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Case report of a traumatic rectal neuroma

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Gastroenterology Report 2016年第4期4卷 331-333,I0003页

作者： Thomas Curran Vitaliy Poylin Robert Kane Anna Harris Jeffrey DGoldsmith deborah Nagle Department of Surgery Division of Colorectal SurgeryBeth Israel Deaconess Medical CenterBostonMAUSA Department of Radiology Beth Israel Deaconess Medical CenterBostonMAUSA Department of Pathology Beth Israel Deaconess Medical CenterBostonMAUSA

Traumatic neuroma is a well-recognized complication of lower extremity amputation,yet has also been noted to occur *** report a clinical case and English-language literature review of traumatic rectal neuroma,a well-k... 详细信息

关键词： Traumatic rectal neuroma transanal endoscopic microsurgery

Characterization of aerosol optical properties, chemical composition and mixing states in the winter season in Shanghai, China

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Journal of Environmental Sciences 2014年第12期26卷 2412-2422页

作者： Yong Tang Yuanlong Huang Ling Li Hong Chen Jianmin Chen Xin Yang Song Gao deborah S.Gross Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan University Fudan-Tyndall Center Fudan University Division of Math Science and Technology Nova Southeastern University Fort Lauderdale FL 33314 USA Department of Chemistry Carleton College Northfield MN 55057 USA

Physical and chemical properties of ambient aerosols at the single particle level were studied in Shanghai from December 22 to 28, 2009. A Cavity-Ring-Down Aerosol Extinction Spectrometer（CRD-AES） and a nephelometer were deployed to measure aerosol light extinction and scattering properties, respectively. An Aerosol Time-of-Flight Mass Spectrometer（ATOFMS）was used to detect single particle sizes and chemical composition. Seven particle types were detected. Air parcels arrived at the sampling site from the vicinity of Shanghai until mid-day of December 25, when they started to originate from North China. The aerosol extinction,scattering, and absorption coefficients all dropped sharply when this cold, clean air *** particles changed from a highly aged type before this meteorological shift to a relatively fresh type afterwards. The aerosol optical properties were dependent on the wind *** with high extinction coefficient and scattering Angstrom exponent（SAE） were observed when the wind blew from the west and northwest, indicating that they were predominantly fine particles. Nitrate and ammonium correlated most strongly with the change in aerosol optical properties. In the elemental carbon/organic carbon（ECOC） particle type, the diurnal trends of single scattering albedo（SSA） and elemental carbon（EC） signal intensity had a negative correlation. We also found a negative correlation（r =-0.87） between high mass-OC particle number fraction and the SSA in a relatively clean period, suggesting that particulate aromatic components might play an important role in light absorption in urban areas.

关键词： Aerosol optical properties Chemical composition CRDS ATOFMS

The past, present, and future of targeted therapeutic approaches in patients with diffuse pleural mesotheliomas

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 194-209页

作者： Michael Offin Bailey Fitzgerald Marjorie G.Zauderer deborah Doroshow Thoracic Oncology Service Department of MedicineMemorial Sloan Kettering Cancer CenterWeill Cornell Medical CollegeNew YorkNY 10065USA Division of Hematology and Medical Oncology Tisch Cancer InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA

Despite our growing understanding of the genomic landscape of diffuse pleural mesotheliomas(DPM),there has been limited success in targeted therapeutic strategies for the *** review summarizes attempts to develop targeted therapies in DPM,focusing on the following targets being clinically explored in recent and ongoing clinical trials:vascular endothelial growth factor,mesothelin,BRCA1-associated protein 1,Wilms tumor 1 protein,NF2/YAP/TAZ,CDKN2,methylthioadenosine phosphorylase,v-domain Ig suppressor T-cell activation,and argininosuccinate synthetase *** preclinical data for these targets are promising,few have efficaciously translated to benefit our *** efforts should seek to expand the availability of preclinical models that faithfully recapitulate DPM biology,develop clinically relevant biomarkers,and refine patient selection criteria for clinical trials.

关键词： Mesothelioma targeted therapy biomarkers genomics

Real-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events

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Stroke & Vascular Neurology 2024年第5期9卷 519-529页

作者： Jason J Sico Xin Hu Laura J Myers deborah Levine Dawn M Bravata Greg W Arling Internal Medicine and Neurology Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Veterans Affairs Connecticut Healthcare SystemWest HavenConnecticutUSA Yale School of Public Health New HavenConnecticutUSA VA Health Services Research and Development(HSR&D)Center for Healthcare Informatics and Communication and the HSR&D Stroke Quality Enhancement Research Initiative(QUERI) IndianapolisIndianaUSA Richard L.Roudebush VA Medical Center IndianapolisIndianaUSA Departments of Medicine and Neurology University of Michigan School of MedicineAnn ArborMichiganUSA Health Services Research and Development(HSR&D)Center for Healthcare Informatics and Communication and the HSR&D Stroke Quality Enhancement Research Initiative(QUERI) Department of Veterans Affairs(VA) Health Services Research and Development(HSR&D)Precision Monitoring to Transform Care(PRISM)Quality Enhancement Research Initiative(QUERI)IndianapolisIndianaUSA Department of Nursing Purdue UniversityWest LafayetteIndianaUSA

Introduction Whether obtaining the more intensive goal systolic blood pressure(SBP)of140mm Hg).Separate multivariable Cox proportional hazard regressions were used to examine the relationship between average SBP groups and time to:(1)mortality and(2)any recurrent vascular event,from 90 days to up to 365 days after discharge from the index emergency department visit or inpatient *** Compared with those with SBP>140mm Hg,patients with SBP between 116 and 130mm Hg had a significantly lower risk of recurrent stroke/TIA(HR 0.77,95%CI 0.60 to 0.99)but not cardiovascular *** with SBP lower than 105mm Hg,compared with those with>140mm Hg demonstrated a statistically significant higher risk of death(HR 2.07,95%CI 1.43 to 3.00),but no statistical differences were found in other SBP *** Data support a more intensive SBP goal to prevent recurrent cerebrovascular events among stroke/TIA patients by 90 days poststroke/TIA compared with less intensive *** low SBPs were associated wit

关键词： dialysis diagnosis TIA

Assessment of landslide susceptibility using DBSCAN-AHD and LD-EV methods

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Journal of Mountain Science 2022年第1期19卷 184-197页

作者： MAO Yi-min MWAKAPESA deborah S LI Yi-can XU Kai-bin NANEHKARAN Yaser A ZHANG Mao-sheng School of Information Engineering Jiangxi University of Science and TechnologyGanzhou 341000China Key Laboratory for Geo-hazards in Loess Area Xi’an 710054China Northwest Nonferrous Geological Mining Group Limited Company Xi’an 710054China

Landslide susceptibility assessment plays a vital role in understanding landslide information in advance and taking preventive as well as control measures. The need to initially specify the number of clusters, difficulty in handling noise and quantifying rainfall data, limits the application of traditional clustering models in landslide susceptibility assessment which then lowers their performance accuracy. Thus, to overcome these limitations, this study proposed an improved clustering algorithm titled the DBSCAN-AHD algorithm, which combines the traditional DBSCAN(Density Based Spatial Clustering of Application with Noise) algorithm and an Adaptive Hausdorff Distance(AHD) for landslide susceptibility modeling. Firstly, AHD was introduced to the traditional DBSCAN to quantify rainfall. Then,the DBSCAN-AHD grouped the mapping units with similar topology and geology characteristics into subclasses without specifying the number of clusters in advance for its ability to handle noise in the ***, the LD-EV(landslide density or eigenvalues) approach was introduced to obtain the susceptibility levels using K-means algorithm. Finally,to verify the model’s performance, statistical indices and the area under the curve(AUC) were applied and compared to the traditional DBSCAN, KPSO, Kmeans and Hierarchical Clustering algorithms,whereby, the proposed model outperformed the others. Also, the obtained susceptibility map can provide references in taking relevant preventive and control measures.

关键词： Landslide susceptibility DBSCAN Machine learning algorithm Uncertain data Clustering algorithm

Exposing the urban continuum:implications and crosscomparison from an interdisciplinary perspective

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International Journal of Digital Earth 2020年第1期13卷 22-44页

作者： Johannes H.Uhl Hamidreza Zoraghein Stefan Leyk deborah Balk Christina Corbane Vasileios Syrris Aneta JFlorczyk Department of Geography University of Colorado BoulderBoulderCOUSA National Center for Atmospheric Research(NCAR) BoulderCOUSA CUNY Institute for Demographic Research and Baruch College City University of New YorkNew York CityNYUSA European Commission Joint Research Centre(JRC)IspraItaly

There is an increasing availability of geospatial data describing patterns of human settlement and population such as various global remote-sensing based built-up land layers,fine-grained census-based population estimates,and publicly available cadastral and building footprint *** development constitutes new integrative modeling opportunities to characterize the continuum of urban,peri-urban,and rural settlements and ***,little research has been done regarding the agreement between such data products in measuring human presence which is measured by different proxy variables(*** of built-up structures derived from different remote sensors,census-derived population counts,or cadastral land parcels).In this work,we quantitatively evaluate and cross-compare the ability of such data to model the urban continuum,using a unique,integrated validation database of cadastral and building footprint data,*** data,and three different versions of the Global Human Settlement Layer(GHSL)derived from remotely sensed *** identify advantages and shortcomings of these data types across different geographic settings in the U.S.,which will inform future data users on implications of data accuracy and suitability for a given application,even in data-poor regions of the world.

关键词： Built-up surfaces Global Human Settlement Layer(GHSL) Sentinel-1 Landsat agreement assessment urban modeling cadastral parcel data U.S.census data

Endoscopic management of difficult common bile duct stones:Where are we now?A comprehensive review

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World Journal of Gastroenterology 2021年第44期27卷 7597-7611页

作者： Alberto Tringali deborah Costa Alessandro Fugazza Matteo Colombo Kareem Khalaf Alessandro Repici Andrea Anderloni Gastroenterology and Endoscopy Unit Department of MedicineConegliano HospitalULSS 2 Marca TrevigianaConegliano 31015Italy Digestive Endoscopy Unit Department of GastroenterologyHumanitas Research Hospital IRCCSRozzano 20089MilanItaly Department of Biomedical Sciences Humanitas UniversityPieve Emanuele 20072MilanItaly

Endoscopic management for difficult common bile duct(CBD)stones still presents a challenge for several reasons,including anatomic anomalies,patients’individual conditions and stone *** recent years,variable methods have emerged that have attributed to higher stone removal success rates,reduced cost and lower adverse *** this review,we outline a stepwise approach in CBD stone *** first line therapy,endoscopic sphincterotomy and large balloon dilation are recommended,due to a 30%-50%reduction of the use of mechanical *** the other hand,cholangioscopy-assisted lithotripsy has been increasingly reported as an effective and safe alternative technique to mechanical lithotripsy but remains to be reserved in special settings due to limited large-scale *** discussed,findings suggest that management needs to be tailored to the patient’s characteristics and anatomical ***,we evaluate the management of CBD stones in various surgical altered anatomy(Billroth II,Roux-en-Y and Roux-en-Y gastric bypass).Moreover,we could conclude that cholangioscopy-assisted lithotripsy needs to be evaluated for primary use,rather than following a failed management *** addition,we discuss the importance of dissecting other techniques,such as the primary use of interventional endoscopic ultrasound for the management of CBD stones when other techniques have *** conclusion,we recognize that endoscopic sphincterotomy and large balloon dilation,mechanical lithotripsy and intraductal lithotripsy substantiate an indication to the management of difficult CBD stones,but emerging techniques are in rapid evolution with encouraging results.

关键词： Common bile duct stones Balloon dilation Endoscopic retrograde cholangiopancreatography Endoscopic ultrasonography Anastomoses,Roux en y Double balloon enteroscopy Mechanical lithotripsy Cholangioscopy

A Theoretically Grounded Question Answering Data Set for Evaluating Machine Common Sense

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Data Intelligence 2024年第1期6卷 1-28页

作者： Henrique Santos Ke Shen Alice M.Mulvehill Mayank Kejriwal deborah L.McGuinness Rensselaer Polytechnic Institute Troy NY Information Sciences Institute Marina del Rey CA

Achieving machine common sense has been a longstanding problem within Artificial *** far,benchmark data sets that are grounded in a theory of common sense and can be used to conduct rigorous,semantic evaluations of common sense reasoning(CSR)systems have been *** expectation of the AI community is that neuro-symbolic reasoners can help bridge this gap towards more dependable systems with common *** propose a novel benchmark,called Theoretically Grounded common sense Reasoning(TG-CSR),modeled as a set of question answering instances,with each instance grounded in a semantic category of common sense,such as space,time,and *** benchmark is few-shot i.e.,only a few training and validation examples are provided in the public release to avoid the possibility of *** from recent evaluations suggest that TG-CSR is challenging even for state-of-the-art statistical *** to its semantic rigor,this benchmark can be used to evaluate the common sense reasoning capabilities of neuro-symbolic systems.

关键词： reasoning Intelligence instance

Development of stem cell-based therapy for Parkinson’s disease

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Translational Neurodegeneration 2015年第1期4卷 120-132页

作者： Fabin Han deborah Baremberg Junyu Gao Jing Duan Xianjie Lu Nan Zhang Qingfa Chen Centre for Stem Cells and Regenerative Medicine The Liaocheng People’s Hospital/Affiliated Liaocheng HospitalTaishan Medical UniversityShandong 252000China

Parkinson’s disease(PD)is one of the most common neurodegenerative disorders of aging,characterized by the degeneration of dopamine neurons(DA neurons)in the substantial nigra,leading to the advent of both motor symptoms and non-motor *** treatments include electrical stimulation of the affected brain areas and dopamine replacement *** though both categories are effective in treating PD patients,the disease progression cannot be *** research advance into cell therapies provides exciting potential for the treatment of *** cell sources include neural stem cells(NSCs)from fetal brain tissues,human embryonic stem cells(hESCs),induced pluripotent stem cells(iPSCs)and directly induced dopamine neurons(iDA neurons).Here,we evaluate the research progress in different cell sources with a focus on using iPSCs as a valuable source and propose key challenges for developing cells suitable for large-scale clinical applications in the treatment of PD.

关键词： Parkinson’s disease Dopamine neuron Neural stem cell Human embryonic stem cells Induced pluripotent stem cell Induced dopamine neuron