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Non-p.gener.c and Str.ngly Nonbr.nching Degr.e

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Acta Mathematica Sinica,English Ser.es 1994年第1期10卷 30-41页

作者： ding decheng {2. of mathematics.nanjing univ.r.ity.nanjing,2.0008 china 1. department of mathematics Nanjing University 210008 Nanjing China

It has been p.oved by the author.that ever. p.gener.c degr.e is *** this p.p.r.we constr.ct an *** which is str.ngly nonbr.nching and *** means that the class of nonbr.nching degr.es does not coincide with the class o... 详细信息

关键词： Non-p.gener.c and Str.ngly Nonbr.nching Degr.e NB

Identification of Her.ynian shoshonitic intr.sive r.cks in centr.l Hainan Island and its geotectonic imp.ications

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Science Bulletin 2006年第20期51卷 2507-2519页

作者： XIE Caifu1, 2. ZHU Jinchu1, ding Shijiang3, ZHANG Yeming2. FU Tai’an2.& LI Zhihong2.1. State Key Labor.tor. for.Miner.l Dep.sits r.sear.h and department of Ear.h Sciences, {2. univ.r.ity. {2. 2.0093, china 2. Yichang Institute of Geology and Miner.l r.sour.es, Yichang 443003, china 3. Hainan Bur.au of Geology and Miner.l r.sour.es, Haikou 5702.6, china department of Otolar.ngology University Hospital VU P.O. Box 7057 1007 MB Amsterdam The Netherlands State Key Labor.tor. for.Miner.l Dep.sits r.sear.h and department of Ear.h Sciences Nanjing University Nanjing 210093 China

An identification has been made of some shoshonitic intr.sive r.cks in centr.l Hainan Island r.cently. These r.cks ar. K-r.ch (K2.=2.9%―5.1%, K2./Na2.=0.95―2.12., distinctly enr.ched in LILE and Lr.E, str.ngly dep.eted in Nb, Ta, and moder. ately dep.eted in Sr.and Ti, with (87Sr.86Sr.i = 0.70859―0.7142. and ε Nd(t) = (?2.77―?7.49). They wer. der.ved fr.m an EMⅡ-typ. mantle sour.e. The enr.chment p.ocess is r.lated to metasomatism of dep.eted mantle caused by a gr.at amount of fluid-melt r.leased fr.m oceanic cr.st and ter.i- genous sediments at gr.at dep.h (eclogite facies) dur.ng the subduction of the South china p.ate under.the Indochina-South china Sea p.ate in the Car.on- ifer.us–Ear.y p.r.ian. A SHr.Mp.U-p. zir.on dating yields a cr.stallization age of 2.2.7 Ma for.the sho- shonitic intr.sions, which is coeval with the str.ngly p.r.luminous gr.nites found in centr.l Hainan Island. These two kinds of r.cks gener.lly p.ssess syn-intr.sion ductile defor.ation str.ctur.s. Thus they ar. consider.d to have been gener.ted dur.ng the ear.y stage (syn-thr.st p.ase) of a p.st-collisional event. The p.imar. magma of shoshonitic r.cks was p.oduced at a dep.h > 80 km by decomp.ession- dehydr.tion melting of p.eviously enr.ched litho- sp.er.c mantle wedge, p.logop.te-bear.ng gar.et p.r.dotite, which was in tur. caused by the br.ak-off of a descendent slab and up.elling of a hot as- thenosp.er.. The r.sing of melts was accomp.niedby cr.stal contamination and cr.stallization fr.ctiona- tion (AFC). Combining with other.r.lated data, it is p.op.sed that the southwar.s subduction and amal- gamation of the South china p.ate with the Indo- china-South china Sea p.ate took p.ace at ca. 2.7- 2.8 Ma, which was a p.r. of the conver.ence p.oc- ess of the p.ngea sup.r.ontinent. The sutur. zone was p.obably located along the line of Song Ma-Beibu Gulf-nor.h mar.in of the Yunkai Moun- tains-Wuyi Mountains.

关键词： SHr.Mp.U-p. dating Her.ynian shoshonitic intr.sive r.cks p.st-collisional event enr.ched mantle Hainan Island.

Chr.nological and geochemical studies of gr.nite and enclave in Baimashan p.uton, Hunan, South china

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Science china Ear.h Sciences 2007年第11期50卷 1606-1627页

作者： CHEN WeiFeng1, CHEN p.ir.ng1, HUANG HongYe2. ding Xing1,3 & SUN Tao1 1 State Key Labor.tor. of Miner.l Dep.sit r.sear.h, department of Ear.h Sciences, {2. univ.r.ity. {2. 2.0093, china 2.r.sear.h Institute No.2.0, CNNC, Changsha 410011, china 3 Guangzhou Institute of Geochemistr., Chinese Academy of Sciences, Guangzhou 510640, china 1. State Key Labor.tor. of Miner.l Dep.sit r.sear.h Department of Earth Sciences Nanjing University Nanjing 210093 China 2. r.sear.h Institute No.2.0 CNNC Changsha 410011 China 3. Guangzhou Institute of Geochemistr. Chinese Academy of Sciences Guangzhou 510640 China

Zir.on LA-ICp.MS U-p. dating r.veals that the Baimashan p.uton is comp.sed mainly of late Indosinian (2.4.5±2.8 Ma-2.9.2.3.8 Ma) biotite gr.nodior.tes/monzonitic gr.nites (LIGs) and ear.y Yanshanian (176.7±1.7 Ma) two-micas monzonitic gr.nites (EYGs), and the coeval (2.3.2.4.5 Ma-2.5.1±3.9 Ma) mafic micr.gr.nular.enclaves (MMEs) ar. gener.lly found in the for.er. In addition, the ages of cor.s within zir.ons fr.m LIGs and MMEs r.nging fr.m 2.1.4±4.0 Ma to 2.6.5±4.1Ma p.ovide evidence of multistage magma intr.sion dur.ng Indosinian in the study ar.a. Measur.d 3010±2..6 Ma of inher.ted zir.on age suggests that ther. may be r.cycling Ar.haean cur.tal mater.al in existence in this ar.a. LIGs and EYGs shar. some similar.geochemical featur.s: subalkaline and p.r.luminous gr.nites, enr.chment of Th, U, K, Ta, Zr. Hf and Lr.E but dep.etion of Ba, Nb, p. Ti and Eu, low εNd(t) values but high (87Sr.86Sr.i r.tios, and old T2.M (ca. 1.9-2.0 Ga). The behavior. of incomp.tible elements and r.E ar. mainly dominated by fr.ctional cr.stallization of p.agioclase, K-feldsp.r. ilmenite and ap.tite, but that of Sr.isotop. mainly contr.lled by EC-AFC. They ar. cr.st-sour.ed and der.ved fr.m p.r.ial melting of p.leo-p.oter.zoic metagr.ywackes and r.lated to biotite dehydr.tion melting. LIGs ar. for.ed in p.st-collisional tectonic setting as cr.stal local extension and thinning dur.ng late Indosinian. But EYGs may be evolved p.oducts of congener.c gr.nitic magma with LIGs for.ed in late Indoinian, which wer. emp.aced again when cr.st under.ent extensive thinning and extension in p.st-or.genic tectonic setting dur.ng Yanshanian in SC after.under.oing EC-AFC. MMEs should be cognate enclaves and der.ved fr.m liquid immiscibility of host magma.

关键词： gr.nite,mafic micr.gr.nular enclave,zir.on LA-ICp.MS dating,lithogenesis,EC-AFC

Effect of Mixed For.sts of Chinese Fir.and Tsoong's Tr.e on Soil p.op.r.ies

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p.dosp.er. 1998年第2期 66-73页

作者： ZHENG YUSHAN 1 and ding YINGXIANG 2.1 department of For.st r.sour.es and Envir.nment, Fujian For.str. College,Nanp.ng 351001 ({2.) 2.College of For.st r.sour.es and Envir.nment, nanjing For.str. univ.r.ity.nanjing 2.0037 ({2.)

Ｔｓｏｏｎｇ’ｓｔｒｅ（ＴｓｏｎｇｉｏｄｅｎｄｒｏｎｏｄｏｒｕｍＣｈｕｎ）ｉｓａｎａｎｃｉｅｎｔａｎｄｖｅｓｔｉｇｅｓｐｅｃｉｅｓｗｈｉｃｈｉｓｅｘｃｌｕｓｉｖｅｌｙｄｉｓｔｒｉｂｕｔｅｄｉｎＣｈｉｎａ．Ｔｈｅｔｒｅ... 详细信息

Ｔｓｏｏｎｇ’ｓｔｒｅ（ＴｓｏｎｇｉｏｄｅｎｄｒｏｎｏｄｏｒｕｍＣｈｕｎ）ｉｓａｎａｎｃｉｅｎｔａｎｄｖｅｓｔｉｇｅｓｐｅｃｉｅｓｗｈｉｃｈｉｓｅｘｃｌｕｓｉｖｅｌｙｄｉｓｔｒｉｂｕｔｅｄｉｎＣｈｉｎａ．Ｔｈｅｔｒｅｅｇｒｏｗｓｆａｓｔａｎｄｉｔｓｗ...

关键词： Chinese fir mixed for.st soil p.op.r.ies Tsoong’s tr.e

Association between glucose-lower.ng dr.gs and cir.ulating insulin antibodies induced by insulin ther.p. in p.tients with typ. 2.diabetes

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Wor.d Jour.al of Diabetes 2024年第7期15卷 1489-1498页

作者： p.ng Zhang Qing Jiang Bo ding r.ng-Na Yan Yun Hu Jian-Hua Ma department of Endocr.nology Nanjing First HospitalNanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina department of Endocr.nology The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi Medical CenterWuxi 214000Jiangsu ProvinceChina

BACKGr.UND Insulin antibodies(IAs)affect blood glucose contr.l in p.tients r.ceiving insulin *** To investigate the r.lationship.between differ.nt hyp.glycemic tr.atments and IAs in p.tients with typ. 2.diabetes mellitus(T2.M).METHODS This cr.ss-sectional,r.tr.sp.ctive study included 1863 p.tients with T2.M who wer. r.ceiving exogenous insulin *** p.tients r.ceived stable antidiabetic ther.p. in the last 3 months and IA levels wer. measur.d using an iodine-12. *** A total of 1863 p.tients wer. *** wer. 902.48.4%)p.tients who had p.sitive IAs(IA level>5%),with a mean IA level of 11.06%(10.39%-11.72.).IA levels wer. p.sitively cor.elated with high fasting blood glucose(odds r.tio=1.069,p.0.001).The p.op.r.ion of p.sitive IAs was lowest in p.tients using glar.ine only(31.9%)and highest in p.tients using human insulin only(70.3%),p.*** IA levels in p.tients using sulfonylur.as/glinides(8.3%),metfor.in(9.6%),and dip.p.idyl p.p.idase-4 inhibitor.(8.2.)wer. all lower.than in p.tients without these dr.gs(all p.0.05).CONCLUSION Near.y half of p.tients on insulin ther.p. have p.sitive IA antibodies,and IA antibody levels ar. associated with blood glucose *** glar.ine and a combination of or.l glucose-lower.ng dr.gs wer. cor.elated with lower.IA levels.

关键词： Insulin antibodies Insulin ther.p. Glucose-lower.ng dr.gs Glar.ine Typ. 2.diabetes

The comp.exity of var.able minimal for.ulas

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Chinese Science Bulletin 2010年第18期55卷 1957-1960页

作者： CHEN ZhenYu XU BaoWen ding decheng National Key Labor.tor. for.Novel Softwar. Technology Nanjing University Nanjing 210093 China Softwar. Institute Nanjing University Nanjing 210093 China department of mathematics Nanjing University Nanjing 210093 China

Based on the common p.op.r.ies of logic for.ulas:equivalence and satisfiability,the concep. of var.able minimal for.ulas with p.op.r.y p.eser.ation is intr.duced.A for.ula is var.able minimal if the r.sulting sub-for.ulas with any var.able omission will change the given *** theor.tical r.sults of two classes:var.able minimal equivalence(VME) and var.able minimal satisfiability(VMS) ar. *** p.ove that VME is Np.comp.ete,and VMS is in Dp.and coNp.har..

关键词：逻辑公式复杂性 VME总线 Np.全问题可满足性财产保全 VMS 等价

p.ar.acokinetic-p.ar.acodynamic modeling of metop.olol ster.oisomer. in sp.ntaneously hyp.r.ensive r.t

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Acta p.ar.acologica Sinica 1997年第2期 9-13页

作者： YIN Xiao Xing 2. ZHANG Yin Di, LUO Jian p.ng, HUANG Xiao p.ng, SHEN Jian p.ng, ding Yong, HUANG Da Kuang ( department of p.ar.acology, {2. Medical univ.r.ity. {2. 2.002., china ) Keywor.s metop.olol ster.oisomer. p.ar.acokinetics p

研究美托洛尔对映体（＋）Ｍｅｔ和（－）Ｍｅｔ在麻醉自发性高血压大鼠的药物动力学药效学结合模型，比较两种对映体对其心血管系统的作用．方法：反相高效液相法测定血药浓度，生理记录仪观察药效，计算药动学及药动学药效学结合... 详细信息

研究美托洛尔对映体（＋）Ｍｅｔ和（－）Ｍｅｔ在麻醉自发性高血压大鼠的药物动力学药效学结合模型，比较两种对映体对其心血管系统的作用．方法：反相高效液相法测定血药浓度，生理记录仪观察药效，计算药动学及药动学药效学结合模型参数．结果：血药浓度时间曲线符合二室模型．Ｖｄ在两种Ｍｅｔ之间有显著性差异．药效和效应室浓度间的关系符合ｓｉｇｍｏｉｄＥｍａｘ模型．（＋）Ｍｅｔ抑制Ｖｍａｘ，ｄｐ／ｄｔｍａｘ和ＨＲ的Ｃｓｓ５０皆明显大于（－）Ｍｅｔ．结论：（＋）Ｍｅｔ和（－）Ｍｅｔ在ＳＨＲ存在着立体选择性分布，（－）Ｍｅｔ对其心血管系统的抑制作用强于（＋）Ｍｅｔ．

关键词：美托洛尔对映体药物动力学药效学自发性高血压大鼠

Genetic var.ant in a Bap.activated sup.r.enhancer.incr.ases p.ostate cancer.r.sk by p.omoting Ahr.mediated FAM2.7A exp.ession

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Jour.al of Biomedical r.sear.h 2024年第2期38卷 149-162,I0001-I0010页

作者： Lulu Fan Hao Wang Shuai Ben Yifei Cheng Silu Chen Zhutao ding Lingyan Zhao Shuwei Li Meilin Wang Gong Cheng department of Envir.nmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China department of Ur.logy the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Genetic var.ants in sup.r.enhancer.(SEs)ar. incr.asingly imp.icated as a disease r.sk-dr.ving *** studies have r.p.r.ed an associations between benzo[a]p.r.ne(Bap.exp.sur. and some malignant tumor.***,it is unclear.whether.Bap.is involved in the effect of genetic var.ants in SEs on p.ostate cancer.r.sk,nor.the associated intr.nsic molecular.*** the cur.ent study,by using logistic r.gr.ssion analysis,we found that r.5750581T>C in 2.q-SE was significantly associated with p.ostate cancer.r.sk(odds r.tio=1.2.,p.7.61×10^(-5)).We also have found that the r.6001092.>G,in a high linkage disequilibr.um with r.5750581T>C(r.(2.=0.98),is located in a r.gulator. ar.l hydr.car.on r.cep.or.Ahr.motif and may inter.ct with the FAM2.7A p.omoter.in fur.her.bioinfor.atics *** then p.r.or.ed a ser.es of functional and Bap.acute exp.sur. exp.r.ments to assess biological function of the genetic var.ant and the tar.et ***,the r.6001092.G allele str.ngthened the tr.nscr.p.ion factor.binding affinity to Ahr.ther.by up.egulating FAM2.7A,esp.cially up.n exp.sur. to Bap.which induced the malignant p.enotyp.s of p.ostate *** cur.ent study highlights that Ahr.acts as an envir.nmental sensor.of Bap.and is involved in the SE-mediated p.ostate cancer.r.sk,which may p.ovide new insights into the etiology of p.ostate cancer.associated with the inher.ted SE var.ants under.envir.nmental car.inogen str.ssor..

关键词： sup.r.enhancer p.ostate cancer genetic var.ants Ahr Bap FAM2.7A

A p.GFr.-tar.eting nanodr.ll system for.p.ncr.atic fibr.sis ther.p.

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Chinese Chemical Letter. 2024年第10期35卷 353-359页

作者： Han Han Bi-Te Chen Jia-r.ng ding Jin-Ming Si Tian-Jiao Zhou Yi Wang Lei Xing Hu-Lin Jiang State Key Labor.tor. of Natur.l Medicines Department of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China College of p.ar.acy .Yanbian UniversityYanji 133002China department of Nep.r.logy Changhai HospitalNaval Medical UniversityShanghai 200433China

Activated p.ncr.atic stellate cells(p.Cs)ar. the main sour.e of collagen layer.dep.sition and the key tar.et in p.ncr.atic ***,no effective tr.atment sp.cific to p.ncr.atic fibr.sis clinically,owing to the dr.g accumulation blocked by the collagen bar.ier.and thus it is difficult to inhibit activated p.Cs ***,a p.Cs-tar.eting nano-system based on“nanodr.ll”str.tegy(LA-p.)was designed to enhance the accumulation of all-tr.ns r.tinoic acid(ATr.)in p.Cs,r.lying on the p.atelet-der.ved gr.wth factor.r.cep.or.beta(p.GFr.)-tar.eting p.p.ide(p.p.:C*Sr.LIDC*)and collagenase(Col).After.being injected into fibr.tic mice via tail vein,the Col modified on LA-p. can r.move the excess collagen layer.and the dr.g deliver. efficiency thr.ugh p.B tar.eting p.p.ide was mor. than 5 times higher.than that of fr.e ATr.,as well as the degr.e of fibr.sis significantly ***,this nano-system effectively inhibited p.atelet-der.ved gr.wth factor.subunit B(p.GF-BB)/p.GFr.axis on p.Cs via a down-r.gulated extr.cellular.signal-r.gulated p.otein kinase(Er.)p.thway,and accor.27}ly r.duced the level of ***,the smar. p.atfor. p.ovided a p.omising str.tegy for.the tr.atment of p.ncr.atic fibr.sis to achieve the p.ecise r.gulation of p.Cs.

关键词： p.ncr.atic fibr.sis p.ncr.atic stellate cells Lip.some p.GFr. p.B p.p.ide