapping in an aqueous *** nanoparticle confinement using electrostatic trapping has been an effective approach to study the fundamental properties of charged molecules under a controlled aqueous ***,geometry-induced electrostatic trapping devices are fabricated using SiOx-based substrates and comprise nanochannels imbedded with nanoindentations such as nanopockets,nanoslits and *** geometry-induced electrostatic trapping devices can only trap negatively charged particles,and therefore,to trap positively charged particles,modification of the device surface is ***,the surface modification process of a nanofluidic device is cumbersome and time ***,here,we present a novel approach for the development of surface-modified geometry-induced electrostatic trapping devices that reduces the surface modification time from nearly 5 days to just a few *** utilized polydimethylsiloxane for the development of a surface-modified geometry-induced electrostatic trapping *** demonstrate the device efficiency and success of the surface modification procedure,a comparison study between a PDMS-based geometry-induced electrostatic trapping device and the surface-modified polydimethylsiloxane-based device was *** device surface was modified with two layers of polyelectrolytes(1:poly(ethyleneimine)and 2:poly(styrenesulfonate)),which led to an overall negatively charged *** experiments revealed the presence of a homogeneous surface charge density inside the fluidic devices and equivalent trapping strengths for the surface-modified and native polydimethylsiloxane-based geometry-induced electrostatic trapping *** work paves the way towards broader use of geometry-induced electrostatic trapping devices in the fields of biosensing,disease d

关键词： trapping modified fluid

Soft electrostatic trapping in nanofluidics

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Microsystems & Nanoengineering 2017年第1期3卷 27-36页

作者： Michael A.Gerspach Nassir Mojarad deepika sharma Thomas Pfohl Yasin Ekinci Swiss Nanoscience Institute Basel 4056Switzerland Laboratory for Micro and Nanotechnology Paul Scherrer InstitutVilligen 5232Switzerland Chemistry Department University of BaselBasel 4056Switzerland Nanotechnology Group ETH ZürichRüschlikon 8803Switzerland Biozentrum University of BaselBasel 4056Switzerland Biomaterials Science Center University of BaselAllschwil 4123Switzerland ABB Switzerland Ltd. SemiconductorsLenzburg 5600Switzerland Institute of Physics University of FreiburgFreiburg 79104Germany

Trapping and manipulation of nano-objects in solution are of great interest and have emerged in a plethora of fields spanning from soft condensed matter to biophysics and medical *** report on establishing a nanofluidic system for reliable and contact-free trapping as well as manipulation of charged nano-objects using elastic polydimethylsiloxane(PDMS)-based *** trapping principle is based on electrostatic repulsion between charged nanofluidic walls and confined charged objects,called geometry-induced electrostatic(GIE)*** gold nanoparticles as probes,we study the performance of the devices by measuring the stiffness and potential depths of the implemented traps,and compare the results with numerical *** trapping 100 nm particles,we observe potential depths of up to Q≅24 k_(B)T that provide stable trapping for many *** advantage of the soft material properties of PDMS,we actively tune the trapping strength and potential depth by elastically reducing the device channel height,which boosts the potential depth up to Q~200 k_(B)T,providing practically permanent contactfree *** to a high-throughput and low-cost fabrication process,ease of use,and excellent trapping performance,our method provides a reliable platform for research and applications in study and manipulation of single nano-objects in fluids.

关键词： contact-free electrostatic nanoparticle trapping PDMS nanofluidic devices high-throughput fabrication single nano-object manipulation soft-lithography

Effect of Chromium on Magnetic Characteristics of Powder Processed Fe-0.35wt%P Alloy

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Journal of Minerals and Materials Characterization and Engineering 2011年第7期10卷 617-624页

作者： deepika sharma Kamlesh Chandra Prabhu Shankar Misra Metallurgical and Materials Engineering Department Indian Institute of Technology Roorkee 247667 India

The present investigation deals with hot powder preform forging technique for the development of high density iron-phosphorus based alloys. These alloys are known for hot-shortness and are therefore not considered suitable for high temperature working. To remove this problem proper soaking at high temperature to eliminate iron- phosphide eutectic and bring entire phosphorus into solution in iron was aimed. Attempting hot forging thereafter completely eliminates hot as well as cold shortness and thereby helps to form these alloys into very thin sheets. It has also been possible to eliminate the use of costly hydrogen atmosphere during sintering by use of addition of carbon as a reducing agent to form CO gas within the compact by reacting with oxygen of iron powder particles. The glassy ceramic coating applied over the compact serves as a protective coating to avoid atmospheric oxygen attack over the compact held at high temperature. Combined application of carbon and glassy ceramic coating has lead to economy in P/M processing for soft magnetic applications. Fe- 0.07C- 0.3O- 0.35wt% P- 0.35wt% Cr alloy so formed yielded coercivity as low as 0.42 Oe, resistivity as high as 21.8 μ cm and total loss as low as 0.170 W/Kg. Such a combination of properties may suit their application in magnetic relays and transformer cores.

关键词： Glassy Ceramic Coating Preform Forging Coercivity

Role of the renin angiotensin system in diabetic nephropathy

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World Journal of Diabetes 2010年第5期1卷 141-145页

作者： Tanuj Chawla deepika sharma Archana Singh Department of Pharmacology Lady Hardinge Medical College and Associated Hospitals Department of Biochemistry Lady Hardinge Medical College and Associated Hospitals Department of Biochemistry University College of Medical Sciences

Diabetic nephropathy has been the cause of lot of morbidity and mortality in the diabetic population. The renin angiotensin system (RAS) is considered to be involved in most of the pathological processes that result in diabetic nephropathy. This system has various subsystems which contribute to the disease pathology. One of these involves angiotensin II (Ang II) which shows increased activity during diabetic nephropathy. This causes hypertrophy of various renal cells and has a pressor effect on arteriolar smooth muscle resulting in increased vascular pressure. Ang II also induces inflammation, apoptosis, cell growth, migration and differentiation. Monocyte chemoattractant protein-1 production responsible for renal fibrosis is also regulated by RAS. Polymorphism of angiotensin converting enzyme (ACE) and Angiotensinogen has been shown to have effects on RAS. Available treatment modalities have proven effective in controlling the progression of nephropathy. Various drugs (based on antagonism of RAS) are currently in the market and others are still under trial. Amongst the approved drugs, ACE inhibitors and angiotensin receptor blockers (ARBs) are widely used in clinical practice. ARBs are shown to be superior to ACE inhibitors in terms of reducing proteinuria but the combined role of ARBs with ACE inhibitors in diabetic nephropathy is under debate.

关键词： Diabetic nephropathy Angiotensin II Monocyte chemoattractant protein-1 Renin angiotensin system

Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India

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World Journal of Gastroenterology 2005年第45期11卷 7165-7168页

作者： Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish deepika R sharma Premashis Kar PCR Hepatitis Laboratory Panacea Biotec Ltd Mohammad Raish

AIM：（1） To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. （2） To assess the efficacy and safety of En/vac- HB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B accine developed and manufactured in India. METHODS： A prospective, comparative, and single blinded trial of rapid （0, 1, and 2 mo） hepatitis B immunization schedulewas reported. A total of three hundred and seven （212 females and 95 males） healthy volunteers divided into three age groups （18-29, 30-39, and 40-49） were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo. RESULTS： Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 （96.5%） subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/ mL, while that in the age group of 30-39 years was 2 096.0 mlU/mL. In third age group of 40-49 years, anti- HBs titer was 1 592.0 mIU/mL. Hyper-responses （anti-HBs≥100 mIU/mL） were shown in 88.0% （271/307） of subjects. Eleven （3.5%） subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions （ADRs）. CONCLUSION： This vaccine （Enivac-HB） is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended

关键词： Enivac-HB Pichia pastoris Anti-HBsantibody Hepatitis B vaccine

Erratum to: Biomineralized and chemically synthesized magnetic nanoparticles: A contrast

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Frontiers of Materials Science 2021年第2期15卷 316-316页

作者： Tanya NANDA Ankita RATHORE deepika sharma Institute of Nano Science and Technology Habitat CentreSector 64Mohali 160062India Present address:School of Biological and Health Systems Engineering Ira A.Fulton Schools of EngineeringArizona State UniversityTempeAZ 85281USA Present address:Academy of Scientific and Innovative Research(AcSir) CSIR-National Institute of Science Communication and Information Resources(NISCAIR)New Delhi 110067India

Erratum to:***.2020,14(4):387^401 DOI:10.1007/s 11706-020-0531-7 Page 391,the caption of Fig.3 uBiomineralization and role of magnetosome membrane proteins in synthesis of BM crystals in MTB(Magnetosome proteins:MamR,... 详细信息

关键词： chemically synthesis magnetic

Spatio-temporal variation of trace elements distributed over surface water of Upper Ganga River Basin in Western Himalayan Region

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Journal of Mountain Science 2023年第1期20卷 145-162页

作者： deepika DIMRI Ambika KUMAR DeepakKumar MISHRA Archana sharma Doon University Dehradun248012India Bhagalpur National College Bhagalpur812007India

The rivers draining from the Himalayan range distribute enormous amount of fresh water to the people living in downstream *** metals flowed with river water can lead to serious impact on ecological system and human ***,the documentation on trace elements of Himalayan rivers is inadequately *** current study deals with the spatial and temporal variability of the major and trace elements of Ganga river water in epirhithron,metarhithron and hyporhithron zone belonging to Himalayan *** samples from nineteen monitoring locations were collected in pre-monsoon(May-June),monsoon(AugustSeptember)and post-monsoon(December)seasons and subjected to be assessed for 20 elements(Ag,Al,Ba,Cd,Ca,Cr,Cu,Fe,Ga,K,Mn,Mg,Na,Ni,Pb,Sr,Th,U,Zn,and Zr)using ICP-OES(Inductively Coupled Plasma-Optical Emission Spectrometer).Different water pollution indexes such as HPI(Heavy Metal Pollution Index),MI(Metal Index)and PI(Pollution Index)were used to describe current water quality status at each monitoring station under particular classified ecological *** studied stations in hyporhithron zone had the value of Metal Index(MI>1),indicating threshold of ***,the highest values of HPI in hyporhithron zone correspond to poor water quality *** with poor water quality were also found to be contaminated as per the Pollution Index(PI),exhibiting high concentrations for element(Fe).However,the epirhithron and metarhithron zone in Himalayan segment showed excellent water quality mainly contributed from natural *** Analysis(CA)and Principal Component Analysis(PCA)were applied to identify the main influential sources for Ganga river water *** Kriging interpolation method was also applied to prepare spatial distribution map of computed indexes(HPI,MI,and PI).With the help of index of local Moran’s I(LMI),identified spatial clusters and spatial outliers revealed the elevated concentration of most elements in hyporhithr

关键词： Trace elements Spatial variation Temporal variation Surface water Ganga River Basin ICP-OES

Defect induced room-temperature ferromagnetism and enhanced photocatalytic activity in Ni-doped ZnO synthesized by electrodeposition

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Chinese Physics B 2020年第10期29卷 566-572页

作者： deepika Raju Kumar Ritesh Kumar Kamdeo Prasad Yadav Pratyush Vaibhav Seema sharma Rakesh Kumar Singh Santosh Kumar College o f Commerce Arts and SciencePatna.BiharIndia Jaypee University o f Engineering and Technology GunaMadhya PradeshIndia Anugrah Narayan College PatnaBiharIndia Aryabhatta Knowledge University PatnaBiharIndia

Zn0.90Ni0.10O nanoparticles have been synthesized by single-bath two-electrode electrodeposition at constant voltage. X-ray diffraction, UV vis and photoluminescence studies reveal that a single-phase polycrystalline hcp wurtzite crystal structure of ZnO is evolved. The material consists of a large number of defects such as oxygen vacancy (Ov) and zinc interstitial (Zi). The magnetization study reveals that the sample exhibits room-temperature global ferromagnetism and the ferromagnetic ordering seems to be defect induced via bound magnetic polaron mechanism, and double exchange is also expected to have played role. Interesting optoelectronic properties have been found in the synthesized sample and the material seems to be a potential candidate to be used as a UV sensor. Such a transition metal doped ZnO based dilute magnetic semiconducting system exhibiting room-temperature ferromagnetism is likely to be first of its kind in the sense that such materials have not yet been reported to be synthesized by the simple method of electrodeposition to the best of our knowledge on the basis of ample literature review.

关键词： dilute magnetic semiconductors(DMS) bound magnetic polaron photoluminescence ferromagnetism

Does dyslipidemia worsen the hearing level in diabetics?

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Journal of Otology 2017年第4期12卷 198-201页

作者： Pratap deepika A. Rajeshwary Shastri U sha M.K. Goutham sharma Raghav Dept of Otorhinolaryngology KSHEMA Nitte University Mangalore 575018 India Dept of Audiology and Speech Language Pathology Nitte Institute of Speech and Hearing Mangalore 575018 India Dept of Medicine KSHEMA Nitte University Mangalore 575018 India

Objective: To identify the effect of dyslipidemia on auditory function detected by Pure Tone Audiometry. To check if dyslipidemia worsens the hearing level in ***: This was a comparative study where 120 subjects between the age group of 20 and 50 years underwent pure tone audiometry, lipid profile and blood sugars. Group 1 consisted of 30 subjects with type 2 diabetes and dyslipidemia; Group 2 had 30 subjects with isolated diabetes;Group 3 had 30 with isolated dyslipidemia and Group 4 included 30 normal subjects as ***: Significant hearing loss was seen only in the group with isolated diabetes(63%). The most common type of hearing loss was high frequency sensorineural hearing loss. When comparison was made between the combinations of different lipid profiles, no association was found to the level of ***: Diabetics are more prone to high frequency hearing loss. Altered lipid profile has no role in causing hearing loss.

关键词： Dyslipidemia Diabetes Pure tone audiometry