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CEACAM-1 Induced CSF3-receptor Downregulation in Bone Marrow Associated With Refractory Neutropenia in Advanced Cirrhosis

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 53-62页

作者： Chhagan Bihari Sukriti Baweja Seggere Murlaikrishna Shasthry deepika lal Preeti Negi Swati Thangariyal Dinesh Mani Tripathi Shiv Kumar Sarin Department of Pathology and Hematology Institute of Liver and Biliary SciencesD1Vasant KunjNew DelhiIndia Department of Molecular and Cellular Medicine Institute of Liver and Biliary SciencesD1Vasant KunjNew DelhiIndia Department of Hepatology Institute of Liver and Biliary SciencesD1Vasant KunjNew DelhiIndia

Background and Aims:Cirrhosis patients exhibit cyto-penia,and,at times refractory neutropenia to granulocyte colony-stimulating factor(G-CSF),which acts through the CSF3-receptor(CSF3R),and changes in CSF3R can affect the *** conducted this study to assess the CSF3R status and its relevance in cirrhotic ***:Cirrhotic patients(n=127)and controls(n=26)with clini-cally indicated bone marrow(BM)examination were *** assessment was done by qRT-PCR and immunohis-tochemistry(IHC)for *** G-CSF,CSF3R,and carcinoembryonic antigen cell adhesion molecule-1(CEACAM1)were *** hematopoietic precursor cells and their alterations were examined by flow *** findings were validated in liver cirrhosis patients who received G-CSF for severe ***:The mean age was 48.6±13.4 years,and 80.3%were *** CSF3R reduction was noted with the advance-ment of cirrhosis,and confirmed by qRT-PCR and IHC in ***3R decline was related to decreased hematopoietic stem cells(HSCs)and downregulation of CSF3R in the re-maining *** confirmed that CEACAM1 led to CSF3R downregulation in BM cells by possible lysosomal *** low peripheral blood-(PB)-CSF3R also predisposed development of infections on *** CSF3R was also associated with nonresponse to exogenous G-CSF treatment of ***-sions:Advanced liver cirrhosis was associated with low CSF3R and high CEACAM1 levels in the BM and circula-tion,making patients prone to infection and inadequate response to exogenous G-CSF.

关键词： Liver cirrhosis Child-Turcott-Pugh score Bone marrow Granulocyte colony stimulating factor CSF3R CEACAM-1 Hematopoietic stem cells Neutropenia

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