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Status of Indian medicinal plants in the International Union for Conservation of Nature and the future of Ayurvedic drugs: Shouldn’t think about Ayurvedic fundamentals?

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Journal of Integrative Medicine 2019年第4期17卷 238-243页

作者： deepak kumar semwal Ashutosh Chauhan An kit kumar Sonali Aswal Ruchi Badoni semwal Abhimanyu kumar Department of Phytochemistry Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Biotechnology Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Research and Development Centre Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Chemistry Pt. Lalit Mohan Sharma Government Postgraduate College Rishikesh Uttarakhand 249201 India Uttarakhand Ayurved University Harrawala Dehradun 248001 India

The present market for herbal drugs is estimated about ?40 billion, which is expected to increase by 16% in next 3-4 years. The current production of many Ayurvedic herbs is less than their market demand, which incentivizes adulteration in the Ayurvedic drug supply chain. The present work aims to highlight the most used Ayurvedic plants that have been listed in the International Union for Conservation of Nature's "red list" of endangered or vulnerable plants. The future of Ayurvedic medicines from these listed plants is uncertain, as the collection of herbs from their natural habitat is prohibited and their cultivation does not meet market demands. Many of these plants, such as Taxus baccata and T. wallichiana, are endangered and are only grown in their natural habitats;their cultivation in other areas is impractical. This is the present state, and will worsen as demand continues to grow, with increasing populations and increasing adoption of this system of medicine. It is possible that in coming years most of the Ayurvedic drugs will be adulterated, and will cause only side effects rather than the therapeutic effects. The Ayurvedic fundamentals are under-explored areas where the Ayurvedic practitioners and research scientists can work together. The scientific work on the basic principles will unravel many unknown or little-known facts of this ancient science. Hence, the present review emphasizes the conservation of Ayurvedic herbs, minimization of the use of medicinal plants and the promotion of the research based on Ayurvedic fundamentals.

关键词： Ayurvedic fundamentals Ayurvedic herbs Endangered plants Polyherbal formulations Prakriti

Ayurvedic concept of Shatkriyakala:a traditional knowledge of cancer pathogenesis and therapy

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Journal of Integrative Medicine 2017年第2期15卷 88-94页

作者： Ashutosh Chauhan deepak kumar semwal Satyendra Prasad Mishra Ruchi Badoni semwal Department of Biotechnology Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Phytochemistry Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Pharmaceutical Sciences Tshwane University of Technology Pretoria 0001 South Africa

The term Kriyakala refers to the recognition of the stage of a disease＇s progress, which helps to determine appropriate measure to correct the imbalance in Doshas （biological factors）. It is a compound expression, comprised of Kriya and Kala, where Kriya means the choice to treatment （medicine, food and daily-routine） used to improve the disturbance in Doshas, and Kala refers to the stage of progress of a disease. Sushruta, an ancient Indian surgeon, has described the concept of Kriyakala in Vamaprashnadhyaya, an ancient Vedic Sanskrit text, which seeks to explain the incidence of Vamas in terms of Doshic disturbances. Vama, in modern parlance, may be described as an inflammatory process that may lead ulceration and chronic inflammation, promoting all stages of carcinogenesis. Abnormal interactions between Prakriti （genotype） and environmental factors vitiate the Doshas and impair immunity, which can lead to aberrant cell growth and cancer. Moreover, the interaction between vitiated Doshas and weak Dhatus （body tissues） manifests as cancers of a specific organ. Shatkriyakala （six stages of progress of a disease）, on the other hand, provides a framework to assess the cancer and its pathogenesis in different stages. According to Ayurvedic concepts, all cancer therapies treat the affected tissues indirectly by eliminating vitiated Doshas, rejuvenating Dhatus and restoring immunity in cancer patients. The present review describes the six stages of Shatkriyakala in detail, with an emphasis on research areas to validate the concept of Shatkriyakala. This traditional knowledge can be utilized with modern technologies to detect predisposition for cancer or diagnose cancer in its early stages.

关键词： medicine, Ayurvedic Shatkriyakala tumors, malignant

A novel bacteriohopanoid from Celtis australis ***

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Chinese Chemical Letters 2011年第1期22卷 81-84页

作者： Ruchi Badoni deepak kumar semwal Prabhakar P.Badoni Sudhir kumar Kothiyal Usha Rawat Department of Chemistry H.N.B.Garhwal UniversitySrinagar 246 174UttarakhandIndia Department of Chemistry Punjab UniversitySector 14Chandigarh 160 014PunjabIndia Department of Chemistry H.N.B.Garhwal University Campus Pauri(Garhwal)UttarakhandIndia

A novel bacteriohopanoid elucidated as 3fl-hydroxy-35-（cyclohexyl-5′-propan-7′-one）-33-ethyl-34-methyl-bactereohopane （1） has been isolated from the bark of Celtis australis （Ulmaceae） together with three known compounds apigenin, quercetin and its glucoside. The structure of 1 was characterized by means of chemical and spectral methods including advanced 2D NMR studies.

关键词： Celtis australis Ulmaceae Bacteriohopane

Ethnomedicinal Investigation of Medicinal Plants of Chakrata Region(Uttarakhand)Used in the Traditional Medicine for Diabetes by Jaunsari Tribe

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Natural Products and Bioprospecting 2019年第3期9卷 175-200页

作者： Ankit kumar Sonali Aswal Ashutosh Chauhan Ruchi Badoni semwal Abhimanyu kumar deepak kumar semwal Research and Development Centre Faculty of Biomedical SciencesUttarakhand Ayurved UniversityHarrawalaDehradun 248001India Department of Biotechnology Faculty of Biomedical SciencesUttarakhand Ayurved UniversityHarrawalaDehradun 248001India Department of Chemistry Pt.Lalit Mohan Sharma Government Postgraduate CollegeRishikeshUttarakhand 249201India Uttarakhand Ayurved University HarrawalaDehradun 248001India Department of Phytochemistry Faculty of Biomedical SciencesUttarakhand Ayurved UniversityHarrawalaDehradun 248001India

The Himalayan region is the treasure house of natural wealth,particularly of medicinal and aromatic *** plants are used by the Indian traditional healers for the past many centuries to treat various ailments such as skin disorders,asthma,diabetes,snake bite,fever,pain,eye diseases,diarrhoea,indigestion,jaundice,burn,wound,liver disorder,CNS disorders and urinary tract *** indigenous traditional knowledge of medicinal plants and therapies of various local communities has been lost due to changes in traditional culture and the introduction of modern ***,it is essential to explore the traditional knowledge of the indigenous medicinal plants mainly in such areas where there is a severe threat to natural vegetation owing to human *** present study aimed to explore the medicinal plants of Chakrata region(Jaunsar-Bawar Hills),Uttarakhand,India used in the folk medicine for the management of diabetes by Jaunsari *** a comprehensive feld survey,the information about the medicinal plants have been mainly collected from the traditional healers and other elderly people belong to the tribal *** the information about the medicinal plants of the study area was documented in a feld *** tools have been used to collect the samples for identifcation purpose and the authentication of the plants was done with the help of *** literature on these plants was also searched from online(PubMed and Scopus)as well as from some textbooks and Ayurvedic classical *** present survey-based work described a total of 54 plants belonging to 47 genera and 30 families used in the traditional medicine for the management of diabetes in Chakrata *** information gathered from the local community revealed that the plants are efective in diabetes and one can use most of them without consulting a practitioner or traditional *** literature revealed that most of the surveyed plants are already used in the pr

关键词： Ayurveda Diabetes Herbal formulations Traditional healers Folk medicine

Efficient Finite Difference WENO Scheme for Hyperbolic Systems withNon-conservativeProducts

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Communications on Applied Mathematics and Computation 2024年第2期6卷 907-962页

作者： Dinshaw S.Balsara deepak Bhoriya Chi-Wang Shu Harish kumar Physics Department University of Notre DameNotre DameUSA ACMS Department University of Notre DameNotre DameUSA Division of Applied Mathematics Brown UniversityProvidenceUSA Department of Mathematics Indian Institute of TechnologyDelhiIndia

Higher order finite difference weighted essentially non-oscillatory(WENO)schemes have been constructed for conservation *** multidimensional problems,they offer a high order accuracy at a fraction of the cost of a finite volume WENO or DG scheme of the comparable *** makes them quite attractive for several science and engineering ***,to the best of our knowledge,such schemes have not been extended to non-linear hyperbolic systems with non-conservative *** this paper,we perform such an extension which improves the domain of the applicability of such *** extension is carried out by writing the scheme in fluctuation *** use the HLLI Riemann solver of Dumbser and Balsara(***.304:275-319,2016)as a building block for carrying out this *** of the use of an HLL building block,the resulting scheme has a proper supersonic *** use of anti-diffusive fluxes ensures that stationary discontinuities can be preserved by the scheme,thus expanding its domain of the *** new finite difference WENO formulation uses the same WENO reconstruction that was used in classical versions,making it very easy for users to transition over to the present *** conservation laws,the new finite difference WENO is shown to perform as well as the classical version of finite difference WENO,with two major advantages:(i)It can capture jumps in stationary linearly degenerate wave families exactly.(i)It only requires the reconstruction to be applied *** examples from hyperbolic PDE systems with non-conservative products are shown which indicate that the scheme works and achieves its design order of the accuracy for smooth multidimensional *** Riemann problems and several novel multidimensional problems that are drawn from compressible Baer-Nunziato multiphase flow,multiphase debris flow and twolayer shallow water equations are also shown to document the robustness of the *** some

关键词： Hyperbolic PDEs Numerical schemes Non-conservative products Stiff source terms Finite difference WENO

Debate on direct-anterior vs posterior approach for hip hemiarthroplasty:The authors’insights

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World Journal of Orthopedics 2024年第5期15卷 486-488页

作者： deepak kumar Tarkik Thami Manjunath Nishani Department of Orthopedics Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

We read and discussed the study entitled“Complication rates after direct anterior vs posterior approach for Hip Hemiarthroplasty in elderly individuals with femoral neck fractures”with great *** authors have done justice to the topic of comparison of anterior and posterior surgical approaches for bipolar hemiarthroplasty which has been an everlasting debate in the existing ***,there are certain aspects of this study that need clarification from the authors.

关键词： Commentary Direct anterior approach Posterior approach Hip hemiarthroplasty

Natural product-based treatment potential for type 2 diabetes mellitus and cardiovascular disease

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World Journal of Diabetes 2024年第7期15卷 1603-1614页

作者： Dharmsheel Shrivastav Satyam kumar Kumbhakar Shivangi Srivastava Desh deepak Singh Amity Institute of Biotechnology Amity University RajasthanJaipur 303002RajasthanIndia Department of Biotechnology Govt Veer Surendra Say P.G.CollegeGariaband 493889ChhattisgarhIndia Department of Life Science Chhatrapati Shahu ji Maharaj UniversityKanpur 208024Uttar PradeshIndia

BACKGROUND Type 2 diabetes(T2D)is a metabolic disease of impaired glucose utilization and a major cause of cardiovascular disease(CVD).The pathogenesis of both diseases shares common risk factors and mechanisms,and both are significant contributors to global morbidity and *** of natural products for T2D mellitus(T2DM)and CVD can be seen as a potential preventive and effective therapeutic *** To critically evaluate the therapeutic potential of natural products in T2D and coronary artery disease(CAD).METHODS By using specific keywords,we strategically searched the PubMed *** controlled trials(RCTs)were searched as the primary focus that examined the effect of natural products on glycemic control,oxidative stress,and antioxidant *** focused on outcomes such as low blood glucose levels,adjustment on markers of oxidative stress and *** screening fulllength papers,we included 9 RCTs in our review that met our inclusion *** In the literature search on the database,we found that various natural products like plant secondary metabolites play a diverse role in the management of *** ginseng,sesame oil and cocoa flavanols proved effective in lowering blood glucose levels and controlling blood pressure,which are key factors in managing T2DM and *** diabetic patients Melissa officinalis effectively reduce inflammation and shows diabetes *** fish oil and flaxseed oil reduced insulin levels and inflammatory markers,suggesting benefits for both *** lipid profile and endothelial function were enhanced by Nigella sativa oil and Terminalia chebula,which is significant for the management of cardiovascular risk factors in *** Bilberry extract also showed promise for improving glycemic control in patients with *** The high level of antioxidant,anti-inflammatory,and anti-angiogenic properties found in natural products makes them promising therapeutic opt

关键词： Type 2 diabetes mellitus Cardiovascular disease Natural products Antioxidants Oxidative stress Therapeutic impact Global burden

Erosion Wear Behaviour of Kenaf/Glass Hybrid Polymer Composites

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Journal of Harbin Institute of Technology(New Series) 2024年第1期31卷 78-89页

作者： Chandrakanta Mishra deepak kumar Mohapatra Chitta Ranjan Deo Punyapriya Mishra Kiran kumar Ekka Department of Mechanical Engineering Veer Surendra Sai University of TechnologySambalpur 768018India

The awareness amongst the researchers to develop an environment friendly sustainable material leads to explore new class of plant-based fiber for making composites. Hybridization of such plant-based fiber with inclusion of engineered fiber is one of the promising methods to not only enhanced the mechanical performance but also suppressed the drawbacks that associate with such plant-based fiber to some extent. A usual hand lay-up method was taken-up in this work to fabricate four layered of hybrid kenaf(K)/glass(G)polyester laminates with different stacking order such as KKKK,KGKG,KGGK,GKKG and GGGG. The erosive character of the laminates was examined under three distinct particle velocities(48m/s, 70m/s,82m/s)and four different impact angles(30°, 45°, 60°, 90°). All fabricated laminates exhibited a semiductile character at lower velocities(48m/s and70m/s)as peak wear rate was observed at45° impact angle. However,they showed a semi-brittle character at high velocity(82m/s)as maximum rate of erosion was noticed at60° impact angle. Again,the influence of stacking order of piles on erosion wear was also clearly noticed. Moreover,the semi-brittle/semi-ductile characterization was also evidenced in accordance to the range of erosion efficiencies. The micro-structures of worn surfaces were inspected thoroughly from the images of scanning electron microscope(SEM)to evident the mechanism of erosion.

关键词： hybrid composites erosion wear void micro⁃hardness

Performance Improvement of Kenaf/Glass Polymer Hybrid Composites by Effective Application of Fish Scale Powder as Filler:A Novel Approach

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Journal of Harbin Institute of Technology(New Series) 2024年第3期31卷 80-96页

作者： Chandrakanta Mishra deepak kumar Mohapatra Chitta Ranjan Deo Chetana Tripathy Kiran kumar Ekka Department of Mechanical Engineering Veer Surendra Sai University of TechnologySambalpur 768018OdishaIndia

Modern technology for developing new items made from renewable resources is becoming more and more popular as a result of rising environmental ***,contemporary polymer composites have included the hybridization of natural fibers with synthetic ones,along with the inclusion of a variety of biowaste filler for developing sustainable *** this work,the kenaf/glass hybrid polyester composites are strengthened by the addition of fish scale(FS),which is taken from the fish􀆳s outermost layer of *** different stacked-order laminates,such as KKKK,KGKG,GKKG,KGGK,and GGGG,are fabricated by using the hand lay-up method with four different weight concentrations of filler content:0%,5%,10%,and 15%.Mechanical possessions such as tensile,flexural,impact strength and micro-hardness have been evaluated through experimentation in accordance with ASTM *** experimental findings revealed that,the tensile strength and micro-hardness value of KGKG laminates with 15wt% of FS filler are found to be maximum of 118.72 MPa and 17.82 HV respectively which are 39.67%and 26.11%greater than that of KGKG laminates without FS ***,the flexural and impact strength of same laminates with 10 wt% FS filler exhibited a maximum value of 142.77 MPa and 62.08 kJ/m^(2).In order to corroborate its applicability for structural and building materials in open environment,the dimensional stability of the composite has been studied through moisture absorption *** influences of FS filler loading on dimensional stability and resistance to moisture absorption capacity of laminates are also *** experimental results reflected that the addition of FS-filler has significantly improved the dimensional stability of the laminates in moist environment by reducing the moisture absorption *** further support the mode of failures,a fractography investigation of fractured surfaces was conducted.

关键词： fish scale fiber polyester hybrid composites mechanical properties

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