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Pneumocystis jiroveci pneumonia and pneumomediastinum in an anti-TNFαnaive patient with ulcerative colitis

World Journal of Gastroenterology 2009年第15期15卷 1897-1900页

作者： James C Lee deborah C bell Richard M Guinness Tariq Ahmad Department of Gastroenterology Royal Devon and Exeter Hospital

We report the case of a 21-year-old man who was noted to have pneumomediastinum during an admission for an acute flare of ulcerative colitis. At that time, he was on maintenance treatment with azathioprine at a dose of 2.25 mg/kg per day, and had not received supplementary steroids for 9 mo. He had never received anti-tumor necrosis factor （TNF）α therapy. Shortly after apparently effective treatment with intravenous steroids and an increased dose of azathioprine, he developed worsening colitic and new respiratory symptoms, and was diagnosed with Pneumocystis jiroveci （carinii） pneumonia （PCP）. Pneumomediastinum is rare in immunocompetent hosts, but is a recognized complication of PCP in human immunodeficiency virus （HIV） patients, although our patient＇s HIV test was negative. Treatment of PCP with co-trimoxazole resulted in resolution of both respiratory and gastrointestinal symptoms, without the need to increase the steroid dose. There is increasing vigilance for opportunistic infections in patients with inflammatory bowel disease following the advent of anti-TNFα therapy. This case emphasizes the importance of considering the possibility of such infections in all patients with inflammatory bowel disease, irrespective of the immunosuppressants they receive, and highlights the potential of steroid-responsive opportunistic infections to mimic worsening colitic symptoms in patients with ulcerative colitis.

关键词： Pneumocystis jiroveci Ulcerative colitis Pneumomediastinum Azathioprine Corticosteroids

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Reporter Genes: A Practical Guide (Methods in Molecular Biology) 1

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丛书名： Methods in Molecular Biology 411

2007年

作者： Siobhan Loughna and deborah Henderson Philip A. Seymour and Maike Sander Maria Limberis Peter bell and James M. Wilson Wolfgang J. Weninger and Timothy J. Mohun George H. Patterson Karin Edoff James S. Dods and Andrea H. Brand Charles G. Bailey and

ISBN: (纸本)9781588297396

Reporter genes have played, and continue to play, a vital role in many areas of biological research by providing a ready means for qualitative and quantitative assessment of the activity of genes and location of gene products in different environments. This book describes practical protocols for experimentation with the most useful reporter genes for mammalian systems that are available

关键词： Genes Reporter

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Artificial Enamel Wear after Prolonged Chewing Simulation against Monolithic Y-TZP Crowns

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Materials Sciences and Applications 2018年第4期9卷 381-392页

作者： deborah Vedana Leonardo Vedana Emerson Alves Martins Peter Brodersen Grace M. De Souza Prosthodontics Department University of Vale do Itajai Itajai Brazil Department of Chemical Engineering and Applied Chemistry Faculty of Applied Science & Engineering University of Toronto Toronto Canada Faculty of Dentistry University of Toronto Toronto Canada

The aim of this study was to evaluate the effect of chewing simulation on wear of artificial enamel abraded against zirconia-based crowns. Fifteen crown preparations were scanned for the manufacturing of crowns using computer-aided-design/computer-aided-machining technique (CAD/cam), according to the following (n = 5): Polished (PM) and glazed (GM) monolithic zirconia (1.5 mm uniform thickness), and Bilayer (BL - 0.8 mm zirconia coping, 0.7 mm porcelain veneer) crowns. The samples were cemented and chewing simulation (2.5 million cycles/0-80N/artificial saliva/37°C) was performed with steatite indenters (6 mm diameter) as antagonists. Assuming the uniformity of the unaged samples, antagonists were scanned using a surface profilometer and the material loss volume was calculated. Roughness of the crowns’ occlusal surface was also analyzed using the profilometer. Scanning electron microscopy was used to characterize the abraded surface. One-way ANOVA and Tukey test (p = 0.05) were employed for analysis of wear results. A significant difference was observed among the groups (p 3 ± 0.015) than those abraded against monolithic zirconia, polished (PM - 0.167 mm3 ± 0.02) and glazed (0.101 mm3 ± 0.03), which were similar to each other. Veneering porcelain results in more pronounced wear of the artificial enamel than monolithic zirconia. However, mastication against monolithic Y-TZP also imposes wear to the opposing teeth.

关键词： Tooth Wear Ceramics Tooth Abrasion Dental Porcelain

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