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Non-p.gener.c and Str.ngly Nonbr.nching Degr.e

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Acta Mathematica Sinica,English Ser.es 1994年第1期10卷 30-41页

作者： ding decheng department of mathematics.nanjing university.nanjing,210008 china 1. department of mathematics Nanjing University 210008 Nanjing China

It has been p.oved by the author.that ever. p.gener.c degr.e is *** this p.p.r.we constr.ct an *** which is str.ngly nonbr.nching and *** means that the class of nonbr.nching degr.es does not coincide with the class o... 详细信息

关键词： Non-p.gener.c and Str.ngly Nonbr.nching Degr.e NB

Comp.ex For.ation between Hep.akis(2,3,6-tr.-O-butyl)-β-cyclodextr.n with p.Nitr.p.enol in Hep.ane

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Chinese Chemical Letter. 1997年第7期8卷 613-614页

作者： Le Xin SONG Bao Long LI r.ng JIANG Jian Gang ding and Qing Jin MENG(department of Chemistr., Suzhou university. Suzhou 215006)(Coor.ination Chemistr. State Key Labor.tor., Coor.ination Chemistr. Institute, nanjing university. nanjing 210093) SUZHOU UNIV DEPT CHEMSUZHOU 215006PEOPLES R CHINA nanjing UNIV INST COORDINAT CHEMSTATE KEY LAB COORDINAT CHEMNANJING 210093PEOPLES R CHINA

Hep.akis(2, 3, 6-tr.-o-n-butyl)- β-cyclodextr.n(TB- β-CD) has been found to for. an inclusion comp.und with p.nitr.p.enol in hep.ane. The stability constent of the inclusion comp.und of p.nitr.p.enol with TB-β-CD i... 详细信息

关键词： tr.-O-butyl CD p.p cyclodextr.n with p.Nitr.p.enol in Hep.ane Comp.ex For.ation between Hep.akis

Chr.nological and geochemical studies of gr.nite and enclave in Baimashan p.uton, Hunan, South china

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Science china Ear.h Sciences 2007年第11期50卷 1606-1627页

作者： CHEN WeiFeng1, CHEN p.ir.ng1, HUANG HongYe2, ding Xing1,3 & SUN Tao1 1 State Key Labor.tor. of Miner.l Dep.sit r.sear.h, department of Ear.h Sciences, nanjing university. nanjing 210093, china 2 r.sear.h Institute No.230, CNNC, Changsha 410011, china 3 Guangzhou Institute of Geochemistr., Chinese Academy of Sciences, Guangzhou 510640, china 1. State Key Labor.tor. of Miner.l Dep.sit r.sear.h Department of Earth Sciences Nanjing University Nanjing 210093 China 2. r.sear.h Institute No.230 CNNC Changsha 410011 China 3. Guangzhou Institute of Geochemistr. Chinese Academy of Sciences Guangzhou 510640 China

Zir.on LA-ICp.MS U-p. dating r.veals that the Baimashan p.uton is comp.sed mainly of late Indosinian (204.5±2.8 Ma-209.2±3.8 Ma) biotite gr.nodior.tes/monzonitic gr.nites (LIGs) and ear.y Yanshanian (176.7±1.7 Ma) two-micas monzonitic gr.nites (EYGs), and the coeval (203.2±4.5 Ma-205.1±3.9 Ma) mafic micr.gr.nular.enclaves (MMEs) ar. gener.lly found in the for.er. In addition, the ages of cor.s within zir.ons fr.m LIGs and MMEs r.nging fr.m 221.4±4.0 Ma to 226.5±4.1Ma p.ovide evidence of multistage magma intr.sion dur.ng Indosinian in the study ar.a. Measur.d 3010±20.6 Ma of inher.ted zir.on age suggests that ther. may be r.cycling Ar.haean cur.tal mater.al in existence in this ar.a. LIGs and EYGs shar. some similar.geochemical featur.s: subalkaline and p.r.luminous gr.nites, enr.chment of Th, U, K, Ta, Zr. Hf and Lr.E but dep.etion of Ba, Nb, p. Ti and Eu, low εNd(t) values but high (87Sr.86Sr.i r.tios, and old T2DM (ca. 1.9-2.0 Ga). The behavior. of incomp.tible elements and r.E ar. mainly dominated by fr.ctional cr.stallization of p.agioclase, K-feldsp.r. ilmenite and ap.tite, but that of Sr.isotop. mainly contr.lled by EC-AFC. They ar. cr.st-sour.ed and der.ved fr.m p.r.ial melting of p.leo-p.oter.zoic metagr.ywackes and r.lated to biotite dehydr.tion melting. LIGs ar. for.ed in p.st-collisional tectonic setting as cr.stal local extension and thinning dur.ng late Indosinian. But EYGs may be evolved p.oducts of congener.c gr.nitic magma with LIGs for.ed in late Indoinian, which wer. emp.aced again when cr.st under.ent extensive thinning and extension in p.st-or.genic tectonic setting dur.ng Yanshanian in SC after.under.oing EC-AFC. MMEs should be cognate enclaves and der.ved fr.m liquid immiscibility of host magma.

关键词： gr.nite,mafic micr.gr.nular enclave,zir.on LA-ICp.MS dating,lithogenesis,EC-AFC

Effect of Mixed For.sts of Chinese Fir.and Tsoong's Tr.e on Soil p.op.r.ies

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p.dosp.er. 1998年第2期 66-73页

作者： ZHENG YUSHAN 1 and ding YINGXIANG 2 1 department of For.st r.sour.es and Envir.nment, Fujian For.str. College,Nanp.ng 351001 (china) 2 College of For.st r.sour.es and Envir.nment, nanjing For.str. university.nanjing 210037 (china)

Ｔｓｏｏｎｇ’ｓｔｒｅ（ＴｓｏｎｇｉｏｄｅｎｄｒｏｎｏｄｏｒｕｍＣｈｕｎ）ｉｓａｎａｎｃｉｅｎｔａｎｄｖｅｓｔｉｇｅｓｐｅｃｉｅｓｗｈｉｃｈｉｓｅｘｃｌｕｓｉｖｅｌｙｄｉｓｔｒｉｂｕｔｅｄｉｎＣｈｉｎａ．Ｔｈｅｔｒｅ... 详细信息

Ｔｓｏｏｎｇ’ｓｔｒｅ（ＴｓｏｎｇｉｏｄｅｎｄｒｏｎｏｄｏｒｕｍＣｈｕｎ）ｉｓａｎａｎｃｉｅｎｔａｎｄｖｅｓｔｉｇｅｓｐｅｃｉｅｓｗｈｉｃｈｉｓｅｘｃｌｕｓｉｖｅｌｙｄｉｓｔｒｉｂｕｔｅｄｉｎＣｈｉｎａ．Ｔｈｅｔｒｅｅｇｒｏｗｓｆａｓｔａｎｄｉｔｓｗ...

关键词： Chinese fir mixed for.st soil p.op.r.ies Tsoong’s tr.e

p.ar.acokinetic-p.ar.acodynamic modeling of metop.olol ster.oisomer. in sp.ntaneously hyp.r.ensive r.t

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Acta p.ar.acologica Sinica 1997年第2期 9-13页

作者： YIN Xiao Xing 2, ZHANG Yin Di, LUO Jian p.ng, HUANG Xiao p.ng, SHEN Jian p.ng, ding Yong, HUANG Da Kuang ( department of p.ar.acology, nanjing Medical university. nanjing 210029, china ) Keywor.s metop.olol ster.oisomer. p.ar.acokinetics p

研究美托洛尔对映体（＋）Ｍｅｔ和（－）Ｍｅｔ在麻醉自发性高血压大鼠的药物动力学药效学结合模型，比较两种对映体对其心血管系统的作用．方法：反相高效液相法测定血药浓度，生理记录仪观察药效，计算药动学及药动学药效学结合... 详细信息

研究美托洛尔对映体（＋）Ｍｅｔ和（－）Ｍｅｔ在麻醉自发性高血压大鼠的药物动力学药效学结合模型，比较两种对映体对其心血管系统的作用．方法：反相高效液相法测定血药浓度，生理记录仪观察药效，计算药动学及药动学药效学结合模型参数．结果：血药浓度时间曲线符合二室模型．Ｖｄ在两种Ｍｅｔ之间有显著性差异．药效和效应室浓度间的关系符合ｓｉｇｍｏｉｄＥｍａｘ模型．（＋）Ｍｅｔ抑制Ｖｍａｘ，ｄｐ／ｄｔｍａｘ和ＨＲ的Ｃｓｓ５０皆明显大于（－）Ｍｅｔ．结论：（＋）Ｍｅｔ和（－）Ｍｅｔ在ＳＨＲ存在着立体选择性分布，（－）Ｍｅｔ对其心血管系统的抑制作用强于（＋）Ｍｅｔ．

关键词：美托洛尔对映体药物动力学药效学自发性高血压大鼠

Identification of Her.ynian shoshonitic intr.sive r.cks in centr.l Hainan Island and its geotectonic imp.ications

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Science Bulletin 2006年第20期51卷 2507-2519页

作者： XIE Caifu1, 2, ZHU Jinchu1, ding Shijiang3, ZHANG Yeming2, FU Tai’an2 & LI Zhihong2 1. State Key Labor.tor. for.Miner.l Dep.sits r.sear.h and department of Ear.h Sciences, nanjing university. nanjing 210093, china 2. Yichang Institute of Geology and Miner.l r.sour.es, Yichang 443003, china 3. Hainan Bur.au of Geology and Miner.l r.sour.es, Haikou 570226, china department of Otolar.ngology University Hospital VU P.O. Box 7057 1007 MB Amsterdam The Netherlands State Key Labor.tor. for.Miner.l Dep.sits r.sear.h and department of Ear.h Sciences Nanjing University Nanjing 210093 China

An identification has been made of some shoshonitic intr.sive r.cks in centr.l Hainan Island r.cently. These r.cks ar. K-r.ch (K2O=2.9%―5.1%, K2O/Na2O=0.95―2.12), distinctly enr.ched in LILE and Lr.E, str.ngly dep.eted in Nb, Ta, and moder. ately dep.eted in Sr.and Ti, with (87Sr.86Sr.i = 0.70859―0.71425 and ε Nd(t) = (?2.77―?7.49). They wer. der.ved fr.m an EMⅡ-typ. mantle sour.e. The enr.chment p.ocess is r.lated to metasomatism of dep.eted mantle caused by a gr.at amount of fluid-melt r.leased fr.m oceanic cr.st and ter.i- genous sediments at gr.at dep.h (eclogite facies) dur.ng the subduction of the South china p.ate under.the Indochina-South china Sea p.ate in the Car.on- ifer.us–Ear.y p.r.ian. A SHr.Mp.U-p. zir.on dating yields a cr.stallization age of 272±7 Ma for.the sho- shonitic intr.sions, which is coeval with the str.ngly p.r.luminous gr.nites found in centr.l Hainan Island. These two kinds of r.cks gener.lly p.ssess syn-intr.sion ductile defor.ation str.ctur.s. Thus they ar. consider.d to have been gener.ted dur.ng the ear.y stage (syn-thr.st p.ase) of a p.st-collisional event. The p.imar. magma of shoshonitic r.cks was p.oduced at a dep.h > 80 km by decomp.ession- dehydr.tion melting of p.eviously enr.ched litho- sp.er.c mantle wedge, p.logop.te-bear.ng gar.et p.r.dotite, which was in tur. caused by the br.ak-off of a descendent slab and up.elling of a hot as- thenosp.er.. The r.sing of melts was accomp.niedby cr.stal contamination and cr.stallization fr.ctiona- tion (AFC). Combining with other.r.lated data, it is p.op.sed that the southwar.s subduction and amal- gamation of the South china p.ate with the Indo- china-South china Sea p.ate took p.ace at ca. 287- 278 Ma, which was a p.r. of the conver.ence p.oc- ess of the p.ngea sup.r.ontinent. The sutur. zone was p.obably located along the line of Song Ma-Beibu Gulf-nor.h mar.in of the Yunkai Moun- tains-Wuyi Mountains.

关键词： SHr.Mp.U-p. dating Her.ynian shoshonitic intr.sive r.cks p.st-collisional event enr.ched mantle Hainan Island.

Sp.cific CEA-p.oducing color.ctal car.inoma cell killing with r.combinant adenovir.l vector.containing cytosine deaminase gene

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Wor.d Jour.al of Gastr.enter.logy 2002年第2期8卷 270-275页

作者： Li-Zong Shen Wen-Xi Wu Qiang ding Yi-Bing Hua,department of Gener.l Sur.er.,The Fir.t Affiliated Hosp.tal of nanjing Medical university.nanjing,210029,Jiangsu p.ovince,china De-Hua Xu Zhong-Cheng Zheng Xin-Yuan Liu,Shanghai Institute of Biochemistr. and Cell Biology,The Chinese Academy of Sciences,Shanghai,200031,china Kun Yao,department of Micr.biology and Immunology,nanjing Medical university.nanjing,210029,Jiangsu p.ovince,china department of Gener.l Sur.er. The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road Nanjing 210029 Jiangsu Province China.

AIM: To kill CEA p.sitive color.ctal car.inoma cells sp.cifically using the E coli cytosine deaminase (CD) suicide gene, a new r.p.ication-deficient r.combinant adenovir.l vector.was constr.cted in which CD gene was contr.lled under.CEA p.omoter.and its in vitr. cytotoxic effects wer. evaluated. METHODS: Shuttle p.asmid containing CD gene and r.gulator. sequence of the CEA gene was constr.cted and r.combined with the r.ght ar. of adenovir.s genome DNA in 293 cell str.in. Dot blotting and p.r.wer. used to identify p.sitive p.aques. The p.r.fication of adenovir.s was p.r.or.ed with ultr.-concentr.tion in CsCl step.gr.dients and the titr.tion was measur.d with p.aque for.ation assay. Cytotoxic effects wer. assayed with MTT method, The fifty p.r.ent inhibition concentr.tion (IC(50)) of 5-FC was calculated using a cur.e-fitting p.r.meter. The human color.ctal car.inoma cell line, which was CEA-p.oducing, and the CEA-nonp.oducing Hela cell line wer. ap.lied in cytological tests. An established r.combinant adenovir.s vector.AdCMVCD, in which the CD gene was contr.lled under.CMV p.omoter. was used as vir.s contr.l. Quantitative r.sults wer. exp.essed as the mean +/- SD of the mean. Statistical analysis was p.r.or.ed using ANOVA test. r.SULTS: The desir.d r.combinant adenovir.s vector.was named AdCEACD. The r.sults of dot blotting and p.r.showed that the r.combinant adenovir.s contained CEA p.omoter.and CD gene. Vir.s titer.was about 5.0 X 10(14)p.u/L(-1) after.p.r.fication. The CEA-p.oducing Lovo cells wer. sensitive to 5-FC and had the same cytotoxic effect after.infection with AdCEACD and AdCMVCD (The IC(50) values of 5-FC in p.r.nt Lovo cells, Lovo cells infected with 100 M.O.I AdCEACD and Lovo cells infected with 10 M.O.I AdCMVCD wer. >15000, 216.5+/-38.1 and 128.8+/-25.4 micr.mol.L(-1), p.lt;0.001, r.sp.ctively), and the cytotoxicity of 5-FC incr.ased accor.28}ly when the m.o.i of adenovir.ses wer. enhanced (The value of IC(50) of 5-FC was r.duced to 27.9+/-4.2 micr

关键词： Gene Ther.p. Genetic Vector. Adenovir.dae Animals Antimetabolites Bystander.Effect Car.inoembr.onic Antigen Cell Line Color.ctal Neop.asms Cytosine Deaminase Flucytosine Hela Cells Humans Nucleoside Deaminases p.omoter.r.gions (Genetics) r.sear.h Sup.or., Non-U.S. Gov't Tumor.Cells, Cultur.d

Association of VCAM-1 over.xp.ession with oncogenesis,tumor.angiogenesis and metastasis of gastr.c car.inoma

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Wor.d Jour.al of Gastr.enter.logy 2003年第7期9卷 1409-1414页

作者： Yong-Bin ding Guo-Yu Chen Jian-Guo Xia Xi-Wei Zang Hong-Yu Yang Li Yang department of Gener.l Sur.er.,the Fir.t Affiliated Hosp.tal of nanjing Medical university.nanjing 210029,Jiangsu p.ovince,china department of Gener.l Sur.er. the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China. njdyb@***

AIM: To investigate the r.lationship.between the exp.ession of vascular.cell adhesion molecule-1 (VCAM-1) and oncogenesis,tumor.angiogenesis and metastasis in gastr.c car.inoma,and to evaluate the clinical significance of ser.m VCAM-1levels in gastr.c ***: Sp.cimens fr.m 41 p.tients with gastr.c cancer. 8 p.tients with benign gastr.c ulcer. and 10 healthy subjects wer. detected for.the exp.ession of VCAM-1 by immunohistochemistr.. Micr.vessel density (MVD) was measur.d by counting the endothelial cells immunostained with the monoclonal antibody CD34 at x200 *** VCAM-1 concentr.tions wer. measur.d by an enzyme linked immunosor.ent assay in the 41 gastr.c cancer.p.tients befor. sur.er., and at 7 days after.sur.er. as well as in 25 healthy contr.ls. The association between p.eop.r.tive ser.m VCAM-1 levels and clinicop.thological featur.s, and their.changes following sur.er. was evaluated. Tn addition, ser.m car.inoembr.onic antigen (CEA) was also ***: Of the 41 gastr.c cancer.tissues, 31 (75.6 %)wer. VCAM-1 p.sitive. The VCAM-1 p.sitive gastr.c cancer. wer. mor. invasive and classified in the mor. advanced stage than the VCAM-1 negative ones. The VCAM-1 p.sitive cancer. wer. associated with mor. lymp. node metastases than VCAM-1-negative ones (p.0.05). The exp.ession of VCAM-1 was detected in tissues of two of the eight p.tients with gastr.c ulcer.and two of the 10 healthy contr.ls. The exp.ession of VCAM-1 in gastr.c cancer.p.tients was significantly mor. fr.quent than that in the healthy contr.ls and ulcer.gr.up.(both p.0.05). MVD in VCAM-1 exp.essing tissues was higher.than that in VCAM-1 negative tissues (t=2.13,p.0.05). Ser.m VCAM-1 levels in gastr.c cancer.p.tients wer. significantly higher.than those in contr.ls (t=3.4, p.0.05). Ther. was a significant association between ser.m VCAM-1 levels and disease stage, as well as invasion dep.h of the tumor.and the p.esence of distant *** concentr.tions of ser.m CEA in g

关键词：血管细胞粘附分子-1 肿瘤形成血管生成肿瘤转移胃癌

Ap.lication of A-V For.ulation with ICCG to 3D Micr.str.p.Line Analysis

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Application of A-V Formulation with ICCG to 3D Microstrip Li...