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A chip-scale second-harmonic source via self-injection-locked all-optical poling

Light(science & Applications) 2023年第12期12卷 2778-2787页

作者： Marco Clementi Edgars Nitiss Junqiu Liu Elena Durán-Valdeiglesias sofiane Belahsene Hélène debr.geas Tobias JKippenberg Camille-sophie Brès Photonic systems Laboratory(PHOsL) École Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland Laboratory of Photonics and Quantum Measurements(LPQM) École Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland Almae Technologies Route de Nozay91460 MarcoussisFrance

second-harmonic generation allows for coherently bridging distant regions of the optical spectrum,with applications ranging from laser technology to self-referencing of frequency ***,accessing the nonlinear response of a medium typically requires high-power bulk sources,specific nonlinear crystals,and complex optical setups,hindering the path toward large-scale *** we address all of these issues by engineering a chip-scale second-harmonic(sH)source based on the frequency doubling of a semiconductor laser self-injection-locked to a silicon nitride *** injection-locking mechanism,combined with a high-Q microresonator,results in an ultra-narrow intrinsic linewidth at the fundamental harmonic frequency as small as 41 *** to the extreme resonant field enhancement,quasi-phase-matched second-order nonlinearity is photoinduced through the coherent photogalvanic effect and the high coherence is mapped on the generated sH *** show how such optical poling technique can be engineered to provide efficient sH generation across the whole C and L telecom bands,in a reconfigurable fashion,overcoming the need for poling *** device operates with milliwatt-level pumping and outputs sH power exceeding 2 mW,for an efficiency as high as 280%/W under electrical *** findings suggest that standalone,highly-coherent,and efficient sH sources can be integrated in current silicon nitride photonics,unlocking the potential of x(2)processes in the next generation of integrated photonic devices.

关键词： resonator harmonic injection

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从儿童原发性结核分离出的菌株对抗痨药物的敏感性

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中华结核和呼吸杂志 1957年第3期05卷 257-257页

作者： Noufflard, debr. Foussereau, Presse méd., 孙艮生(译)

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结核性脑膜炎治疗的现代方法及结果

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中华结核和呼吸杂志 1958年第4期06卷 300-300页

作者： R. debr. et al., Am. Rev. Tuberc. (suppl.) 周耀南(摘译)

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Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease

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World Journal of Gastroenterology 2013年第30期19卷 4935-4943页

作者： Jan sderman Elisabeth Norén Malin Christiansson Hanna Bragde Raphaele Thiébaut Jean-Pierre Hugot Curt Tysk Colm A O'Morain Miquel Gassull Yigael Finkel Jean-Frédéric Colombel Marc Lémann sven Almer Division of Medical Diagnostics Ryhov County Hospital55185 JnkpingSweden Department of Clinical and Experimental Medicine Linkping University58183 LinkpingSweden INsERM U843Université Paris DiderotHpital Robert Debré75019 ParisFrance Université ParisDiderot sorbonne Paris-Cité UMR84375018 ParisFrance Assistance Publique-Hopitaux de Paris Hopital Robert Debré75019 ParisFrance Division of Gastroenterology Department of MedicineUniversity HospitalSchool of Health and Medical Sciencesrebro University70185 rebroSweden school of Health and Medical sciences rebro University70185 rebroSweden Department of Gastroenterology Adelaide and Meath HospitalTallaghtDublin 24Ireland Trinity College Dublin College GreenDublin 2Ireland Health sciences Research Institute Germans Trias i Pujol08916 BadalonaSpain Department of Gastroenterology Sachs' Children's HospitalSdersjukhuset11861 StockholmSweden EPIMAD group Registre EPIMADService d'Epidémiologie et de Santé PubliqueHpital CalmetteCentre Hospitalier Universitaire de Lille59037 LilleFrance Icahn school of Medicine at Mount sinai New YorkNY 10029United States GETAID group Groupe d'Etude Thérapeutiques des Affections Inflammatoires DigestivesService de gastroentérologieHpital Saint Louis75010 ParisFrance Department of Gastroenterology UHL County Council of stergtland58185 Link pingSweden Division of Gastroenterology Karolinska InstitutetDepartment of Gastroenterology and HepatologyKarolinska university hospital14186 StockholmSweden

AIM:To investigate a possible genetic influence of claudin(CLDN)1,CLDN2 and CLDN4 in the etiology of inflammatory bowel ***:Allelic association between genetic regions of CLDN1,CLDN2 or CLDN4 and patients with inflammatory bowel disease,Crohn's disease(CD)or ulcerative colitis were investigated using both a casecontrol study approach(one case randomly selected from each of 191 swedish inflammatory bowel disease families and 333 controls)and a family-based study(463 non-swedish European inflammatory bowel disease-families).A nonsynonymous coding single nucleotide polymorphism in MORC4,located on the same linkage block as CLDN2,was investigated for association,as were two novel CLDN2 single nucleotide polymorphism markers,identified by ***:A single nucleotide polymorphism marker(rs12014762)located in the genetic region of CLDN2 was significantly associated to CD(case-control allelic OR = 1.98,95%CI:1.17-3.35,P = 0.007).MORC4 was present on the same linkage block as this CD *** the case-control approach,a significant association(case control allelic OR = 1.61,95%CI:1.08-2.41,P = 0.018)was found between CD and a nonsynonymous coding single nucleotide polymorphism(rs6622126)in *** association between the CLDN2 marker and CD was not replicated in the familybased *** colitis was not associated to any of the single nucleotide polymorphism ***:These findings suggest that a variant of the CLDN2-MORC4 region predisposes to CD in a swedish population.

关键词： Crohn’s disease Genetic predisposition Inflammatory bowel disease single nucleotide polymorphism Tight junctions

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Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers

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World Journal of Gastroenterology 2008年第7期14卷 1053-1059页

作者： Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur Centre de RechercheJean-Pierre Aubert-JPARC INSERM U837Equipe Mucinesdifférenciation et cancérogenèseépithélialesLaboratoire deBiochimie et Biologie MoléculaireCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Laboratoire d'Anatomie et CytologiePathologiques CHRU de LilleLilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Service de Chirurgie Digestiveet GénéraleCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Laboratoire d'Anatomie et Cytologie PathologiquesCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837and Laboratoire de Biochimie etBiologie MoléculaireCHRU de LilleLilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Laboratoire de Biochimie et Biologie MoléculaireCHRU de LilleLilleFrance Laboratoire d'Immunologie et GénétiqueTunis-ElManarTunisie Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837LilleFrance Laboratoire de Biochimie et Biologie Moléculaire CHRU de LilleLilleFrance Centre de RechercheJean-Pierre Aubert-JPARC INSERM U837Equipe Mucinesdifférenciation et cancérogenèseépithélialesLaboratoire de Biochimie et Biologie MoléculaireCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance present address INsERMU843 Université Paris 7Hpital R.DebréParisFrance

AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-ssRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal ***:The CA-ssRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MsI)status[42 with highfrequency MsI(MsI-H)and 44 microsatellite stable(Mss)]and their respective normal *** effect of the CA-ssRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and ***:Mutations in CA-ssRⅠwere detected in 86%(36 of 42)of MsI-H colorectal tumors and 0%(0 of 44)ofMss tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(Pssion of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-ssRⅠstatus in tumors or normal ***:Our results suggest that CA-ssRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer.

关键词： Epidermal growth factor receptor Microsatellite instability Allelic imbalance Gene polymorphism Expression Colorectal cancer

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双胎妊娠的胎先露类型对分娩方式的影响:1992—2000年614例患者研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 15-16页

作者： sibony O. Touitou s. Luton D. 张新艳 Department of Perinatalogy Service de Gynecologie-ObstetriqueHpital Robert Debré48 Boulevard Sérurier75019 ParisFrance

Objectives:To study modes of delivery and neonatal morbidity of twins as a function of their presentation. study design:The study related to 614 consecutive patientswho gave birth to twins in the maternity ward of the Hpital Robert debr.from 1992 to 2000. Group A (n = 529) included patients who gave birth after 33 weeks of gestation and group B (n = 85) before 33 weeks. The parameters studied were the mode of delivery,the need for intubation at birth,5-min Apgar score sfer to intensive care,death in the neonatal period. The chi-square test was used for statistical analysis. Results:In group A,significantly more cesarean sections were performed for breech-breech (22.6%)-and breech-vertex (16%) presentations than for vertex-vertex (10.3%) and vertex-breech (4.6%) presentations. In group B,there was no significant difference in the rate of vaginal delivery. second vertex twins of group A had significantly higher frequencies of intubation (3%) at birth and transfer to intensive care (3%) than the vertex first twins born by vaginal delivery (p = 0.01). These percentages were not significantly different from those observed for the second twins born by planned Cesarean section before the start of labor (2.8 and 5.6%,respectively). In group B,neonatal parameters did not differ significantly with the type of presentation at delivery. Conclusions:The type of presentation should not influence the choice of mode of delivery of twin pregnancies,whatever the gestational age.

关键词：胎先露双胎妊娠头先露计划剖宫产新生儿发病率周前阴道分娩率分娩发动气管插管率新生儿期

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一些小于胎龄儿的出生个体中肥胖快速形成的时间进程及影响其成年时的人体测量指标

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 55-56页

作者： Ezzahir N. Alberti C. Deghmoun s. D. Jaquet 王经纬 INsERM Unité457 Hpital Robert Debré 48 boulevard Sérurier 75019 Paris France Dr.

Although necessary for a normal final height in individuals who were born smal l for gestational age (sGA), catch-up growth is associated with drastic changes in body composition that have been suspected to favor the later development of the long-term metabolic complications by promoting central adiposity; however, the specific contribution of catch-up itself on these later complications remai ns unclear. Therefore, the aim of the study was to characterize the dynamic chan ges in adiposity during childhood in individuals who were born sGA and to invest igate their consequences on adulthood. The magnitude and the time course of post natal changes in body mass index (BMI) relative to birth and their consequences on adult adiposity were investigated in 127 adults who were born sGA and had ava ilable serial anthropometric data in childhood (0-6 y) and adulthood. Catch-up in BMI, observed in 91 %of individuals who were born sGA, was mostly completed within the first or second year of age. Overall, adult BMI was correlated with the magnitude of gain in BMI during childhood. However, this effect was signific ant only when this gain persisted after the first year of life. similarly, the i nfluence of the magnitude in gain in BMI on the risk for adult BMI >25 kg/m2 was significantly influenced by the age at which the gain in BMI occurred. In summa ry, although the extent of catch-up in BMI affects adiposity in adulthood, this effect is mostly deleterious when occurring after 1 y of age, suggesting that a rapid catch-up process should be more suitable than a delayed one. Whether thi s observation holds through regarding the metabolic syndrome remains to be eluci dated.

关键词：小于胎龄儿人体测量儿童期肥胖成人体重代谢综合征生时向心性肥胖动态变化特征成人期特异

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severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

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World Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy Anais R.Briant Etienne Javouhey sophie Breinig Julia Dina Marion Caseris Francois Angoulvant stephane Leteurtre Morgan Recher David W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive Care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-Cite ParisFrance Biostatistics and Clinical Research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andPediatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical school Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU sainte Justine Research Center MontréalCanada

Background severe acute respiratory syndrome coronavirus-2(sARs-CoV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of sARs-CoV-2 on the mortality rate associated with sARs-CoV-2-related illnesses in the pediatric intensive care unit(PICU).secondary objectives were to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old with positive sARs-CoV-2 polymerase chain reactions(PCRs)[acute corona virus disease 2019(COVID-19)or incidental sARs-CoV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMs)recorded in the French PICU registry(PICURe)between september 1,2021,and August 31,*** patients were classified and compared according to their living status at the end of their PICU *** patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of sARs-CoV-2 as the cause of death was classified into four categories:certain,very probable,possible,or unlikely,and was defined by any of the first three *** There were 948 patients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to sARs-CoV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to sARs-CoV-2 was considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients were admitted for pediatric inflam-matory multisystem syndrome(PIMs).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** sARs-CoV-2 mortality in the French pediatric population was *** though the imputability of sARs-Cov-2 on mortality was considered in almost two-thirds of cases,this imputability was considered certain in only one case.

关键词： Death Pediatric intensive care unit sARs-CoV-2

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人为性皮炎:31例患者的回顾性研究(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 32-32页

作者： Verraes-Derancourt s. Derancourt C. Poot F. 李晓莉 service de Dermatologie H■pital Robert DebréAve.du Général Koenig51092 Reims Cedex

*** outcome for patients with dermatitis artefacta is not well *** primary objective of this single-centre retrospective study was to describe the initial clinical aspects and the prognosis of the *** secondary objective was to describe the somatic and psychological management and longterm treatment of these *** and *** of patients with dermatitis artefacta followed in the dermatology department over the 15 last years were reviewed independently by 2 *** criteria consisted of evocative clinical pictures and the exclusion of other forms of *** collection included:file analysis,photographs,review questionnaires sent to general practitioner or completed during a phone call to patients(follow-up data).***-one patient files were selected:23 women and 8 men,mean age 31 years(sD = 14.8).Clinical aspects included:erythema(50%),ulceration(37%),crust(23%)and blisters(17%).The main sites were the face(67%)and arms(43%).Topical treatment was prescribed in all cases and systemic treatment was prescribedin 23%of *** support was offered to 65%of the patients and was accepted by 50%.A follow-up study was performed for 17 patients and showed serious complications in 4 cases consisting of psychosis(n = 2)and/or severe self-mutilation(n = 3)occurring over several years following diagnosis(5 years for one patient and 12 years for 2 patients).*** results confirm the usual and characteristics of dermatitis artefacta such as predominance in young female patients,with lesions affecting visible areas(face,upper legs).In contrastwith published studies,no cases of attempted suicide were observed in our series,although severe dermatitis artefacta was evidenced in only a minority of patients.

关键词：人为性皮炎皮肤科医师职业医师疾病分析资料收集自杀倾向单中心问卷调查

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羊水消化酶测定诊断脊柱裂脊膜膨出引起的胎儿肛门失禁

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世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 62-62页

作者： Talabani H. Dreux s. Luton D. F. Muller 刘凯 Biochimie Hormonale Hpital Robert Debré 48 Boulevard Sérurier 75935 Paris Cedex 19 France.Dr

The goals of this study were to determine whether anal sphincter dysfunction in spina bifida develops during fetal life or after birth and whether it reflects the severity of spina bifida and therefore can be used as a criterion to select the cases that could benefit from in utero surgery. Total protein and digestive enzyme activities [γ-glutamyl transpeptidase (GGTP), aminopeptidase M (AMP), and alkaline phosphatase isoenzymes including the intestinal form (iALP)] were assayed retrospectively in amniotic fluid from 80 myelomeningocele spina bifida cases without unrelated associated malformation (gestational age 14-33 wk). A normal enzyme activity profile was observed in 46 of the 80 cases. Two abnormal profiles were observed: 1) bilious vomiting, characterized by abnormally high GGTP and AMP activities but normal iALP, and 2) digestive enzyme leakage, characterized by abnormally high activities of GGTP, AMP, and iALP, typical of anal incontinence. No relation was observed between these enzyme activity profiles and the different secondary signs of spina bifida or the level of the damage. In concluson, anal sphincter dysfunction in spina bifida revealed by amniotic fluid digestive enzyme activities occurred before 24 wk in fetal life in 28.7%of cases. This criterion may be indicative of the severity of spina bifida and therefore perhaps could be used to select cases that are suited to in utero surgery. It could also be used to establish the potential benefit of this surgery in fecal incontinence.

关键词：肛门失禁脊膜膨出脊柱裂胎儿期羊水括约肌功能障碍酶测定 γ-谷氨酰转肽酶诊断消化

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