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Design optimization of first wall and breeder unit module size for the Indian HCCB blanket module

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Plasma Science and Technology 2018年第6期20卷 200-210页

作者： deepak sharma Paritosh CHAUDHURI Institute for Plasma Research Bhat Gandhinagar Gujarat-382428 India

The Indian test blanket module（TBM） program in ITER is one of the major steps in the Indian fusion reactor program for carrying out the R＆D activities in the critical areas like design of tritium breeding blankets relevant to future Indian fusion devices（ITER relevant and DEMO）.The Indian Lead–Lithium Cooled Ceramic Breeder（LLCB） blanket concept is one of the Indian DEMO relevant TBM,to be tested in ITER as a part of the TBM ***-Cooled Ceramic Breeder（HCCB） is an alternative blanket concept that consists of lithium titanate（Li_2TiO_3） as ceramic breeder（CB） material in the form of packed pebble beds and beryllium as the neutron ***,attentions are given to the optimization of first wall coolant channel design and size of breeder unit module considering coolant pressure and thermal loads for the proposed Indian HCCB blanket based on ITER relevant TBM and loading *** analyses will help proceeding further in designing blankets for loads relevant to the future fusion device.

关键词： first wall blanket breeder unit thermal hydraulics structural analysis HCCB(helium-cooled ceramic breeder)

Implications of metabolic dysfunction associated fatty liver disease in COVID-19

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World Journal of Clinical Cases 2023年第6期11卷 1275-1286页

作者： Raja Chakraborty deepak sharma Devesh U Kapoor Akanksha Dwivedi Rakhi Khabiya Saikat Sen Institute of Pharmacy Assam Don Bosco UniversityGuwahati 782402AssamIndia School of Medical Sciences Adamas UniversityKolkata 700126West BengalIndia Department of Pharmacy Dr.Dayaram Patel Pharmacy CollegeBardoli 394601GujaratIndia Department of Pharmacy Acropolis Institute of Pharmaceutical Education&ResearchIndore 453771Madhya PradeshIndia Faculty of Pharmaceutical Science Assam down town UniversityGuwahati 781026AssamIndia

Metabolic associated fatty liver disorder(MAFLD)characterizes the contributing etiologies(i.e.,type 2 diabetes mellitus,metabolic syndrome,overweight)of individuals with fatty liver disease that affects 1/3rd of the world *** 2020,the coronavirus disease 2019(COVID-19)crisis was unprecedented,and people with different comorbidities became more susceptible to the infection caused by severe acute respiratory syndrome coronavirus *** patients are frequently obese with added metabolic menace like diabetes,hypertension,and dyslipidemia leading to greater jeopardy of *** patients are 4 to 6-fold more prone towards ***-19 induces liver injury with elevated levels of aspartate aminotransferase and alanine aminotransferase and insignificantly elevated ***,MAFLD in COVID-19 patients worsens the condition *** evidence highlighting the interaction between MAFLD and altered liver functioning in COVID-19 suggested that COVID-19 patients with pre-existing MAFLD are at greater risk of morbidity or intensive care unit *** hepatic injury,enhanced levels of inflammatory cytokines,declined hepatic mitochondrial activity,and compromised immunity are considered as some underlying *** main focus of this review is to discuss the implications of metabolic dysfunction associated with fatty liver disease in COVID-19 *** review systematically analyzes the effect of striking two worldwide pandemics(MAFLD and COVID-19)together in the present era.

关键词： Metabolic associated fatty liver disorder COVID-19 Metabolic dysfunction Hepatic damage Cytokine storm

Biotransformation,multifunctional recycling mechanism of nanostructures,and evaluation of the safety of nanoscale materials

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Particuology 2023年第11期82卷 76-86页

作者： Debjyoti Talukdar Parveen Kumar Benu Chaudhary deepak sharma Nishant Yadav Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Waleed Hassan Almalki Sami IAlzarea Imran Kazmi Ashutosh Pareek Gaurav Gupta Madan Mohan Gupta Department of Medical Research Armenian Russian International University“Mkhitar Gosh”YerevanArmenia Shri Ram College of Pharmacy KarnalHaryanaIndia Guru Gobind Singh College of Pharmacy YamunanagarHaryanaIndia Department of Pharmaceutical Technology SOMSAdamas UniversityBarasat-Barracpore RoadKolkataWest BengalIndia B.S.Anangpuria Institute of Pharmacy FaridabadHaryanaIndia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl Kharj11942Saudi Arabia Department of Pharmacology College of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyJouf UniversitySakakaAl-JoufSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacy Banasthali VidyapithBanasthali-RajasthanIndia School of Pharmacy Suresh Gyan Vihar UniversityJagatpura302017Mahal RoadJaipurIndia Department of Pharmacology Saveetha Dental CollegeSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia Uttaranchal Institute of Pharmaceutical Sciences Uttaranchal UniversityDehradunIndia School of Pharmacy Faculty of Medical SciencesThe University of the West IndiesSt.AugustineTrinidad and Tobago

Current evidence of concept analyses recommending nanotechnology for biomedical uses abounds in recent research. The area of biotechnology interfaces with nanostructures, reconfigures their composition, and alters their characteristics;which influences the dispersion of the particles, the biotransformation they cause, and their potential toxic effect. It is vital to link the idea of the lifecycle of nanostructures to the biological impacts and use methodologies to identify, estimate, and track the gradual bioprocessing of nanostructures in vivo, from a body-wide level to a nanoscopic size. This is necessary because understanding how nanostructures processing, degradation, persistence, and recycling predict potential exposure risks. The safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding of the recycling and transformations of nanomaterials in a living organism. Long-term fate in the body is crucial, as it governs potential environmental risks to human health. Strategies may be used to manage the long-term outcome of nanostructures in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. The lifespan of nanoparticles, a flexible and biocompatible category of nanostructures that have made it into clinical trials, is the subject of this article. Strategies may be used to manage the long-term outcome of nanoparticles in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. This review explained the safety of nanoscale materials, biotransformation, and the multifunctional recycling mechanism of nanostructures.

关键词： Nanostructure Nanoparticle Biotransformation Toxiceffect Environmental risk

Neutronic analysis of Indian helium-cooled solid breeder tritium breeding module for testing in ITER

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Plasma Science and Technology 2022年第6期24卷 189-195页

作者： H L SWAMI deepak sharma C DANANI P CHAUDHARI R SRINIVASAN Rajesh KUMAR Institute for Plasma Research Gandhinagar 382428India Homi Bhabha National Institute AnushaktinagarMumbai 400094India

India has proposed the helium-cooled solid breeder blanket concept as a tritium breeding module to be tested in *** module has lithium titanate for tritium breeding and beryllium for neutron *** also enhances tritium breeding.A design for the module is prepared for detailed *** analysis is performed to assess the tritium breeding rate,neutron distribution,and heat distribution in the *** tritium production distribution in submodules is evaluated to support the tritium transport *** tritium breeding density in the radial direction of the module is also assessed for further optimization of the *** heat deposition profile of the entire module is generated to support the heat removal circuit *** estimated neutron spectrum in the radial direction also provides a more in-depth picture of the nuclear interactions inside the material *** total tritium produced in the HCSB module is around 13.87 mg per full day of operation of ITER,considering the 400 s ON time and 1400 s dwell *** estimated nuclear heat load on the entire module is around 474 kW,which will be removed by the high-pressure helium cooling *** heat deposition in the test blanket model(TBM)is huge(around 9 GJ)for an entire day of operation of ITER,which demonstrates the scale of power that can be produced through a fusion reactor *** per the Brayton cycle,it is equivalent to 3.6 GJ of electrical *** terms of power production,this would be around 1655 MWh *** evaluation is carried out using the MCNP5 Monte Carlo radiation transport code and FEDNL 2.1 nuclear cross section *** HCSB TBM neutronic performance demonstrates the tritium production capability and high heat deposition.

关键词： HCSB TBM tritium nuclear heat ITER

Identification and characterization of irregular consumptions of load data

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Journal of Modern Power Systems and Clean Energy 2017年第3期5卷 465-477页

作者： Desh deepak sharma S.N.SINGH Jeremy LIN Elham FORUZAN Indian Institute of Technology KanpurKanpurIndia PJM Interconnection AudubonPAUSA Department of Electrical Engineering University of Nebraska–LincolnLincolnNEUSA

The historical information of loadings on substation helps in evaluation of size of photovoltaic(PV)generation and energy storages for peak shaving and distribution system upgrade deferral. A method, based on consumption data, is proposed to separate the unusual consumption and to form the clusters of similar regular consumption. The method does optimal partition of the load pattern data into core points and border points, high and less dense regions, respectively. The local outlier factor, which does not require fixed probability distribution of data and statistical measures, ranks the unusual consumptions on only the border points, which are a few percent of the complete data. The suggested method finds the optimal or close to optimal number of clusters of similar shape of load patterns to detect regular peak and valley load demands on different days. Furthermore,identification and characterization of features pertaining to unusual consumptions in load pattern data have been done on border points only. The effectiveness of the proposed method and characterization is tested on two practical distribution systems.

关键词： Density based clustering Irregular consumption Local outlier factor Peak demand Valley demand

Comparative study on various dielectric barriers and their effect on breakdown voltage

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High Voltage 2018年第1期3卷 51-59页

作者： Elham Foruzan Amir A.S.Akmal Kaveh Niayesh Jeremy Lin Desh deepak sharma Department of Electrical and Computer Engineering University of Nebraska-LincolnLincolnNE 68588USA Department of Electrical and Computer Engineering University of TehranTehranIran Department of Electric Power Engineering Norwegian University of Science and TechnologyTrondheimNorway PJM Interconnection AudubonPA 19403USA Department of Electrical Engineering MJP Rohilkhand UniversityBareilly(UP)India

Non-pressurised air is extensively used as basic insulation medium in high-voltage ***,an inherent property of air-insulated design is that the system tends to become physically *** the other hand,the application of dielectric barriers can increase the breakdown voltage and therefore decrease the size of the *** this study,the impact of dielectric barriers on breakdown voltage enhancement is investigated under both direct current(dc)and alternating current(ac)applied *** this purpose,three kinds of dielectric barriers in two different high-voltage electrode structures are *** the first structure,several experiments are carried out with four different electrode arrangements,keeping the inter-electrode gap constant while varying the position of the dielectric barrier between the *** the second structure,the inter-electrode gap is varied while the high-voltage electrode is covered with dielectric *** influences of different parameters such as inter-electrode spacing,electric field non-uniformity factor,and dielectric materials on the breakdown voltage are investigated for applied 50 Hz ac and dc *** addition,a simulation model to approximately calculate the breakdown voltage is proposed and validated with the experimental results.

关键词： breakdown dielectric electrode

Targeting brain tumors with innovative nanocarriers:bridging the gap through the blood-brain barrier

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Oncology Research 2024年第5期32卷 877-897页

作者： KARAN WADHWA PAYAL CHAUHAN SHOBHIT KUMAR RAKESH PAHWA RAVINDER VERMA RAJAT GOYAL GOVIND SINGH ARCHANA sharma NEHA RAO deepak KAUSHIK Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak124001India Department of Pharmaceutical Technology Meerut Institute of Engineering and Technology(MIET)NH-58Delhi-Roorkee HighwayMeerut250005India Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra136119India Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani127021India MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana133207India Delhi Pharmaceutical Sciences and Research University(DIPSAR) Delhi Pharmaceutical Sciences and Research UniversityNew Delhi110017India

Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive *** high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells around GBM,which avert the entry of chemotherapeutic drugs into the ***:Recently,several researchers have designed novel nanocarrier systems like liposomes,dendrimers,metallic nanoparticles,nanodiamonds,and nanorobot approaches,allowing drugs to infiltrate the BBB more efficiently,opening up innovative avenues to prevail over therapy problems and radiation ***:Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases,for example,PubMed,Science Direct,Google Scholar,and others,using specific keyword combinations,including“glioblastoma,”“brain tumor,”“nanocarriers,”and several ***:This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM *** of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

关键词： Glioblastoma Brain tumor Blood-brain barrier Liposomes Metallic nanoparticles Nanocarriers

Technology Landscape for Epidemiological Prediction and Diagnosis of COVID-19

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Computers, Materials & Continua 2021年第5期67卷 1679-1696页

作者： Siddhant Banyal Rinky Dwivedi Koyel Datta Gupta deepak Kumar sharma Fadi Al-Turjman Leonardo Mostarda Department of Instrumentation and Control Netaji Subhas University of TechnologyNew Delhi110078India Department of Computer Science&Engineering Maharaja Surajmal Institute of TechnologyNew Delhi110058India Department of Information Technology Netaji Subhas University of TechnologyNew Delhi110078India Research Center for AI and IoT Near East UniversityNicosiaMersin10Turkey Computer Science Department Camerino UniversityCamerino62032Italy

The COVID-19 outbreak initiated from the Chinese city of Wuhanand eventually affected almost every nation around the globe. From China,the disease started spreading to the rest of the world. After China, Italybecame the next epicentre of the virus and witnessed a very high death *** nations like the USA became severely hit by SARS-CoV-2 virus. TheWorld Health Organisation, on 11th March 2020, declared COVID-19 a pandemic. To combat the epidemic, the nations from every corner of the worldhas instituted various policies like physical distancing, isolation of infectedpopulation and researching on the potential vaccine of SARS-CoV-2. Toidentify the impact of various policies implemented by the affected countrieson the pandemic spread, a myriad of AI-based models have been presented toanalyse and predict the epidemiological trends of COVID-19. In this work, theauthors present a detailed study of different articial intelligence frameworksapplied for predictive analysis of COVID-19 patient record. The forecastingmodels acquire information from records to detect the pandemic spreadingand thus enabling an opportunity to take immediate actions to reduce thespread of the virus. This paper addresses the research issues and correspondingsolutions associated with the prediction and detection of infectious diseaseslike COVID-19. It further focuses on the study of vaccinations to cope withthe pandemic. Finally, the research challenges in terms of data availability,reliability, the accuracy of the existing prediction models and other open issuesare discussed to outline the future course of this study.

关键词： COVID-19 diagnosis deep learning forecasting models machine learning metaheuristics prediction big data pandemic

One-Pot Green Synthesis of 1, 4-Dihydropyridine Derivatives Using Polyindole TiO2 Nanocatalyst by Solvent Free Method

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Open Journal of Composite Materials 2024年第3期14卷 109-123页

作者： deepak Babasaheb Phasage Sanjay K. sharma Balram Tripathi Sonia Chahar Srivastava Department of Chemistry JECRC University Jaipur India S. S. Jain Subodh PG College Jaipur India

This study used a Polyindole in combination with TiO2 nanocatalyst as an efficient heterogeneous catalyst to carry out a multi-component Hantzsch reaction involving different aromatic aldehydes with methyl acetoacetate, and aqueous ammonium to create 1,4-dihydropyridine derivatives under solvent free condition at ambient temperature. A broad range of aldehydes and methyl acetoacetates, ranging from heteroaromatic to polyaromatic one, with high level of functional group tolerance can be used to provide the desired products possessing relevant medicinal moiety in high yields. This technology has prospective advantages over current protocols, including the utilization of a cheap, stable, recyclable, and safe catalyst, quicker reaction times with higher yields and simple product isolation.

关键词： TiO2 Nanocatalyst Green Synthesis Surface Morphology