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中国两栖动物保护需求总述

中国科学（C辑） 2006年第6期36卷 570-580,581页

作者：谢锋刘惠宁 Simon N Stuart Janice S Chanson Neil A Cox debra l fischman 中国科学院成都生物研究所嘉道理农场和植物园 IUCN-SSC/CI-CABS Biodiversity Assessment Unit Center for Applied Biodiversity Science Conservation International Washington DC 20036 USA GIS laboratory Center for Applied Biodiversity Science Conservation International Washington DC 20036 USA

通过对中国两栖动物物种生物多样性现状的全面分析,与世界许多国家相比,中国是一个重要的全球优先保护地区.横断山区、南岭山区和武夷山区3个区域的两栖动物物种多样性特别丰富.有尾两栖类物种较无尾类受胁程度更高.几个物种数相对较少... 详细信息

通过对中国两栖动物物种生物多样性现状的全面分析,与世界许多国家相比,中国是一个重要的全球优先保护地区.横断山区、南岭山区和武夷山区3个区域的两栖动物物种多样性特别丰富.有尾两栖类物种较无尾类受胁程度更高.几个物种数相对较少的铃蟾科、隐腮鲵科、小鲵科和蝾螈科显示出了高的受胁倾向.像世界其它地方一样,高海拔地区溪流繁殖的森林物种受胁程度更高.对中国两栖动物而言,生境丧失、污染和过度捕捉是最主要的致危因素.过度捕捉虽然影响不如生境丧失深远,但它更可能导致一个物种种群的快速衰落.针对5个方面的保护挑战,提出了优先研究领域和保护行动方面的建议.

关键词：两栖动物保护现状优先区域和类群适合生境保护挑战保护建议

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Percutaneous coronary intervention of totally occluded coronary venous bypass grafts:An exercise in futility?

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World Journal of Cardiology 2021年第9期13卷 493-502页

作者： Evan W Nardone Brandon M Madsen Melissa M McCarey David l fischman Nicholas J Ruggiero Paul Walinsky Alec Vishnevsky Michael P Savage Department of Medicine Thomas Jefferson UniversityPhiladelphiaPA 19107United States Department of Anesthesiology Medstar Georgetown University HospitalWashingtonDC 20007United States Jefferson Clinical Research Institue Thomas Jefferson UniversityPhiladelphiaPA 19107United States

BACKGROUND Percutaneous coronary intervention(PCI)of diseased saphenous vein grafts(SVG)continues to pose a clinical *** PCI guidelines give a class III recommendation against performing PCI on chronically occluded ***,contemporary outcomes after SVG intervention have incrementally improved with distal protection devices,intracoronary vasodilators,drug-eluting stents,and prolonged dual antiplatelet *** To reassess the procedural and long-term outcomes of PCI for totally occluded SVG with contemporary *** This was a retrospective observational study conducted at a single university *** study population consisted of 35 consecutive patients undergoing PCI of totally occluded ***-procedure dual antiplatelet therapy was continued for a minimum of one year and aspirin was continued *** outcomes were assessed at a mean follow-up of 1221±1038 *** primary outcome was freedom from a major adverse cardiac event(MACE)defined as the occurrence of any of the following:death,myocardial infarction,stroke,repeat bypass surgery,repeat PCI,or graft *** The study group included 29 men and 6 women with a mean age of 69±12 *** was present in 14(40%)*** patients had Canadian Heart Classification class III or IV *** presentation was an acute coronary syndrome in 34(97%)*** SVG age was 12±5 *** duration of occlusion was acute(24 h to 30 d)in 26%,and late(>30 d)in 40%.PCI was initially successful in 29/35 SVG occlusions(83%).Total stent length was 52±35 *** complications of distal embolization or no-reflow occurred in 6(17%)*** longer term follow-up,MACE-free survival was only 30%at 3 years and 17%at 5 *** PCI of totally occluded SVG can be performed with a high procedural success ***,its clinical utility remains limited by poor follow-up outcomes.

关键词： Coronary artery bypass grafting Coronary stents Chronic total occlusion Percutaneous coronary intervention Restenosis Saphenous vein grafts

Intrahepatic flow diversion prior to segmental Yttrium-90 radioembolization for challenging tumor vasculature

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Journal of Interventional Medicine 2022年第2期5卷 79-83页

作者： lindsay B.Young Marcin Kolber Michael J.King Mona Ranade Vivian l.Bishay Rahul S.Patel Francis S.Nowakowski Aaron M.fischman Robert A.lookstein Edward Kim Icahn School of Medicine at Mount Sinai Deparmnent of Dignostc Molecular and lterventionl RadiologyOne Gustave L.Levry Place Box 1234NY100296574New YorkUSA University of Teras Southwestem Medical Center Division of Vascular and Inerentional Radiology5323 Hary Hines BhvdTx753909316DallasUSA David Geffen School of Medicine at the Univerity of Calfornia-loS Angeles Deparment of Itrentionol Radiology27235 Toumey RoadSuite 1500Califormia91355ValenciaUSA

Background: Hepatic tumors with complex vascular supply or poor relative perfusion are prone to decreased rates of objective response. This is compounded in the setting of Yttrium-90(Y90) transarterial radioembolization(TARE), which is minimally embolic and flow-dependent, relying on high threshold dose for complete ***: We describe our experience with intrahepatic flow diversion(FD) prior to TARE of hepatocellular carcinoma(HCC) with challenging vascular *** and methods: Between April 2014 and January 2020, 886 cases of coinciding MAA or TARE and bland embolization or temporary occlusion were *** embolizations performed for more routine purposes were excluded. FD was performed by bland embolization or temporary occlusion of vessels supplying non-malignant parenchyma in cases where flow was not preferential to target tumor. lesion characteristics, vascular supply, treatment approach, angiography, and adverse events(AEs) were reviewed. Radiographic response was assessed using mRECIST ***: 22 cases of FD of focal HCC were identified. Embolics included calibrated microspheres(n = 11), microcoils(n = 4), gelfoam(n = 3), temporary balloon occlusion(n = 2) and temporary deployment of a microvascular plug(n = 1). Post-treatment SPECT-CT dosimetry coverage was concordant with target lesions in all cases. Mean follow-up was 16.7 months(1.4–45 mos). Tumor-specific response per m RECIST was 41% complete response, 50% objective response, and 59% disease control rate. No major adverse events or grade 3/4 hepatotoxicity were ***: Our findings suggest that FD prior to TARE is safe and potentially effective in treating HCC with complex vascular supply or poor tumor perfusion.

关键词： embolization routine balloon

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Burn injury differentially alters whole-blood and organ glutathione synthesis rates: An experimental model

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Burns & Trauma 2013年第2期1卷 87-94页

作者： Zhe-Wei Fei Vernon R. Young Xiao-Ming lu Andrew B. Rhodes Ronald G.Tompkins Alan J. fischman Yong-Ming Yu Shriners Burns Hospital and Burn & Trauma Service Massachusetts General Hospital Harvard Medical School Boston MA 02114 Shriners Burns Hospital and Burn & Trauma Service Massachusetts General Hospital Harvard Medical School Boston MA 02114 laboratory of Human Nutrition Massachusetts Institute of Technology Cambridge MA 02142 USA

Previous studies from our laboratories revealed a reduced rate of whole-blood (WB) glutathione (GSH) synthesis in severely burned patients. To determine whether WB GSH metabolism is an indicator of the status of GSH metabolism in one or more of the major organs, we used a burn rabbit model to determine GSH concentrations and rates of synthesis in WB, liver, lungs, kidney, and skeletal muscle. l-[1-13C]-cysteine was infused intravenously for 6 h in rabbits at 3 days post-burn and in sham burn controls. WB and organ 13C-enrichment of cysteine and GSH was determined by gas chromatography/mass spectrometry. Plasma cysteine metabolic flux was increased significantly (P llowing burn injury. WB, liver, and lung GSH concentrations (P = 0.054, P ly) and fractional rates of GSH synthesis (P ly) were reduced at 3 days post-burn. Kidney was unaffected. There also appears to be an increased rate of GSH transport out of the liver after burn injury. Hence, there is a differential impact of burn injury on tissue and organ GSH status, with WB qualitatively reflecting the changes in lung and liver. It will be important to determine whether these changes are due to alterations in the intrinsic capacity for GSH synthesis and/or availability of amino acid precursors of GSH.

关键词： Burn injury glutathione glutathione concentration synthesis rate whole blood

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肥胖动脉栓塞术治疗肥胖症试验:1年结果

国际医学放射学杂志 2019年第4期 492-492页

作者：吴酥 C.R.Weiss G.O.Abiola A.M.fischman l.J.Cheskin J.Vairavamurthy B.P.Holly Russell H.Morgan Department of Radiology and Radiological Science The Johns Hopkins University School of Medicine

摘要肥胖栓塞术是治疗肥胖病人的一种新的血管内治疗方法。然而,肥胖栓塞术的安全性和有效性尚不清楚。目的评估术后12个月内严重肥胖成人肥胖栓塞术的安全性和

关键词：肥胖症栓塞术安全性和有效性