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Energy-Dissipative and Soften Resistant Hydrogels Based on Chitosan Physical Network: From Construction to Application

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Chinese Journal of Chemistry 2022年第17期40卷 2118-2134页

作者： Yanyu Yang decheng wu College of Materials Science and Engineering Zhengzhou UniversityZhengzhouHenan450001 China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong518055 China

In spite of biological tissue-like peculiarity,multifarious functionalities and great application prospect,the low mechanics and soften behavior of hydrogels still retain a problem to be addressed for repetitive weight-bearing fields of flexible electronics,actuators,substitutions of soft tissues,wound dressing,wearable or implantable devices.Due to the distinct combination of diversity,reversibility and impressive disruption-reconstruction capacity,the chitosan physical cross-links can server as recoverable“sacrificial bonds”to construct multifarious energy-dissipative and anti-soften hydrogels and further broaden their diversified applications.In this review,we summarized the gelation mechanisms of chitosan physical networks and highlighted the chitosan physical network based hydrogels in rational design,construction principle,and structure and performance regulation.The recent progress in functional hydrogels for flexible electronics and biomaterials was systematically discussed.Overall,the review will provide comprehensive guidelines on the design principle,performance modulation and functionality construction of energy-dissipative and soften resistant hydrogels.

关键词： Gels Physicalcross-Links Mechanical properties Functionality Sensors

In situ Injectable Tetra-PEG Hydrogel Bioadhesive for Sutureless Repair of Gastrointestinal Perforation

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Chinese Journal of Chemistry 2023年第23期41卷 3339-3348页

作者： Shurong Li Yiwen Xian Gang He Luyuan Chen Zhihui Chen Yonglong Hong Chong Zhang decheng wu Guangdong Provincial Key Laboratory of Advanced Biomaterials Department of Biomedical EngineeringSouthern University of Science and TechnologyNo.1088 Xueyuan AvenueNanshan DistrictShenzhenGuangdong518055 China These authors contribute equally. Stomatology Center Shenzhen HospitalSouthern Medical UniversityNo.1333 New RoadBaoan DistrictShenzhenGuangdong518101 China

Hydrogel bioadhesives represent promising and efficient alternatives to sutures or staples for gastrointestinal(GI)perforation management.However,several concerns remain for the existing bioadhesives including slow and/or weak adhesive,poor mechanical strength,low biocompatibility,and poor biodegradability,which largely limit their clinical application in GI perforation repair.In this work,we introduce an in situ injectable Tetra-PEG hydrogel bioadhesive(SS)composed of tetra-armed poly(ethylene glycol)amine(Tetra-PEG-NH2)and tetra-armed poly(ethylene glycol)succinimidyl succinate(Tetra-PEG-SS)for the sutureless repair of GI defects.The SS hydrogel exhibits rapid gelation behavior and high burst pressure and is capable of providing instant robust adhesion and fluid-tight sealing in the ex vivo porcine intestinal and gastric models.Importantly,the succinyl ester linkers in the SS hydrogel endow the bioadhesive with suitable in vivo degradability to match the new GI tissue formation.The in vivo evaluation in the rat GI injured model further demonstrates the successful sutureless sealing and repair of the intestine and stomach by the SS hydrogel with the advantages of neglectable postsurgical adhesion,suppressed inflammation,and enhanced angiogenesis.Together,our results support potential clinical applications of the SS bioadhesive for the high-efficient repair of GI perforation.

关键词： Gastrointestinal perforation Bioadhesives Gels Biological activity Sutureless repair Regenerative wound healing

Dynamically tunable microwave perfect absorber with flexible and lightweight properties based on magnetorheological material

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Progress in Natural Science:Materials International 2023年第6期33卷 843-853页

作者： Xin Huang Yu Wang Dachao Chen Pingan Yang Mengjie Shou decheng wu Jia Zhu Zhihao Zhou Rui Li School of Automation Chongqing University of Posts and Telecommunications

In this paper, a microwave perfect absorber based on magnetorheological material is proposed and investigated.The absorber achieves broad-band, flexible, and lightweight properties through the fusion of a metasurface.Firstly, full-wave numerical simulation is conducted, demonstrating that the proposed absorber achieves a peak absorption of 99.99 % at 13.95 GHz. Additionally, a broad bandwidth of 90 % absorption is observed from 10GHz to 18 GHz in full-wave simulation, and the experimental results ranges from 11.7 GHz to 16.1 GHz.Importantly, the proposed absorber could be fabricated using an easy and low-cost method where laser engraving method is adopted. Experimental measurements in the microwave anechoic chamber confirm that the experimental results align well with the simulation. Furthermore, the absorption mechanism of the proposed absorber is investigated through a detailed analysis of the electric field and magnetic field. This study presents an effective approach for achieving lightweight and flexible electromagnetic protection materials in the microwave range,which could facilitate the practical application of absorbers in the field of military anti-reconnaissance.

关键词： Broadband Lightweight Magnetorheological material Metamaterial absorber

Multifunctional microcapsules:A theranostic agent for US/MR/PAT multi-modality imaging and synergistic chemo-photothermal osteosarcoma therapy

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Bioactive Materials 2022年第1期7卷 453-465页

作者： Hufei Wang Sijia Xu Daoyang Fan Xiaowen Geng Guang Zhi decheng wu Hong Shen Fei Yang Xiao Zhou Xing Wang Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China Department of Orthopaedic The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Cardiology Chinese PLA General HospitalBeijing100853China

Development of versatile theranostic agents that simultaneously integrate therapeutic and diagnostic features remains a clinical urgent.Herein,we aimed to prepare uniform PEGylated(lactic-co-glycolic acid)(PLGA)microcapsules(PB@(Fe_(3)O_(4)@PEG-PLGA)MCs)with superparamagnetic Fe3O4 nanoparticles embedded in the shell and Prussian blue(PB)NPs inbuilt in the cavity via a premix membrane emulsification(PME)method.On account of the eligible geometry and multiple load capacity,these MCs could be used as efficient multi-modality contrast agents to simultaneously enhance the contrasts of US,MR and PAT imaging.In-built PB NPs furnished the MCs with excellent photothermal conversion property and embedded Fe_(3)O_(4)NPs endowed the magnetic location for fabrication of targeted drug delivery system.Notably,after further in-situ encapsulation of antitumor drug of DOX,(PB+DOX)@(Fe_(3)O_(4)@PEG-PLGA)MCs possessed more unique advantages on achieving near infrared(NIR)-responsive drug delivery and magnetic-guided chemo-photothermal synergistic osteosarcoma therapy.In vitro and in vivo studies revealed these biocompatible(PB+DOX)@(Fe_(3)O_(4)@PEG-PLGA)MCs could effectively target to the tumor tissue with superior therapeutic effect against the invasion of osteosarcoma and alleviation of osteolytic lesions,which will be developed as a smart platform integrating multi-modality imaging capabilities and synergistic effect with high therapy efficacy.

关键词： Multi-modality imaging Microcapsule Photothermal therapy Drug delivery Osteosarcoma

Exploring cutting-edge hydrogel technologies and their biomedical applications

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Bioactive Materials 2018年第4期3卷 446-447页

作者： decheng wu Xiaoyang Xu Chemical and Material Engineering New Jersey Institute of TechnologyNewarkNJUnited States Institute of Chemistry Chinese Academy of SciencesBeijingChina

Hydrogels have emerged as three-dimensional biomaterials with potential biomedical applications in numerous fields including drug delivery and tissue engineering.They have particularly garnered great interest from researchers due to their excellent biocompatibility,ability to encapsulate,protect,and deliver bioactive therapeutics,capacity for sustained release,and their ability to act as implantable scaffolds and support tissue regeneration.This special issue,consisting of eight papers,addresses some of the greatest challenges in hydrogel technology and showcases its capabilities,focusing on the applications of hydrogels in bone regeneration[1][2],stem cell therapy[3],hemostasis[4],stroke[5],cancer treatments[6][7],and biological activities in general[8].

关键词： sustained release biomaterials

Facile fabrication of a biocompatible composite gel with sustained release of aspirin for bone regeneration

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Bioactive Materials 2022年第5期7卷 130-139页

作者： Yunfan Zhang Xueyu Dou Lingyun Zhang Hufei Wang Ting Zhang Rushui Bai Qiannan Sun Xing Wang Tingting Yu decheng wu Bing Han Xuliang Deng Department of Orthodontics Peking University School and Hospital of StomatologyBeijingPR China National Center of Stomatology National Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory for Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijingPR China Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijingPR China University of Chinese Academy of Sciences BeijingPR China Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijingPR China

Hydrogels are extracellular-matrix-like biomimetic materials that have wide biomedical applications in tissue engineering and drug delivery.However,most hydrogels cannot simultaneously fulfill the mechanical and cell compatibility requirements.In the present study,we prepared a semi-interpenetrating network composite gel(CG)by incorporating short chain chitosan(CS)into a covalent tetra-armed poly(ethylene glycol)network.In addition to satisfying physicochemical,mechanics,biocompatibility,and cell affinity requirements,this CG easily encapsulated acetylsalicylic acid(ASA)via electrostatic interactions and chain entanglement,achieving sustained release for over 14 days and thus promoting periodontal ligament stem cell(PDLSC)proliferation and osteogenic differentiation.In vivo studies corroborated the capacity of PDLSCs and ASA-laden CG to enhance new bone regeneration in situ using a mouse calvarial bone defect model.This might be attributed to PDLSCs and host mesenchymal stem cells expressing monocyte chemoattractant protein-1,which upregulated M2 macrophage recruitment and polarization in situ,indicating its appealing potential in bone tissue engineering.

关键词： Hydrogel Aspirin Chitosan Drug sustained-release Bone tissue engineering

Polyhedral Oligomeric Silsesquioxanes(POSS)-based Hybrid Materials:Molecular Design,Solution Self.Assembly and Biomedical Applications

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Chinese Journal of Chemistry 2021年第3期39卷 757-774页

作者： Linfeng Fan Xing Wang decheng wu Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics&ChemistryInstitute of ChemistryChinese Academy of SciencesBejing 100190China University of Chinese Academy of Sciences Bejjing 100049China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong 518055China

Owing to the tremendous advantages and unique well-defined nanoscale structure,polyhedral oligomeric silsesquioxanes(POSS)have received considerable interest in the design of novel organic-inorganic hybrid nanomaterials with all manner of prominent capabilities,which is rec-ognized as a new generation of promising materials for advanced applications of material sci-ence,engineering science and biomedical fields.Benefitting from the recent progress in combi-nation of controlled/living polymerization and emerging click chemistry,POSS-based hybrid ma-terials with ingenious design,versatile topological structure and sophisticated multifunctionality have been successfully fabricated and developed into abundant well-defined hybrid nanostruc-tures with desired physicochemical properties.Tailor-made amphiphilic molecular design and nanosized hybrid architecture provide opportunities for the self-assembly of POSS-based hybrid materials with unique hierarchical morphologies in selective solvents.Through the in-depth understanding of structure-properties relationship,POSS-based hybrid materials can achieve the modulation of precise control of self-assembling process and multi-purpose applications with improved material performances.In this review,we summarize the recent advances of POSS-based hybrid materials in molecular design,self-assembly behavior in solutions and poten-tial biomedical applications with main concerns on drug delivery,gene therapy,bioimaging and tissue engineering field.Finally,future directions and remaining challenges for further advance-ment of POSS-based hybrid materials are proposed and discussed.

关键词： POSS Hybrids Topology Self-assembly Drug delivery Bone regeneration

A Versatile Crosslinking Strategy on Facile Fabrication of Fluorescent Hydrogels via o-Phthalaldehyde Ternary Condensation

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Chinese Journal of Chemistry 2021年第8期39卷 2195-2200页

作者： Qingchen Cao Hufei Wang Xing Wang decheng wu Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong 518055China

It is of great sighificance to develop rapid crosslinking strategies to enrich the functions of hydrogels and simplify the preparation process of hydrogels.Herein,we applied the ternary condensation reaction of o-phthalaldehyde(OPA)with thiol and amino moieties to con struct hydrogel n etworks with fast gelati on rate,excellent mecha nical stre ngth,and favorable stability.

关键词： Rapid gelation Polymerization Fluorescence Gels Aldehydes

Generalized Array Architecture with Multiple Sub-Arrays and Hole-Repair Algorithm for DOA Estimation

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Computers, Materials & Continua 2020年第7期64卷 589-605页

作者： Sheng Liu Hailin Cao decheng wu Xiyuan Chen School of Data Science Tongren UniversityTongren554300China Laboratory of Aerocraft Tracking Telemetering Command and Communication Chongqing UniversityChongqing400044China Department of Mechanical Engineering Stanford UniversityStanford94305USA

Arranging multiple identical sub-arrays in a special way can enhance degrees of freedom(DOFs)and obtain a hole-free difference co-array(DCA).In this paper,by adjusting the interval of adjacent sub-arrays,a kind of generalized array architecture with larger aperture is proposed.Although some holes may exist in the DCA of the proposed array,they are distributed uniformly.Utilizing the partial continuity of the DCA,an extended covariance matrix can be constructed.Singular value decomposition(SVD)is used to obtain an extended signal sub-space,by which the direction-of-arrival(DOA)estimation algorithm for quasi-stationary signals is given.In order to eliminating angle ambiguity caused by the holes of DCA,the estimation of signal parameters via rotational invariance techniques(ESPRIT)is used to construct a matrix that includes all angle information.Utilizing this matrix,a secondary extended signal sub-space can be obtained.This signal sub-space is corresponding to a hole-free DCA.Then,dealing with the further extended signal sub-space by multiple signal classification(MUSIC)algorithm,the unambiguous DOAs of all incident signals can be estimated.Some simulation results are shown to prove the improved performance of proposed generalized array architecture in DOA estimation and the effectiveness of corresponding hole-repair algorithm in eliminating angle ambiguity.

关键词： Multiple sub-arrays DOA estimation difference co-array hole-repair