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芒果苷对前列腺癌耐药细胞耐药性的逆转作用

中药药理与临床 2017年第4期33卷 31-35页

作者：罗花邓家刚朱丹谭德超郭宏伟广西中药药效重点实验室南宁530001 广西医科大学药学院南宁530021 长寿与老年相关疾病教育部重点实验室南宁530021

目的:探讨芒果苷对人前列腺癌对紫杉醇耐药性的逆转作用。方法:MTS法检测芒果苷对PC3、DU145、PC3-TXR、DU145-TXR细胞活性的影响;MTS法检测芒果苷联合紫杉醇对耐药细胞株PC3-TXR和DU145-TXR活性的影响;单细胞克隆形成实验检测芒果苷联... 详细信息

目的:探讨芒果苷对人前列腺癌对紫杉醇耐药性的逆转作用。方法:MTS法检测芒果苷对PC3、DU145、PC3-TXR、DU145-TXR细胞活性的影响;MTS法检测芒果苷联合紫杉醇对耐药细胞株PC3-TXR和DU145-TXR活性的影响;单细胞克隆形成实验检测芒果苷联合紫杉醇对PC3-TXR和DU145-TXR克隆形成能力的影响;细胞划痕实验检测芒果苷联合紫杉醇对PC3-TXR和DU145-TXR转移能力的影响。结果:芒果苷在作用于PC3细胞48h和72h时其半数抑制浓度(IC50)分别为151.03μM和163.03μM,具有较明显的抑制作用,但对DU145、PC3-TXR和DU145-TXR的增殖无明显影响;芒果苷(25μM)可明显增强紫杉醇(25n M)抑制PC3-TXR和DU145-TXR的细胞活性及克隆形成能力;芒果苷(100μM)可显著增强紫杉醇(25n M)抑制PC3-TXR和DU145-TXR迁移的能力。结论:芒果苷可增强紫杉醇对前列腺癌耐药株增殖和转移的抑制作用,提示芒果苷对前列腺癌耐药细胞耐药性有逆转作用。

关键词：芒果苷紫杉醇前列腺癌耐药

核电厂主给水泵再循环流量调节阀控制策略优化

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电工技术 2020年第21期 171-171,174页

作者：谭德超王权康凯海南核电有限公司海南昌江572733

结合昌江核电厂现场实际运行情况,对其电动主给水泵再循环流量调节阀控制逻辑进行改造,以改善设备运行状况,降低蒸汽发生器水位波动风险,保障机组安全稳定运行。

关键词：主给水泵再循环流量调节阀控制逻辑

Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity

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Neural Regeneration Research 2025年第9期20卷 2577-2578页

作者： Jiazi tan Chin-Tong Ong Temasek Life Sciences Laboratory National University of SingaporeSingapore Department of Biological Sciences National University of SingaporeSingapore

Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous *** are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.

关键词： metabolism glycoprotein maintain

Copper-catalyzed C–H bond functionalization enabled by programmed alternating current

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Science China Chemistry 2025年第01期 10-11页

作者： Zhoumei tan Kun Xu Chengchu Zeng Beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life Science Beijing University of Technology

Synthetic electrochemistry has been selected as one of the Top Ten Emerging Technologies in Chemistry in 2023 by International Union of Pure and Applied Chemistry (IUPAC)[1]. It has emerged as a sustainable platform for organic synthesis and has exhibited a wide range of applications from academia to industry [2]. However, electrosynthesis has been predominantly performed by using direct current (DC).

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao tan Junling Lü Chunchi Zhang Dong Liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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牛膝酒对膝骨关节炎模型大鼠的作用研究

中医药导报 2024年第10期30卷 54-59页

作者：秦焕云刘子熙谭德超苏海潇陈岩侯林山东中医药大学青岛中医药科学院山东青岛266041 山东中医药大学经典药酒研究所山东青岛266041

目的:探讨牛膝酒对膝骨关节炎(KOA)模型大鼠的作用。方法:SD大鼠通过膝关节腔内注射碘乙酸钠溶液(60 mg/mL)建立KOA模型。将36只造模成功的大鼠随机分为模型组、牛膝酒低剂量组、牛膝酒中剂量组、牛膝酒高剂量组、塞来昔布组及黄酒组,... 详细信息

目的:探讨牛膝酒对膝骨关节炎(KOA)模型大鼠的作用。方法:SD大鼠通过膝关节腔内注射碘乙酸钠溶液(60 mg/mL)建立KOA模型。将36只造模成功的大鼠随机分为模型组、牛膝酒低剂量组、牛膝酒中剂量组、牛膝酒高剂量组、塞来昔布组及黄酒组,另设空白对照组,每组6只,给予相应药物干预21 d(每天灌胃1次),每7 d测定膝关节肿胀度。观察各组大鼠关节肿胀度变化、膝关节表面病变情况、关节软骨病理情况并采用改良Mankin's评分标准进行评分,检测血清中IL-1β、TNF-α、IL-6及基质金属蛋白酶(MMP)-3、超氧化物歧化酶(SOD)水平。结果:与空白对照组比较,模型组大鼠各阶段膝关节肿胀度均升高(P<0.01),关节软骨表面损伤严重,可见炎症细胞聚集、软骨细胞减少且分布不均匀,基质染色重度减少,潮线不完整,改良Mankin's评分升高(P<0.01);血清中IL-1β、TNF-α、IL-6、MMP-3水平升高(P<0.01),SOD水平降低(P<0.01)。与模型组比较,牛膝酒低、中、高剂量组大鼠各阶段关节肿胀度均降低(P<0.05),关节软骨表面损伤、病理形态均有不同程度的改善;牛膝酒高剂量组血清中IL-1β、TNF-α、IL-6、MMP-3水平降低(P<0.05或P<0.01),SOD水平升高(P<0.01)。结论:牛膝酒可以缓解KOA模型大鼠关节肿胀及关节软骨损伤。这可能与其抑制炎症反应、调节软骨细胞代谢、拮抗氧化应激反应有关。

关键词：膝骨关节炎牛膝酒黄酒关节软骨大鼠

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew Shang Sui Chaolin tan Zhenglin Du Jinlong Su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior