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A network based efficient drug repurposing strategy for targeting diabesity

Genes & Diseases 2023年第2期10卷 340-343页

作者： Subhajit Dutta Ted Natoli deep chanda Sindhuja Rajavelu Debojyoti De Laboratory of Cellular Differentiation & Metabolic Disorder Department of BiotechnologyNational Institute of TechnologyDurgapurWest Bengal 713209India Cancer Program Broad Institute of MIT and HarvardCambridgeMA 02142USA

Type II diabetes and obesity are two of the most prevalent metabolic disorders effecting a huge population throughout the world. Research over the last decade has unequivocally established considerable molecular links between them and hence they are often described in conjugation as ‘diabesity’. The hallmarks of type II diabetes are primarily reduced insulin sensitivity, progressive insulin resistance and consequent hyperinsulinemia.1 Whereas, hyperinsulinemia promotes a plethora of fat synthesis from excess circulating carbohydrate and hyperactive fat storage mechanisms, ultimately inducing hepatic steatosis, myosteatosis and pancreatic steatosis.1 This in turn, aggravates the insulin sensitivity further, inflicting more insulin resistance and even more hyperinsulinemia. Needless to mention that the vicious process in turn, promotes uncontrolled weight gain1 and many secondary metabolic disorders. The prevalent anti-diabetic and anti-obesity medications comes with several limitations ranging from inefficiency to adverse side effects.2 Here, we report an efficient strategy of repositioning previously approved drugs with novel indication in the context of diabesity by investigating deregulated signalling axes affecting patients with both the disorders. Our approach relies extensively on deciphering the strength of gene association in various interactomes, as it is known that within networks, genes linked to similar disease phenotypes tend to be functionally similar3 and remain proximal to each other.4 Moreover, the potential drug targets associated to a disease pathway also cluster proximal to the disease pathways.

关键词： hence primarily network

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Development of a Tribofidelic Human Heel Surrogate for Barefoot Slip Testing

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Journal of Bionic Engineering 2022年第2期19卷 429-439页

作者： Subhodip Chatterjee Arnab chanda Centre for Biomedical Engineering Indian Institute of Technology DelhiNew Delhi 110016India Department of Biomedical Engineering All India Institute of Medical ScienceNew Delhi 110029India

Barefoot slips contribute to over 37% of recurrent fall-related injuries across all age *** study slip risk across a wide range of flooring conditions,slip meters with barefoot surrogates(i.e.,sensors,as per ASTM standard nomenclature)such as animal skins and rubbers have been used to date,which exhibit biomechanical and frictional properties widely different from the barefoot human *** of a surrogate which can accurately simulate the human heel skin properties would be immensely beneficial for realistic assessment of barefoot slipping risk.A novel surrogate was developed using 3D scanning and printing,and biomimetics,which precisely simulates the biomechanical and frictional properties of the barefoot human heel *** slip testing was conducted with this surrogate on three common bathroom floorings and with six different *** of Friction(COF)results similar to human slipping experiments,high repeatability and reproducibility across wet and oily flooring conditions,were confirmed through experiments with the developed heel skin *** heel skin surrogate would be an indispensable model for accurate estimation of barefoot risk against slips and falls in bathrooms,bathtubs,and swimming pools.

关键词： Barefoot Surrogate Slip Fall Bathroom Bathtub

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Optimal inventory policies for short life cycle successive generations’ technology products

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Journal of Management Analytics 2022年第2期9卷 261-286页

作者： Gaurav Nagpal Udayan chanda Department of Management BITS PilaniPilani CampusPilaniRajasthan 333031India

In this paper,a new Economic Order Quantity(EOQ)model for a successive generation of technology products has been *** classical EOQ model is based on the assumption that the demand rate is *** it cannot be used for technology products where competition-substitution among products is a usual *** address this problem,the EOQ model proposed in this article is considered a demand model for a technology product that follows the innovation-diffusion process.A numerical example has been illustrated and a comprehensive sensitivity analysis is conducted to understand the path of the optimal planning horizon and optimal costs under varied innovation and imitation *** sensitivity analysis of the introduction timing of the second generation has been performed to know the applicability of the model in actual *** behavior of the model has been discussed in detail in the numerical illustration section.

关键词： Economic order quantity innovation diffusion technological innovations coefficient of innovation coefficient of imitation successive generations

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A Bayesian network model on the interlinkage between Socially Responsible HRM,employee satisfaction,employee commitment and organizational performance

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Journal of Management Analytics 2020年第1期7卷 105-138页

作者： Udayan chanda Praveen Goyal Department of Management BITS PilaniPilaniRajasthanIndia

In recent years several studies have been made to understand the impact of Socially Responsible HRM practices on Organizational *** progress,community and environment play an important role in the sustainable growth of an ***,organizations are always looking for the ways to improve the employee satisfaction vis-a-vis commitment to improve the *** studies have shown that as employees are important stakeholder,hence formulating proper Socially Responsible HRM practices may help organization to better the returns on *** main objective of the study is to identify the relationship among various dimensions of Socially Responsible HRM practices with dimensions of employee satisfaction,employee commitment and organizational performance for Indian manufacturing sector by using Bayesian Network *** of the study establish the relationship between dimensions of Socially Responsible HRM and Organizational Performance.

关键词： socially responsible HRM manufacturing industry employee satisfaction employee commitment organizational performance Bayesian network

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Optimal ordering policy for short life-cycle products under credit financing with dynamic adoption in supply chain

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Journal of Management Analytics 2019年第3期6卷 269-301页

作者： Udayan chanda Alok Kumar Department of Management BITS PilaniPilaniIndia FORE School of Management New DelhiIndia

Traditional inventory models are mostly ignorant of the life cycle dynamics of a technology product;hence,they often fail to identify different dimensions of inventory *** paper attempts to investigate the relationship between adoption behavior of customers using life cycle dynamics and associated trade credit policies in order to optimize the total inventory *** demand model used in this paper treats sales as a function of awareness diffusion and *** is considered as a function of feedback effects from users/***’s optimal strategies for short life cycle product under credit financing were determined ***,numerical examples have been used to support the theoretical *** results have further been used to gain some managerial insights.

关键词： inventory stage-wise diffusion unfavorable information short life cycle trade credit

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Effect of wire tension on different output responses during wire electric discharge machining on AISI 304 stainless steel

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Defence Technology（防务技术） 2019年第4期15卷 541-544页

作者： Tina Chaudhary Arshad Noor Siddiquee Arindam Kumar chanda Department of Mechanical and Automation Engineering Indira Gandhi Delhi Technical University for Women Kashmere Gate New Delhi India Department of Mechanical Engineering Jamia Millia Islamia (a Central University) New Delhi India Department of Mechanical and Automation Engineering G.B. Pant Engineering College New Delhi India

WEDM is used in machining conductive materials where it is required to obtained complicated and intricate shapes with high *** applications are in the field of automobile,medical industries,aerospace *** is an economical machining option with short product development *** roughness,kerf width,Material removal rate,Recast layer hardness and surface microhardness in WEDM are most important *** this paper,effect of varied Wire tension on SR,KW,MRR,RCL hardness and surface microhardness on AISI 304 have been *** on time,pulse off time,current and dielectric fluid are taken as fixed *** show that Wire tension influences the SR,MRR and Surface microhardness and has no effect on kerf width in case of Stainless steel304.

关键词： Wire EDM Wire tension Material removal rate Surface roughness Kerf width Micro-hardness

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Protective effect of Polyalthia longifolia *** leaves on ethanol and ethanol/HCl induced ulcer in rats and its antimicrobial potency

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Asian Pacific Journal of Tropical Medicine 2011年第9期4卷 673-679页

作者： Sumitra chanda Yogesh Baravalia Mital Kaneria Phytochemical Pharmacological and Microbiological LaboratoryDepartment of BiosciencesSaurashtra UniversityRajkot-360 005GujaratIndia

Objective:To explore antiulcer and antimicrobial properties of methanolic extract of Polyalthia longifolia ***:Gastroprotective potential of Polyalthia longifolia was studied on ethanol and ethanol/HCl induced ulcers at 2 different doses(270 and 540 mg/kg/body weight). Antimicrobial efficacy of Polyalthia longifolia(25 mg/mL) was also studied against six gram positive,seven gram negative bacteria and five fungi by agar well diffusion *** inhibitory concentration was determined by agar well diffusion method in two fold serial dilution, in the range of 97-25 000μg/***:The reduction of ulcer index in Polyalthia longifolia treated animals was found to be statistically significant with respect to control *** Polyalthia longifolia exhibited ulcer protection activity in dose dependent manner and was also better than the *** antimicrobial activity,gram positive bacteria were more susceptible to Polyalthia longifolia than gram negative bacteria and fungal ***:Results obtained confirm the antiulcer and antimicrobial potential of the Polyalthia longifolia.

关键词： Polyalthia longifolia Antimicrobial activity Antiulcer activity Ulcer index Methanol extract

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Stability analysis of a thin-walled cylinder in turning operation using the semi-discretization method

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Acta Mechanica Sinica 2014年第2期30卷 214-222页

作者： Arnab chanda Achim Fischer Peter Eberhard Santosha Kumar Dwivedy Institute of Engineering and Computational Mechanics University of Stuttgart

In this work, the stability of a flexible thin cylindrical workpiece in turning is analyzed. A process model is derived based on a finite element representation of the workpiece flexibility and a nonlinear cutting force law. Repeated cutting of the same surface due to overlapping cuts is modeled with the help of a time delay. The stability of the so obtained system of periodic delay differential equations is then determined using an approximation as a time-discrete system and Floquet theory. The time-discrete system is obtained using the semi-discretization method. The method is implemented to analyze the stability of two different workpiece models of different thicknesses for different tool positions with respect to the jaw end. It is shown that the stability chart depends on the tool position as well as on the thickness.

关键词： Machine tools Stability Chatter

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Hepatoprotective effect of Woodfordia fruticosa Kurz flowers on diclofenac sodium induced liver toxicity in rats

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 342-346页

作者： Yogesh Baravalia Yogeshkumar Vaghasiya Sumitra chanda Phytochemical Pharmacological and Microbiological LaboratoryDepartment of BiosciencesSaurashtra UniversityRajkot-360 005GujaratIndia

Objective:To evaluate the protective effect of Woodfordia fruticosa Kurz flowers against experimentally induced liver toxicity in ***:Two different doses of methanol extract of Woodfordia fruticosa(WFM) were evaluated for the hepatoprotective activity against diclofenac sodium induced hepatotoxicity in *** biochemical parameters like alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total protein(TP),albumin(ALB),blood urea nitrogen(BUN) from serum;total protein(TP),glutathione (GSH) levels,catalase(CAT) and glutathione peroxidase(GPx) activities from liver were studied; histopathologic changes of liver were also ***:WFM effectively reduced the elevated levels of serum ALT,AST,ALP and BUN,enhanced the reduced TP,ALB and hepatic GSH,CAT,GPx *** histopathological analysis suggested that WFM decreased the degree of liver fibrosis induced by ***:This study demonstrates the hepatoprotective activity of WFM and thus scientifically support the use of this plant in traditional medicine for the treatment of liver disorders.

关键词： Woodfordia fruticosa Diclofenac Hepatoprotective Biochemical analysis Histopathology

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Bayesian network on labour dissonance:a social sector development challenge to India

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Journal of Management Analytics 2016年第1期3卷 80-111页

作者： Udayan chanda Remica Aggarwal Department of Management BITS PilaniPilani CampusPilaniIndia

India’s unorganized labour force contributes about one third of the total labour *** scenario is even worse in the Indian automotive industry which employs a little over 7%on a permanent *** get exaggerated due to the outdated labour laws,ironically established to support and protect *** disappointing areas in the labour contract act and labour laws have led to unfair wage practices and a hostile work environment,giving way to labour *** research paper discusses the key issues of labour dissonance in the Indian automobile industry using a Bayesian network ***-life casestudy examples from the Indian automobile industry were considered to identify the rationale behind labour *** analysis of a set of 250 responses helped us to understand the associations among key attributes of labour dissatisfaction.

关键词： labour unrest unorganized labour force unfair wage practices Bayesian network

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